Nocturnin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Nocturnin

Gene product:

Endonuclease/Exonuclease/phosphatase family, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H4S7_LEIDO

TriTrypDb:

LdBPK_010020.1 , LdCL_010005200 , LDHU3_01.0040

Length:

553

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H4S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4S7

Function

Biological processes
Term	Name	Level	Count
GO:0007623	circadian rhythm	2	11
GO:0010468	regulation of gene expression	5	11
GO:0019222	regulation of metabolic process	3	11
GO:0032501	multicellular organismal process	1	11
GO:0032922	circadian regulation of gene expression	2	11
GO:0048511	rhythmic process	1	11
GO:0050789	regulation of biological process	2	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11

Molecular functions
Term	Name	Level	Count
GO:0000175	3'-5'-RNA exonuclease activity	7	11
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0004519	endonuclease activity	5	2
GO:0004527	exonuclease activity	5	11
GO:0004532	RNA exonuclease activity	5	11
GO:0004535	poly(A)-specific ribonuclease activity	8	11
GO:0004540	RNA nuclease activity	4	11
GO:0008408	3'-5' exonuclease activity	6	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	11
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.450
CLV_C14_Caspase3-7	36	40	PF00656	0.623
CLV_C14_Caspase3-7	538	542	PF00656	0.392
CLV_NRD_NRD_1	156	158	PF00675	0.297
CLV_NRD_NRD_1	210	212	PF00675	0.280
CLV_NRD_NRD_1	3	5	PF00675	0.582
CLV_NRD_NRD_1	395	397	PF00675	0.340
CLV_NRD_NRD_1	480	482	PF00675	0.319
CLV_NRD_NRD_1	73	75	PF00675	0.544
CLV_NRD_NRD_1	90	92	PF00675	0.346
CLV_PCSK_FUR_1	393	397	PF00082	0.282
CLV_PCSK_KEX2_1	156	158	PF00082	0.279
CLV_PCSK_KEX2_1	178	180	PF00082	0.306
CLV_PCSK_KEX2_1	3	5	PF00082	0.582
CLV_PCSK_KEX2_1	395	397	PF00082	0.311
CLV_PCSK_KEX2_1	73	75	PF00082	0.503
CLV_PCSK_KEX2_1	90	92	PF00082	0.446
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.306
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.494
CLV_PCSK_SKI1_1	179	183	PF00082	0.297
CLV_PCSK_SKI1_1	297	301	PF00082	0.357
CLV_PCSK_SKI1_1	481	485	PF00082	0.403
CLV_PCSK_SKI1_1	549	553	PF00082	0.608
CLV_PCSK_SKI1_1	75	79	PF00082	0.442
CLV_Separin_Metazoa	162	166	PF03568	0.355
CLV_Separin_Metazoa	335	339	PF03568	0.410
DEG_APCC_DBOX_1	296	304	PF00400	0.357
DEG_Nend_Nbox_1	1	3	PF02207	0.563
DOC_CKS1_1	150	155	PF01111	0.282
DOC_CKS1_1	428	433	PF01111	0.462
DOC_CKS1_1	437	442	PF01111	0.383
DOC_MAPK_gen_1	156	163	PF00069	0.410
DOC_MAPK_gen_1	265	273	PF00069	0.279
DOC_MAPK_gen_1	383	391	PF00069	0.347
DOC_MAPK_MEF2A_6	267	275	PF00069	0.279
DOC_PP2B_LxvP_1	245	248	PF13499	0.410
DOC_PP2B_LxvP_1	507	510	PF13499	0.279
DOC_PP4_FxxP_1	150	153	PF00568	0.287
DOC_PP4_FxxP_1	495	498	PF00568	0.297
DOC_USP7_MATH_1	13	17	PF00917	0.742
DOC_USP7_MATH_1	311	315	PF00917	0.331
DOC_USP7_MATH_1	378	382	PF00917	0.355
DOC_USP7_MATH_1	49	53	PF00917	0.406
DOC_USP7_UBL2_3	478	482	PF12436	0.322
DOC_WW_Pin1_4	109	114	PF00397	0.516
DOC_WW_Pin1_4	149	154	PF00397	0.378
DOC_WW_Pin1_4	427	432	PF00397	0.376
DOC_WW_Pin1_4	436	441	PF00397	0.393
DOC_WW_Pin1_4	454	459	PF00397	0.391
LIG_14-3-3_CanoR_1	3	12	PF00244	0.533
LIG_14-3-3_CanoR_1	352	358	PF00244	0.303
LIG_14-3-3_CanoR_1	393	402	PF00244	0.364
LIG_14-3-3_CanoR_1	95	100	PF00244	0.411
LIG_APCC_ABBA_1	531	536	PF00400	0.363
LIG_BIR_III_4	104	108	PF00653	0.543
LIG_BIR_III_4	304	308	PF00653	0.355
LIG_BIR_III_4	398	402	PF00653	0.306
LIG_deltaCOP1_diTrp_1	536	543	PF00928	0.494
LIG_deltaCOP1_diTrp_1	92	99	PF00928	0.324
LIG_FHA_1	109	115	PF00498	0.563
LIG_FHA_1	270	276	PF00498	0.286
LIG_FHA_1	342	348	PF00498	0.357
LIG_FHA_1	498	504	PF00498	0.297
LIG_FHA_2	110	116	PF00498	0.445
LIG_FHA_2	299	305	PF00498	0.433
LIG_LIR_Apic_2	492	498	PF02991	0.297
LIG_LIR_Gen_1	98	105	PF02991	0.419
LIG_LIR_Nem_3	184	190	PF02991	0.306
LIG_LIR_Nem_3	490	496	PF02991	0.279
LIG_LIR_Nem_3	541	546	PF02991	0.479
LIG_LIR_Nem_3	92	96	PF02991	0.335
LIG_MYND_1	149	153	PF01753	0.287
LIG_PCNA_yPIPBox_3	178	190	PF02747	0.326
LIG_Pex14_1	539	543	PF04695	0.527
LIG_SH2_CRK	195	199	PF00017	0.279
LIG_SH2_CRK	402	406	PF00017	0.355
LIG_SH2_SRC	139	142	PF00017	0.419
LIG_SH2_SRC	496	499	PF00017	0.355
LIG_SH2_STAP1	367	371	PF00017	0.410
LIG_SH2_STAT3	488	491	PF00017	0.335
LIG_SH2_STAT5	189	192	PF00017	0.281
LIG_SH2_STAT5	274	277	PF00017	0.396
LIG_SH2_STAT5	371	374	PF00017	0.360
LIG_SH3_3	116	122	PF00018	0.400
LIG_SH3_3	345	351	PF00018	0.297
LIG_SH3_3	74	80	PF00018	0.445
LIG_SUMO_SIM_anti_2	472	480	PF11976	0.355
LIG_SUMO_SIM_par_1	298	304	PF11976	0.410
LIG_SUMO_SIM_par_1	505	514	PF11976	0.279
LIG_TRAF2_1	226	229	PF00917	0.410
LIG_TYR_ITIM	193	198	PF00017	0.357
LIG_WRC_WIRS_1	96	101	PF05994	0.389
MOD_CDK_SPK_2	427	432	PF00069	0.282
MOD_CDK_SPxxK_3	149	156	PF00069	0.378
MOD_CK1_1	109	115	PF00069	0.521
MOD_CK1_1	314	320	PF00069	0.322
MOD_CK1_1	82	88	PF00069	0.452
MOD_CK2_1	109	115	PF00069	0.475
MOD_CK2_1	42	48	PF00069	0.638
MOD_CMANNOS	353	356	PF00535	0.279
MOD_GlcNHglycan	15	18	PF01048	0.641
MOD_GlcNHglycan	44	47	PF01048	0.677
MOD_GlcNHglycan	5	8	PF01048	0.583
MOD_GSK3_1	177	184	PF00069	0.428
MOD_GSK3_1	194	201	PF00069	0.297
MOD_GSK3_1	24	31	PF00069	0.700
MOD_GSK3_1	278	285	PF00069	0.279
MOD_GSK3_1	535	542	PF00069	0.411
MOD_GSK3_1	79	86	PF00069	0.503
MOD_N-GLC_1	269	274	PF02516	0.297
MOD_NEK2_1	198	203	PF00069	0.280
MOD_NEK2_1	24	29	PF00069	0.714
MOD_NEK2_1	464	469	PF00069	0.467
MOD_NEK2_1	477	482	PF00069	0.381
MOD_NEK2_1	84	89	PF00069	0.442
MOD_NEK2_2	194	199	PF00069	0.297
MOD_NEK2_2	547	552	PF00069	0.560
MOD_PIKK_1	40	46	PF00454	0.518
MOD_PIKK_1	487	493	PF00454	0.279
MOD_PIKK_1	79	85	PF00454	0.526
MOD_PKA_1	3	9	PF00069	0.611
MOD_PKA_2	24	30	PF00069	0.687
MOD_PKA_2	3	9	PF00069	0.555
MOD_PKA_2	33	39	PF00069	0.680
MOD_PKA_2	351	357	PF00069	0.264
MOD_PKA_2	394	400	PF00069	0.352
MOD_Plk_1	269	275	PF00069	0.297
MOD_Plk_1	535	541	PF00069	0.330
MOD_Plk_4	194	200	PF00069	0.327
MOD_Plk_4	269	275	PF00069	0.410
MOD_Plk_4	298	304	PF00069	0.398
MOD_Plk_4	33	39	PF00069	0.713
MOD_Plk_4	366	372	PF00069	0.399
MOD_Plk_4	50	56	PF00069	0.561
MOD_ProDKin_1	109	115	PF00069	0.511
MOD_ProDKin_1	149	155	PF00069	0.378
MOD_ProDKin_1	427	433	PF00069	0.376
MOD_ProDKin_1	436	442	PF00069	0.393
MOD_ProDKin_1	454	460	PF00069	0.391
MOD_SUMO_rev_2	170	180	PF00179	0.306
MOD_SUMO_rev_2	45	52	PF00179	0.582
TRG_DiLeu_BaEn_2	145	151	PF01217	0.322
TRG_ENDOCYTIC_2	195	198	PF00928	0.264
TRG_ENDOCYTIC_2	402	405	PF00928	0.355
TRG_ER_diArg_1	117	120	PF00400	0.493
TRG_ER_diArg_1	2	4	PF00400	0.591
TRG_ER_diArg_1	394	396	PF00400	0.327
TRG_NLS_MonoExtN_4	478	485	PF00514	0.306
TRG_NLS_MonoExtN_4	70	77	PF00514	0.480
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	549	553	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Q6	Leptomonas seymouri	64%	100%
A0A0S4JIK0	Bodo saltans	42%	87%
A0A1X0P355	Trypanosomatidae	47%	99%
A4H336	Leishmania braziliensis	84%	100%
A4HRC4	Leishmania infantum	97%	98%
C9ZXH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ABZ1	Leishmania major	94%	99%
E9AJ88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	98%
V5B795	Trypanosoma cruzi	51%	99%