Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H4T6_LEIDO

TriTrypDb:

LdBPK_010170.1 , LdCL_010006700 , LDHU3_01.0190

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H4T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4T6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.711
CLV_MEL_PAP_1	299	305	PF00089	0.707
CLV_NRD_NRD_1	205	207	PF00675	0.800
CLV_NRD_NRD_1	30	32	PF00675	0.823
CLV_NRD_NRD_1	301	303	PF00675	0.710
CLV_PCSK_KEX2_1	205	207	PF00082	0.800
CLV_PCSK_KEX2_1	30	32	PF00082	0.827
CLV_PCSK_KEX2_1	301	303	PF00082	0.608
CLV_PCSK_KEX2_1	332	334	PF00082	0.604
CLV_PCSK_KEX2_1	431	433	PF00082	0.608
CLV_PCSK_KEX2_1	50	52	PF00082	0.503
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.604
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.608
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.751
CLV_PCSK_SKI1_1	285	289	PF00082	0.583
CLV_PCSK_SKI1_1	296	300	PF00082	0.512
CLV_PCSK_SKI1_1	46	50	PF00082	0.625
DEG_APCC_DBOX_1	216	224	PF00400	0.604
DEG_APCC_DBOX_1	230	238	PF00400	0.484
DEG_SPOP_SBC_1	137	141	PF00917	0.708
DOC_ANK_TNKS_1	159	166	PF00023	0.750
DOC_CKS1_1	306	311	PF01111	0.670
DOC_CYCLIN_RxL_1	61	70	PF00134	0.642
DOC_MAPK_gen_1	217	225	PF00069	0.560
DOC_MAPK_gen_1	443	452	PF00069	0.785
DOC_MAPK_MEF2A_6	251	259	PF00069	0.629
DOC_PP2B_LxvP_1	101	104	PF13499	0.611
DOC_PP2B_LxvP_1	363	366	PF13499	0.571
DOC_PP4_FxxP_1	25	28	PF00568	0.611
DOC_PP4_FxxP_1	377	380	PF00568	0.690
DOC_USP7_MATH_1	120	124	PF00917	0.723
DOC_USP7_MATH_1	137	141	PF00917	0.526
DOC_USP7_MATH_1	175	179	PF00917	0.806
DOC_USP7_MATH_1	279	283	PF00917	0.572
DOC_USP7_MATH_1	338	342	PF00917	0.686
DOC_USP7_MATH_1	396	400	PF00917	0.776
DOC_USP7_MATH_1	411	415	PF00917	0.592
DOC_USP7_MATH_1	86	90	PF00917	0.767
DOC_USP7_UBL2_3	46	50	PF12436	0.722
DOC_WW_Pin1_4	112	117	PF00397	0.760
DOC_WW_Pin1_4	121	126	PF00397	0.721
DOC_WW_Pin1_4	20	25	PF00397	0.818
DOC_WW_Pin1_4	305	310	PF00397	0.743
DOC_WW_Pin1_4	375	380	PF00397	0.755
DOC_WW_Pin1_4	416	421	PF00397	0.760
DOC_WW_Pin1_4	423	428	PF00397	0.714
LIG_14-3-3_CanoR_1	231	237	PF00244	0.635
LIG_14-3-3_CanoR_1	244	248	PF00244	0.410
LIG_14-3-3_CanoR_1	322	331	PF00244	0.697
LIG_14-3-3_CanoR_1	369	374	PF00244	0.759
LIG_14-3-3_CanoR_1	400	408	PF00244	0.769
LIG_14-3-3_CanoR_1	446	451	PF00244	0.710
LIG_Actin_WH2_2	299	317	PF00022	0.538
LIG_BIR_III_2	85	89	PF00653	0.611
LIG_BRCT_BRCA1_1	21	25	PF00533	0.626
LIG_deltaCOP1_diTrp_1	194	200	PF00928	0.787
LIG_deltaCOP1_diTrp_1	266	276	PF00928	0.616
LIG_DLG_GKlike_1	369	376	PF00625	0.488
LIG_FHA_1	428	434	PF00498	0.760
LIG_FHA_1	451	457	PF00498	0.705
LIG_FHA_2	183	189	PF00498	0.716
LIG_FHA_2	315	321	PF00498	0.660
LIG_FHA_2	343	349	PF00498	0.671
LIG_FHA_2	80	86	PF00498	0.675
LIG_Integrin_RGD_1	71	73	PF01839	0.751
LIG_LIR_Apic_2	192	198	PF02991	0.713
LIG_LIR_Apic_2	22	28	PF02991	0.617
LIG_LIR_Gen_1	185	191	PF02991	0.765
LIG_LIR_Gen_1	252	261	PF02991	0.567
LIG_LIR_Gen_1	96	104	PF02991	0.612
LIG_LIR_Nem_3	185	189	PF02991	0.767
LIG_LIR_Nem_3	199	203	PF02991	0.586
LIG_LIR_Nem_3	252	257	PF02991	0.564
LIG_LIR_Nem_3	422	428	PF02991	0.613
LIG_LIR_Nem_3	96	101	PF02991	0.614
LIG_MYND_1	312	316	PF01753	0.573
LIG_SH2_CRK	425	429	PF00017	0.621
LIG_SH2_CRK	98	102	PF00017	0.620
LIG_SH2_NCK_1	344	348	PF00017	0.795
LIG_SH2_NCK_1	425	429	PF00017	0.609
LIG_SH2_STAP1	265	269	PF00017	0.513
LIG_SH2_STAP1	98	102	PF00017	0.620
LIG_SH2_STAT3	238	241	PF00017	0.546
LIG_SH2_STAT5	134	137	PF00017	0.710
LIG_SH2_STAT5	238	241	PF00017	0.508
LIG_SH2_STAT5	258	261	PF00017	0.306
LIG_SH2_STAT5	339	342	PF00017	0.746
LIG_SH2_STAT5	344	347	PF00017	0.740
LIG_SH3_1	307	313	PF00018	0.691
LIG_SH3_2	310	315	PF14604	0.562
LIG_SH3_3	124	130	PF00018	0.577
LIG_SH3_3	169	175	PF00018	0.814
LIG_SH3_3	21	27	PF00018	0.805
LIG_SH3_3	306	312	PF00018	0.689
LIG_SH3_3	405	411	PF00018	0.729
LIG_SH3_3	414	420	PF00018	0.606
LIG_SUMO_SIM_anti_2	233	238	PF11976	0.540
LIG_SUMO_SIM_par_1	167	173	PF11976	0.818
LIG_SUMO_SIM_par_1	276	282	PF11976	0.536
LIG_SUMO_SIM_par_1	371	378	PF11976	0.492
LIG_TRAF2_1	351	354	PF00917	0.687
LIG_UBA3_1	65	69	PF00899	0.643
LIG_ULM_U2AF65_1	30	35	PF00076	0.698
MOD_CK1_1	136	142	PF00069	0.786
MOD_CK1_1	173	179	PF00069	0.728
MOD_CK1_1	267	273	PF00069	0.625
MOD_CK1_1	305	311	PF00069	0.704
MOD_CK1_1	37	43	PF00069	0.719
MOD_CK1_1	406	412	PF00069	0.669
MOD_CK1_1	415	421	PF00069	0.746
MOD_CK1_1	57	63	PF00069	0.492
MOD_CK1_1	76	82	PF00069	0.531
MOD_CK2_1	165	171	PF00069	0.821
MOD_CK2_1	182	188	PF00069	0.514
MOD_CK2_1	190	196	PF00069	0.697
MOD_CK2_1	347	353	PF00069	0.635
MOD_CK2_1	39	45	PF00069	0.822
MOD_Cter_Amidation	203	206	PF01082	0.797
MOD_GlcNHglycan	135	138	PF01048	0.729
MOD_GlcNHglycan	150	154	PF01048	0.565
MOD_GlcNHglycan	392	395	PF01048	0.778
MOD_GlcNHglycan	403	406	PF01048	0.602
MOD_GlcNHglycan	408	411	PF01048	0.538
MOD_GlcNHglycan	421	424	PF01048	0.508
MOD_GlcNHglycan	51	54	PF01048	0.744
MOD_GlcNHglycan	56	59	PF01048	0.688
MOD_GlcNHglycan	75	78	PF01048	0.564
MOD_GlcNHglycan	88	91	PF01048	0.565
MOD_GSK3_1	133	140	PF00069	0.780
MOD_GSK3_1	16	23	PF00069	0.677
MOD_GSK3_1	338	345	PF00069	0.676
MOD_GSK3_1	34	41	PF00069	0.567
MOD_GSK3_1	388	395	PF00069	0.791
MOD_GSK3_1	411	418	PF00069	0.765
MOD_GSK3_1	419	426	PF00069	0.663
MOD_GSK3_1	446	453	PF00069	0.711
MOD_GSK3_1	6	13	PF00069	0.748
MOD_GSK3_1	93	100	PF00069	0.646
MOD_N-GLC_1	120	125	PF02516	0.714
MOD_N-GLC_1	16	21	PF02516	0.755
MOD_N-GLC_1	212	217	PF02516	0.532
MOD_N-GLC_2	362	364	PF02516	0.681
MOD_NEK2_1	133	138	PF00069	0.789
MOD_NEK2_1	323	328	PF00069	0.745
MOD_NEK2_1	368	373	PF00069	0.699
MOD_NEK2_1	388	393	PF00069	0.772
MOD_NEK2_1	49	54	PF00069	0.747
MOD_NMyristoyl	1	7	PF02799	0.785
MOD_PIKK_1	170	176	PF00454	0.812
MOD_PKA_2	204	210	PF00069	0.794
MOD_PKA_2	230	236	PF00069	0.632
MOD_PKA_2	243	249	PF00069	0.412
MOD_PKA_2	314	320	PF00069	0.585
MOD_PKA_2	34	40	PF00069	0.766
MOD_PKA_2	368	374	PF00069	0.700
MOD_PKA_2	406	412	PF00069	0.671
MOD_PKA_2	79	85	PF00069	0.776
MOD_PKB_1	33	41	PF00069	0.636
MOD_Plk_1	16	22	PF00069	0.621
MOD_Plk_1	215	221	PF00069	0.700
MOD_Plk_1	267	273	PF00069	0.625
MOD_Plk_1	333	339	PF00069	0.583
MOD_Plk_2-3	182	188	PF00069	0.764
MOD_Plk_2-3	190	196	PF00069	0.697
MOD_Plk_4	139	145	PF00069	0.714
MOD_Plk_4	165	171	PF00069	0.821
MOD_Plk_4	232	238	PF00069	0.538
MOD_Plk_4	279	285	PF00069	0.480
MOD_Plk_4	369	375	PF00069	0.499
MOD_Plk_4	383	389	PF00069	0.680
MOD_Plk_4	412	418	PF00069	0.710
MOD_Plk_4	57	63	PF00069	0.724
MOD_ProDKin_1	112	118	PF00069	0.762
MOD_ProDKin_1	121	127	PF00069	0.716
MOD_ProDKin_1	20	26	PF00069	0.814
MOD_ProDKin_1	305	311	PF00069	0.742
MOD_ProDKin_1	375	381	PF00069	0.756
MOD_ProDKin_1	416	422	PF00069	0.759
MOD_ProDKin_1	423	429	PF00069	0.712
MOD_SUMO_for_1	331	334	PF00179	0.689
TRG_DiLeu_BaEn_1	295	300	PF01217	0.651
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.578
TRG_ENDOCYTIC_2	186	189	PF00928	0.715
TRG_ENDOCYTIC_2	258	261	PF00928	0.425
TRG_ENDOCYTIC_2	425	428	PF00928	0.623
TRG_ENDOCYTIC_2	98	101	PF00928	0.621
TRG_ER_diArg_1	217	220	PF00400	0.557
TRG_ER_diArg_1	259	262	PF00400	0.522
TRG_ER_diArg_1	30	33	PF00400	0.728
TRG_ER_diArg_1	300	302	PF00400	0.698
TRG_ER_diArg_1	445	448	PF00400	0.710

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H341	Leishmania braziliensis	52%	100%
A4HRD8	Leishmania infantum	99%	100%
E9AC06	Leishmania major	85%	100%
E9AJA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	97%