Bromodomain_factor_2_protein_putative/GeneDB:LmjF.36.2980

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IW45_LEIDO

TriTrypDb:

LdBPK_363130.1 , LdCL_360037800 , LDHU3_36.4330

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IW45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IW45

PDB structure(s): 5c4q_A , 5c4q_B

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.714
CLV_C14_Caspase3-7	221	225	PF00656	0.718
CLV_NRD_NRD_1	134	136	PF00675	0.573
CLV_NRD_NRD_1	170	172	PF00675	0.642
CLV_NRD_NRD_1	57	59	PF00675	0.377
CLV_PCSK_KEX2_1	102	104	PF00082	0.566
CLV_PCSK_KEX2_1	169	171	PF00082	0.642
CLV_PCSK_KEX2_1	5	7	PF00082	0.522
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.620
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.522
CLV_PCSK_SKI1_1	103	107	PF00082	0.567
CLV_PCSK_SKI1_1	98	102	PF00082	0.584
DEG_Nend_UBRbox_2	1	3	PF02207	0.668
DEG_SCF_TRCP1_1	205	210	PF00400	0.731
DOC_CKS1_1	48	53	PF01111	0.302
DOC_CYCLIN_RxL_1	98	111	PF00134	0.608
DOC_MAPK_FxFP_2	32	35	PF00069	0.302
DOC_MAPK_gen_1	98	107	PF00069	0.599
DOC_PP4_FxxP_1	32	35	PF00568	0.274
DOC_USP7_MATH_1	108	112	PF00917	0.545
DOC_USP7_UBL2_3	136	140	PF12436	0.669
DOC_USP7_UBL2_3	98	102	PF12436	0.618
DOC_WW_Pin1_4	47	52	PF00397	0.302
LIG_14-3-3_CanoR_1	103	108	PF00244	0.507
LIG_CtBP_PxDLS_1	51	55	PF00389	0.274
LIG_FHA_1	122	128	PF00498	0.621
LIG_FHA_2	213	219	PF00498	0.626
LIG_FHA_2	48	54	PF00498	0.486
LIG_FHA_2	66	72	PF00498	0.328
LIG_GBD_Chelix_1	76	84	PF00786	0.289
LIG_LIR_Gen_1	91	100	PF02991	0.356
LIG_LIR_Nem_3	91	96	PF02991	0.332
LIG_SH2_NCK_1	45	49	PF00017	0.417
LIG_SH2_STAT5	104	107	PF00017	0.514
LIG_SH3_3	45	51	PF00018	0.386
LIG_SUMO_SIM_anti_2	75	81	PF11976	0.434
LIG_SUMO_SIM_par_1	75	81	PF11976	0.302
LIG_TRAF2_1	192	195	PF00917	0.621
LIG_TRAF2_1	198	201	PF00917	0.636
LIG_TRAF2_1	215	218	PF00917	0.593
LIG_TRAF2_1	7	10	PF00917	0.507
MOD_CK1_1	111	117	PF00069	0.651
MOD_CK1_1	181	187	PF00069	0.659
MOD_CK1_1	189	195	PF00069	0.608
MOD_CK1_1	212	218	PF00069	0.676
MOD_CK1_1	222	228	PF00069	0.623
MOD_CK2_1	189	195	PF00069	0.622
MOD_CK2_1	212	218	PF00069	0.617
MOD_CK2_1	34	40	PF00069	0.314
MOD_CK2_1	65	71	PF00069	0.374
MOD_GlcNHglycan	110	113	PF01048	0.536
MOD_GlcNHglycan	184	187	PF01048	0.683
MOD_GlcNHglycan	205	208	PF01048	0.794
MOD_GlcNHglycan	209	212	PF01048	0.692
MOD_GlcNHglycan	36	39	PF01048	0.286
MOD_GSK3_1	177	184	PF00069	0.678
MOD_GSK3_1	201	208	PF00069	0.671
MOD_GSK3_1	222	229	PF00069	0.709
MOD_NEK2_1	1	6	PF00069	0.696
MOD_NEK2_1	52	57	PF00069	0.383
MOD_NEK2_1	78	83	PF00069	0.381
MOD_PIKK_1	88	94	PF00454	0.302
MOD_PKA_1	169	175	PF00069	0.648
MOD_PKA_2	169	175	PF00069	0.644
MOD_PKA_2	186	192	PF00069	0.518
MOD_Plk_1	129	135	PF00069	0.561
MOD_Plk_1	219	225	PF00069	0.720
MOD_Plk_1	52	58	PF00069	0.274
MOD_Plk_2-3	195	201	PF00069	0.608
MOD_Plk_2-3	219	225	PF00069	0.768
MOD_Plk_4	15	21	PF00069	0.417
MOD_ProDKin_1	47	53	PF00069	0.302
TRG_ENDOCYTIC_2	104	107	PF00928	0.495
TRG_ENDOCYTIC_2	44	47	PF00928	0.314
TRG_ER_diArg_1	169	171	PF00400	0.645
TRG_NLS_MonoExtN_4	98	105	PF00514	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7A0	Leptomonas seymouri	73%	100%
A0A0S4KPA6	Bodo saltans	41%	93%
A0A1X0NM37	Trypanosomatidae	51%	100%
A0A422NLU0	Trypanosoma rangeli	50%	100%
A4HPG4	Leishmania braziliensis	79%	100%
A4ID86	Leishmania infantum	100%	100%
D0A3H5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AT76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1C1	Leishmania major	92%	99%
V5BPW0	Trypanosoma cruzi	52%	100%