HAP2-GCS1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

similar to leishmania major. l411.4-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IW91_LEIDO

TriTrypDb:

LdBPK_364050.1 , LdCL_360047500 , LDHU3_36.5430

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	11
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3Q8IW91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IW91

Function

Biological processes
Term	Name	Level	Count
GO:0007338	single fertilization	3	11
GO:0009566	fertilization	2	11
GO:0022414	reproductive process	1	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0008289	lipid binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	522	524	PF00675	0.439
CLV_PCSK_KEX2_1	522	524	PF00082	0.504
CLV_PCSK_SKI1_1	254	258	PF00082	0.399
CLV_PCSK_SKI1_1	452	456	PF00082	0.499
CLV_PCSK_SKI1_1	523	527	PF00082	0.522
CLV_PCSK_SKI1_1	530	534	PF00082	0.481
DEG_APCC_DBOX_1	94	102	PF00400	0.304
DEG_SPOP_SBC_1	193	197	PF00917	0.316
DEG_SPOP_SBC_1	459	463	PF00917	0.239
DOC_CKS1_1	19	24	PF01111	0.503
DOC_CYCLIN_yCln2_LP_2	285	291	PF00134	0.304
DOC_MAPK_MEF2A_6	28	35	PF00069	0.225
DOC_PP1_RVXF_1	252	258	PF00149	0.304
DOC_PP1_RVXF_1	496	503	PF00149	0.177
DOC_PP2B_LxvP_1	256	259	PF13499	0.210
DOC_PP2B_LxvP_1	285	288	PF13499	0.266
DOC_USP7_MATH_1	155	159	PF00917	0.284
DOC_USP7_MATH_1	242	246	PF00917	0.337
DOC_USP7_MATH_1	261	265	PF00917	0.149
DOC_USP7_MATH_1	290	294	PF00917	0.297
DOC_USP7_MATH_1	436	440	PF00917	0.239
DOC_USP7_MATH_1	459	463	PF00917	0.309
DOC_USP7_MATH_1	72	76	PF00917	0.306
DOC_WW_Pin1_4	18	23	PF00397	0.485
DOC_WW_Pin1_4	194	199	PF00397	0.303
DOC_WW_Pin1_4	302	307	PF00397	0.315
DOC_WW_Pin1_4	507	512	PF00397	0.274
LIG_14-3-3_CanoR_1	116	125	PF00244	0.235
LIG_14-3-3_CanoR_1	236	242	PF00244	0.344
LIG_14-3-3_CanoR_1	268	276	PF00244	0.316
LIG_14-3-3_CanoR_1	381	385	PF00244	0.311
LIG_14-3-3_CanoR_1	417	423	PF00244	0.341
LIG_14-3-3_CanoR_1	479	487	PF00244	0.309
LIG_14-3-3_CanoR_1	507	511	PF00244	0.228
LIG_14-3-3_CanoR_1	530	539	PF00244	0.342
LIG_14-3-3_CanoR_1	95	101	PF00244	0.240
LIG_Actin_WH2_2	365	383	PF00022	0.286
LIG_Actin_WH2_2	94	111	PF00022	0.312
LIG_deltaCOP1_diTrp_1	538	544	PF00928	0.269
LIG_EVH1_1	19	23	PF00568	0.328
LIG_FHA_1	133	139	PF00498	0.251
LIG_FHA_1	155	161	PF00498	0.300
LIG_FHA_1	199	205	PF00498	0.315
LIG_FHA_1	213	219	PF00498	0.291
LIG_FHA_1	271	277	PF00498	0.336
LIG_FHA_1	39	45	PF00498	0.245
LIG_FHA_1	407	413	PF00498	0.264
LIG_FHA_1	451	457	PF00498	0.265
LIG_FHA_1	459	465	PF00498	0.249
LIG_FHA_1	50	56	PF00498	0.280
LIG_FHA_1	6	12	PF00498	0.475
LIG_FHA_1	82	88	PF00498	0.220
LIG_FHA_2	148	154	PF00498	0.292
LIG_FHA_2	32	38	PF00498	0.304
LIG_FHA_2	533	539	PF00498	0.239
LIG_LIR_Gen_1	130	139	PF02991	0.352
LIG_LIR_Gen_1	283	292	PF02991	0.213
LIG_LIR_Gen_1	366	373	PF02991	0.291
LIG_LIR_Gen_1	538	547	PF02991	0.304
LIG_LIR_Nem_3	283	287	PF02991	0.201
LIG_LIR_Nem_3	307	312	PF02991	0.205
LIG_LIR_Nem_3	366	372	PF02991	0.220
LIG_LIR_Nem_3	421	425	PF02991	0.265
LIG_LIR_Nem_3	538	542	PF02991	0.375
LIG_SH2_CRK	422	426	PF00017	0.272
LIG_SH2_CRK	556	560	PF00017	0.287
LIG_SH2_PTP2	413	416	PF00017	0.345
LIG_SH2_PTP2	427	430	PF00017	0.234
LIG_SH2_STAP1	200	204	PF00017	0.281
LIG_SH2_STAP1	556	560	PF00017	0.287
LIG_SH2_STAT5	10	13	PF00017	0.399
LIG_SH2_STAT5	100	103	PF00017	0.278
LIG_SH2_STAT5	200	203	PF00017	0.319
LIG_SH2_STAT5	308	311	PF00017	0.304
LIG_SH2_STAT5	349	352	PF00017	0.241
LIG_SH2_STAT5	413	416	PF00017	0.276
LIG_SH2_STAT5	427	430	PF00017	0.156
LIG_SH3_3	136	142	PF00018	0.314
LIG_SH3_3	17	23	PF00018	0.369
LIG_SH3_3	467	473	PF00018	0.170
LIG_SH3_3	510	516	PF00018	0.213
LIG_SH3_3	75	81	PF00018	0.304
LIG_SUMO_SIM_par_1	29	34	PF11976	0.210
LIG_SUMO_SIM_par_1	290	295	PF11976	0.213
LIG_TRAF2_1	473	476	PF00917	0.344
LIG_TYR_ITIM	411	416	PF00017	0.341
LIG_TYR_ITIM	425	430	PF00017	0.259
LIG_WRC_WIRS_1	354	359	PF05994	0.251
MOD_CK1_1	130	136	PF00069	0.283
MOD_CK1_1	18	24	PF00069	0.395
MOD_CK1_1	192	198	PF00069	0.265
MOD_CK1_1	264	270	PF00069	0.325
MOD_CK1_1	311	317	PF00069	0.304
MOD_CK1_1	353	359	PF00069	0.324
MOD_CK1_1	38	44	PF00069	0.270
MOD_CK1_1	468	474	PF00069	0.308
MOD_CK2_1	147	153	PF00069	0.213
MOD_CK2_1	40	46	PF00069	0.292
MOD_CK2_1	532	538	PF00069	0.239
MOD_GlcNHglycan	139	142	PF01048	0.520
MOD_GlcNHglycan	204	207	PF01048	0.456
MOD_GlcNHglycan	229	232	PF01048	0.446
MOD_GlcNHglycan	250	254	PF01048	0.466
MOD_GlcNHglycan	259	262	PF01048	0.489
MOD_GlcNHglycan	294	297	PF01048	0.509
MOD_GSK3_1	1	8	PF00069	0.491
MOD_GSK3_1	123	130	PF00069	0.262
MOD_GSK3_1	189	196	PF00069	0.296
MOD_GSK3_1	198	205	PF00069	0.213
MOD_GSK3_1	212	219	PF00069	0.307
MOD_GSK3_1	257	264	PF00069	0.267
MOD_GSK3_1	308	315	PF00069	0.306
MOD_GSK3_1	31	38	PF00069	0.307
MOD_GSK3_1	368	375	PF00069	0.191
MOD_GSK3_1	40	47	PF00069	0.280
MOD_GSK3_1	436	443	PF00069	0.282
MOD_GSK3_1	477	484	PF00069	0.310
MOD_GSK3_1	494	501	PF00069	0.156
MOD_GSK3_1	68	75	PF00069	0.273
MOD_GSK3_1	96	103	PF00069	0.291
MOD_N-GLC_1	161	166	PF02516	0.504
MOD_N-GLC_1	202	207	PF02516	0.340
MOD_N-GLC_1	418	423	PF02516	0.474
MOD_N-GLC_1	459	464	PF02516	0.466
MOD_N-GLC_1	498	503	PF02516	0.449
MOD_N-GLC_2	297	299	PF02516	0.504
MOD_NEK2_1	1	6	PF00069	0.422
MOD_NEK2_1	108	113	PF00069	0.306
MOD_NEK2_1	132	137	PF00069	0.279
MOD_NEK2_1	202	207	PF00069	0.286
MOD_NEK2_1	312	317	PF00069	0.213
MOD_NEK2_1	35	40	PF00069	0.217
MOD_NEK2_1	380	385	PF00069	0.270
MOD_NEK2_1	405	410	PF00069	0.301
MOD_NEK2_1	412	417	PF00069	0.262
MOD_NEK2_1	465	470	PF00069	0.306
MOD_NEK2_1	494	499	PF00069	0.300
MOD_NEK2_1	532	537	PF00069	0.345
MOD_NEK2_1	542	547	PF00069	0.351
MOD_NEK2_1	55	60	PF00069	0.304
MOD_NEK2_1	76	81	PF00069	0.289
MOD_NEK2_2	161	166	PF00069	0.304
MOD_NMyristoyl	1	7	PF02799	0.338
MOD_OFUCOSY	318	325	PF10250	0.423
MOD_PIKK_1	313	319	PF00454	0.219
MOD_PKA_2	108	114	PF00069	0.284
MOD_PKA_2	235	241	PF00069	0.224
MOD_PKA_2	264	270	PF00069	0.260
MOD_PKA_2	380	386	PF00069	0.308
MOD_PKA_2	436	442	PF00069	0.239
MOD_PKA_2	506	512	PF00069	0.216
MOD_Plk_1	161	167	PF00069	0.272
MOD_Plk_1	31	37	PF00069	0.304
MOD_Plk_1	418	424	PF00069	0.301
MOD_Plk_1	459	465	PF00069	0.304
MOD_Plk_1	47	53	PF00069	0.307
MOD_Plk_1	498	504	PF00069	0.287
MOD_Plk_4	127	133	PF00069	0.336
MOD_Plk_4	134	140	PF00069	0.258
MOD_Plk_4	35	41	PF00069	0.306
MOD_Plk_4	460	466	PF00069	0.282
MOD_Plk_4	481	487	PF00069	0.301
MOD_Plk_4	55	61	PF00069	0.328
MOD_Plk_4	96	102	PF00069	0.312
MOD_ProDKin_1	18	24	PF00069	0.482
MOD_ProDKin_1	194	200	PF00069	0.303
MOD_ProDKin_1	302	308	PF00069	0.315
MOD_ProDKin_1	507	513	PF00069	0.274
MOD_SUMO_for_1	516	519	PF00179	0.311
TRG_DiLeu_BaEn_1	538	543	PF01217	0.408
TRG_ENDOCYTIC_2	131	134	PF00928	0.304
TRG_ENDOCYTIC_2	199	202	PF00928	0.304
TRG_ENDOCYTIC_2	413	416	PF00928	0.309
TRG_ENDOCYTIC_2	422	425	PF00928	0.235
TRG_ENDOCYTIC_2	427	430	PF00928	0.203
TRG_ENDOCYTIC_2	556	559	PF00928	0.317
TRG_ENDOCYTIC_2	561	564	PF00928	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A060A682	Tetrahymena thermophila	21%	78%
A0A0N1I7I3	Leptomonas seymouri	50%	93%
A0A0S4KHY6	Bodo saltans	25%	86%
A0A1X0P0J5	Trypanosomatidae	25%	94%
A0A3R7NLN3	Trypanosoma rangeli	24%	99%
A4HPQ3	Leishmania braziliensis	75%	99%
A4ID10	Leishmania infantum	99%	100%
D0A4L4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	93%
Q4Q129	Leishmania major	93%	100%
V5BFV7	Trypanosoma cruzi	26%	98%