Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H4T2_LEIDO

TriTrypDb:

LdBPK_010120.1 , LdCL_010006200 , LDHU3_01.0140

Length:

657

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H4T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4T2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	571	575	PF00656	0.732
CLV_C14_Caspase3-7	623	627	PF00656	0.760
CLV_C14_Caspase3-7	651	655	PF00656	0.593
CLV_NRD_NRD_1	175	177	PF00675	0.675
CLV_NRD_NRD_1	236	238	PF00675	0.634
CLV_NRD_NRD_1	357	359	PF00675	0.777
CLV_NRD_NRD_1	360	362	PF00675	0.699
CLV_NRD_NRD_1	92	94	PF00675	0.752
CLV_PCSK_FUR_1	358	362	PF00082	0.622
CLV_PCSK_FUR_1	643	647	PF00082	0.588
CLV_PCSK_KEX2_1	175	177	PF00082	0.675
CLV_PCSK_KEX2_1	319	321	PF00082	0.665
CLV_PCSK_KEX2_1	357	359	PF00082	0.777
CLV_PCSK_KEX2_1	360	362	PF00082	0.699
CLV_PCSK_KEX2_1	645	647	PF00082	0.788
CLV_PCSK_KEX2_1	92	94	PF00082	0.783
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.665
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.788
CLV_PCSK_SKI1_1	506	510	PF00082	0.733
CLV_PCSK_SKI1_1	645	649	PF00082	0.697
DEG_SCF_FBW7_1	532	539	PF00400	0.629
DEG_SPOP_SBC_1	149	153	PF00917	0.619
DEG_SPOP_SBC_1	200	204	PF00917	0.722
DEG_SPOP_SBC_1	31	35	PF00917	0.707
DEG_SPOP_SBC_1	348	352	PF00917	0.716
DEG_SPOP_SBC_1	419	423	PF00917	0.660
DEG_SPOP_SBC_1	474	478	PF00917	0.829
DEG_SPOP_SBC_1	601	605	PF00917	0.667
DOC_CKS1_1	313	318	PF01111	0.538
DOC_CKS1_1	66	71	PF01111	0.683
DOC_CYCLIN_RxL_1	639	652	PF00134	0.583
DOC_MAPK_gen_1	272	280	PF00069	0.754
DOC_PP2B_LxvP_1	404	407	PF13499	0.850
DOC_PP2B_LxvP_1	434	437	PF13499	0.621
DOC_PP2B_LxvP_1	54	57	PF13499	0.782
DOC_USP7_MATH_1	127	131	PF00917	0.720
DOC_USP7_MATH_1	149	153	PF00917	0.650
DOC_USP7_MATH_1	291	295	PF00917	0.682
DOC_USP7_MATH_1	30	34	PF00917	0.711
DOC_USP7_MATH_1	348	352	PF00917	0.716
DOC_USP7_MATH_1	370	374	PF00917	0.832
DOC_USP7_MATH_1	437	441	PF00917	0.793
DOC_USP7_MATH_1	442	446	PF00917	0.755
DOC_USP7_MATH_1	458	462	PF00917	0.560
DOC_USP7_MATH_1	474	478	PF00917	0.566
DOC_USP7_MATH_1	481	485	PF00917	0.706
DOC_USP7_MATH_1	508	512	PF00917	0.653
DOC_USP7_MATH_1	553	557	PF00917	0.791
DOC_USP7_MATH_1	601	605	PF00917	0.776
DOC_USP7_MATH_1	630	634	PF00917	0.803
DOC_WW_Pin1_4	155	160	PF00397	0.680
DOC_WW_Pin1_4	194	199	PF00397	0.833
DOC_WW_Pin1_4	282	287	PF00397	0.614
DOC_WW_Pin1_4	312	317	PF00397	0.545
DOC_WW_Pin1_4	366	371	PF00397	0.730
DOC_WW_Pin1_4	393	398	PF00397	0.764
DOC_WW_Pin1_4	407	412	PF00397	0.716
DOC_WW_Pin1_4	519	524	PF00397	0.834
DOC_WW_Pin1_4	532	537	PF00397	0.609
DOC_WW_Pin1_4	546	551	PF00397	0.648
DOC_WW_Pin1_4	569	574	PF00397	0.787
DOC_WW_Pin1_4	579	584	PF00397	0.697
DOC_WW_Pin1_4	65	70	PF00397	0.684
DOC_WW_Pin1_4	75	80	PF00397	0.594
DOC_WW_Pin1_4	98	103	PF00397	0.730
LIG_14-3-3_CanoR_1	119	124	PF00244	0.621
LIG_14-3-3_CanoR_1	133	139	PF00244	0.632
LIG_14-3-3_CanoR_1	140	146	PF00244	0.697
LIG_14-3-3_CanoR_1	147	157	PF00244	0.560
LIG_14-3-3_CanoR_1	19	23	PF00244	0.765
LIG_14-3-3_CanoR_1	191	199	PF00244	0.835
LIG_14-3-3_CanoR_1	219	229	PF00244	0.612
LIG_14-3-3_CanoR_1	360	370	PF00244	0.834
LIG_APCC_ABBA_1	240	245	PF00400	0.624
LIG_BRCT_BRCA1_1	439	443	PF00533	0.818
LIG_FHA_1	224	230	PF00498	0.511
LIG_FHA_1	234	240	PF00498	0.512
LIG_FHA_1	33	39	PF00498	0.810
LIG_FHA_1	366	372	PF00498	0.640
LIG_FHA_1	53	59	PF00498	0.452
LIG_FHA_1	533	539	PF00498	0.741
LIG_FHA_1	560	566	PF00498	0.686
LIG_FHA_1	65	71	PF00498	0.596
LIG_FHA_2	201	207	PF00498	0.663
LIG_FHA_2	222	228	PF00498	0.708
LIG_FHA_2	313	319	PF00498	0.641
LIG_FHA_2	329	335	PF00498	0.397
LIG_FHA_2	499	505	PF00498	0.766
LIG_FHA_2	86	92	PF00498	0.751
LIG_LIR_Apic_2	338	344	PF02991	0.775
LIG_LIR_Apic_2	60	64	PF02991	0.786
LIG_LIR_Gen_1	151	162	PF02991	0.613
LIG_LIR_Gen_1	241	250	PF02991	0.507
LIG_LIR_Nem_3	151	157	PF02991	0.619
LIG_LIR_Nem_3	241	246	PF02991	0.506
LIG_LIR_Nem_3	642	647	PF02991	0.588
LIG_Rb_pABgroove_1	237	245	PF01858	0.628
LIG_SH2_CRK	105	109	PF00017	0.602
LIG_SH2_CRK	341	345	PF00017	0.785
LIG_SH2_CRK	61	65	PF00017	0.786
LIG_SH2_NCK_1	170	174	PF00017	0.708
LIG_SH2_NCK_1	243	247	PF00017	0.614
LIG_SH2_NCK_1	341	345	PF00017	0.785
LIG_SH2_SRC	243	246	PF00017	0.617
LIG_SH2_SRC	339	342	PF00017	0.783
LIG_SH2_STAP1	20	24	PF00017	0.743
LIG_SH2_STAP1	243	247	PF00017	0.614
LIG_SH2_STAT5	105	108	PF00017	0.686
LIG_SH2_STAT5	123	126	PF00017	0.498
LIG_SH2_STAT5	20	23	PF00017	0.743
LIG_SH2_STAT5	270	273	PF00017	0.656
LIG_SH2_STAT5	313	316	PF00017	0.643
LIG_SH3_1	581	587	PF00018	0.737
LIG_SH3_2	451	456	PF14604	0.612
LIG_SH3_3	154	160	PF00018	0.608
LIG_SH3_3	342	348	PF00018	0.762
LIG_SH3_3	396	402	PF00018	0.802
LIG_SH3_3	448	454	PF00018	0.608
LIG_SH3_3	468	474	PF00018	0.615
LIG_SH3_3	486	492	PF00018	0.522
LIG_SH3_3	547	553	PF00018	0.781
LIG_SH3_3	563	569	PF00018	0.640
LIG_SH3_3	581	587	PF00018	0.552
LIG_SH3_3	604	610	PF00018	0.766
LIG_SUMO_SIM_anti_2	296	304	PF11976	0.458
LIG_SUMO_SIM_par_1	238	245	PF11976	0.465
LIG_SUMO_SIM_par_1	461	466	PF11976	0.746
LIG_SxIP_EBH_1	72	86	PF03271	0.615
LIG_TRAF2_1	315	318	PF00917	0.656
LIG_WW_3	198	202	PF00397	0.742
MOD_CDK_SPxK_1	519	525	PF00069	0.835
MOD_CDK_SPxxK_3	194	201	PF00069	0.746
MOD_CDK_SPxxK_3	312	319	PF00069	0.537
MOD_CDK_SPxxK_3	65	72	PF00069	0.597
MOD_CK1_1	110	116	PF00069	0.501
MOD_CK1_1	122	128	PF00069	0.525
MOD_CK1_1	158	164	PF00069	0.806
MOD_CK1_1	193	199	PF00069	0.833
MOD_CK1_1	202	208	PF00069	0.683
MOD_CK1_1	209	215	PF00069	0.488
MOD_CK1_1	33	39	PF00069	0.717
MOD_CK1_1	350	356	PF00069	0.810
MOD_CK1_1	364	370	PF00069	0.609
MOD_CK1_1	534	540	PF00069	0.794
MOD_CK1_1	94	100	PF00069	0.766
MOD_CK2_1	150	156	PF00069	0.621
MOD_CK2_1	221	227	PF00069	0.673
MOD_CK2_1	287	293	PF00069	0.597
MOD_CK2_1	312	318	PF00069	0.652
MOD_CK2_1	328	334	PF00069	0.398
MOD_CK2_1	458	464	PF00069	0.825
MOD_CK2_1	498	504	PF00069	0.764
MOD_CK2_1	508	514	PF00069	0.637
MOD_CK2_1	85	91	PF00069	0.749
MOD_Cter_Amidation	173	176	PF01082	0.693
MOD_DYRK1A_RPxSP_1	98	102	PF00069	0.610
MOD_GlcNHglycan	124	127	PF01048	0.686
MOD_GlcNHglycan	129	132	PF01048	0.691
MOD_GlcNHglycan	160	163	PF01048	0.811
MOD_GlcNHglycan	193	196	PF01048	0.750
MOD_GlcNHglycan	289	292	PF01048	0.625
MOD_GlcNHglycan	353	356	PF01048	0.670
MOD_GlcNHglycan	433	437	PF01048	0.794
MOD_GlcNHglycan	439	442	PF01048	0.743
MOD_GlcNHglycan	444	447	PF01048	0.658
MOD_GlcNHglycan	49	53	PF01048	0.746
MOD_GlcNHglycan	528	531	PF01048	0.753
MOD_GlcNHglycan	626	630	PF01048	0.819
MOD_GlcNHglycan	93	96	PF01048	0.832
MOD_GlcNHglycan	98	101	PF01048	0.737
MOD_GSK3_1	106	113	PF00069	0.603
MOD_GSK3_1	134	141	PF00069	0.743
MOD_GSK3_1	190	197	PF00069	0.840
MOD_GSK3_1	202	209	PF00069	0.631
MOD_GSK3_1	287	294	PF00069	0.615
MOD_GSK3_1	30	37	PF00069	0.724
MOD_GSK3_1	343	350	PF00069	0.651
MOD_GSK3_1	360	367	PF00069	0.670
MOD_GSK3_1	389	396	PF00069	0.734
MOD_GSK3_1	437	444	PF00069	0.738
MOD_GSK3_1	48	55	PF00069	0.554
MOD_GSK3_1	506	513	PF00069	0.726
MOD_GSK3_1	532	539	PF00069	0.787
MOD_GSK3_1	541	548	PF00069	0.744
MOD_GSK3_1	601	608	PF00069	0.823
MOD_GSK3_1	648	655	PF00069	0.698
MOD_GSK3_1	81	88	PF00069	0.821
MOD_GSK3_1	94	101	PF00069	0.609
MOD_N-GLC_1	425	430	PF02516	0.719
MOD_NEK2_1	139	144	PF00069	0.744
MOD_NEK2_1	150	155	PF00069	0.597
MOD_NEK2_1	328	333	PF00069	0.658
MOD_NEK2_1	418	423	PF00069	0.777
MOD_NEK2_1	482	487	PF00069	0.825
MOD_NEK2_1	602	607	PF00069	0.659
MOD_NEK2_1	620	625	PF00069	0.535
MOD_OFUCOSY	106	111	PF10250	0.596
MOD_PIKK_1	258	264	PF00454	0.595
MOD_PIKK_1	463	469	PF00454	0.756
MOD_PIKK_1	476	482	PF00454	0.577
MOD_PIKK_1	553	559	PF00454	0.757
MOD_PIKK_1	605	611	PF00454	0.783
MOD_PIKK_1	613	619	PF00454	0.773
MOD_PKA_1	360	366	PF00069	0.634
MOD_PKA_2	132	138	PF00069	0.740
MOD_PKA_2	139	145	PF00069	0.659
MOD_PKA_2	18	24	PF00069	0.742
MOD_PKA_2	190	196	PF00069	0.840
MOD_PKA_2	200	206	PF00069	0.667
MOD_PKA_2	360	366	PF00069	0.713
MOD_PKA_2	91	97	PF00069	0.831
MOD_PKB_1	358	366	PF00069	0.739
MOD_PKB_1	46	54	PF00069	0.684
MOD_Plk_1	135	141	PF00069	0.746
MOD_Plk_1	463	469	PF00069	0.843
MOD_Plk_1	48	54	PF00069	0.659
MOD_Plk_4	119	125	PF00069	0.604
MOD_Plk_4	150	156	PF00069	0.621
MOD_Plk_4	34	40	PF00069	0.812
MOD_Plk_4	458	464	PF00069	0.804
MOD_Plk_4	482	488	PF00069	0.743
MOD_ProDKin_1	155	161	PF00069	0.684
MOD_ProDKin_1	194	200	PF00069	0.831
MOD_ProDKin_1	282	288	PF00069	0.606
MOD_ProDKin_1	312	318	PF00069	0.542
MOD_ProDKin_1	366	372	PF00069	0.727
MOD_ProDKin_1	393	399	PF00069	0.759
MOD_ProDKin_1	407	413	PF00069	0.712
MOD_ProDKin_1	519	525	PF00069	0.835
MOD_ProDKin_1	532	538	PF00069	0.611
MOD_ProDKin_1	546	552	PF00069	0.645
MOD_ProDKin_1	569	575	PF00069	0.790
MOD_ProDKin_1	579	585	PF00069	0.697
MOD_ProDKin_1	65	71	PF00069	0.683
MOD_ProDKin_1	75	81	PF00069	0.591
MOD_ProDKin_1	98	104	PF00069	0.729
MOD_SUMO_rev_2	499	508	PF00179	0.844
TRG_DiLeu_BaEn_4	317	323	PF01217	0.669
TRG_DiLeu_BaLyEn_6	643	648	PF01217	0.588
TRG_ENDOCYTIC_2	154	157	PF00928	0.631
TRG_ENDOCYTIC_2	243	246	PF00928	0.496
TRG_ER_diArg_1	175	178	PF00400	0.705
TRG_ER_diArg_1	228	231	PF00400	0.688
TRG_ER_diArg_1	357	360	PF00400	0.795
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.809
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	320	325	PF00026	0.684
TRG_Pf-PMV_PEXEL_1	646	650	PF00026	0.695

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H327	Leishmania braziliensis	50%	86%
A4HRD3	Leishmania infantum	100%	100%
E9AC01	Leishmania major	84%	100%