A distinct subfamily of CDD/CDA-like deaminases, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

A distinct subfamily of CDD/CDA-like deaminases, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IWI0_LEIDO

TriTrypDb:

LdBPK_366200.1 , LdCL_360069400 , LDHU3_36.8210

Length:

624

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IWI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IWI0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.694
CLV_C14_Caspase3-7	481	485	PF00656	0.397
CLV_C14_Caspase3-7	606	610	PF00656	0.528
CLV_NRD_NRD_1	444	446	PF00675	0.292
CLV_NRD_NRD_1	506	508	PF00675	0.390
CLV_NRD_NRD_1	570	572	PF00675	0.312
CLV_NRD_NRD_1	594	596	PF00675	0.419
CLV_PCSK_KEX2_1	150	152	PF00082	0.479
CLV_PCSK_KEX2_1	506	508	PF00082	0.390
CLV_PCSK_KEX2_1	570	572	PF00082	0.328
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.479
CLV_PCSK_SKI1_1	232	236	PF00082	0.488
CLV_PCSK_SKI1_1	544	548	PF00082	0.292
CLV_PCSK_SKI1_1	551	555	PF00082	0.292
CLV_PCSK_SKI1_1	570	574	PF00082	0.332
CLV_PCSK_SKI1_1	596	600	PF00082	0.413
CLV_PCSK_SKI1_1	70	74	PF00082	0.650
DEG_APCC_DBOX_1	191	199	PF00400	0.514
DEG_SCF_FBW7_1	494	500	PF00400	0.346
DEG_SCF_FBW7_1	516	522	PF00400	0.292
DEG_SPOP_SBC_1	63	67	PF00917	0.599
DOC_CDC14_PxL_1	195	203	PF14671	0.516
DOC_CKS1_1	494	499	PF01111	0.402
DOC_CKS1_1	516	521	PF01111	0.292
DOC_CKS1_1	71	76	PF01111	0.606
DOC_MAPK_DCC_7	150	160	PF00069	0.508
DOC_MAPK_DCC_7	194	203	PF00069	0.517
DOC_MAPK_gen_1	506	512	PF00069	0.390
DOC_MAPK_gen_1	595	602	PF00069	0.292
DOC_MAPK_MEF2A_6	151	160	PF00069	0.515
DOC_MAPK_MEF2A_6	194	203	PF00069	0.517
DOC_MAPK_MEF2A_6	595	602	PF00069	0.292
DOC_PP1_RVXF_1	181	187	PF00149	0.502
DOC_PP1_RVXF_1	593	600	PF00149	0.419
DOC_PP2B_LxvP_1	536	539	PF13499	0.500
DOC_PP2B_LxvP_1	600	603	PF13499	0.410
DOC_PP2B_LxvP_1	92	95	PF13499	0.574
DOC_PP4_FxxP_1	10	13	PF00568	0.379
DOC_SPAK_OSR1_1	159	163	PF12202	0.559
DOC_USP7_MATH_1	320	324	PF00917	0.484
DOC_USP7_MATH_1	440	444	PF00917	0.337
DOC_USP7_MATH_1	497	501	PF00917	0.339
DOC_USP7_MATH_1	50	54	PF00917	0.682
DOC_USP7_MATH_1	519	523	PF00917	0.292
DOC_USP7_MATH_1	88	92	PF00917	0.667
DOC_WW_Pin1_4	113	118	PF00397	0.742
DOC_WW_Pin1_4	160	165	PF00397	0.527
DOC_WW_Pin1_4	493	498	PF00397	0.402
DOC_WW_Pin1_4	515	520	PF00397	0.292
DOC_WW_Pin1_4	590	595	PF00397	0.402
DOC_WW_Pin1_4	64	69	PF00397	0.659
DOC_WW_Pin1_4	70	75	PF00397	0.623
DOC_WW_Pin1_4	97	102	PF00397	0.757
LIG_14-3-3_CanoR_1	176	186	PF00244	0.472
LIG_14-3-3_CanoR_1	200	206	PF00244	0.508
LIG_14-3-3_CanoR_1	246	255	PF00244	0.522
LIG_14-3-3_CanoR_1	430	436	PF00244	0.286
LIG_14-3-3_CanoR_1	451	461	PF00244	0.307
LIG_14-3-3_CanoR_1	523	530	PF00244	0.308
LIG_Actin_WH2_2	557	572	PF00022	0.283
LIG_APCC_ABBA_1	258	263	PF00400	0.368
LIG_BIR_II_1	1	5	PF00653	0.521
LIG_BRCT_BRCA1_1	10	14	PF00533	0.412
LIG_BRCT_BRCA1_2	10	16	PF00533	0.441
LIG_EVH1_1	92	96	PF00568	0.576
LIG_EVH1_2	156	160	PF00568	0.545
LIG_FHA_1	231	237	PF00498	0.417
LIG_FHA_1	271	277	PF00498	0.603
LIG_FHA_1	336	342	PF00498	0.475
LIG_FHA_1	408	414	PF00498	0.631
LIG_FHA_1	427	433	PF00498	0.318
LIG_FHA_1	453	459	PF00498	0.311
LIG_FHA_1	46	52	PF00498	0.652
LIG_FHA_1	538	544	PF00498	0.292
LIG_FHA_1	571	577	PF00498	0.312
LIG_FHA_2	106	112	PF00498	0.788
LIG_FHA_2	307	313	PF00498	0.391
LIG_FHA_2	34	40	PF00498	0.462
LIG_FHA_2	371	377	PF00498	0.502
LIG_FHA_2	457	463	PF00498	0.292
LIG_FHA_2	476	482	PF00498	0.292
LIG_FHA_2	599	605	PF00498	0.343
LIG_FHA_2	64	70	PF00498	0.642
LIG_LIR_Apic_2	8	13	PF02991	0.372
LIG_LIR_Gen_1	29	35	PF02991	0.371
LIG_LIR_Gen_1	334	342	PF02991	0.443
LIG_LIR_Gen_1	383	393	PF02991	0.480
LIG_LIR_Gen_1	408	416	PF02991	0.510
LIG_LIR_Nem_3	29	33	PF02991	0.376
LIG_LIR_Nem_3	334	339	PF02991	0.438
LIG_LIR_Nem_3	383	388	PF02991	0.454
LIG_LIR_Nem_3	408	414	PF02991	0.499
LIG_LIR_Nem_3	459	463	PF02991	0.419
LIG_LIR_Nem_3	6	12	PF02991	0.433
LIG_NRP_CendR_1	622	624	PF00754	0.521
LIG_Pex14_1	332	336	PF04695	0.458
LIG_Pex14_2	10	14	PF04695	0.369
LIG_PTB_Apo_2	315	322	PF02174	0.443
LIG_PTB_Apo_2	554	561	PF02174	0.292
LIG_SH2_PTP2	161	164	PF00017	0.576
LIG_SH2_PTP2	30	33	PF00017	0.358
LIG_SH2_SRC	259	262	PF00017	0.439
LIG_SH2_STAT5	146	149	PF00017	0.427
LIG_SH2_STAT5	161	164	PF00017	0.426
LIG_SH2_STAT5	18	21	PF00017	0.386
LIG_SH2_STAT5	225	228	PF00017	0.430
LIG_SH2_STAT5	259	262	PF00017	0.461
LIG_SH2_STAT5	30	33	PF00017	0.364
LIG_SH2_STAT5	58	61	PF00017	0.489
LIG_SH3_1	446	452	PF00018	0.298
LIG_SH3_2	94	99	PF14604	0.624
LIG_SH3_3	150	156	PF00018	0.385
LIG_SH3_3	196	202	PF00018	0.529
LIG_SH3_3	362	368	PF00018	0.441
LIG_SH3_3	446	452	PF00018	0.298
LIG_SH3_3	555	561	PF00018	0.292
LIG_SH3_3	65	71	PF00018	0.650
LIG_SH3_3	90	96	PF00018	0.712
LIG_SUMO_SIM_anti_2	338	344	PF11976	0.464
LIG_SUMO_SIM_par_1	31	39	PF11976	0.406
LIG_TRAF2_1	478	481	PF00917	0.390
LIG_UBA3_1	413	418	PF00899	0.402
LIG_WRC_WIRS_1	432	437	PF05994	0.225
LIG_WRC_WIRS_1	457	462	PF05994	0.419
LIG_WW_3	328	332	PF00397	0.372
MOD_CDC14_SPxK_1	163	166	PF00782	0.585
MOD_CDK_SPK_2	160	165	PF00069	0.581
MOD_CDK_SPK_2	590	595	PF00069	0.402
MOD_CDK_SPxK_1	160	166	PF00069	0.582
MOD_CDK_SPxK_1	590	596	PF00069	0.402
MOD_CDK_SPxK_1	64	70	PF00069	0.723
MOD_CDK_SPxxK_3	97	104	PF00069	0.626
MOD_CK1_1	100	106	PF00069	0.706
MOD_CK1_1	113	119	PF00069	0.602
MOD_CK1_1	123	129	PF00069	0.552
MOD_CK1_1	274	280	PF00069	0.543
MOD_CK1_1	426	432	PF00069	0.288
MOD_CK1_1	456	462	PF00069	0.292
MOD_CK1_1	517	523	PF00069	0.328
MOD_CK1_1	53	59	PF00069	0.641
MOD_CK2_1	105	111	PF00069	0.782
MOD_CK2_1	288	294	PF00069	0.527
MOD_CK2_1	475	481	PF00069	0.402
MOD_CK2_1	598	604	PF00069	0.343
MOD_CK2_1	63	69	PF00069	0.730
MOD_DYRK1A_RPxSP_1	70	74	PF00069	0.751
MOD_GlcNHglycan	130	133	PF01048	0.724
MOD_GlcNHglycan	290	293	PF01048	0.439
MOD_GlcNHglycan	382	385	PF01048	0.578
MOD_GlcNHglycan	497	500	PF01048	0.480
MOD_GlcNHglycan	519	522	PF01048	0.292
MOD_GlcNHglycan	55	58	PF01048	0.753
MOD_GlcNHglycan	78	81	PF01048	0.681
MOD_GSK3_1	100	107	PF00069	0.675
MOD_GSK3_1	119	126	PF00069	0.570
MOD_GSK3_1	270	277	PF00069	0.575
MOD_GSK3_1	431	438	PF00069	0.367
MOD_GSK3_1	452	459	PF00069	0.292
MOD_GSK3_1	493	500	PF00069	0.343
MOD_GSK3_1	515	522	PF00069	0.379
MOD_N-GLC_1	247	252	PF02516	0.436
MOD_N-GLC_1	378	383	PF02516	0.475
MOD_N-GLC_1	426	431	PF02516	0.419
MOD_N-GLC_2	396	398	PF02516	0.388
MOD_N-GLC_2	464	466	PF02516	0.419
MOD_NEK2_1	119	124	PF00069	0.658
MOD_NEK2_1	247	252	PF00069	0.462
MOD_NEK2_1	337	342	PF00069	0.385
MOD_NEK2_1	349	354	PF00069	0.418
MOD_NEK2_1	370	375	PF00069	0.469
MOD_NEK2_1	378	383	PF00069	0.462
MOD_NEK2_1	431	436	PF00069	0.382
MOD_NEK2_1	589	594	PF00069	0.315
MOD_NEK2_2	5	10	PF00069	0.560
MOD_NEK2_2	582	587	PF00069	0.419
MOD_OFUCOSY	174	181	PF10250	0.529
MOD_OFUCOSY	245	251	PF10250	0.465
MOD_PIKK_1	3	9	PF00454	0.505
MOD_PKA_1	570	576	PF00069	0.307
MOD_PKA_2	105	111	PF00069	0.728
MOD_PKA_2	522	528	PF00069	0.308
MOD_PKA_2	570	576	PF00069	0.419
MOD_PKB_1	104	112	PF00069	0.627
MOD_PKB_1	192	200	PF00069	0.516
MOD_PKB_1	402	410	PF00069	0.563
MOD_Plk_1	262	268	PF00069	0.559
MOD_Plk_1	274	280	PF00069	0.402
MOD_Plk_1	407	413	PF00069	0.656
MOD_Plk_1	426	432	PF00069	0.334
MOD_Plk_1	582	588	PF00069	0.359
MOD_Plk_2-3	409	415	PF00069	0.547
MOD_Plk_4	26	32	PF00069	0.498
MOD_Plk_4	262	268	PF00069	0.354
MOD_Plk_4	337	343	PF00069	0.515
MOD_Plk_4	396	402	PF00069	0.452
MOD_Plk_4	420	426	PF00069	0.312
MOD_Plk_4	453	459	PF00069	0.292
MOD_Plk_4	5	11	PF00069	0.458
MOD_Plk_4	582	588	PF00069	0.397
MOD_ProDKin_1	113	119	PF00069	0.741
MOD_ProDKin_1	160	166	PF00069	0.528
MOD_ProDKin_1	493	499	PF00069	0.402
MOD_ProDKin_1	515	521	PF00069	0.292
MOD_ProDKin_1	590	596	PF00069	0.402
MOD_ProDKin_1	64	70	PF00069	0.663
MOD_ProDKin_1	97	103	PF00069	0.760
MOD_SUMO_for_1	416	419	PF00179	0.337
MOD_SUMO_rev_2	340	349	PF00179	0.511
TRG_AP2beta_CARGO_1	334	343	PF09066	0.467
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.431
TRG_ENDOCYTIC_2	18	21	PF00928	0.423
TRG_ENDOCYTIC_2	30	33	PF00928	0.307
TRG_ER_diArg_1	191	194	PF00400	0.541
TRG_ER_diArg_1	401	404	PF00400	0.378
TRG_ER_diArg_1	505	507	PF00400	0.309
TRG_ER_diArg_1	569	571	PF00400	0.397
TRG_ER_diArg_1	621	624	PF00400	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9C3	Leptomonas seymouri	67%	98%
A0A1X0NLM5	Trypanosomatidae	41%	100%
A0A3R7NP46	Trypanosoma rangeli	41%	100%
A4HQB2	Leishmania braziliensis	79%	100%
D0A3Z2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AU29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q0G6	Leishmania major	91%	100%
V5B3J9	Trypanosoma cruzi	40%	100%