RanBD1 domain-containing protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IWI8_LEIDO

TriTrypDb:

LdBPK_366420.1 , LdCL_360071700 , LDHU3_36.8520

Length:

323

Annotations

Annotations by Jardim et al.

Intracellular signaling, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Phosphorylation

Amastigote: 17

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IWI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IWI8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051028	mRNA transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051236	establishment of RNA localization	3	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.670
CLV_C14_Caspase3-7	186	190	PF00656	0.538
CLV_NRD_NRD_1	158	160	PF00675	0.601
CLV_PCSK_SKI1_1	203	207	PF00082	0.479
CLV_PCSK_SKI1_1	266	270	PF00082	0.484
DEG_SPOP_SBC_1	21	25	PF00917	0.656
DOC_CKS1_1	61	66	PF01111	0.546
DOC_CYCLIN_RxL_1	263	272	PF00134	0.467
DOC_MAPK_gen_1	241	249	PF00069	0.504
DOC_PP4_FxxP_1	18	21	PF00568	0.716
DOC_PP4_FxxP_1	296	299	PF00568	0.450
DOC_PP4_FxxP_1	32	35	PF00568	0.511
DOC_USP7_MATH_1	110	114	PF00917	0.596
DOC_USP7_MATH_1	151	155	PF00917	0.575
DOC_USP7_MATH_1	21	25	PF00917	0.618
DOC_USP7_UBL2_3	273	277	PF12436	0.430
DOC_WW_Pin1_4	220	225	PF00397	0.535
DOC_WW_Pin1_4	48	53	PF00397	0.603
DOC_WW_Pin1_4	57	62	PF00397	0.585
DOC_WW_Pin1_4	96	101	PF00397	0.602
LIG_BIR_III_4	187	191	PF00653	0.626
LIG_BRCT_BRCA1_1	104	108	PF00533	0.606
LIG_BRCT_BRCA1_1	144	148	PF00533	0.587
LIG_BRCT_BRCA1_1	28	32	PF00533	0.717
LIG_FHA_1	289	295	PF00498	0.442
LIG_LIR_Apic_2	17	21	PF02991	0.715
LIG_LIR_Apic_2	29	35	PF02991	0.569
LIG_LIR_Nem_3	66	70	PF02991	0.630
LIG_Pex14_2	104	108	PF04695	0.612
LIG_SH2_STAP1	258	262	PF00017	0.455
LIG_SH2_STAT5	214	217	PF00017	0.427
LIG_SH2_STAT5	292	295	PF00017	0.377
LIG_SH3_3	133	139	PF00018	0.585
LIG_SH3_3	58	64	PF00018	0.715
LIG_SUMO_SIM_par_1	279	287	PF11976	0.447
LIG_TRFH_1	32	36	PF08558	0.562
LIG_UBA3_1	268	273	PF00899	0.503
LIG_WRC_WIRS_1	152	157	PF05994	0.575
MOD_CDK_SPK_2	57	62	PF00069	0.585
MOD_CDK_SPxK_1	220	226	PF00069	0.535
MOD_CK1_1	113	119	PF00069	0.617
MOD_CK1_1	23	29	PF00069	0.724
MOD_CK1_1	41	47	PF00069	0.644
MOD_CK1_1	48	54	PF00069	0.649
MOD_CK1_1	75	81	PF00069	0.672
MOD_CK1_1	83	89	PF00069	0.660
MOD_CK1_1	9	15	PF00069	0.614
MOD_CK1_1	91	97	PF00069	0.603
MOD_CK2_1	151	157	PF00069	0.611
MOD_CK2_1	269	275	PF00069	0.442
MOD_GlcNHglycan	113	116	PF01048	0.691
MOD_GlcNHglycan	149	152	PF01048	0.526
MOD_GlcNHglycan	199	203	PF01048	0.694
MOD_GlcNHglycan	40	43	PF01048	0.606
MOD_GlcNHglycan	75	78	PF01048	0.659
MOD_GlcNHglycan	90	93	PF01048	0.607
MOD_GSK3_1	147	154	PF00069	0.552
MOD_GSK3_1	188	195	PF00069	0.650
MOD_GSK3_1	21	28	PF00069	0.715
MOD_GSK3_1	267	274	PF00069	0.467
MOD_GSK3_1	302	309	PF00069	0.447
MOD_GSK3_1	34	41	PF00069	0.606
MOD_GSK3_1	48	55	PF00069	0.674
MOD_GSK3_1	56	63	PF00069	0.653
MOD_GSK3_1	69	76	PF00069	0.782
MOD_GSK3_1	79	86	PF00069	0.676
MOD_GSK3_1	91	98	PF00069	0.787
MOD_N-GLC_1	260	265	PF02516	0.432
MOD_N-GLC_1	303	308	PF02516	0.468
MOD_NEK2_1	260	265	PF00069	0.436
MOD_NEK2_1	269	274	PF00069	0.422
MOD_NEK2_1	294	299	PF00069	0.443
MOD_NEK2_1	45	50	PF00069	0.660
MOD_Plk_1	260	266	PF00069	0.448
MOD_Plk_4	151	157	PF00069	0.573
MOD_Plk_4	288	294	PF00069	0.421
MOD_ProDKin_1	220	226	PF00069	0.535
MOD_ProDKin_1	48	54	PF00069	0.605
MOD_ProDKin_1	57	63	PF00069	0.582
MOD_ProDKin_1	96	102	PF00069	0.603
MOD_SUMO_rev_2	229	238	PF00179	0.561
MOD_SUMO_rev_2	272	279	PF00179	0.421
TRG_DiLeu_BaEn_1	275	280	PF01217	0.422
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.449
TRG_NLS_MonoExtC_3	158	164	PF00514	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFC6	Leptomonas seymouri	58%	77%
A0A0S4IHX6	Bodo saltans	30%	91%
A4HQD5	Leishmania braziliensis	70%	100%
A4IE27	Leishmania infantum	100%	100%
E9AU51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q0E4	Leishmania major	92%	100%