Eukaryotic translation initiation factor 3 subunit 8, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 3 subunit c

Species:

Leishmania donovani

UniProt:

A0A3Q8IWP7_LEIDO

TriTrypDb:

LdBPK_367320.1 , LdCL_360085800 , LDHU3_36.9700

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005852	eukaryotic translation initiation factor 3 complex	2	10
GO:0032991	protein-containing complex	1	10
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IWP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IWP7

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0003743	translation initiation factor activity	4	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0008135	translation factor activity, RNA binding	3	10
GO:0031369	translation initiation factor binding	3	10
GO:0045182	translation regulator activity	1	10
GO:0090079	translation regulator activity, nucleic acid binding	2	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	364	368	PF00656	0.624
CLV_C14_Caspase3-7	9	13	PF00656	0.709
CLV_NRD_NRD_1	208	210	PF00675	0.699
CLV_NRD_NRD_1	229	231	PF00675	0.661
CLV_NRD_NRD_1	232	234	PF00675	0.701
CLV_NRD_NRD_1	330	332	PF00675	0.370
CLV_NRD_NRD_1	351	353	PF00675	0.386
CLV_NRD_NRD_1	598	600	PF00675	0.683
CLV_NRD_NRD_1	642	644	PF00675	0.634
CLV_NRD_NRD_1	93	95	PF00675	0.669
CLV_PCSK_KEX2_1	229	231	PF00082	0.653
CLV_PCSK_KEX2_1	332	334	PF00082	0.355
CLV_PCSK_KEX2_1	351	353	PF00082	0.233
CLV_PCSK_KEX2_1	600	602	PF00082	0.620
CLV_PCSK_KEX2_1	642	644	PF00082	0.634
CLV_PCSK_KEX2_1	83	85	PF00082	0.626
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.368
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.561
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.601
CLV_PCSK_SKI1_1	132	136	PF00082	0.533
CLV_PCSK_SKI1_1	17	21	PF00082	0.848
CLV_PCSK_SKI1_1	233	237	PF00082	0.677
CLV_PCSK_SKI1_1	244	248	PF00082	0.585
CLV_PCSK_SKI1_1	309	313	PF00082	0.424
CLV_PCSK_SKI1_1	485	489	PF00082	0.437
CLV_PCSK_SKI1_1	498	502	PF00082	0.322
CLV_PCSK_SKI1_1	76	80	PF00082	0.617
DEG_Nend_UBRbox_3	1	3	PF02207	0.744
DEG_SPOP_SBC_1	5	9	PF00917	0.833
DOC_CYCLIN_yClb1_LxF_4	126	131	PF00134	0.722
DOC_CYCLIN_yCln2_LP_2	501	504	PF00134	0.586
DOC_MAPK_gen_1	132	140	PF00069	0.618
DOC_MAPK_gen_1	209	217	PF00069	0.588
DOC_MAPK_gen_1	229	237	PF00069	0.672
DOC_MAPK_MEF2A_6	338	345	PF00069	0.639
DOC_MAPK_MEF2A_6	381	390	PF00069	0.659
DOC_MAPK_RevD_3	339	352	PF00069	0.668
DOC_PP1_RVXF_1	126	132	PF00149	0.677
DOC_PP1_RVXF_1	307	314	PF00149	0.639
DOC_PP2B_LxvP_1	500	503	PF13499	0.568
DOC_USP7_MATH_1	5	9	PF00917	0.836
DOC_USP7_MATH_1	55	59	PF00917	0.632
DOC_USP7_UBL2_3	146	150	PF12436	0.725
DOC_USP7_UBL2_3	247	251	PF12436	0.594
DOC_USP7_UBL2_3	596	600	PF12436	0.622
DOC_WW_Pin1_4	478	483	PF00397	0.659
DOC_WW_Pin1_4	547	552	PF00397	0.712
LIG_14-3-3_CanoR_1	601	607	PF00244	0.634
LIG_14-3-3_CanoR_1	619	628	PF00244	0.585
LIG_Actin_WH2_2	295	311	PF00022	0.639
LIG_Actin_WH2_2	376	393	PF00022	0.624
LIG_Actin_WH2_2	451	468	PF00022	0.639
LIG_Actin_WH2_2	557	574	PF00022	0.503
LIG_BRCT_BRCA1_1	341	345	PF00533	0.624
LIG_deltaCOP1_diTrp_1	240	248	PF00928	0.587
LIG_deltaCOP1_diTrp_1	73	82	PF00928	0.530
LIG_EH_1	29	33	PF12763	0.795
LIG_eIF4E_1	288	294	PF01652	0.668
LIG_FHA_1	142	148	PF00498	0.649
LIG_FHA_1	289	295	PF00498	0.661
LIG_FHA_1	364	370	PF00498	0.576
LIG_FHA_1	422	428	PF00498	0.595
LIG_FHA_1	548	554	PF00498	0.730
LIG_FHA_1	622	628	PF00498	0.503
LIG_FHA_2	175	181	PF00498	0.622
LIG_FHA_2	211	217	PF00498	0.616
LIG_FHA_2	35	41	PF00498	0.674
LIG_FHA_2	585	591	PF00498	0.644
LIG_GBD_Chelix_1	515	523	PF00786	0.424
LIG_IBAR_NPY_1	532	534	PF08397	0.659
LIG_LIR_Gen_1	178	188	PF02991	0.618
LIG_LIR_Gen_1	297	307	PF02991	0.590
LIG_LIR_Gen_1	374	383	PF02991	0.675
LIG_LIR_Gen_1	587	593	PF02991	0.558
LIG_LIR_Gen_1	620	630	PF02991	0.656
LIG_LIR_Gen_1	662	673	PF02991	0.543
LIG_LIR_Nem_3	130	134	PF02991	0.526
LIG_LIR_Nem_3	178	184	PF02991	0.627
LIG_LIR_Nem_3	297	302	PF02991	0.578
LIG_LIR_Nem_3	304	310	PF02991	0.535
LIG_LIR_Nem_3	342	348	PF02991	0.654
LIG_LIR_Nem_3	374	380	PF02991	0.659
LIG_LIR_Nem_3	494	500	PF02991	0.568
LIG_LIR_Nem_3	587	592	PF02991	0.611
LIG_LIR_Nem_3	662	668	PF02991	0.522
LIG_NRBOX	518	524	PF00104	0.631
LIG_NRP_CendR_1	728	731	PF00754	0.837
LIG_PCNA_PIPBox_1	110	119	PF02747	0.722
LIG_PCNA_PIPBox_1	407	416	PF02747	0.639
LIG_PCNA_yPIPBox_3	407	418	PF02747	0.639
LIG_PCNA_yPIPBox_3	443	454	PF02747	0.623
LIG_PCNA_yPIPBox_3	652	661	PF02747	0.575
LIG_Pex14_1	242	246	PF04695	0.477
LIG_Pex14_1	248	252	PF04695	0.483
LIG_Pex14_2	32	36	PF04695	0.810
LIG_Rb_pABgroove_1	339	347	PF01858	0.668
LIG_REV1ctd_RIR_1	250	259	PF16727	0.645
LIG_SH2_CRK	181	185	PF00017	0.641
LIG_SH2_CRK	360	364	PF00017	0.632
LIG_SH2_CRK	497	501	PF00017	0.636
LIG_SH2_CRK	544	548	PF00017	0.548
LIG_SH2_GRB2like	212	215	PF00017	0.618
LIG_SH2_GRB2like	616	619	PF00017	0.582
LIG_SH2_NCK_1	544	548	PF00017	0.638
LIG_SH2_SRC	406	409	PF00017	0.620
LIG_SH2_STAP1	181	185	PF00017	0.643
LIG_SH2_STAT5	212	215	PF00017	0.575
LIG_SH2_STAT5	288	291	PF00017	0.634
LIG_SH2_STAT5	307	310	PF00017	0.448
LIG_SH2_STAT5	420	423	PF00017	0.634
LIG_SH2_STAT5	542	545	PF00017	0.537
LIG_SH2_STAT5	576	579	PF00017	0.530
LIG_SH2_STAT5	602	605	PF00017	0.579
LIG_SH2_STAT5	616	619	PF00017	0.483
LIG_SH2_STAT5	665	668	PF00017	0.520
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.657
LIG_SUMO_SIM_anti_2	316	322	PF11976	0.639
LIG_SUMO_SIM_anti_2	364	375	PF11976	0.636
LIG_SUMO_SIM_anti_2	608	613	PF11976	0.555
LIG_SUMO_SIM_par_1	136	142	PF11976	0.619
LIG_TRAF2_1	303	306	PF00917	0.668
LIG_TRAF2_1	37	40	PF00917	0.740
LIG_TYR_ITIM	358	363	PF00017	0.608
LIG_TYR_ITIM	566	571	PF00017	0.586
LIG_TYR_ITSM	177	184	PF00017	0.506
LIG_WRC_WIRS_1	310	315	PF05994	0.624
LIG_WRC_WIRS_1	586	591	PF05994	0.588
MOD_CDK_SPxxK_3	478	485	PF00069	0.668
MOD_CK1_1	15	21	PF00069	0.721
MOD_CK1_1	238	244	PF00069	0.576
MOD_CK1_1	362	368	PF00069	0.639
MOD_CK1_1	517	523	PF00069	0.668
MOD_CK1_1	623	629	PF00069	0.604
MOD_CK1_1	650	656	PF00069	0.601
MOD_CK1_1	8	14	PF00069	0.704
MOD_CK2_1	130	136	PF00069	0.608
MOD_CK2_1	174	180	PF00069	0.719
MOD_CK2_1	210	216	PF00069	0.674
MOD_CK2_1	294	300	PF00069	0.623
MOD_CK2_1	34	40	PF00069	0.654
MOD_CK2_1	4	10	PF00069	0.699
MOD_CK2_1	556	562	PF00069	0.682
MOD_CK2_1	591	597	PF00069	0.545
MOD_CK2_1	602	608	PF00069	0.399
MOD_CK2_1	71	77	PF00069	0.557
MOD_CMANNOS	33	36	PF00535	0.810
MOD_GlcNHglycan	186	191	PF01048	0.658
MOD_GlcNHglycan	216	220	PF01048	0.582
MOD_GlcNHglycan	396	399	PF01048	0.412
MOD_GlcNHglycan	519	522	PF01048	0.415
MOD_GlcNHglycan	593	596	PF01048	0.557
MOD_GlcNHglycan	655	658	PF01048	0.630
MOD_GSK3_1	284	291	PF00069	0.625
MOD_GSK3_1	359	366	PF00069	0.607
MOD_GSK3_1	372	379	PF00069	0.515
MOD_GSK3_1	390	397	PF00069	0.643
MOD_GSK3_1	4	11	PF00069	0.788
MOD_GSK3_1	426	433	PF00069	0.588
MOD_GSK3_1	543	550	PF00069	0.614
MOD_GSK3_1	584	591	PF00069	0.568
MOD_GSK3_1	617	624	PF00069	0.617
MOD_GSK3_1	647	654	PF00069	0.567
MOD_GSK3_1	681	688	PF00069	0.693
MOD_N-GLC_1	294	299	PF02516	0.439
MOD_N-GLC_1	367	372	PF02516	0.321
MOD_N-GLC_1	617	622	PF02516	0.620
MOD_N-GLC_1	651	656	PF02516	0.597
MOD_N-GLC_1	671	676	PF02516	0.634
MOD_N-GLC_1	71	76	PF02516	0.654
MOD_NEK2_1	215	220	PF00069	0.484
MOD_NEK2_1	359	364	PF00069	0.626
MOD_NEK2_1	396	401	PF00069	0.643
MOD_NEK2_1	4	9	PF00069	0.783
MOD_NEK2_1	421	426	PF00069	0.602
MOD_NEK2_1	464	469	PF00069	0.668
MOD_NEK2_1	614	619	PF00069	0.521
MOD_NEK2_2	602	607	PF00069	0.520
MOD_PIKK_1	301	307	PF00454	0.618
MOD_PKA_1	229	235	PF00069	0.686
MOD_PKA_2	229	235	PF00069	0.686
MOD_PKA_2	390	396	PF00069	0.624
MOD_Plk_1	15	21	PF00069	0.747
MOD_Plk_1	215	221	PF00069	0.583
MOD_Plk_1	266	272	PF00069	0.481
MOD_Plk_1	367	373	PF00069	0.593
MOD_Plk_1	620	626	PF00069	0.613
MOD_Plk_1	650	656	PF00069	0.603
MOD_Plk_1	671	677	PF00069	0.631
MOD_Plk_1	71	77	PF00069	0.649
MOD_Plk_2-3	10	16	PF00069	0.848
MOD_Plk_2-3	130	136	PF00069	0.670
MOD_Plk_4	15	21	PF00069	0.866
MOD_Plk_4	223	229	PF00069	0.637
MOD_Plk_4	284	290	PF00069	0.680
MOD_Plk_4	367	373	PF00069	0.579
MOD_Plk_4	483	489	PF00069	0.661
MOD_Plk_4	514	520	PF00069	0.586
MOD_Plk_4	623	629	PF00069	0.545
MOD_ProDKin_1	478	484	PF00069	0.659
MOD_ProDKin_1	547	553	PF00069	0.720
MOD_SUMO_for_1	50	53	PF00179	0.737
MOD_SUMO_for_1	526	529	PF00179	0.603
MOD_SUMO_rev_2	124	134	PF00179	0.629
TRG_DiLeu_BaEn_1	136	141	PF01217	0.590
TRG_DiLeu_BaEn_1	496	501	PF01217	0.615
TRG_DiLeu_BaEn_1	608	613	PF01217	0.565
TRG_DiLeu_BaEn_2	87	93	PF01217	0.621
TRG_ENDOCYTIC_2	181	184	PF00928	0.607
TRG_ENDOCYTIC_2	212	215	PF00928	0.589
TRG_ENDOCYTIC_2	307	310	PF00928	0.554
TRG_ENDOCYTIC_2	360	363	PF00928	0.565
TRG_ENDOCYTIC_2	497	500	PF00928	0.586
TRG_ENDOCYTIC_2	544	547	PF00928	0.543
TRG_ENDOCYTIC_2	568	571	PF00928	0.576
TRG_ENDOCYTIC_2	665	668	PF00928	0.529
TRG_ER_diArg_1	228	230	PF00400	0.679
TRG_ER_diArg_1	331	334	PF00400	0.639
TRG_ER_diArg_1	599	602	PF00400	0.622
TRG_ER_diArg_1	641	643	PF00400	0.625
TRG_NLS_Bipartite_1	83	98	PF00514	0.615
TRG_NLS_MonoExtN_4	596	603	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.748
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I262	Leptomonas seymouri	76%	99%
A0A1X0NL84	Trypanosomatidae	38%	100%
A0A422NVW4	Trypanosoma rangeli	39%	100%
A4HQM0	Leishmania braziliensis	93%	100%
A4ICD8	Leishmania infantum	100%	100%
A7E471	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	22%	84%
E9AUD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q055	Leishmania major	98%	100%
Q54X97	Dictyostelium discoideum	23%	78%
Q6BJF7	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	22%	86%
Q6P1V4	Xenopus tropicalis	23%	79%
Q6PFQ2	Danio rerio	22%	79%
V5DDW8	Trypanosoma cruzi	39%	100%