Alternative oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Alternative oxidase

Gene product:

alternative oxidase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IWB1_LEIDO

TriTrypDb:

LdBPK_364600.1 , LdCL_360053100 , LDHU3_36.6210

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0070469	respirasome	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IWB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IWB1

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0010230	alternative respiration	7	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0009916	alternative oxidase activity	5	8
GO:0016491	oxidoreductase activity	2	8
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	3	8
GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	4	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	383	387	PF00656	0.571
CLV_C14_Caspase3-7	415	419	PF00656	0.461
CLV_NRD_NRD_1	162	164	PF00675	0.604
CLV_NRD_NRD_1	33	35	PF00675	0.529
CLV_PCSK_KEX2_1	162	164	PF00082	0.607
CLV_PCSK_KEX2_1	33	35	PF00082	0.561
CLV_PCSK_PC7_1	158	164	PF00082	0.607
CLV_PCSK_SKI1_1	10	14	PF00082	0.567
CLV_PCSK_SKI1_1	158	162	PF00082	0.501
CLV_PCSK_SKI1_1	240	244	PF00082	0.517
CLV_PCSK_SKI1_1	390	394	PF00082	0.407
CLV_PCSK_SKI1_1	425	429	PF00082	0.375
DEG_APCC_DBOX_1	9	17	PF00400	0.713
DEG_Nend_UBRbox_3	1	3	PF02207	0.636
DEG_SPOP_SBC_1	426	430	PF00917	0.454
DOC_ANK_TNKS_1	431	438	PF00023	0.454
DOC_CYCLIN_RxL_1	155	164	PF00134	0.287
DOC_MAPK_MEF2A_6	108	117	PF00069	0.556
DOC_MAPK_MEF2A_6	136	143	PF00069	0.556
DOC_MAPK_MEF2A_6	397	406	PF00069	0.551
DOC_MAPK_MEF2A_6	6	13	PF00069	0.763
DOC_PP1_RVXF_1	117	124	PF00149	0.517
DOC_PP4_MxPP_1	84	87	PF00568	0.656
DOC_USP7_MATH_1	12	16	PF00917	0.711
DOC_USP7_MATH_1	149	153	PF00917	0.430
DOC_USP7_MATH_1	180	184	PF00917	0.393
DOC_USP7_MATH_1	204	208	PF00917	0.367
DOC_USP7_MATH_1	211	215	PF00917	0.409
DOC_USP7_MATH_1	231	235	PF00917	0.171
DOC_USP7_MATH_1	300	304	PF00917	0.556
DOC_USP7_MATH_1	39	43	PF00917	0.769
DOC_USP7_MATH_1	408	412	PF00917	0.533
DOC_USP7_MATH_1	416	420	PF00917	0.533
DOC_USP7_MATH_1	436	440	PF00917	0.399
DOC_USP7_MATH_1	47	51	PF00917	0.728
DOC_WW_Pin1_4	102	107	PF00397	0.527
DOC_WW_Pin1_4	181	186	PF00397	0.356
DOC_WW_Pin1_4	189	194	PF00397	0.356
DOC_WW_Pin1_4	227	232	PF00397	0.332
DOC_WW_Pin1_4	378	383	PF00397	0.592
DOC_WW_Pin1_4	390	395	PF00397	0.577
LIG_14-3-3_CanoR_1	136	140	PF00244	0.496
LIG_14-3-3_CanoR_1	33	43	PF00244	0.698
LIG_14-3-3_CanoR_1	477	483	PF00244	0.696
LIG_14-3-3_CanoR_1	90	100	PF00244	0.534
LIG_BRCT_BRCA1_1	182	186	PF00533	0.407
LIG_BRCT_BRCA1_1	41	45	PF00533	0.715
LIG_BRCT_BRCA1_1	77	81	PF00533	0.592
LIG_eIF4E_1	281	287	PF01652	0.430
LIG_FHA_1	136	142	PF00498	0.520
LIG_FHA_1	277	283	PF00498	0.376
LIG_FHA_1	306	312	PF00498	0.517
LIG_FHA_1	365	371	PF00498	0.458
LIG_FHA_1	38	44	PF00498	0.656
LIG_FHA_1	473	479	PF00498	0.691
LIG_FHA_2	176	182	PF00498	0.351
LIG_FHA_2	261	267	PF00498	0.317
LIG_FHA_2	297	303	PF00498	0.537
LIG_FHA_2	426	432	PF00498	0.525
LIG_FHA_2	440	446	PF00498	0.510
LIG_FHA_2	92	98	PF00498	0.502
LIG_HCF-1_HBM_1	232	235	PF13415	0.407
LIG_LIR_Gen_1	183	193	PF02991	0.379
LIG_LIR_Gen_1	279	289	PF02991	0.376
LIG_LIR_Gen_1	304	314	PF02991	0.522
LIG_LIR_Gen_1	68	75	PF02991	0.736
LIG_LIR_Gen_1	78	88	PF02991	0.634
LIG_LIR_Nem_3	183	189	PF02991	0.379
LIG_LIR_Nem_3	279	284	PF02991	0.392
LIG_LIR_Nem_3	454	460	PF02991	0.556
LIG_LIR_Nem_3	68	74	PF02991	0.722
LIG_LYPXL_S_1	287	291	PF13949	0.430
LIG_LYPXL_yS_3	288	291	PF13949	0.556
LIG_NRBOX	238	244	PF00104	0.342
LIG_NRBOX	268	274	PF00104	0.501
LIG_SH2_CRK	253	257	PF00017	0.407
LIG_SH2_STAT5	133	136	PF00017	0.549
LIG_SH2_STAT5	156	159	PF00017	0.376
LIG_SH2_STAT5	22	25	PF00017	0.757
LIG_SH2_STAT5	235	238	PF00017	0.342
LIG_SH2_STAT5	281	284	PF00017	0.430
LIG_SH2_STAT5	29	32	PF00017	0.665
LIG_SH2_STAT5	298	301	PF00017	0.438
LIG_SH2_STAT5	69	72	PF00017	0.730
LIG_SH3_3	196	202	PF00018	0.408
LIG_SH3_3	319	325	PF00018	0.551
LIG_SH3_3	399	405	PF00018	0.607
LIG_SUMO_SIM_anti_2	261	266	PF11976	0.342
LIG_SUMO_SIM_anti_2	445	450	PF11976	0.517
LIG_SUMO_SIM_par_1	439	445	PF11976	0.534
LIG_TRAF2_1	299	302	PF00917	0.556
LIG_TRAF2_1	350	353	PF00917	0.607
LIG_TRFH_1	285	289	PF08558	0.287
LIG_TYR_ITIM	251	256	PF00017	0.430
LIG_TYR_ITIM	329	334	PF00017	0.376
LIG_UBA3_1	478	486	PF00899	0.641
LIG_WRC_WIRS_1	71	76	PF05994	0.530
MOD_CDK_SPxK_1	102	108	PF00069	0.430
MOD_CDK_SPxxK_3	390	397	PF00069	0.424
MOD_CK1_1	15	21	PF00069	0.698
MOD_CK1_1	164	170	PF00069	0.458
MOD_CK1_1	218	224	PF00069	0.427
MOD_CK1_1	37	43	PF00069	0.697
MOD_CK1_1	378	384	PF00069	0.451
MOD_CK1_1	419	425	PF00069	0.385
MOD_CK1_1	439	445	PF00069	0.415
MOD_CK1_1	50	56	PF00069	0.716
MOD_CK2_1	175	181	PF00069	0.369
MOD_CK2_1	226	232	PF00069	0.418
MOD_CK2_1	260	266	PF00069	0.357
MOD_CK2_1	296	302	PF00069	0.404
MOD_CK2_1	91	97	PF00069	0.355
MOD_DYRK1A_RPxSP_1	390	394	PF00069	0.424
MOD_GlcNHglycan	167	170	PF01048	0.296
MOD_GlcNHglycan	193	196	PF01048	0.451
MOD_GlcNHglycan	220	223	PF01048	0.451
MOD_GlcNHglycan	377	380	PF01048	0.509
MOD_GlcNHglycan	397	400	PF01048	0.411
MOD_GlcNHglycan	413	417	PF01048	0.491
MOD_GlcNHglycan	45	48	PF01048	0.660
MOD_GlcNHglycan	49	52	PF01048	0.653
MOD_GlcNHglycan	60	63	PF01048	0.753
MOD_GSK3_1	11	18	PF00069	0.709
MOD_GSK3_1	135	142	PF00069	0.402
MOD_GSK3_1	161	168	PF00069	0.393
MOD_GSK3_1	171	178	PF00069	0.354
MOD_GSK3_1	211	218	PF00069	0.508
MOD_GSK3_1	220	227	PF00069	0.390
MOD_GSK3_1	296	303	PF00069	0.424
MOD_GSK3_1	34	41	PF00069	0.719
MOD_GSK3_1	408	415	PF00069	0.486
MOD_GSK3_1	43	50	PF00069	0.687
MOD_N-GLC_1	164	169	PF02516	0.425
MOD_NEK2_1	101	106	PF00069	0.464
MOD_NEK2_1	117	122	PF00069	0.509
MOD_NEK2_1	139	144	PF00069	0.413
MOD_NEK2_1	161	166	PF00069	0.505
MOD_NEK2_1	215	220	PF00069	0.436
MOD_NEK2_1	224	229	PF00069	0.418
MOD_NEK2_1	45	50	PF00069	0.642
MOD_NEK2_1	478	483	PF00069	0.613
MOD_NEK2_1	57	62	PF00069	0.749
MOD_NEK2_1	70	75	PF00069	0.551
MOD_PIKK_1	171	177	PF00454	0.385
MOD_PIKK_1	305	311	PF00454	0.430
MOD_PIKK_1	34	40	PF00454	0.703
MOD_PIKK_1	472	478	PF00454	0.676
MOD_PIKK_1	91	97	PF00454	0.501
MOD_PKA_2	135	141	PF00069	0.376
MOD_PKA_2	161	167	PF00069	0.435
MOD_PKA_2	211	217	PF00069	0.488
MOD_Plk_1	231	237	PF00069	0.501
MOD_Plk_1	260	266	PF00069	0.376
MOD_Plk_1	300	306	PF00069	0.376
MOD_Plk_1	412	418	PF00069	0.504
MOD_Plk_4	135	141	PF00069	0.341
MOD_Plk_4	211	217	PF00069	0.429
MOD_Plk_4	231	237	PF00069	0.258
MOD_Plk_4	301	307	PF00069	0.378
MOD_Plk_4	436	442	PF00069	0.501
MOD_Plk_4	65	71	PF00069	0.660
MOD_ProDKin_1	102	108	PF00069	0.390
MOD_ProDKin_1	181	187	PF00069	0.430
MOD_ProDKin_1	189	195	PF00069	0.430
MOD_ProDKin_1	227	233	PF00069	0.397
MOD_ProDKin_1	378	384	PF00069	0.480
MOD_ProDKin_1	390	396	PF00069	0.459
MOD_SUMO_rev_2	413	422	PF00179	0.462
TRG_DiLeu_BaEn_1	238	243	PF01217	0.353
TRG_DiLeu_BaLyEn_6	474	479	PF01217	0.622
TRG_ENDOCYTIC_2	156	159	PF00928	0.376
TRG_ENDOCYTIC_2	253	256	PF00928	0.430
TRG_ENDOCYTIC_2	281	284	PF00928	0.430
TRG_ENDOCYTIC_2	288	291	PF00928	0.430
TRG_ENDOCYTIC_2	331	334	PF00928	0.341
TRG_ENDOCYTIC_2	71	74	PF00928	0.602
TRG_ER_diArg_1	161	163	PF00400	0.424
TRG_ER_diArg_1	33	35	PF00400	0.630
TRG_NES_CRM1_1	261	274	PF08389	0.440
TRG_NES_CRM1_1	459	471	PF08389	0.424
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	240	245	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	458	463	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P770	Leptomonas seymouri	54%	100%
A0A422P567	Trypanosoma rangeli	32%	100%
A4HPV5	Leishmania braziliensis	69%	100%
A4IDL7	Leishmania infantum	100%	100%
E9ATM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q0X6	Leishmania major	90%	100%