Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IW63_LEIDO

TriTrypDb:

LdBPK_363460.1 , LdCL_360041500 , LDHU3_36.4730

Length:

815

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IW63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IW63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	416	420	PF00656	0.538
CLV_NRD_NRD_1	122	124	PF00675	0.816
CLV_NRD_NRD_1	276	278	PF00675	0.756
CLV_NRD_NRD_1	402	404	PF00675	0.523
CLV_NRD_NRD_1	414	416	PF00675	0.452
CLV_NRD_NRD_1	438	440	PF00675	0.508
CLV_NRD_NRD_1	47	49	PF00675	0.701
CLV_NRD_NRD_1	499	501	PF00675	0.608
CLV_NRD_NRD_1	512	514	PF00675	0.551
CLV_NRD_NRD_1	523	525	PF00675	0.536
CLV_NRD_NRD_1	539	541	PF00675	0.490
CLV_NRD_NRD_1	576	578	PF00675	0.568
CLV_NRD_NRD_1	586	588	PF00675	0.531
CLV_NRD_NRD_1	606	608	PF00675	0.381
CLV_NRD_NRD_1	628	630	PF00675	0.574
CLV_NRD_NRD_1	647	649	PF00675	0.364
CLV_NRD_NRD_1	657	659	PF00675	0.510
CLV_NRD_NRD_1	677	679	PF00675	0.434
CLV_NRD_NRD_1	739	741	PF00675	0.605
CLV_NRD_NRD_1	775	777	PF00675	0.634
CLV_NRD_NRD_1	92	94	PF00675	0.588
CLV_NRD_NRD_1	98	100	PF00675	0.646
CLV_PCSK_FUR_1	537	541	PF00082	0.613
CLV_PCSK_FUR_1	584	588	PF00082	0.606
CLV_PCSK_KEX2_1	276	278	PF00082	0.760
CLV_PCSK_KEX2_1	402	404	PF00082	0.508
CLV_PCSK_KEX2_1	414	416	PF00082	0.507
CLV_PCSK_KEX2_1	438	440	PF00082	0.482
CLV_PCSK_KEX2_1	47	49	PF00082	0.701
CLV_PCSK_KEX2_1	512	514	PF00082	0.577
CLV_PCSK_KEX2_1	522	524	PF00082	0.512
CLV_PCSK_KEX2_1	539	541	PF00082	0.517
CLV_PCSK_KEX2_1	576	578	PF00082	0.568
CLV_PCSK_KEX2_1	586	588	PF00082	0.531
CLV_PCSK_KEX2_1	605	607	PF00082	0.429
CLV_PCSK_KEX2_1	628	630	PF00082	0.593
CLV_PCSK_KEX2_1	646	648	PF00082	0.401
CLV_PCSK_KEX2_1	657	659	PF00082	0.584
CLV_PCSK_KEX2_1	677	679	PF00082	0.444
CLV_PCSK_KEX2_1	739	741	PF00082	0.533
CLV_PCSK_KEX2_1	775	777	PF00082	0.615
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.634
CLV_PCSK_PC1ET2_1	646	648	PF00082	0.616
CLV_PCSK_PC1ET2_1	775	777	PF00082	0.615
CLV_PCSK_PC7_1	410	416	PF00082	0.552
CLV_PCSK_PC7_1	642	648	PF00082	0.612
CLV_PCSK_SKI1_1	209	213	PF00082	0.607
CLV_PCSK_SKI1_1	298	302	PF00082	0.487
CLV_PCSK_SKI1_1	331	335	PF00082	0.582
CLV_PCSK_SKI1_1	410	414	PF00082	0.583
CLV_PCSK_SKI1_1	470	474	PF00082	0.540
CLV_PCSK_SKI1_1	609	613	PF00082	0.648
CLV_PCSK_SKI1_1	628	632	PF00082	0.399
CLV_PCSK_SKI1_1	658	662	PF00082	0.642
CLV_PCSK_SKI1_1	731	735	PF00082	0.554
CLV_PCSK_SKI1_1	804	808	PF00082	0.547
DOC_CKS1_1	272	277	PF01111	0.803
DOC_CKS1_1	278	283	PF01111	0.678
DOC_CYCLIN_RxL_1	295	302	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	278	284	PF00134	0.697
DOC_MAPK_MEF2A_6	184	193	PF00069	0.503
DOC_PP2B_LxvP_1	301	304	PF13499	0.495
DOC_USP7_MATH_1	122	126	PF00917	0.721
DOC_USP7_MATH_1	128	132	PF00917	0.677
DOC_USP7_MATH_1	146	150	PF00917	0.789
DOC_USP7_MATH_1	245	249	PF00917	0.757
DOC_USP7_MATH_1	372	376	PF00917	0.708
DOC_USP7_MATH_1	377	381	PF00917	0.692
DOC_USP7_UBL2_3	30	34	PF12436	0.658
DOC_USP7_UBL2_3	598	602	PF12436	0.573
DOC_USP7_UBL2_3	605	609	PF12436	0.571
DOC_WW_Pin1_4	124	129	PF00397	0.710
DOC_WW_Pin1_4	142	147	PF00397	0.750
DOC_WW_Pin1_4	154	159	PF00397	0.674
DOC_WW_Pin1_4	173	178	PF00397	0.733
DOC_WW_Pin1_4	212	217	PF00397	0.704
DOC_WW_Pin1_4	241	246	PF00397	0.725
DOC_WW_Pin1_4	264	269	PF00397	0.714
DOC_WW_Pin1_4	271	276	PF00397	0.672
DOC_WW_Pin1_4	277	282	PF00397	0.626
DOC_WW_Pin1_4	343	348	PF00397	0.664
DOC_WW_Pin1_4	350	355	PF00397	0.301
DOC_WW_Pin1_4	363	368	PF00397	0.434
LIG_14-3-3_CanoR_1	221	226	PF00244	0.802
LIG_14-3-3_CanoR_1	264	268	PF00244	0.749
LIG_14-3-3_CanoR_1	331	340	PF00244	0.536
LIG_14-3-3_CanoR_1	414	418	PF00244	0.567
LIG_14-3-3_CanoR_1	731	738	PF00244	0.601
LIG_Actin_WH2_2	308	326	PF00022	0.598
LIG_BIR_II_1	1	5	PF00653	0.724
LIG_deltaCOP1_diTrp_1	735	744	PF00928	0.532
LIG_EH1_1	766	774	PF00400	0.543
LIG_FHA_1	291	297	PF00498	0.566
LIG_FHA_1	473	479	PF00498	0.584
LIG_FHA_1	55	61	PF00498	0.602
LIG_FHA_1	590	596	PF00498	0.610
LIG_FHA_1	749	755	PF00498	0.522
LIG_FHA_2	174	180	PF00498	0.776
LIG_FHA_2	414	420	PF00498	0.544
LIG_FHA_2	711	717	PF00498	0.624
LIG_FHA_2	766	772	PF00498	0.503
LIG_FHA_2	78	84	PF00498	0.596
LIG_LIR_Gen_1	183	194	PF02991	0.677
LIG_LIR_Gen_1	419	429	PF02991	0.435
LIG_LIR_Gen_1	751	760	PF02991	0.480
LIG_LIR_Gen_1	762	770	PF02991	0.411
LIG_LIR_Nem_3	12	17	PF02991	0.734
LIG_LIR_Nem_3	183	189	PF02991	0.673
LIG_LIR_Nem_3	37	42	PF02991	0.553
LIG_LIR_Nem_3	419	424	PF02991	0.423
LIG_LIR_Nem_3	751	755	PF02991	0.490
LIG_LIR_Nem_3	762	766	PF02991	0.403
LIG_MAD2	295	303	PF02301	0.547
LIG_MYND_1	226	230	PF01753	0.764
LIG_NRBOX	296	302	PF00104	0.461
LIG_Pex14_2	318	322	PF04695	0.523
LIG_SH2_CRK	14	18	PF00017	0.729
LIG_SH2_CRK	421	425	PF00017	0.480
LIG_SH2_CRK	437	441	PF00017	0.383
LIG_SH2_CRK	752	756	PF00017	0.534
LIG_SH2_STAP1	307	311	PF00017	0.542
LIG_SH2_STAT3	544	547	PF00017	0.467
LIG_SH2_STAT5	35	38	PF00017	0.652
LIG_SH2_STAT5	405	408	PF00017	0.547
LIG_SH2_STAT5	640	643	PF00017	0.677
LIG_SH3_2	272	277	PF14604	0.770
LIG_SH3_3	145	151	PF00018	0.789
LIG_SH3_3	17	23	PF00018	0.593
LIG_SH3_3	195	201	PF00018	0.743
LIG_SH3_3	269	275	PF00018	0.668
LIG_SUMO_SIM_anti_2	768	774	PF11976	0.585
LIG_SUMO_SIM_par_1	768	774	PF11976	0.585
LIG_TRAF2_1	136	139	PF00917	0.735
LIG_TRAF2_1	168	171	PF00917	0.808
LIG_TRAF2_1	450	453	PF00917	0.707
LIG_TRAF2_1	516	519	PF00917	0.582
LIG_TRAF2_1	705	708	PF00917	0.573
LIG_TYR_ITSM	10	17	PF00017	0.671
LIG_UBA3_1	480	488	PF00899	0.575
LIG_WRC_WIRS_1	315	320	PF05994	0.502
MOD_CDK_SPK_2	271	276	PF00069	0.801
MOD_CDK_SPK_2	350	355	PF00069	0.414
MOD_CDK_SPK_2	363	368	PF00069	0.434
MOD_CDK_SPxK_1	271	277	PF00069	0.762
MOD_CDK_SPxxK_3	343	350	PF00069	0.661
MOD_CK1_1	147	153	PF00069	0.717
MOD_CK1_1	166	172	PF00069	0.674
MOD_CK1_1	203	209	PF00069	0.777
MOD_CK1_1	353	359	PF00069	0.432
MOD_CK1_1	375	381	PF00069	0.699
MOD_CK1_1	457	463	PF00069	0.690
MOD_CK2_1	173	179	PF00069	0.770
MOD_CK2_1	34	40	PF00069	0.684
MOD_CK2_1	77	83	PF00069	0.619
MOD_Cter_Amidation	91	94	PF01082	0.669
MOD_DYRK1A_RPxSP_1	264	268	PF00069	0.798
MOD_GlcNHglycan	105	108	PF01048	0.727
MOD_GlcNHglycan	152	155	PF01048	0.743
MOD_GlcNHglycan	165	168	PF01048	0.768
MOD_GlcNHglycan	209	212	PF01048	0.784
MOD_GlcNHglycan	247	250	PF01048	0.797
MOD_GlcNHglycan	374	377	PF01048	0.725
MOD_GlcNHglycan	379	382	PF01048	0.686
MOD_GSK3_1	124	131	PF00069	0.678
MOD_GSK3_1	142	149	PF00069	0.750
MOD_GSK3_1	150	157	PF00069	0.668
MOD_GSK3_1	203	210	PF00069	0.745
MOD_GSK3_1	211	218	PF00069	0.587
MOD_GSK3_1	232	239	PF00069	0.775
MOD_GSK3_1	241	248	PF00069	0.765
MOD_GSK3_1	263	270	PF00069	0.718
MOD_GSK3_1	286	293	PF00069	0.602
MOD_GSK3_1	371	378	PF00069	0.670
MOD_GSK3_1	413	420	PF00069	0.568
MOD_GSK3_1	5	12	PF00069	0.711
MOD_GSK3_1	727	734	PF00069	0.564
MOD_LATS_1	207	213	PF00433	0.605
MOD_NEK2_1	313	318	PF00069	0.479
MOD_NEK2_1	413	418	PF00069	0.476
MOD_NEK2_1	588	593	PF00069	0.574
MOD_NEK2_1	69	74	PF00069	0.755
MOD_NEK2_2	307	312	PF00069	0.515
MOD_PIKK_1	128	134	PF00454	0.761
MOD_PIKK_1	215	221	PF00454	0.727
MOD_PIKK_1	385	391	PF00454	0.606
MOD_PIKK_1	5	11	PF00454	0.754
MOD_PIKK_1	698	704	PF00454	0.618
MOD_PKA_1	646	652	PF00069	0.547
MOD_PKA_2	122	128	PF00069	0.737
MOD_PKA_2	263	269	PF00069	0.782
MOD_PKA_2	372	378	PF00069	0.636
MOD_PKA_2	413	419	PF00069	0.573
MOD_PKA_2	589	595	PF00069	0.585
MOD_PKA_2	646	652	PF00069	0.624
MOD_PKA_2	718	724	PF00069	0.633
MOD_PKA_2	727	733	PF00069	0.596
MOD_PKB_1	3	11	PF00069	0.755
MOD_Plk_1	232	238	PF00069	0.634
MOD_Plk_1	313	319	PF00069	0.555
MOD_Plk_1	494	500	PF00069	0.565
MOD_Plk_1	69	75	PF00069	0.694
MOD_Plk_2-3	314	320	PF00069	0.506
MOD_Plk_4	419	425	PF00069	0.519
MOD_Plk_4	72	78	PF00069	0.691
MOD_Plk_4	765	771	PF00069	0.493
MOD_ProDKin_1	124	130	PF00069	0.705
MOD_ProDKin_1	142	148	PF00069	0.745
MOD_ProDKin_1	154	160	PF00069	0.674
MOD_ProDKin_1	173	179	PF00069	0.733
MOD_ProDKin_1	212	218	PF00069	0.701
MOD_ProDKin_1	241	247	PF00069	0.727
MOD_ProDKin_1	264	270	PF00069	0.714
MOD_ProDKin_1	271	277	PF00069	0.673
MOD_ProDKin_1	343	349	PF00069	0.653
MOD_ProDKin_1	350	356	PF00069	0.298
MOD_ProDKin_1	363	369	PF00069	0.439
MOD_SUMO_for_1	611	614	PF00179	0.641
MOD_SUMO_for_1	705	708	PF00179	0.543
MOD_SUMO_for_1	807	810	PF00179	0.582
MOD_SUMO_rev_2	591	600	PF00179	0.634
MOD_SUMO_rev_2	745	751	PF00179	0.484
TRG_DiLeu_BaEn_4	170	176	PF01217	0.807
TRG_DiLeu_BaEn_4	626	632	PF01217	0.686
TRG_ENDOCYTIC_2	14	17	PF00928	0.737
TRG_ENDOCYTIC_2	421	424	PF00928	0.416
TRG_ENDOCYTIC_2	437	440	PF00928	0.413
TRG_ENDOCYTIC_2	752	755	PF00928	0.542
TRG_ER_diArg_1	220	223	PF00400	0.790
TRG_ER_diArg_1	275	277	PF00400	0.786
TRG_ER_diArg_1	413	415	PF00400	0.537
TRG_ER_diArg_1	437	439	PF00400	0.493
TRG_ER_diArg_1	46	48	PF00400	0.662
TRG_ER_diArg_1	511	513	PF00400	0.583
TRG_ER_diArg_1	522	524	PF00400	0.564
TRG_ER_diArg_1	537	540	PF00400	0.401
TRG_ER_diArg_1	584	587	PF00400	0.598
TRG_ER_diArg_1	738	740	PF00400	0.618
TRG_ER_diArg_1	783	786	PF00400	0.637
TRG_ER_diArg_1	794	797	PF00400	0.438
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	415	419	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	500	505	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	515	519	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	523	527	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	629	633	PF00026	0.679
TRG_Pf-PMV_PEXEL_1	731	735	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	786	791	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCJ0	Leptomonas seymouri	47%	99%
A0A1X0P4M8	Trypanosomatidae	30%	97%
A0A3R7KTP5	Trypanosoma rangeli	31%	100%
A4HPJ7	Leishmania braziliensis	73%	100%
D0A8L7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	94%
E9AHX5	Leishmania infantum	100%	100%
E9ATA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q188	Leishmania major	95%	100%
V5BS35	Trypanosoma cruzi	29%	100%