RNA ligase/6-phosphofructo-2-kinase/NACHT domain/AAA domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA ligase/AAA domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IWN9_LEIDO

TriTrypDb:

LdBPK_367180.1 , LdCL_360084400 , LDHU3_36.9550

Length:

905

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IWN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IWN9

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016874	ligase activity	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	372	376	PF00656	0.455
CLV_C14_Caspase3-7	521	525	PF00656	0.384
CLV_C14_Caspase3-7	75	79	PF00656	0.492
CLV_MEL_PAP_1	152	158	PF00089	0.259
CLV_NRD_NRD_1	115	117	PF00675	0.271
CLV_NRD_NRD_1	160	162	PF00675	0.293
CLV_NRD_NRD_1	181	183	PF00675	0.400
CLV_NRD_NRD_1	207	209	PF00675	0.335
CLV_NRD_NRD_1	340	342	PF00675	0.502
CLV_NRD_NRD_1	459	461	PF00675	0.273
CLV_NRD_NRD_1	501	503	PF00675	0.232
CLV_NRD_NRD_1	534	536	PF00675	0.304
CLV_NRD_NRD_1	554	556	PF00675	0.293
CLV_NRD_NRD_1	613	615	PF00675	0.510
CLV_NRD_NRD_1	868	870	PF00675	0.648
CLV_NRD_NRD_1	879	881	PF00675	0.671
CLV_PCSK_KEX2_1	160	162	PF00082	0.290
CLV_PCSK_KEX2_1	181	183	PF00082	0.404
CLV_PCSK_KEX2_1	207	209	PF00082	0.317
CLV_PCSK_KEX2_1	339	341	PF00082	0.514
CLV_PCSK_KEX2_1	459	461	PF00082	0.318
CLV_PCSK_KEX2_1	5	7	PF00082	0.485
CLV_PCSK_KEX2_1	501	503	PF00082	0.218
CLV_PCSK_KEX2_1	534	536	PF00082	0.304
CLV_PCSK_KEX2_1	613	615	PF00082	0.418
CLV_PCSK_KEX2_1	868	870	PF00082	0.540
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.536
CLV_PCSK_SKI1_1	138	142	PF00082	0.390
CLV_PCSK_SKI1_1	150	154	PF00082	0.326
CLV_PCSK_SKI1_1	245	249	PF00082	0.292
CLV_PCSK_SKI1_1	297	301	PF00082	0.316
CLV_PCSK_SKI1_1	35	39	PF00082	0.311
CLV_PCSK_SKI1_1	602	606	PF00082	0.412
CLV_PCSK_SKI1_1	692	696	PF00082	0.521
CLV_PCSK_SKI1_1	70	74	PF00082	0.271
CLV_PCSK_SKI1_1	802	806	PF00082	0.399
DEG_APCC_DBOX_1	149	157	PF00400	0.326
DEG_APCC_DBOX_1	34	42	PF00400	0.429
DEG_APCC_DBOX_1	392	400	PF00400	0.363
DEG_APCC_DBOX_1	718	726	PF00400	0.505
DEG_Nend_UBRbox_2	1	3	PF02207	0.397
DOC_CKS1_1	14	19	PF01111	0.492
DOC_CYCLIN_RxL_1	145	157	PF00134	0.461
DOC_CYCLIN_RxL_1	689	699	PF00134	0.536
DOC_MAPK_gen_1	295	304	PF00069	0.365
DOC_MAPK_gen_1	339	347	PF00069	0.402
DOC_MAPK_gen_1	391	400	PF00069	0.296
DOC_MAPK_gen_1	501	512	PF00069	0.466
DOC_MAPK_gen_1	534	542	PF00069	0.335
DOC_MAPK_gen_1	647	656	PF00069	0.409
DOC_MAPK_MEF2A_6	287	296	PF00069	0.469
DOC_MAPK_MEF2A_6	391	400	PF00069	0.329
DOC_MAPK_MEF2A_6	650	658	PF00069	0.364
DOC_MAPK_NFAT4_5	287	295	PF00069	0.434
DOC_PP1_RVXF_1	690	696	PF00149	0.575
DOC_PP4_FxxP_1	558	561	PF00568	0.381
DOC_SPAK_OSR1_1	748	752	PF12202	0.399
DOC_USP7_MATH_1	250	254	PF00917	0.409
DOC_USP7_MATH_1	306	310	PF00917	0.444
DOC_USP7_MATH_1	407	411	PF00917	0.435
DOC_USP7_MATH_1	580	584	PF00917	0.490
DOC_USP7_MATH_1	634	638	PF00917	0.419
DOC_USP7_MATH_1	77	81	PF00917	0.307
DOC_WW_Pin1_4	13	18	PF00397	0.483
DOC_WW_Pin1_4	256	261	PF00397	0.390
DOC_WW_Pin1_4	423	428	PF00397	0.355
LIG_14-3-3_CanoR_1	305	311	PF00244	0.327
LIG_14-3-3_CanoR_1	316	321	PF00244	0.378
LIG_14-3-3_CanoR_1	379	387	PF00244	0.521
LIG_14-3-3_CanoR_1	393	399	PF00244	0.257
LIG_14-3-3_CanoR_1	418	428	PF00244	0.410
LIG_14-3-3_CanoR_1	650	655	PF00244	0.426
LIG_14-3-3_CanoR_1	696	705	PF00244	0.576
LIG_14-3-3_CanoR_1	755	761	PF00244	0.459
LIG_14-3-3_CanoR_1	802	808	PF00244	0.372
LIG_14-3-3_CanoR_1	831	837	PF00244	0.517
LIG_Actin_WH2_2	651	668	PF00022	0.412
LIG_APCC_ABBA_1	142	147	PF00400	0.259
LIG_APCC_ABBAyCdc20_2	308	314	PF00400	0.291
LIG_BIR_III_4	437	441	PF00653	0.215
LIG_BRCT_BRCA1_1	214	218	PF00533	0.404
LIG_BRCT_BRCA1_1	50	54	PF00533	0.284
LIG_Clathr_ClatBox_1	488	492	PF01394	0.271
LIG_deltaCOP1_diTrp_1	97	106	PF00928	0.316
LIG_FHA_1	22	28	PF00498	0.572
LIG_FHA_1	381	387	PF00498	0.528
LIG_FHA_1	395	401	PF00498	0.312
LIG_FHA_1	630	636	PF00498	0.424
LIG_FHA_1	660	666	PF00498	0.433
LIG_FHA_1	712	718	PF00498	0.427
LIG_FHA_1	790	796	PF00498	0.418
LIG_FHA_2	18	24	PF00498	0.530
LIG_FHA_2	221	227	PF00498	0.404
LIG_FHA_2	257	263	PF00498	0.292
LIG_FHA_2	370	376	PF00498	0.515
LIG_FHA_2	466	472	PF00498	0.281
LIG_FHA_2	628	634	PF00498	0.516
LIG_GBD_Chelix_1	412	420	PF00786	0.292
LIG_IRF3_LxIS_1	621	628	PF10401	0.299
LIG_LIR_Apic_2	185	189	PF02991	0.290
LIG_LIR_Gen_1	215	225	PF02991	0.404
LIG_LIR_Gen_1	269	278	PF02991	0.270
LIG_LIR_Gen_1	298	307	PF02991	0.391
LIG_LIR_Gen_1	426	434	PF02991	0.350
LIG_LIR_Gen_1	686	695	PF02991	0.579
LIG_LIR_Gen_1	747	756	PF02991	0.375
LIG_LIR_Nem_3	124	128	PF02991	0.160
LIG_LIR_Nem_3	215	221	PF02991	0.454
LIG_LIR_Nem_3	257	261	PF02991	0.322
LIG_LIR_Nem_3	269	274	PF02991	0.239
LIG_LIR_Nem_3	298	304	PF02991	0.323
LIG_LIR_Nem_3	426	431	PF02991	0.272
LIG_LIR_Nem_3	686	690	PF02991	0.584
LIG_LIR_Nem_3	747	752	PF02991	0.386
LIG_LIR_Nem_3	870	875	PF02991	0.649
LIG_NRBOX	415	421	PF00104	0.292
LIG_NRBOX	620	626	PF00104	0.480
LIG_PCNA_yPIPBox_3	455	465	PF02747	0.308
LIG_Pex14_1	106	110	PF04695	0.335
LIG_Pex14_1	254	258	PF04695	0.404
LIG_Pex14_1	504	508	PF04695	0.404
LIG_Pex14_1	707	711	PF04695	0.535
LIG_Pex14_2	121	125	PF04695	0.160
LIG_SH2_GRB2like	762	765	PF00017	0.433
LIG_SH2_GRB2like	882	885	PF00017	0.495
LIG_SH2_NCK_1	515	519	PF00017	0.335
LIG_SH2_PTP2	301	304	PF00017	0.427
LIG_SH2_SRC	320	323	PF00017	0.432
LIG_SH2_SRC	762	765	PF00017	0.542
LIG_SH2_STAP1	515	519	PF00017	0.335
LIG_SH2_STAT3	779	782	PF00017	0.465
LIG_SH2_STAT5	110	113	PF00017	0.215
LIG_SH2_STAT5	258	261	PF00017	0.378
LIG_SH2_STAT5	30	33	PF00017	0.428
LIG_SH2_STAT5	301	304	PF00017	0.443
LIG_SH2_STAT5	320	323	PF00017	0.488
LIG_SH2_STAT5	519	522	PF00017	0.277
LIG_SH2_STAT5	762	765	PF00017	0.533
LIG_SH2_STAT5	779	782	PF00017	0.422
LIG_SH3_3	233	239	PF00018	0.339
LIG_SH3_3	677	683	PF00018	0.572
LIG_SH3_3	706	712	PF00018	0.608
LIG_SH3_3	732	738	PF00018	0.599
LIG_SH3_3	750	756	PF00018	0.519
LIG_Sin3_3	271	278	PF02671	0.404
LIG_SUMO_SIM_anti_2	397	402	PF11976	0.390
LIG_SUMO_SIM_anti_2	486	492	PF11976	0.428
LIG_SUMO_SIM_par_1	271	276	PF11976	0.282
LIG_SUMO_SIM_par_1	486	492	PF11976	0.398
LIG_SUMO_SIM_par_1	602	607	PF11976	0.427
LIG_SUMO_SIM_par_1	637	644	PF11976	0.568
LIG_TRAF2_1	421	424	PF00917	0.312
LIG_TRAF2_1	562	565	PF00917	0.551
LIG_WRC_WIRS_1	122	127	PF05994	0.160
MOD_CK1_1	101	107	PF00069	0.431
MOD_CK1_1	219	225	PF00069	0.466
MOD_CK1_1	356	362	PF00069	0.524
MOD_CK1_1	369	375	PF00069	0.481
MOD_CK1_1	426	432	PF00069	0.477
MOD_CK1_1	480	486	PF00069	0.335
MOD_CK1_1	50	56	PF00069	0.361
MOD_CK1_1	523	529	PF00069	0.335
MOD_CK1_1	583	589	PF00069	0.482
MOD_CK1_1	628	634	PF00069	0.560
MOD_CK1_1	641	647	PF00069	0.456
MOD_CK1_1	686	692	PF00069	0.613
MOD_CK1_1	863	869	PF00069	0.463
MOD_CK2_1	220	226	PF00069	0.404
MOD_CK2_1	331	337	PF00069	0.522
MOD_CK2_1	540	546	PF00069	0.493
MOD_CK2_1	559	565	PF00069	0.310
MOD_CK2_1	627	633	PF00069	0.417
MOD_CK2_1	673	679	PF00069	0.455
MOD_GlcNHglycan	333	336	PF01048	0.512
MOD_GlcNHglycan	355	358	PF01048	0.413
MOD_GlcNHglycan	479	482	PF01048	0.322
MOD_GlcNHglycan	484	488	PF01048	0.298
MOD_GlcNHglycan	524	528	PF01048	0.223
MOD_GlcNHglycan	542	545	PF01048	0.232
MOD_GlcNHglycan	606	609	PF01048	0.352
MOD_GlcNHglycan	643	646	PF01048	0.677
MOD_GlcNHglycan	698	701	PF01048	0.500
MOD_GlcNHglycan	734	738	PF01048	0.604
MOD_GlcNHglycan	770	773	PF01048	0.556
MOD_GSK3_1	100	107	PF00069	0.426
MOD_GSK3_1	13	20	PF00069	0.571
MOD_GSK3_1	212	219	PF00069	0.368
MOD_GSK3_1	250	257	PF00069	0.473
MOD_GSK3_1	312	319	PF00069	0.484
MOD_GSK3_1	419	426	PF00069	0.383
MOD_GSK3_1	447	454	PF00069	0.335
MOD_GSK3_1	625	632	PF00069	0.436
MOD_GSK3_1	634	641	PF00069	0.526
MOD_GSK3_1	703	710	PF00069	0.632
MOD_GSK3_1	711	718	PF00069	0.568
MOD_GSK3_1	774	781	PF00069	0.479
MOD_GSK3_1	789	796	PF00069	0.286
MOD_GSK3_1	803	810	PF00069	0.483
MOD_GSK3_1	818	825	PF00069	0.480
MOD_N-GLC_1	254	259	PF02516	0.292
MOD_N-GLC_1	494	499	PF02516	0.404
MOD_N-GLC_1	860	865	PF02516	0.463
MOD_N-GLC_1	875	880	PF02516	0.413
MOD_NEK2_1	100	105	PF00069	0.335
MOD_NEK2_1	121	126	PF00069	0.271
MOD_NEK2_1	248	253	PF00069	0.456
MOD_NEK2_1	380	385	PF00069	0.517
MOD_NEK2_1	414	419	PF00069	0.384
MOD_NEK2_1	604	609	PF00069	0.418
MOD_NEK2_1	638	643	PF00069	0.529
MOD_NEK2_1	672	677	PF00069	0.497
MOD_NEK2_1	780	785	PF00069	0.546
MOD_NEK2_1	807	812	PF00069	0.440
MOD_NEK2_1	822	827	PF00069	0.512
MOD_NEK2_1	832	837	PF00069	0.312
MOD_PIKK_1	206	212	PF00454	0.404
MOD_PIKK_1	366	372	PF00454	0.417
MOD_PIKK_1	419	425	PF00454	0.425
MOD_PIKK_1	494	500	PF00454	0.404
MOD_PIKK_1	55	61	PF00454	0.558
MOD_PIKK_1	778	784	PF00454	0.427
MOD_PIKK_1	875	881	PF00454	0.639
MOD_PKA_1	868	874	PF00069	0.532
MOD_PKA_2	154	160	PF00069	0.259
MOD_PKA_2	206	212	PF00069	0.335
MOD_PKA_2	366	372	PF00069	0.452
MOD_PKA_2	381	387	PF00069	0.518
MOD_PKA_2	649	655	PF00069	0.523
MOD_PKA_2	825	831	PF00069	0.454
MOD_PKA_2	868	874	PF00069	0.703
MOD_PKB_1	731	739	PF00069	0.489
MOD_Plk_1	101	107	PF00069	0.335
MOD_Plk_1	212	218	PF00069	0.349
MOD_Plk_1	219	225	PF00069	0.349
MOD_Plk_1	254	260	PF00069	0.292
MOD_Plk_1	47	53	PF00069	0.472
MOD_Plk_1	523	529	PF00069	0.382
MOD_Plk_1	789	795	PF00069	0.348
MOD_Plk_1	860	866	PF00069	0.469
MOD_Plk_2-3	220	226	PF00069	0.292
MOD_Plk_2-3	860	866	PF00069	0.469
MOD_Plk_4	101	107	PF00069	0.428
MOD_Plk_4	121	127	PF00069	0.263
MOD_Plk_4	316	322	PF00069	0.497
MOD_Plk_4	394	400	PF00069	0.421
MOD_Plk_4	616	622	PF00069	0.422
MOD_Plk_4	634	640	PF00069	0.358
MOD_Plk_4	756	762	PF00069	0.347
MOD_Plk_4	77	83	PF00069	0.335
MOD_Plk_4	794	800	PF00069	0.342
MOD_ProDKin_1	13	19	PF00069	0.482
MOD_ProDKin_1	256	262	PF00069	0.390
MOD_ProDKin_1	423	429	PF00069	0.355
MOD_SUMO_for_1	4	7	PF00179	0.492
TRG_DiLeu_BaEn_1	269	274	PF01217	0.349
TRG_DiLeu_BaEn_1	484	489	PF01217	0.326
TRG_DiLeu_BaLyEn_6	415	420	PF01217	0.400
TRG_DiLeu_BaLyEn_6	689	694	PF01217	0.538
TRG_ENDOCYTIC_2	258	261	PF00928	0.333
TRG_ENDOCYTIC_2	301	304	PF00928	0.342
TRG_ENDOCYTIC_2	882	885	PF00928	0.495
TRG_ER_diArg_1	160	163	PF00400	0.376
TRG_ER_diArg_1	180	182	PF00400	0.176
TRG_ER_diArg_1	33	36	PF00400	0.409
TRG_ER_diArg_1	338	341	PF00400	0.502
TRG_ER_diArg_1	364	367	PF00400	0.430
TRG_ER_diArg_1	390	393	PF00400	0.374
TRG_ER_diArg_1	459	461	PF00400	0.349
TRG_ER_diArg_1	501	503	PF00400	0.206
TRG_ER_diArg_1	730	733	PF00400	0.687
TRG_NES_CRM1_1	262	276	PF08389	0.270
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	418	423	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.314
TRG_Pf-PMV_PEXEL_1	743	747	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8U3	Leptomonas seymouri	53%	95%
A0A1X0NM11	Trypanosomatidae	35%	100%
A0A422NVW3	Trypanosoma rangeli	33%	100%
A4HQK6	Leishmania braziliensis	79%	100%
A4ICC6	Leishmania infantum	99%	100%
D0A3Q8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AUC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q069	Leishmania major	92%	100%
V5BM71	Trypanosoma cruzi	33%	100%