Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H4T3_LEIDO

TriTrypDb:

LdBPK_010130.1 , LdCL_010006300 , LDHU3_01.0150

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H4T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4T3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.471
CLV_C14_Caspase3-7	22	26	PF00656	0.632
CLV_NRD_NRD_1	113	115	PF00675	0.556
CLV_NRD_NRD_1	240	242	PF00675	0.655
CLV_NRD_NRD_1	290	292	PF00675	0.468
CLV_NRD_NRD_1	311	313	PF00675	0.624
CLV_NRD_NRD_1	327	329	PF00675	0.566
CLV_PCSK_FUR_1	110	114	PF00082	0.438
CLV_PCSK_KEX2_1	112	114	PF00082	0.566
CLV_PCSK_KEX2_1	240	242	PF00082	0.655
CLV_PCSK_KEX2_1	311	313	PF00082	0.625
CLV_PCSK_KEX2_1	327	329	PF00082	0.562
CLV_PCSK_SKI1_1	299	303	PF00082	0.503
DEG_APCC_DBOX_1	83	91	PF00400	0.408
DEG_SPOP_SBC_1	261	265	PF00917	0.677
DEG_SPOP_SBC_1	353	357	PF00917	0.647
DOC_MAPK_gen_1	291	298	PF00069	0.523
DOC_PIKK_1	283	290	PF02985	0.584
DOC_PP2B_LxvP_1	175	178	PF13499	0.469
DOC_USP7_MATH_1	10	14	PF00917	0.608
DOC_USP7_MATH_1	213	217	PF00917	0.641
DOC_USP7_MATH_1	221	225	PF00917	0.675
DOC_USP7_MATH_1	307	311	PF00917	0.636
DOC_USP7_MATH_1	317	321	PF00917	0.695
DOC_USP7_MATH_1	336	340	PF00917	0.590
DOC_USP7_MATH_1	349	353	PF00917	0.632
DOC_USP7_MATH_1	47	51	PF00917	0.570
DOC_USP7_MATH_1	65	69	PF00917	0.406
DOC_WW_Pin1_4	192	197	PF00397	0.652
DOC_WW_Pin1_4	321	326	PF00397	0.679
DOC_WW_Pin1_4	37	42	PF00397	0.743
LIG_14-3-3_CanoR_1	149	154	PF00244	0.406
LIG_14-3-3_CanoR_1	188	196	PF00244	0.649
LIG_14-3-3_CanoR_1	338	343	PF00244	0.665
LIG_14-3-3_CanoR_1	345	354	PF00244	0.552
LIG_Actin_WH2_2	134	151	PF00022	0.417
LIG_Actin_WH2_2	72	90	PF00022	0.508
LIG_BIR_II_1	1	5	PF00653	0.590
LIG_BRCT_BRCA1_1	151	155	PF00533	0.406
LIG_FHA_1	142	148	PF00498	0.384
LIG_FHA_1	38	44	PF00498	0.681
LIG_FHA_2	231	237	PF00498	0.716
LIG_FHA_2	52	58	PF00498	0.462
LIG_LIR_Gen_1	68	76	PF02991	0.449
LIG_LIR_Nem_3	68	72	PF02991	0.446
LIG_NRP_CendR_1	363	364	PF00754	0.628
LIG_Pex14_2	155	159	PF04695	0.417
LIG_PTB_Apo_2	168	175	PF02174	0.457
LIG_PTB_Phospho_1	168	174	PF10480	0.461
LIG_SH2_SRC	23	26	PF00017	0.647
LIG_SH2_STAT5	174	177	PF00017	0.478
LIG_TRAF2_1	132	135	PF00917	0.406
LIG_TRAF2_1	161	164	PF00917	0.454
LIG_UBA3_1	286	292	PF00899	0.487
LIG_WRC_WIRS_1	52	57	PF05994	0.448
LIG_WW_3	324	328	PF00397	0.710
MOD_CDC14_SPxK_1	195	198	PF00782	0.673
MOD_CDK_SPxK_1	192	198	PF00069	0.669
MOD_CDK_SPxK_1	321	327	PF00069	0.574
MOD_CDK_SPxxK_3	321	328	PF00069	0.577
MOD_CK1_1	189	195	PF00069	0.781
MOD_CK1_1	203	209	PF00069	0.591
MOD_CK1_1	222	228	PF00069	0.625
MOD_CK1_1	262	268	PF00069	0.695
MOD_CK1_1	271	277	PF00069	0.577
MOD_CK1_1	310	316	PF00069	0.666
MOD_CK1_1	337	343	PF00069	0.641
MOD_CK1_1	344	350	PF00069	0.628
MOD_CK1_1	352	358	PF00069	0.668
MOD_CK1_1	51	57	PF00069	0.602
MOD_CK2_1	136	142	PF00069	0.538
MOD_CK2_1	158	164	PF00069	0.467
MOD_CK2_1	230	236	PF00069	0.715
MOD_CK2_1	47	53	PF00069	0.479
MOD_CK2_1	65	71	PF00069	0.422
MOD_GlcNHglycan	209	212	PF01048	0.632
MOD_GlcNHglycan	215	218	PF01048	0.630
MOD_GlcNHglycan	221	224	PF01048	0.618
MOD_GlcNHglycan	270	273	PF01048	0.655
MOD_GlcNHglycan	319	322	PF01048	0.713
MOD_GlcNHglycan	347	350	PF01048	0.642
MOD_GlcNHglycan	37	40	PF01048	0.642
MOD_GlcNHglycan	6	9	PF01048	0.786
MOD_GSK3_1	184	191	PF00069	0.709
MOD_GSK3_1	203	210	PF00069	0.712
MOD_GSK3_1	268	275	PF00069	0.741
MOD_GSK3_1	317	324	PF00069	0.653
MOD_GSK3_1	334	341	PF00069	0.637
MOD_GSK3_1	345	352	PF00069	0.770
MOD_GSK3_1	353	360	PF00069	0.572
MOD_GSK3_1	37	44	PF00069	0.624
MOD_GSK3_1	47	54	PF00069	0.427
MOD_GSK3_1	75	82	PF00069	0.501
MOD_N-GLC_1	149	154	PF02516	0.406
MOD_NEK2_1	1	6	PF00069	0.588
MOD_NEK2_1	133	138	PF00069	0.528
MOD_NEK2_1	148	153	PF00069	0.334
MOD_NEK2_1	205	210	PF00069	0.656
MOD_NEK2_1	260	265	PF00069	0.741
MOD_NEK2_1	354	359	PF00069	0.713
MOD_NEK2_1	79	84	PF00069	0.499
MOD_PIKK_1	1	7	PF00454	0.577
MOD_PIKK_1	186	192	PF00454	0.678
MOD_PIKK_1	82	88	PF00454	0.459
MOD_PK_1	113	119	PF00069	0.466
MOD_PK_1	149	155	PF00069	0.409
MOD_PKA_1	113	119	PF00069	0.466
MOD_PKA_2	113	119	PF00069	0.437
MOD_PKA_2	148	154	PF00069	0.408
MOD_PKA_2	310	316	PF00069	0.612
MOD_PKA_2	337	343	PF00069	0.562
MOD_PKA_2	344	350	PF00069	0.558
MOD_Plk_1	141	147	PF00069	0.402
MOD_Plk_1	149	155	PF00069	0.429
MOD_Plk_1	19	25	PF00069	0.571
MOD_Plk_4	133	139	PF00069	0.498
MOD_Plk_4	200	206	PF00069	0.686
MOD_Plk_4	349	355	PF00069	0.632
MOD_ProDKin_1	192	198	PF00069	0.654
MOD_ProDKin_1	321	327	PF00069	0.681
MOD_ProDKin_1	37	43	PF00069	0.737
MOD_SUMO_rev_2	161	167	PF00179	0.413
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.526
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.571
TRG_ENDOCYTIC_2	69	72	PF00928	0.433
TRG_ER_diArg_1	109	112	PF00400	0.524
TRG_ER_diArg_1	296	299	PF00400	0.495
TRG_ER_diArg_1	326	328	PF00400	0.674
TRG_ER_diArg_1	331	334	PF00400	0.627
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P3	Leptomonas seymouri	53%	92%
A4H328	Leishmania braziliensis	71%	100%
A4HRD4	Leishmania infantum	99%	100%
E9AC02	Leishmania major	90%	100%
E9AJ99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%