Paraflagellar rod component, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IWA4_LEIDO

TriTrypDb:

LdBPK_364440.1 , LdCL_360051600 , LDHU3_36.6020

Length:

1123

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0031514	motile cilium	5	4
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

A0A3Q8IWA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IWA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	287	289	PF00675	0.549
CLV_NRD_NRD_1	725	727	PF00675	0.471
CLV_PCSK_KEX2_1	333	335	PF00082	0.503
CLV_PCSK_KEX2_1	42	44	PF00082	0.494
CLV_PCSK_KEX2_1	651	653	PF00082	0.548
CLV_PCSK_KEX2_1	813	815	PF00082	0.502
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.531
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.494
CLV_PCSK_PC1ET2_1	651	653	PF00082	0.548
CLV_PCSK_PC1ET2_1	813	815	PF00082	0.502
CLV_PCSK_SKI1_1	1057	1061	PF00082	0.590
CLV_PCSK_SKI1_1	1081	1085	PF00082	0.693
CLV_PCSK_SKI1_1	112	116	PF00082	0.343
CLV_PCSK_SKI1_1	179	183	PF00082	0.405
CLV_PCSK_SKI1_1	202	206	PF00082	0.467
CLV_PCSK_SKI1_1	492	496	PF00082	0.521
CLV_PCSK_SKI1_1	513	517	PF00082	0.525
CLV_PCSK_SKI1_1	52	56	PF00082	0.567
CLV_PCSK_SKI1_1	561	565	PF00082	0.416
CLV_PCSK_SKI1_1	620	624	PF00082	0.488
CLV_PCSK_SKI1_1	727	731	PF00082	0.536
CLV_PCSK_SKI1_1	813	817	PF00082	0.382
CLV_Separin_Metazoa	1009	1013	PF03568	0.526
CLV_Separin_Metazoa	203	207	PF03568	0.476
DEG_APCC_DBOX_1	1056	1064	PF00400	0.585
DEG_APCC_DBOX_1	491	499	PF00400	0.548
DEG_MDM2_SWIB_1	274	282	PF02201	0.239
DEG_Nend_Nbox_1	1	3	PF02207	0.502
DOC_CYCLIN_RxL_1	202	212	PF00134	0.480
DOC_CYCLIN_RxL_1	530	544	PF00134	0.455
DOC_CYCLIN_RxL_1	852	865	PF00134	0.458
DOC_CYCLIN_RxL_1	941	951	PF00134	0.487
DOC_CYCLIN_RxL_1	987	998	PF00134	0.437
DOC_MAPK_gen_1	143	149	PF00069	0.548
DOC_MAPK_gen_1	333	339	PF00069	0.519
DOC_MAPK_gen_1	458	466	PF00069	0.487
DOC_MAPK_gen_1	6	16	PF00069	0.484
DOC_MAPK_gen_1	749	758	PF00069	0.324
DOC_MAPK_gen_1	813	819	PF00069	0.464
DOC_MAPK_MEF2A_6	458	466	PF00069	0.537
DOC_MAPK_MEF2A_6	503	510	PF00069	0.564
DOC_MAPK_MEF2A_6	561	568	PF00069	0.398
DOC_MAPK_MEF2A_6	929	938	PF00069	0.559
DOC_MAPK_NFAT4_5	561	569	PF00069	0.359
DOC_PP1_RVXF_1	162	168	PF00149	0.316
DOC_PP1_RVXF_1	911	918	PF00149	0.470
DOC_USP7_MATH_1	1026	1030	PF00917	0.398
DOC_USP7_MATH_1	160	164	PF00917	0.499
DOC_USP7_MATH_1	369	373	PF00917	0.500
DOC_USP7_MATH_1	54	58	PF00917	0.494
DOC_USP7_MATH_1	590	594	PF00917	0.494
DOC_USP7_UBL2_3	144	148	PF12436	0.490
DOC_WW_Pin1_4	1069	1074	PF00397	0.563
DOC_WW_Pin1_4	309	314	PF00397	0.532
DOC_WW_Pin1_4	468	473	PF00397	0.566
DOC_WW_Pin1_4	668	673	PF00397	0.613
DOC_WW_Pin1_4	85	90	PF00397	0.468
LIG_14-3-3_CanoR_1	1095	1101	PF00244	0.680
LIG_14-3-3_CanoR_1	112	122	PF00244	0.434
LIG_14-3-3_CanoR_1	269	275	PF00244	0.547
LIG_14-3-3_CanoR_1	340	349	PF00244	0.521
LIG_14-3-3_CanoR_1	411	417	PF00244	0.416
LIG_14-3-3_CanoR_1	43	51	PF00244	0.437
LIG_14-3-3_CanoR_1	458	463	PF00244	0.518
LIG_14-3-3_CanoR_1	530	536	PF00244	0.430
LIG_14-3-3_CanoR_1	628	637	PF00244	0.457
LIG_14-3-3_CanoR_1	691	697	PF00244	0.430
LIG_14-3-3_CanoR_1	814	818	PF00244	0.472
LIG_14-3-3_CanoR_1	929	936	PF00244	0.517
LIG_14-3-3_CanoR_1	970	978	PF00244	0.567
LIG_Actin_WH2_2	389	405	PF00022	0.511
LIG_Actin_WH2_2	899	915	PF00022	0.502
LIG_APCC_ABBA_1	207	212	PF00400	0.475
LIG_APCC_ABBAyCdc20_2	206	212	PF00400	0.480
LIG_BRCT_BRCA1_1	215	219	PF00533	0.455
LIG_BRCT_BRCA1_1	272	276	PF00533	0.410
LIG_BRCT_BRCA1_1	291	295	PF00533	0.500
LIG_BRCT_BRCA1_1	913	917	PF00533	0.473
LIG_BRCT_BRCA1_1	995	999	PF00533	0.475
LIG_Clathr_ClatBox_1	208	212	PF01394	0.553
LIG_FHA_1	1102	1108	PF00498	0.692
LIG_FHA_1	114	120	PF00498	0.526
LIG_FHA_1	448	454	PF00498	0.441
LIG_FHA_1	459	465	PF00498	0.424
LIG_FHA_1	720	726	PF00498	0.593
LIG_FHA_1	814	820	PF00498	0.503
LIG_FHA_2	194	200	PF00498	0.567
LIG_FHA_2	291	297	PF00498	0.441
LIG_FHA_2	514	520	PF00498	0.441
LIG_FHA_2	560	566	PF00498	0.445
LIG_FHA_2	663	669	PF00498	0.512
LIG_FHA_2	692	698	PF00498	0.477
LIG_FHA_2	715	721	PF00498	0.484
LIG_FHA_2	750	756	PF00498	0.499
LIG_FHA_2	785	791	PF00498	0.606
LIG_FHA_2	81	87	PF00498	0.518
LIG_FHA_2	949	955	PF00498	0.543
LIG_FHA_2	970	976	PF00498	0.514
LIG_Integrin_RGD_1	952	954	PF01839	0.418
LIG_IRF3_LxIS_1	373	380	PF10401	0.487
LIG_LIR_Gen_1	22	30	PF02991	0.480
LIG_LIR_Gen_1	312	319	PF02991	0.561
LIG_LIR_Nem_3	1033	1039	PF02991	0.421
LIG_LIR_Nem_3	1072	1077	PF02991	0.675
LIG_LIR_Nem_3	136	141	PF02991	0.357
LIG_LIR_Nem_3	196	200	PF02991	0.514
LIG_LIR_Nem_3	22	27	PF02991	0.476
LIG_LIR_Nem_3	312	318	PF02991	0.534
LIG_LIR_Nem_3	780	786	PF02991	0.514
LIG_NRBOX	204	210	PF00104	0.515
LIG_NRBOX	978	984	PF00104	0.519
LIG_PCNA_yPIPBox_3	248	260	PF02747	0.503
LIG_Pex14_2	137	141	PF04695	0.358
LIG_Pex14_2	274	278	PF04695	0.231
LIG_PTB_Apo_2	264	271	PF02174	0.531
LIG_PTB_Phospho_1	264	270	PF10480	0.538
LIG_REV1ctd_RIR_1	13	22	PF16727	0.486
LIG_SH2_CRK	1074	1078	PF00017	0.717
LIG_SH2_PTP2	315	318	PF00017	0.403
LIG_SH2_STAT3	1100	1103	PF00017	0.717
LIG_SH2_STAT5	1036	1039	PF00017	0.471
LIG_SH2_STAT5	109	112	PF00017	0.473
LIG_SH2_STAT5	1100	1103	PF00017	0.678
LIG_SH2_STAT5	113	116	PF00017	0.457
LIG_SH2_STAT5	166	169	PF00017	0.398
LIG_SH2_STAT5	315	318	PF00017	0.564
LIG_SH2_STAT5	363	366	PF00017	0.415
LIG_SH2_STAT5	367	370	PF00017	0.404
LIG_SH2_STAT5	448	451	PF00017	0.454
LIG_SH2_STAT5	552	555	PF00017	0.384
LIG_SH2_STAT5	556	559	PF00017	0.451
LIG_SH2_STAT5	873	876	PF00017	0.506
LIG_SH2_STAT5	947	950	PF00017	0.579
LIG_SH3_3	848	854	PF00018	0.545
LIG_SH3_3	86	92	PF00018	0.510
LIG_SUMO_SIM_anti_2	504	509	PF11976	0.496
LIG_SUMO_SIM_anti_2	694	700	PF11976	0.449
LIG_SUMO_SIM_anti_2	793	800	PF11976	0.495
LIG_SUMO_SIM_anti_2	972	980	PF11976	0.520
LIG_SUMO_SIM_par_1	1103	1108	PF11976	0.729
LIG_SUMO_SIM_par_1	228	234	PF11976	0.537
LIG_SUMO_SIM_par_1	504	509	PF11976	0.568
LIG_SUMO_SIM_par_1	609	615	PF11976	0.452
LIG_SUMO_SIM_par_1	697	702	PF11976	0.475
LIG_SUMO_SIM_par_1	815	820	PF11976	0.470
LIG_SUMO_SIM_par_1	873	879	PF11976	0.490
LIG_SUMO_SIM_par_1	93	98	PF11976	0.561
LIG_TRAF2_1	474	477	PF00917	0.579
LIG_TRAF2_1	672	675	PF00917	0.632
LIG_TRAF2_1	972	975	PF00917	0.537
LIG_TYR_ITSM	1070	1077	PF00017	0.680
LIG_UBA3_1	1	9	PF00899	0.492
LIG_UBA3_1	420	426	PF00899	0.518
LIG_WRC_WIRS_1	232	237	PF05994	0.441
MOD_CDK_SPxK_1	1069	1075	PF00069	0.573
MOD_CK1_1	1062	1068	PF00069	0.510
MOD_CK1_1	158	164	PF00069	0.467
MOD_CK1_1	242	248	PF00069	0.462
MOD_CK1_1	28	34	PF00069	0.461
MOD_CK1_1	471	477	PF00069	0.543
MOD_CK1_1	541	547	PF00069	0.449
MOD_CK1_1	569	575	PF00069	0.292
MOD_CK1_1	719	725	PF00069	0.550
MOD_CK1_1	883	889	PF00069	0.450
MOD_CK1_1	923	929	PF00069	0.542
MOD_CK1_1	98	104	PF00069	0.500
MOD_CK2_1	166	172	PF00069	0.502
MOD_CK2_1	193	199	PF00069	0.559
MOD_CK2_1	471	477	PF00069	0.522
MOD_CK2_1	559	565	PF00069	0.430
MOD_CK2_1	662	668	PF00069	0.532
MOD_CK2_1	691	697	PF00069	0.477
MOD_CK2_1	714	720	PF00069	0.462
MOD_CK2_1	749	755	PF00069	0.523
MOD_CK2_1	788	794	PF00069	0.642
MOD_CK2_1	80	86	PF00069	0.454
MOD_CK2_1	87	93	PF00069	0.486
MOD_CK2_1	969	975	PF00069	0.508
MOD_GlcNHglycan	103	106	PF01048	0.409
MOD_GlcNHglycan	157	160	PF01048	0.483
MOD_GlcNHglycan	179	182	PF01048	0.495
MOD_GlcNHglycan	218	222	PF01048	0.384
MOD_GlcNHglycan	241	244	PF01048	0.476
MOD_GlcNHglycan	36	39	PF01048	0.657
MOD_GlcNHglycan	46	49	PF01048	0.518
MOD_GlcNHglycan	509	513	PF01048	0.465
MOD_GlcNHglycan	606	609	PF01048	0.533
MOD_GlcNHglycan	700	704	PF01048	0.417
MOD_GlcNHglycan	711	714	PF01048	0.407
MOD_GlcNHglycan	867	870	PF01048	0.524
MOD_GlcNHglycan	888	892	PF01048	0.312
MOD_GlcNHglycan	895	899	PF01048	0.396
MOD_GlcNHglycan	922	925	PF01048	0.508
MOD_GSK3_1	1089	1096	PF00069	0.610
MOD_GSK3_1	168	175	PF00069	0.494
MOD_GSK3_1	177	184	PF00069	0.462
MOD_GSK3_1	213	220	PF00069	0.408
MOD_GSK3_1	25	32	PF00069	0.460
MOD_GSK3_1	270	277	PF00069	0.448
MOD_GSK3_1	291	298	PF00069	0.468
MOD_GSK3_1	307	314	PF00069	0.370
MOD_GSK3_1	541	548	PF00069	0.369
MOD_GSK3_1	590	597	PF00069	0.455
MOD_GSK3_1	624	631	PF00069	0.406
MOD_GSK3_1	681	688	PF00069	0.470
MOD_GSK3_1	716	723	PF00069	0.495
MOD_GSK3_1	784	791	PF00069	0.593
MOD_GSK3_1	834	841	PF00069	0.560
MOD_GSK3_1	883	890	PF00069	0.425
MOD_GSK3_1	907	914	PF00069	0.526
MOD_GSK3_1	965	972	PF00069	0.612
MOD_GSK3_1	984	991	PF00069	0.145
MOD_N-GLC_1	1013	1018	PF02516	0.393
MOD_N-GLC_1	1069	1074	PF02516	0.521
MOD_N-GLC_1	340	345	PF02516	0.546
MOD_N-GLC_1	377	382	PF02516	0.421
MOD_N-GLC_1	398	403	PF02516	0.385
MOD_N-GLC_1	499	504	PF02516	0.526
MOD_N-GLC_1	531	536	PF02516	0.406
MOD_N-GLC_1	538	543	PF02516	0.373
MOD_N-GLC_1	559	564	PF02516	0.339
MOD_N-GLC_1	566	571	PF02516	0.314
MOD_N-GLC_1	691	696	PF02516	0.459
MOD_N-GLC_1	761	766	PF02516	0.484
MOD_N-GLC_1	777	782	PF02516	0.306
MOD_N-GLC_1	794	799	PF02516	0.449
MOD_N-GLC_1	962	967	PF02516	0.523
MOD_N-GLC_1	98	103	PF02516	0.464
MOD_N-GLC_1	984	989	PF02516	0.427
MOD_N-GLC_2	580	582	PF02516	0.300
MOD_N-GLC_2	709	711	PF02516	0.437
MOD_NEK2_1	1050	1055	PF00069	0.455
MOD_NEK2_1	274	279	PF00069	0.443
MOD_NEK2_1	290	295	PF00069	0.203
MOD_NEK2_1	304	309	PF00069	0.368
MOD_NEK2_1	377	382	PF00069	0.469
MOD_NEK2_1	508	513	PF00069	0.541
MOD_NEK2_1	531	536	PF00069	0.364
MOD_NEK2_1	538	543	PF00069	0.318
MOD_NEK2_1	545	550	PF00069	0.284
MOD_NEK2_1	566	571	PF00069	0.365
MOD_NEK2_1	594	599	PF00069	0.410
MOD_NEK2_1	624	629	PF00069	0.421
MOD_NEK2_1	639	644	PF00069	0.341
MOD_NEK2_1	714	719	PF00069	0.462
MOD_NEK2_1	758	763	PF00069	0.443
MOD_NEK2_1	80	85	PF00069	0.490
MOD_NEK2_1	838	843	PF00069	0.441
MOD_NEK2_1	846	851	PF00069	0.411
MOD_NEK2_1	887	892	PF00069	0.358
MOD_NEK2_1	946	951	PF00069	0.546
MOD_NEK2_1	962	967	PF00069	0.541
MOD_NEK2_1	983	988	PF00069	0.477
MOD_NEK2_2	133	138	PF00069	0.364
MOD_NEK2_2	19	24	PF00069	0.469
MOD_PIKK_1	1089	1095	PF00454	0.591
MOD_PIKK_1	236	242	PF00454	0.493
MOD_PIKK_1	928	934	PF00454	0.509
MOD_PK_1	143	149	PF00069	0.586
MOD_PKA_1	143	149	PF00069	0.509
MOD_PKA_1	41	47	PF00069	0.683
MOD_PKA_1	813	819	PF00069	0.464
MOD_PKA_2	1094	1100	PF00069	0.632
MOD_PKA_2	236	242	PF00069	0.445
MOD_PKA_2	410	416	PF00069	0.468
MOD_PKA_2	44	50	PF00069	0.439
MOD_PKA_2	813	819	PF00069	0.554
MOD_PKA_2	907	913	PF00069	0.524
MOD_PKA_2	928	934	PF00069	0.545
MOD_PKA_2	969	975	PF00069	0.460
MOD_PKB_1	626	634	PF00069	0.363
MOD_Plk_1	1013	1019	PF00069	0.364
MOD_Plk_1	1050	1056	PF00069	0.536
MOD_Plk_1	1089	1095	PF00069	0.591
MOD_Plk_1	274	280	PF00069	0.238
MOD_Plk_1	398	404	PF00069	0.378
MOD_Plk_1	518	524	PF00069	0.429
MOD_Plk_1	531	537	PF00069	0.311
MOD_Plk_1	559	565	PF00069	0.344
MOD_Plk_1	614	620	PF00069	0.495
MOD_Plk_1	624	630	PF00069	0.334
MOD_Plk_1	660	666	PF00069	0.477
MOD_Plk_1	679	685	PF00069	0.264
MOD_Plk_1	691	697	PF00069	0.316
MOD_Plk_1	777	783	PF00069	0.432
MOD_Plk_1	794	800	PF00069	0.435
MOD_Plk_1	834	840	PF00069	0.525
MOD_Plk_1	98	104	PF00069	0.500
MOD_Plk_1	984	990	PF00069	0.449
MOD_Plk_2-3	559	565	PF00069	0.463
MOD_Plk_4	1062	1068	PF00069	0.514
MOD_Plk_4	133	139	PF00069	0.464
MOD_Plk_4	19	25	PF00069	0.472
MOD_Plk_4	231	237	PF00069	0.465
MOD_Plk_4	311	317	PF00069	0.492
MOD_Plk_4	369	375	PF00069	0.442
MOD_Plk_4	379	385	PF00069	0.455
MOD_Plk_4	479	485	PF00069	0.474
MOD_Plk_4	518	524	PF00069	0.514
MOD_Plk_4	548	554	PF00069	0.415
MOD_Plk_4	685	691	PF00069	0.528
MOD_Plk_4	777	783	PF00069	0.480
MOD_Plk_4	794	800	PF00069	0.505
MOD_Plk_4	846	852	PF00069	0.405
MOD_ProDKin_1	1069	1075	PF00069	0.573
MOD_ProDKin_1	309	315	PF00069	0.530
MOD_ProDKin_1	468	474	PF00069	0.558
MOD_ProDKin_1	668	674	PF00069	0.624
MOD_ProDKin_1	85	91	PF00069	0.473
MOD_SUMO_for_1	622	625	PF00179	0.554
MOD_SUMO_rev_2	1112	1122	PF00179	0.702
MOD_SUMO_rev_2	615	624	PF00179	0.555
TRG_DiLeu_BaEn_1	794	799	PF01217	0.499
TRG_DiLeu_BaEn_2	202	208	PF01217	0.477
TRG_DiLeu_BaEn_3	776	782	PF01217	0.472
TRG_DiLeu_BaEn_4	974	980	PF01217	0.522
TRG_DiLeu_BaLyEn_6	493	498	PF01217	0.538
TRG_ENDOCYTIC_2	1036	1039	PF00928	0.435
TRG_ENDOCYTIC_2	1074	1077	PF00928	0.719
TRG_ENDOCYTIC_2	197	200	PF00928	0.490
TRG_ENDOCYTIC_2	315	318	PF00928	0.578
TRG_ENDOCYTIC_2	654	657	PF00928	0.468
TRG_ER_diArg_1	43	46	PF00400	0.473
TRG_ER_diArg_1	626	629	PF00400	0.579
TRG_NES_CRM1_1	1058	1071	PF08389	0.471
TRG_NES_CRM1_1	199	212	PF08389	0.521
TRG_NES_CRM1_1	879	893	PF08389	0.378
TRG_NLS_MonoCore_2	39	44	PF00514	0.474
TRG_NLS_MonoExtC_3	40	45	PF00514	0.479
TRG_NLS_MonoExtN_4	40	46	PF00514	0.486
TRG_Pf-PMV_PEXEL_1	676	680	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	751	755	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	773	777	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFA2	Leptomonas seymouri	53%	100%
A0A0S4JML5	Bodo saltans	30%	100%
A0A1X0P080	Trypanosomatidae	37%	100%
A0A422MVT9	Trypanosoma rangeli	35%	100%
A4HPU2	Leishmania braziliensis	73%	100%
A4IE50	Leishmania infantum	100%	100%
D0A481	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ATK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q0Z1	Leishmania major	92%	100%
V5DLP2	Trypanosoma cruzi	36%	100%