Vacuolar_protein_sorting-associated_protein-like_ protein/GeneDB:LmjF.36.3420

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar protein sorting-associated protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IW72_LEIDO

TriTrypDb:

LdBPK_363580.1 , LdCL_360042800 , LDHU3_36.4860

Length:

361

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0005829	cytosol	2	1
GO:0030904	retromer complex	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098796	membrane protein complex	2	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Amastigote: 14

Expansion

Sequence features

A0A3Q8IW72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IW72

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0016482	cytosolic transport	4	1
GO:0042147	retrograde transport, endosome to Golgi	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.293
CLV_C14_Caspase3-7	266	270	PF00656	0.278
CLV_NRD_NRD_1	243	245	PF00675	0.293
CLV_NRD_NRD_1	329	331	PF00675	0.403
CLV_PCSK_KEX2_1	317	319	PF00082	0.381
CLV_PCSK_KEX2_1	329	331	PF00082	0.401
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.382
CLV_PCSK_SKI1_1	100	104	PF00082	0.390
CLV_PCSK_SKI1_1	213	217	PF00082	0.275
CLV_PCSK_SKI1_1	245	249	PF00082	0.393
CLV_PCSK_SKI1_1	304	308	PF00082	0.389
CLV_PCSK_SKI1_1	318	322	PF00082	0.313
DEG_APCC_DBOX_1	280	288	PF00400	0.275
DEG_APCC_DBOX_1	303	311	PF00400	0.393
DEG_Nend_Nbox_1	1	3	PF02207	0.577
DEG_SCF_FBW7_1	69	76	PF00400	0.353
DEG_SCF_FBW7_2	268	275	PF00400	0.393
DOC_CDC14_PxL_1	284	292	PF14671	0.275
DOC_CKS1_1	117	122	PF01111	0.393
DOC_CKS1_1	70	75	PF01111	0.338
DOC_MAPK_gen_1	317	327	PF00069	0.362
DOC_MAPK_MEF2A_6	304	311	PF00069	0.338
DOC_MAPK_NFAT4_5	304	312	PF00069	0.393
DOC_PP1_RVXF_1	98	104	PF00149	0.295
DOC_PP4_FxxP_1	125	128	PF00568	0.319
DOC_PP4_FxxP_1	247	250	PF00568	0.353
DOC_USP7_MATH_1	176	180	PF00917	0.300
DOC_USP7_MATH_1	73	77	PF00917	0.368
DOC_USP7_MATH_2	128	134	PF00917	0.319
DOC_USP7_UBL2_3	150	154	PF12436	0.398
DOC_USP7_UBL2_3	225	229	PF12436	0.327
DOC_USP7_UBL2_3	317	321	PF12436	0.393
DOC_USP7_UBL2_3	62	66	PF12436	0.393
DOC_WW_Pin1_4	116	121	PF00397	0.353
DOC_WW_Pin1_4	152	157	PF00397	0.361
DOC_WW_Pin1_4	268	273	PF00397	0.275
DOC_WW_Pin1_4	288	293	PF00397	0.123
DOC_WW_Pin1_4	69	74	PF00397	0.313
LIG_14-3-3_CanoR_1	335	341	PF00244	0.642
LIG_Actin_WH2_2	270	287	PF00022	0.271
LIG_BRCT_BRCA1_1	52	56	PF00533	0.401
LIG_CaMK_CASK_1	161	166	PF00069	0.355
LIG_eIF4E_1	237	243	PF01652	0.401
LIG_EVH1_2	336	340	PF00568	0.469
LIG_FHA_1	269	275	PF00498	0.294
LIG_FHA_2	117	123	PF00498	0.275
LIG_FHA_2	329	335	PF00498	0.518
LIG_FHA_2	36	42	PF00498	0.313
LIG_FHA_2	91	97	PF00498	0.321
LIG_LIR_Apic_2	122	128	PF02991	0.319
LIG_LIR_Apic_2	246	250	PF02991	0.319
LIG_LIR_Apic_2	60	64	PF02991	0.401
LIG_LIR_Gen_1	119	128	PF02991	0.357
LIG_LIR_Gen_1	14	22	PF02991	0.588
LIG_LIR_Gen_1	291	301	PF02991	0.401
LIG_LIR_Gen_1	47	57	PF02991	0.403
LIG_LIR_Nem_3	119	124	PF02991	0.319
LIG_LIR_Nem_3	132	137	PF02991	0.347
LIG_LIR_Nem_3	14	18	PF02991	0.648
LIG_LIR_Nem_3	234	240	PF02991	0.295
LIG_LIR_Nem_3	291	297	PF02991	0.289
LIG_LIR_Nem_3	47	52	PF02991	0.403
LIG_LIR_Nem_3	53	59	PF02991	0.405
LIG_LIR_Nem_3	92	97	PF02991	0.389
LIG_MYND_1	288	292	PF01753	0.275
LIG_PAM2_1	154	166	PF00658	0.218
LIG_PCNA_yPIPBox_3	198	210	PF02747	0.393
LIG_PCNA_yPIPBox_3	81	95	PF02747	0.361
LIG_Pex14_2	121	125	PF04695	0.401
LIG_SH2_CRK	134	138	PF00017	0.319
LIG_SH2_CRK	49	53	PF00017	0.401
LIG_SH2_GRB2like	294	297	PF00017	0.414
LIG_SH2_NCK_1	49	53	PF00017	0.401
LIG_SH2_STAP1	211	215	PF00017	0.275
LIG_SH2_STAT3	143	146	PF00017	0.393
LIG_SH2_STAT3	319	322	PF00017	0.387
LIG_SH2_STAT3	78	81	PF00017	0.393
LIG_SH2_STAT5	143	146	PF00017	0.278
LIG_SH2_STAT5	184	187	PF00017	0.307
LIG_SH2_STAT5	283	286	PF00017	0.275
LIG_SH2_STAT5	305	308	PF00017	0.275
LIG_SH2_STAT5	319	322	PF00017	0.368
LIG_SH3_3	67	73	PF00018	0.353
LIG_SUMO_SIM_par_1	44	50	PF11976	0.344
LIG_TRAF2_1	331	334	PF00917	0.462
LIG_TYR_ITIM	235	240	PF00017	0.295
LIG_UBA3_1	21	29	PF00899	0.456
MOD_CDK_SPxxK_3	152	159	PF00069	0.361
MOD_CK1_1	16	22	PF00069	0.586
MOD_CK1_1	339	345	PF00069	0.590
MOD_CK1_1	76	82	PF00069	0.393
MOD_CK2_1	116	122	PF00069	0.275
MOD_CK2_1	328	334	PF00069	0.439
MOD_CK2_1	57	63	PF00069	0.295
MOD_CK2_1	90	96	PF00069	0.298
MOD_Cter_Amidation	315	318	PF01082	0.381
MOD_GlcNHglycan	125	128	PF01048	0.356
MOD_GlcNHglycan	177	181	PF01048	0.366
MOD_GlcNHglycan	341	344	PF01048	0.713
MOD_GlcNHglycan	349	352	PF01048	0.596
MOD_GSK3_1	335	342	PF00069	0.578
MOD_GSK3_1	69	76	PF00069	0.359
MOD_NEK2_1	123	128	PF00069	0.283
MOD_NEK2_1	171	176	PF00069	0.286
MOD_NEK2_1	185	190	PF00069	0.275
MOD_PIKK_1	171	177	PF00454	0.275
MOD_PK_1	154	160	PF00069	0.393
MOD_PKA_2	185	191	PF00069	0.286
MOD_PKA_2	328	334	PF00069	0.503
MOD_Plk_2-3	35	41	PF00069	0.373
MOD_Plk_4	290	296	PF00069	0.393
MOD_ProDKin_1	116	122	PF00069	0.353
MOD_ProDKin_1	152	158	PF00069	0.361
MOD_ProDKin_1	268	274	PF00069	0.275
MOD_ProDKin_1	288	294	PF00069	0.123
MOD_ProDKin_1	69	75	PF00069	0.313
MOD_SUMO_for_1	158	161	PF00179	0.393
MOD_SUMO_rev_2	208	216	PF00179	0.295
MOD_SUMO_rev_2	31	38	PF00179	0.309
MOD_SUMO_rev_2	39	43	PF00179	0.324
TRG_ENDOCYTIC_2	134	137	PF00928	0.295
TRG_ENDOCYTIC_2	138	141	PF00928	0.295
TRG_ENDOCYTIC_2	237	240	PF00928	0.295
TRG_ENDOCYTIC_2	294	297	PF00928	0.288
TRG_ENDOCYTIC_2	49	52	PF00928	0.401
TRG_ER_diArg_1	140	143	PF00400	0.342
TRG_ER_diArg_1	328	330	PF00400	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N0	Leptomonas seymouri	75%	100%
A0A1X0P3C6	Trypanosomatidae	60%	100%
A0A422NA47	Trypanosoma rangeli	60%	100%
A4HPK9	Leishmania braziliensis	87%	100%
A4ID55	Leishmania infantum	100%	100%
D0A8K4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ATC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O01258	Caenorhabditis elegans	37%	100%
O75436	Homo sapiens	34%	100%
P40335	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	95%
P40336	Mus musculus	34%	100%
Q0VD53	Bos taurus	34%	100%
Q10243	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q28HT6	Xenopus tropicalis	35%	100%
Q4G0F5	Homo sapiens	30%	100%
Q4Q176	Leishmania major	96%	100%
Q55CA0	Dictyostelium discoideum	36%	100%
Q5BKM4	Xenopus tropicalis	30%	100%
Q5R436	Pongo abelii	30%	100%
Q68F29	Xenopus laevis	32%	100%
Q6AY86	Rattus norvegicus	33%	100%
Q6DFB9	Xenopus laevis	31%	100%
Q6DFU4	Xenopus laevis	34%	100%
Q6DH23	Danio rerio	31%	100%
Q6IRD0	Xenopus laevis	34%	100%
Q6TNP8	Danio rerio	33%	100%
Q7ZV03	Danio rerio	31%	100%
Q8C0E2	Mus musculus	30%	100%
Q8I4T1	Plasmodium falciparum (isolate 3D7)	34%	100%
Q9FJD0	Arabidopsis thaliana	35%	100%
Q9T091	Arabidopsis thaliana	35%	100%
Q9W552	Drosophila melanogaster	34%	76%
V5BMH4	Trypanosoma cruzi	60%	100%