LeishMANIAdb
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Glucose transporter 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glucose transporter 2
Gene product:
glucose transporter 1
Species:
Leishmania donovani
UniProt:
A0A3Q8IWJ4_LEIDO
TriTrypDb:
LdBPK_366560.1 , LdCL_360073300 , LDHU3_36.8700
Length:
653

Annotations

LeishMANIAdb annotations

Publication identifier(s): 30068561 23766511
These proteins are related to other Eukaryotic proton-coupled hexose transporters, but the family has extremely expanded in parazitic species.. Subcellular localization depends on the actual paralogue. In L. mexicana, the GT2 protein (E9AU63) is found on the cell membrane, GT3 (E9AU62) is largely located at the ER while GT1 (E9AU64) is flagellar.. Localization: ER (experimental) / Cell surface (experimental) / Flagellar (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 3
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 39
NetGPI no yes: 0, no: 39
Cellular components
Term Name Level Count
GO:0016020 membrane 2 40
GO:0110165 cellular anatomical entity 1 40
GO:0005886 plasma membrane 3 3
GO:0051286 cell tip 3 3
GO:0060187 cell pole 2 3

Expansion

Sequence features

A0A3Q8IWJ4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IWJ4

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 16
GO:0008643 carbohydrate transport 5 16
GO:0051179 localization 1 16
GO:0051234 establishment of localization 2 16
GO:0071702 organic substance transport 4 16
GO:0009987 cellular process 1 1
GO:0015749 monosaccharide transmembrane transport 4 1
GO:0034219 carbohydrate transmembrane transport 3 1
GO:0055085 transmembrane transport 2 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 40
GO:0015144 carbohydrate transmembrane transporter activity 3 15
GO:0022857 transmembrane transporter activity 2 40
GO:0015145 monosaccharide transmembrane transporter activity 5 2
GO:0015149 hexose transmembrane transporter activity 6 2
GO:0051119 sugar transmembrane transporter activity 4 2
GO:0005353 fructose transmembrane transporter activity 7 1
GO:0005354 galactose transmembrane transporter activity 7 1
GO:0015578 mannose transmembrane transporter activity 7 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 103 107 PF00656 0.582
CLV_C14_Caspase3-7 625 629 PF00656 0.672
CLV_NRD_NRD_1 199 201 PF00675 0.561
CLV_NRD_NRD_1 56 58 PF00675 0.388
CLV_PCSK_KEX2_1 199 201 PF00082 0.484
CLV_PCSK_KEX2_1 331 333 PF00082 0.335
CLV_PCSK_KEX2_1 626 628 PF00082 0.477
CLV_PCSK_KEX2_1 631 633 PF00082 0.565
CLV_PCSK_PC1ET2_1 331 333 PF00082 0.347
CLV_PCSK_PC1ET2_1 626 628 PF00082 0.477
CLV_PCSK_PC1ET2_1 631 633 PF00082 0.565
CLV_PCSK_PC7_1 627 633 PF00082 0.423
CLV_PCSK_SKI1_1 488 492 PF00082 0.268
CLV_PCSK_SKI1_1 57 61 PF00082 0.395
DEG_ODPH_VHL_1 458 469 PF01847 0.347
DOC_CKS1_1 44 49 PF01111 0.585
DOC_CKS1_1 96 101 PF01111 0.573
DOC_CYCLIN_RxL_1 485 495 PF00134 0.535
DOC_MAPK_gen_1 329 338 PF00069 0.483
DOC_MAPK_HePTP_8 301 313 PF00069 0.435
DOC_MAPK_MEF2A_6 271 279 PF00069 0.482
DOC_MAPK_MEF2A_6 304 313 PF00069 0.319
DOC_MAPK_MEF2A_6 329 338 PF00069 0.493
DOC_MAPK_NFAT4_5 304 312 PF00069 0.388
DOC_PP1_RVXF_1 269 275 PF00149 0.482
DOC_PP2B_LxvP_1 59 62 PF13499 0.591
DOC_PP2B_LxvP_1 81 84 PF13499 0.564
DOC_PP4_FxxP_1 260 263 PF00568 0.455
DOC_PP4_FxxP_1 619 622 PF00568 0.356
DOC_SPAK_OSR1_1 304 308 PF12202 0.417
DOC_USP7_MATH_1 119 123 PF00917 0.612
DOC_USP7_MATH_1 263 267 PF00917 0.473
DOC_USP7_MATH_1 512 516 PF00917 0.349
DOC_USP7_UBL2_3 517 521 PF12436 0.299
DOC_USP7_UBL2_3 626 630 PF12436 0.674
DOC_WW_Pin1_4 117 122 PF00397 0.642
DOC_WW_Pin1_4 35 40 PF00397 0.786
DOC_WW_Pin1_4 43 48 PF00397 0.718
DOC_WW_Pin1_4 65 70 PF00397 0.594
DOC_WW_Pin1_4 95 100 PF00397 0.778
LIG_14-3-3_CanoR_1 169 175 PF00244 0.363
LIG_14-3-3_CanoR_1 199 205 PF00244 0.354
LIG_14-3-3_CanoR_1 222 228 PF00244 0.315
LIG_14-3-3_CanoR_1 271 275 PF00244 0.493
LIG_14-3-3_CanoR_1 559 564 PF00244 0.475
LIG_BIR_II_1 1 5 PF00653 0.790
LIG_BIR_III_2 36 40 PF00653 0.596
LIG_BRCT_BRCA1_1 119 123 PF00533 0.568
LIG_BRCT_BRCA1_1 144 148 PF00533 0.348
LIG_BRCT_BRCA1_1 152 156 PF00533 0.287
LIG_BRCT_BRCA1_1 242 246 PF00533 0.284
LIG_BRCT_BRCA1_1 358 362 PF00533 0.313
LIG_BRCT_BRCA1_1 380 384 PF00533 0.455
LIG_BRCT_BRCA1_1 481 485 PF00533 0.420
LIG_deltaCOP1_diTrp_1 296 305 PF00928 0.326
LIG_FHA_1 331 337 PF00498 0.494
LIG_FHA_1 341 347 PF00498 0.255
LIG_FHA_1 386 392 PF00498 0.429
LIG_FHA_1 434 440 PF00498 0.367
LIG_FHA_1 525 531 PF00498 0.369
LIG_FHA_1 565 571 PF00498 0.376
LIG_FHA_1 581 587 PF00498 0.278
LIG_FHA_1 96 102 PF00498 0.655
LIG_FHA_2 213 219 PF00498 0.354
LIG_FHA_2 23 29 PF00498 0.698
LIG_FHA_2 62 68 PF00498 0.754
LIG_GBD_Chelix_1 264 272 PF00786 0.446
LIG_LIR_Apic_2 258 263 PF02991 0.455
LIG_LIR_Gen_1 120 131 PF02991 0.563
LIG_LIR_Gen_1 273 282 PF02991 0.347
LIG_LIR_Gen_1 296 306 PF02991 0.315
LIG_LIR_Gen_1 381 391 PF02991 0.397
LIG_LIR_Gen_1 417 428 PF02991 0.495
LIG_LIR_Gen_1 562 571 PF02991 0.280
LIG_LIR_Nem_3 120 126 PF02991 0.520
LIG_LIR_Nem_3 145 151 PF02991 0.330
LIG_LIR_Nem_3 273 277 PF02991 0.349
LIG_LIR_Nem_3 294 300 PF02991 0.257
LIG_LIR_Nem_3 381 387 PF02991 0.379
LIG_LIR_Nem_3 417 421 PF02991 0.583
LIG_LIR_Nem_3 562 566 PF02991 0.404
LIG_LYPXL_S_1 510 514 PF13949 0.336
LIG_LYPXL_yS_3 511 514 PF13949 0.272
LIG_NRBOX 271 277 PF00104 0.562
LIG_NRBOX 382 388 PF00104 0.439
LIG_Pex14_2 380 384 PF04695 0.445
LIG_Pex14_2 493 497 PF04695 0.435
LIG_Pex14_2 532 536 PF04695 0.288
LIG_Pex14_2 552 556 PF04695 0.480
LIG_Pex14_2 619 623 PF04695 0.379
LIG_PTB_Apo_2 573 580 PF02174 0.324
LIG_PTB_Phospho_1 573 579 PF10480 0.366
LIG_SH2_CRK 152 156 PF00017 0.289
LIG_SH2_NCK_1 204 208 PF00017 0.277
LIG_SH2_SRC 448 451 PF00017 0.304
LIG_SH2_STAP1 152 156 PF00017 0.312
LIG_SH2_STAT3 321 324 PF00017 0.504
LIG_SH2_STAT5 190 193 PF00017 0.324
LIG_SH2_STAT5 202 205 PF00017 0.328
LIG_SH2_STAT5 321 324 PF00017 0.450
LIG_SH2_STAT5 420 423 PF00017 0.613
LIG_SH2_STAT5 483 486 PF00017 0.542
LIG_SH2_STAT5 5 8 PF00017 0.596
LIG_SH2_STAT5 545 548 PF00017 0.371
LIG_SH2_STAT5 88 91 PF00017 0.599
LIG_SH3_2 53 58 PF14604 0.594
LIG_SH3_3 313 319 PF00018 0.319
LIG_SH3_3 50 56 PF00018 0.756
LIG_SH3_3 506 512 PF00018 0.313
LIG_SH3_3 574 580 PF00018 0.326
LIG_SH3_3 90 96 PF00018 0.771
LIG_SUMO_SIM_anti_2 385 391 PF11976 0.319
LIG_TRFH_1 618 622 PF08558 0.356
MOD_CDK_SPxxK_3 69 76 PF00069 0.580
MOD_CK1_1 122 128 PF00069 0.541
MOD_CK1_1 205 211 PF00069 0.310
MOD_CK1_1 236 242 PF00069 0.306
MOD_CK1_1 385 391 PF00069 0.397
MOD_CK1_1 495 501 PF00069 0.395
MOD_CK1_1 515 521 PF00069 0.335
MOD_CK1_1 645 651 PF00069 0.778
MOD_CK1_1 86 92 PF00069 0.770
MOD_CK2_1 111 117 PF00069 0.712
MOD_CK2_1 203 209 PF00069 0.332
MOD_CK2_1 212 218 PF00069 0.340
MOD_CK2_1 22 28 PF00069 0.701
MOD_CK2_1 225 231 PF00069 0.323
MOD_CK2_1 236 242 PF00069 0.285
MOD_CK2_1 288 294 PF00069 0.436
MOD_Cter_Amidation 628 631 PF01082 0.495
MOD_Cter_Amidation 638 641 PF01082 0.556
MOD_GlcNHglycan 1 4 PF01048 0.528
MOD_GlcNHglycan 10 13 PF01048 0.569
MOD_GlcNHglycan 205 208 PF01048 0.475
MOD_GlcNHglycan 227 230 PF01048 0.497
MOD_GlcNHglycan 235 238 PF01048 0.456
MOD_GlcNHglycan 242 245 PF01048 0.425
MOD_GlcNHglycan 586 589 PF01048 0.451
MOD_GlcNHglycan 590 593 PF01048 0.450
MOD_GlcNHglycan 647 650 PF01048 0.565
MOD_GSK3_1 18 25 PF00069 0.771
MOD_GSK3_1 194 201 PF00069 0.289
MOD_GSK3_1 233 240 PF00069 0.274
MOD_GSK3_1 3 10 PF00069 0.754
MOD_GSK3_1 378 385 PF00069 0.369
MOD_GSK3_1 433 440 PF00069 0.333
MOD_GSK3_1 471 478 PF00069 0.341
MOD_GSK3_1 479 486 PF00069 0.318
MOD_GSK3_1 492 499 PF00069 0.252
MOD_GSK3_1 580 587 PF00069 0.325
MOD_GSK3_1 61 68 PF00069 0.749
MOD_GSK3_1 641 648 PF00069 0.647
MOD_N-GLC_1 183 188 PF02516 0.513
MOD_N-GLC_2 576 578 PF02516 0.384
MOD_NEK2_1 156 161 PF00069 0.284
MOD_NEK2_1 246 251 PF00069 0.329
MOD_NEK2_1 255 260 PF00069 0.269
MOD_NEK2_1 264 269 PF00069 0.196
MOD_NEK2_1 356 361 PF00069 0.275
MOD_NEK2_1 395 400 PF00069 0.465
MOD_NEK2_1 433 438 PF00069 0.327
MOD_NEK2_1 472 477 PF00069 0.352
MOD_NEK2_1 492 497 PF00069 0.128
MOD_NEK2_1 643 648 PF00069 0.648
MOD_NEK2_2 194 199 PF00069 0.318
MOD_NEK2_2 379 384 PF00069 0.417
MOD_NEK2_2 483 488 PF00069 0.508
MOD_OFUCOSY 191 198 PF10250 0.486
MOD_PIKK_1 111 117 PF00454 0.587
MOD_PIKK_1 18 24 PF00454 0.774
MOD_PIKK_1 212 218 PF00454 0.331
MOD_PIKK_1 545 551 PF00454 0.363
MOD_PIKK_1 561 567 PF00454 0.324
MOD_PIKK_1 71 77 PF00454 0.572
MOD_PKA_2 198 204 PF00069 0.358
MOD_PKA_2 223 229 PF00069 0.340
MOD_PKA_2 270 276 PF00069 0.508
MOD_PKB_1 557 565 PF00069 0.475
MOD_Plk_4 151 157 PF00069 0.335
MOD_Plk_4 246 252 PF00069 0.346
MOD_Plk_4 255 261 PF00069 0.295
MOD_Plk_4 270 276 PF00069 0.453
MOD_Plk_4 282 288 PF00069 0.290
MOD_Plk_4 356 362 PF00069 0.326
MOD_Plk_4 379 385 PF00069 0.324
MOD_Plk_4 479 485 PF00069 0.335
MOD_Plk_4 492 498 PF00069 0.302
MOD_ProDKin_1 117 123 PF00069 0.633
MOD_ProDKin_1 35 41 PF00069 0.785
MOD_ProDKin_1 43 49 PF00069 0.719
MOD_ProDKin_1 65 71 PF00069 0.596
MOD_ProDKin_1 95 101 PF00069 0.779
TRG_AP2beta_CARGO_1 294 304 PF09066 0.347
TRG_DiLeu_BaEn_1 296 301 PF01217 0.335
TRG_DiLeu_BaLyEn_6 423 428 PF01217 0.513
TRG_ENDOCYTIC_2 152 155 PF00928 0.265
TRG_ENDOCYTIC_2 418 421 PF00928 0.557
TRG_ENDOCYTIC_2 511 514 PF00928 0.272
TRG_ENDOCYTIC_2 544 547 PF00928 0.408
TRG_ER_diArg_1 221 224 PF00400 0.297
TRG_ER_diArg_1 556 559 PF00400 0.482
TRG_NLS_MonoExtC_3 56 61 PF00514 0.587
TRG_NLS_MonoExtN_4 56 61 PF00514 0.594
TRG_NLS_MonoExtN_4 627 634 PF00514 0.652

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2E1 Leptomonas seymouri 53% 100%
A0A0N0P3Z7 Leptomonas seymouri 44% 85%
A0A0N0P4D8 Leptomonas seymouri 48% 88%
A0A0N1IG16 Leptomonas seymouri 71% 100%
A0A0N1P9H5 Leptomonas seymouri 46% 100%
A0A0S4J363 Bodo saltans 28% 100%
A0A0S4JDF9 Bodo saltans 39% 100%
A0A0S4JEY7 Bodo saltans 40% 100%
A0A0S4JH90 Bodo saltans 36% 100%
A0A0S4JS00 Bodo saltans 33% 100%
A0A1X0NLE0 Trypanosomatidae 57% 100%
A0A1X0NM05 Trypanosomatidae 56% 100%
A0A1X0NN62 Trypanosomatidae 52% 100%
A0A1X0P9L7 Trypanosomatidae 36% 100%
A0A381N054 Leishmania infantum 97% 100%
A0A3Q8IDK1 Leishmania donovani 43% 100%
A0A3Q8IK60 Leishmania donovani 97% 100%
A0A3R7KPU3 Trypanosoma rangeli 36% 100%
A0A3S7WY58 Leishmania donovani 22% 100%
A0A3S7XC27 Leishmania donovani 95% 100%
A0A422MNQ4 Trypanosoma rangeli 55% 100%
A4HL65 Leishmania braziliensis 40% 100%
A4HQD6 Leishmania braziliensis 85% 100%
A4HQD7 Leishmania braziliensis 86% 100%
A4HQE7 Leishmania braziliensis 90% 100%
A4I0Q6 Leishmania infantum 22% 100%
A4I8N6 Leishmania infantum 43% 100%
A4IC83 Leishmania infantum 99% 100%
C9ZMM0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
D0A3U1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
D0A3U2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
D0A3U3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9AU62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9AU63 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9AU64 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9AWQ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9B3K8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
K0E3U9 Aspergillus rugulosus 22% 100%
O34718 Bacillus subtilis (strain 168) 21% 100%
O74849 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 100%
P12336 Rattus norvegicus 22% 100%
P13865 Leishmania enriettii 83% 100%
P20303 Sus scrofa 23% 100%
P39003 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 20% 100%
P39004 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 20% 100%
P39924 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P47185 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P53631 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P54854 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
Q01441 Leishmania donovani 43% 100%
Q06221 Trypanosoma brucei brucei 46% 100%
Q06222 Trypanosoma brucei brucei 47% 100%
Q09037 Trypanosoma brucei brucei 45% 100%
Q10PW9 Oryza sativa subsp. japonica 21% 100%
Q27115 Trypanosoma vivax 46% 100%
Q4Q0D0 Leishmania major 89% 100%
Q4Q0D1 Leishmania major 94% 100%
Q4Q0D2 Leishmania major 92% 100%
Q4Q4J1 Leishmania major 43% 100%
Q4QAR5 Leishmania major 22% 100%
Q8TFG1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 100%
Q9P3U6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS