Glycoprotein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Glycoprotein

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H4S6_LEIDO

TriTrypDb:

LdBPK_010010.1 , LdCL_010005100 , LDHU3_01.0030

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 15, no: 2
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A0A3S5H4S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H4S6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.704
CLV_NRD_NRD_1	274	276	PF00675	0.471
CLV_NRD_NRD_1	282	284	PF00675	0.556
CLV_NRD_NRD_1	306	308	PF00675	0.641
CLV_PCSK_KEX2_1	160	162	PF00082	0.610
CLV_PCSK_KEX2_1	273	275	PF00082	0.505
CLV_PCSK_KEX2_1	280	282	PF00082	0.515
CLV_PCSK_KEX2_1	306	308	PF00082	0.641
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.666
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.578
CLV_PCSK_SKI1_1	105	109	PF00082	0.684
CLV_PCSK_SKI1_1	112	116	PF00082	0.638
CLV_PCSK_SKI1_1	2	6	PF00082	0.621
CLV_PCSK_SKI1_1	233	237	PF00082	0.729
DEG_APCC_DBOX_1	1	9	PF00400	0.351
DEG_Nend_UBRbox_1	1	4	PF02207	0.475
DEG_SPOP_SBC_1	24	28	PF00917	0.506
DEG_SPOP_SBC_1	59	63	PF00917	0.345
DOC_MAPK_MEF2A_6	2	10	PF00069	0.437
DOC_USP7_MATH_1	204	208	PF00917	0.534
DOC_USP7_MATH_1	210	214	PF00917	0.532
DOC_USP7_MATH_1	297	301	PF00917	0.709
DOC_USP7_MATH_1	30	34	PF00917	0.377
DOC_USP7_MATH_1	328	332	PF00917	0.714
DOC_USP7_MATH_1	69	73	PF00917	0.345
DOC_WW_Pin1_4	126	131	PF00397	0.454
LIG_14-3-3_CanoR_1	133	141	PF00244	0.570
LIG_14-3-3_CanoR_1	306	311	PF00244	0.741
LIG_BRCT_BRCA1_1	176	180	PF00533	0.477
LIG_BRCT_BRCA1_1	35	39	PF00533	0.369
LIG_deltaCOP1_diTrp_1	100	108	PF00928	0.441
LIG_eIF4E_1	157	163	PF01652	0.492
LIG_FHA_1	109	115	PF00498	0.494
LIG_FHA_1	132	138	PF00498	0.463
LIG_FHA_1	179	185	PF00498	0.421
LIG_FHA_2	127	133	PF00498	0.563
LIG_FHA_2	140	146	PF00498	0.440
LIG_FHA_2	296	302	PF00498	0.790
LIG_FHA_2	95	101	PF00498	0.470
LIG_GBD_Chelix_1	251	259	PF00786	0.512
LIG_IRF3_LxIS_1	258	265	PF10401	0.351
LIG_LIR_Apic_2	232	237	PF02991	0.546
LIG_LIR_Gen_1	140	149	PF02991	0.514
LIG_LIR_Gen_1	177	188	PF02991	0.482
LIG_LIR_Gen_1	45	55	PF02991	0.448
LIG_LIR_Nem_3	100	104	PF02991	0.446
LIG_LIR_Nem_3	140	144	PF02991	0.498
LIG_LIR_Nem_3	151	155	PF02991	0.446
LIG_LIR_Nem_3	177	183	PF02991	0.423
LIG_LIR_Nem_3	186	190	PF02991	0.409
LIG_LIR_Nem_3	313	319	PF02991	0.686
LIG_LIR_Nem_3	45	51	PF02991	0.384
LIG_SH2_CRK	104	108	PF00017	0.508
LIG_SH2_GRB2like	141	144	PF00017	0.413
LIG_SH2_GRB2like	290	293	PF00017	0.875
LIG_SH2_PTP2	256	259	PF00017	0.379
LIG_SH2_SRC	188	191	PF00017	0.540
LIG_SH2_SRC	319	322	PF00017	0.669
LIG_SH2_STAP1	25	29	PF00017	0.381
LIG_SH2_STAT3	290	293	PF00017	0.717
LIG_SH2_STAT5	141	144	PF00017	0.482
LIG_SH2_STAT5	188	191	PF00017	0.480
LIG_SH2_STAT5	219	222	PF00017	0.587
LIG_SH2_STAT5	256	259	PF00017	0.487
LIG_SH3_1	198	204	PF00018	0.475
LIG_SH3_3	161	167	PF00018	0.457
LIG_SH3_3	198	204	PF00018	0.548
LIG_SUMO_SIM_par_1	42	47	PF11976	0.325
LIG_TRAF2_1	65	68	PF00917	0.429
LIG_TYR_ITIM	119	124	PF00017	0.468
LIG_TYR_ITIM	254	259	PF00017	0.486
MOD_CDK_SPxxK_3	126	133	PF00069	0.429
MOD_CK1_1	215	221	PF00069	0.545
MOD_CK1_1	33	39	PF00069	0.443
MOD_CK2_1	139	145	PF00069	0.498
MOD_CK2_1	295	301	PF00069	0.747
MOD_CK2_1	327	333	PF00069	0.844
MOD_CK2_1	62	68	PF00069	0.417
MOD_CK2_1	94	100	PF00069	0.472
MOD_Cter_Amidation	158	161	PF01082	0.694
MOD_Cter_Amidation	222	225	PF01082	0.636
MOD_GlcNHglycan	167	170	PF01048	0.724
MOD_GlcNHglycan	206	209	PF01048	0.639
MOD_GlcNHglycan	214	217	PF01048	0.823
MOD_GlcNHglycan	32	35	PF01048	0.635
MOD_GlcNHglycan	62	65	PF01048	0.625
MOD_GlcNHglycan	71	74	PF01048	0.641
MOD_GlcNHglycan	79	82	PF01048	0.674
MOD_GSK3_1	139	146	PF00069	0.557
MOD_GSK3_1	171	178	PF00069	0.503
MOD_GSK3_1	19	26	PF00069	0.425
MOD_GSK3_1	211	218	PF00069	0.582
MOD_GSK3_1	302	309	PF00069	0.739
MOD_GSK3_1	311	318	PF00069	0.782
MOD_GSK3_1	55	62	PF00069	0.401
MOD_N-GLC_1	153	158	PF02516	0.745
MOD_N-GLC_1	239	244	PF02516	0.779
MOD_NEK2_1	107	112	PF00069	0.457
MOD_NEK2_1	211	216	PF00069	0.461
MOD_NEK2_1	262	267	PF00069	0.573
MOD_NEK2_1	302	307	PF00069	0.717
MOD_NEK2_1	310	315	PF00069	0.700
MOD_NEK2_1	60	65	PF00069	0.375
MOD_PIKK_1	227	233	PF00454	0.577
MOD_PIKK_1	285	291	PF00454	0.755
MOD_PIKK_1	295	301	PF00454	0.720
MOD_PIKK_1	94	100	PF00454	0.447
MOD_PK_1	311	317	PF00069	0.707
MOD_PKA_1	306	312	PF00069	0.749
MOD_PKA_2	108	114	PF00069	0.414
MOD_PKA_2	132	138	PF00069	0.415
MOD_PKA_2	306	312	PF00069	0.724
MOD_Plk_1	153	159	PF00069	0.536
MOD_Plk_1	239	245	PF00069	0.522
MOD_Plk_2-3	321	327	PF00069	0.813
MOD_Plk_4	153	159	PF00069	0.505
MOD_Plk_4	245	251	PF00069	0.363
MOD_Plk_4	311	317	PF00069	0.763
MOD_ProDKin_1	126	132	PF00069	0.452
TRG_ENDOCYTIC_2	104	107	PF00928	0.485
TRG_ENDOCYTIC_2	121	124	PF00928	0.425
TRG_ENDOCYTIC_2	141	144	PF00928	0.431
TRG_ENDOCYTIC_2	256	259	PF00928	0.472
TRG_ER_diArg_1	272	275	PF00400	0.746
TRG_ER_diArg_1	281	283	PF00400	0.839

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P471	Leptomonas seymouri	38%	100%
A0A0N1I022	Leptomonas seymouri	49%	98%
A0A1X0NWG7	Trypanosomatidae	24%	91%
A0A1X0NWG9	Trypanosomatidae	25%	92%
A0A1X0NXT1	Trypanosomatidae	24%	92%
A0A1X0NY10	Trypanosomatidae	27%	100%
A0A3Q8IBH3	Leishmania donovani	36%	100%
A4H335	Leishmania braziliensis	85%	100%
A4HRC3	Leishmania infantum	100%	100%
A4HYN5	Leishmania infantum	37%	100%
E9ABZ0	Leishmania major	95%	100%
E9AI94	Leishmania braziliensis	35%	100%
E9AJ87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AUH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
Q4QD05	Leishmania major	36%	100%
V5DS51	Trypanosoma cruzi	29%	94%