ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IW98_LEIDO

TriTrypDb:

LdBPK_364210.1 , LdCL_360049200 , LDHU3_36.5640

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IW98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IW98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.679
CLV_NRD_NRD_1	146	148	PF00675	0.542
CLV_NRD_NRD_1	171	173	PF00675	0.751
CLV_NRD_NRD_1	310	312	PF00675	0.608
CLV_NRD_NRD_1	319	321	PF00675	0.575
CLV_NRD_NRD_1	396	398	PF00675	0.754
CLV_NRD_NRD_1	413	415	PF00675	0.581
CLV_NRD_NRD_1	428	430	PF00675	0.544
CLV_PCSK_KEX2_1	146	148	PF00082	0.540
CLV_PCSK_KEX2_1	171	173	PF00082	0.654
CLV_PCSK_KEX2_1	310	312	PF00082	0.629
CLV_PCSK_KEX2_1	319	321	PF00082	0.612
CLV_PCSK_KEX2_1	395	397	PF00082	0.706
CLV_PCSK_KEX2_1	413	415	PF00082	0.552
CLV_PCSK_KEX2_1	428	430	PF00082	0.544
CLV_PCSK_KEX2_1	434	436	PF00082	0.555
CLV_PCSK_KEX2_1	473	475	PF00082	0.585
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.554
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.533
CLV_PCSK_PC7_1	392	398	PF00082	0.731
CLV_PCSK_SKI1_1	225	229	PF00082	0.706
CLV_PCSK_SKI1_1	256	260	PF00082	0.590
CLV_PCSK_SKI1_1	473	477	PF00082	0.537
CLV_PCSK_SKI1_1	77	81	PF00082	0.325
CLV_PCSK_SKI1_1	99	103	PF00082	0.351
DEG_APCC_DBOX_1	110	118	PF00400	0.527
DEG_APCC_DBOX_1	171	179	PF00400	0.441
DEG_APCC_DBOX_1	76	84	PF00400	0.550
DEG_Nend_UBRbox_2	1	3	PF02207	0.710
DOC_CYCLIN_RxL_1	134	145	PF00134	0.378
DOC_MAPK_gen_1	108	117	PF00069	0.538
DOC_MAPK_HePTP_8	131	143	PF00069	0.452
DOC_MAPK_MEF2A_6	134	143	PF00069	0.290
DOC_MAPK_MEF2A_6	256	263	PF00069	0.361
DOC_MAPK_RevD_3	131	147	PF00069	0.418
DOC_PP1_RVXF_1	136	143	PF00149	0.378
DOC_PP2B_LxvP_1	215	218	PF13499	0.496
DOC_PP2B_PxIxI_1	263	269	PF00149	0.203
DOC_USP7_MATH_1	273	277	PF00917	0.337
DOC_USP7_MATH_1	312	316	PF00917	0.411
DOC_USP7_MATH_1	321	325	PF00917	0.453
DOC_USP7_MATH_1	339	343	PF00917	0.515
DOC_USP7_MATH_1	366	370	PF00917	0.485
DOC_USP7_MATH_1	380	384	PF00917	0.411
DOC_USP7_MATH_1	493	497	PF00917	0.346
DOC_WW_Pin1_4	193	198	PF00397	0.438
DOC_WW_Pin1_4	335	340	PF00397	0.532
DOC_WW_Pin1_4	43	48	PF00397	0.574
LIG_14-3-3_CanoR_1	111	115	PF00244	0.527
LIG_14-3-3_CanoR_1	311	321	PF00244	0.422
LIG_14-3-3_CanoR_1	332	340	PF00244	0.538
LIG_14-3-3_CanoR_1	474	479	PF00244	0.385
LIG_APCC_ABBA_1	512	517	PF00400	0.315
LIG_BRCT_BRCA1_1	446	450	PF00533	0.330
LIG_EH1_1	285	293	PF00400	0.343
LIG_EVH1_1	215	219	PF00568	0.527
LIG_FHA_1	121	127	PF00498	0.320
LIG_FHA_1	207	213	PF00498	0.599
LIG_FHA_1	335	341	PF00498	0.593
LIG_FHA_1	382	388	PF00498	0.414
LIG_FHA_1	66	72	PF00498	0.604
LIG_FHA_1	74	80	PF00498	0.516
LIG_FHA_2	369	375	PF00498	0.489
LIG_FHA_2	44	50	PF00498	0.618
LIG_FHA_2	67	73	PF00498	0.609
LIG_FHA_2	95	101	PF00498	0.576
LIG_LIR_Gen_1	510	515	PF02991	0.378
LIG_LIR_Nem_3	447	453	PF02991	0.336
LIG_LIR_Nem_3	510	514	PF02991	0.375
LIG_MYND_1	323	327	PF01753	0.511
LIG_NRBOX	139	145	PF00104	0.346
LIG_NRBOX	296	302	PF00104	0.327
LIG_Pex14_1	106	110	PF04695	0.568
LIG_Rb_LxCxE_1	510	526	PF01857	0.382
LIG_SH2_CRK	511	515	PF00017	0.372
LIG_SH2_NCK_1	478	482	PF00017	0.361
LIG_SH2_STAP1	122	126	PF00017	0.347
LIG_SH2_STAP1	457	461	PF00017	0.319
LIG_SH2_STAT5	122	125	PF00017	0.360
LIG_SH2_STAT5	37	40	PF00017	0.600
LIG_SH3_1	213	219	PF00018	0.500
LIG_SH3_3	213	219	PF00018	0.534
LIG_SH3_3	258	264	PF00018	0.323
LIG_SH3_3	315	321	PF00018	0.374
LIG_SUMO_SIM_anti_2	127	132	PF11976	0.347
LIG_SUMO_SIM_par_1	125	132	PF11976	0.469
LIG_TRAF2_1	416	419	PF00917	0.399
LIG_TRAF2_1	421	424	PF00917	0.405
LIG_TRAF2_1	501	504	PF00917	0.372
LIG_UBA3_1	130	134	PF00899	0.411
LIG_UBA3_1	179	186	PF00899	0.565
MOD_CK1_1	129	135	PF00069	0.476
MOD_CK1_1	333	339	PF00069	0.611
MOD_CK1_1	369	375	PF00069	0.595
MOD_CK1_1	65	71	PF00069	0.518
MOD_CK2_1	142	148	PF00069	0.509
MOD_CK2_1	244	250	PF00069	0.506
MOD_CK2_1	368	374	PF00069	0.686
MOD_CK2_1	446	452	PF00069	0.399
MOD_CK2_1	66	72	PF00069	0.514
MOD_CK2_1	94	100	PF00069	0.475
MOD_Cter_Amidation	169	172	PF01082	0.574
MOD_GlcNHglycan	148	151	PF01048	0.506
MOD_GlcNHglycan	156	159	PF01048	0.585
MOD_GlcNHglycan	275	278	PF01048	0.441
MOD_GlcNHglycan	288	291	PF01048	0.382
MOD_GlcNHglycan	293	296	PF01048	0.280
MOD_GlcNHglycan	332	335	PF01048	0.621
MOD_GlcNHglycan	367	371	PF01048	0.673
MOD_GlcNHglycan	39	42	PF01048	0.518
MOD_GlcNHglycan	446	449	PF01048	0.451
MOD_GSK3_1	113	120	PF00069	0.313
MOD_GSK3_1	122	129	PF00069	0.264
MOD_GSK3_1	142	149	PF00069	0.275
MOD_GSK3_1	150	157	PF00069	0.490
MOD_GSK3_1	189	196	PF00069	0.600
MOD_GSK3_1	326	333	PF00069	0.653
MOD_GSK3_1	335	342	PF00069	0.655
MOD_GSK3_1	366	373	PF00069	0.670
MOD_GSK3_1	442	449	PF00069	0.509
MOD_GSK3_1	516	523	PF00069	0.363
MOD_GSK3_1	62	69	PF00069	0.511
MOD_NEK2_1	110	115	PF00069	0.279
MOD_NEK2_1	126	131	PF00069	0.279
MOD_NEK2_1	142	147	PF00069	0.389
MOD_NEK2_1	152	157	PF00069	0.628
MOD_NEK2_1	179	184	PF00069	0.621
MOD_NEK2_1	286	291	PF00069	0.367
MOD_NEK2_1	347	352	PF00069	0.718
MOD_NEK2_1	444	449	PF00069	0.400
MOD_NEK2_1	453	458	PF00069	0.355
MOD_NEK2_2	159	164	PF00069	0.599
MOD_NEK2_2	493	498	PF00069	0.445
MOD_NEK2_2	516	521	PF00069	0.354
MOD_PIKK_1	189	195	PF00454	0.677
MOD_PIKK_1	244	250	PF00454	0.634
MOD_PKA_1	146	152	PF00069	0.504
MOD_PKA_2	110	116	PF00069	0.369
MOD_PKA_2	146	152	PF00069	0.504
MOD_PKA_2	520	526	PF00069	0.397
MOD_PKA_2	63	69	PF00069	0.547
MOD_PKA_2	73	79	PF00069	0.407
MOD_Plk_1	13	19	PF00069	0.569
MOD_Plk_1	516	522	PF00069	0.375
MOD_Plk_1	62	68	PF00069	0.516
MOD_Plk_2-3	206	212	PF00069	0.593
MOD_Plk_4	110	116	PF00069	0.296
MOD_Plk_4	179	185	PF00069	0.530
MOD_Plk_4	296	302	PF00069	0.495
MOD_Plk_4	321	327	PF00069	0.708
MOD_Plk_4	382	388	PF00069	0.670
MOD_Plk_4	507	513	PF00069	0.461
MOD_ProDKin_1	193	199	PF00069	0.553
MOD_ProDKin_1	335	341	PF00069	0.684
MOD_ProDKin_1	43	49	PF00069	0.451
MOD_SUMO_rev_2	400	407	PF00179	0.550
MOD_SUMO_rev_2	468	475	PF00179	0.439
MOD_SUMO_rev_2	503	510	PF00179	0.485
MOD_SUMO_rev_2	95	103	PF00179	0.437
TRG_DiLeu_BaEn_1	358	363	PF01217	0.744
TRG_DiLeu_BaEn_4	210	216	PF01217	0.708
TRG_ENDOCYTIC_2	36	39	PF00928	0.575
TRG_ENDOCYTIC_2	511	514	PF00928	0.367
TRG_ER_diArg_1	318	320	PF00400	0.473
TRG_ER_diArg_1	394	397	PF00400	0.712
TRG_ER_diArg_1	413	415	PF00400	0.637
TRG_ER_diArg_1	427	429	PF00400	0.459
TRG_Pf-PMV_PEXEL_1	413	418	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL78	Leptomonas seymouri	68%	100%
A0A1X0P397	Trypanosomatidae	35%	100%
A0A3R7KTQ7	Trypanosoma rangeli	32%	100%
A4HPR9	Leishmania braziliensis	82%	99%
A4ICZ4	Leishmania infantum	99%	100%
E9ATI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q114	Leishmania major	95%	100%
V5B6V7	Trypanosoma cruzi	33%	100%