Calmodulin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Calmodulin

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IW35_LEIDO

TriTrypDb:

LdBPK_362960.1 , LdCL_360036000 , LDHU3_36.4110

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3Q8IW35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IW35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.599
CLV_C14_Caspase3-7	322	326	PF00656	0.669
CLV_C14_Caspase3-7	328	332	PF00656	0.633
CLV_C14_Caspase3-7	428	432	PF00656	0.699
CLV_C14_Caspase3-7	504	508	PF00656	0.708
CLV_NRD_NRD_1	12	14	PF00675	0.376
CLV_NRD_NRD_1	181	183	PF00675	0.629
CLV_NRD_NRD_1	264	266	PF00675	0.322
CLV_NRD_NRD_1	473	475	PF00675	0.502
CLV_PCSK_FUR_1	467	471	PF00082	0.542
CLV_PCSK_KEX2_1	12	14	PF00082	0.416
CLV_PCSK_KEX2_1	320	322	PF00082	0.554
CLV_PCSK_KEX2_1	469	471	PF00082	0.507
CLV_PCSK_KEX2_1	472	474	PF00082	0.510
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.453
CLV_PCSK_PC7_1	467	473	PF00082	0.544
CLV_PCSK_SKI1_1	12	16	PF00082	0.408
CLV_PCSK_SKI1_1	167	171	PF00082	0.559
CLV_PCSK_SKI1_1	247	251	PF00082	0.382
CLV_PCSK_SKI1_1	255	259	PF00082	0.359
CLV_PCSK_SKI1_1	309	313	PF00082	0.448
DEG_APCC_DBOX_1	11	19	PF00400	0.595
DEG_Nend_Nbox_1	1	3	PF02207	0.630
DOC_CKS1_1	5	10	PF01111	0.623
DOC_CYCLIN_RxL_1	10	21	PF00134	0.598
DOC_CYCLIN_RxL_1	252	262	PF00134	0.607
DOC_MAPK_FxFP_2	3	6	PF00069	0.610
DOC_MAPK_gen_1	130	139	PF00069	0.544
DOC_MAPK_MEF2A_6	133	141	PF00069	0.542
DOC_PIKK_1	579	586	PF02985	0.715
DOC_PP1_RVXF_1	11	18	PF00149	0.605
DOC_PP4_FxxP_1	3	6	PF00568	0.615
DOC_PP4_FxxP_1	370	373	PF00568	0.675
DOC_USP7_MATH_1	243	247	PF00917	0.617
DOC_USP7_UBL2_3	255	259	PF12436	0.609
DOC_USP7_UBL2_3	277	281	PF12436	0.603
DOC_WW_Pin1_4	4	9	PF00397	0.657
DOC_WW_Pin1_4	431	436	PF00397	0.731
DOC_WW_Pin1_4	511	516	PF00397	0.703
LIG_14-3-3_CanoR_1	182	187	PF00244	0.293
LIG_14-3-3_CanoR_1	283	289	PF00244	0.620
LIG_14-3-3_CanoR_1	44	50	PF00244	0.292
LIG_AP2alpha_1	374	378	PF02296	0.680
LIG_APCC_ABBA_1	234	239	PF00400	0.568
LIG_BRCT_BRCA1_1	245	249	PF00533	0.567
LIG_BRCT_BRCA1_1	515	519	PF00533	0.687
LIG_Clathr_ClatBox_1	107	111	PF01394	0.328
LIG_Clathr_ClatBox_1	65	69	PF01394	0.341
LIG_CSL_BTD_1	432	435	PF09270	0.731
LIG_deltaCOP1_diTrp_1	241	249	PF00928	0.561
LIG_DLG_GKlike_1	182	189	PF00625	0.288
LIG_EH1_1	141	149	PF00400	0.512
LIG_EH1_1	151	159	PF00400	0.351
LIG_eIF4E_1	53	59	PF01652	0.379
LIG_FHA_1	26	32	PF00498	0.412
LIG_FHA_1	83	89	PF00498	0.345
LIG_FHA_2	182	188	PF00498	0.379
LIG_FHA_2	320	326	PF00498	0.650
LIG_FHA_2	442	448	PF00498	0.848
LIG_FHA_2	52	58	PF00498	0.351
LIG_GBD_Chelix_1	582	590	PF00786	0.496
LIG_Integrin_RGD_1	474	476	PF01839	0.509
LIG_LIR_Apic_2	367	373	PF02991	0.677
LIG_LIR_Apic_2	447	452	PF02991	0.714
LIG_LIR_Apic_2	509	515	PF02991	0.682
LIG_LIR_Gen_1	111	120	PF02991	0.351
LIG_LIR_Gen_1	184	194	PF02991	0.465
LIG_LIR_Gen_1	195	205	PF02991	0.212
LIG_LIR_Gen_1	287	296	PF02991	0.543
LIG_LIR_Gen_1	313	323	PF02991	0.577
LIG_LIR_Gen_1	39	50	PF02991	0.387
LIG_LIR_LC3C_4	33	36	PF02991	0.328
LIG_LIR_Nem_3	111	115	PF02991	0.351
LIG_LIR_Nem_3	16	22	PF02991	0.533
LIG_LIR_Nem_3	184	189	PF02991	0.413
LIG_LIR_Nem_3	192	197	PF02991	0.254
LIG_LIR_Nem_3	202	208	PF02991	0.295
LIG_LIR_Nem_3	287	291	PF02991	0.610
LIG_LIR_Nem_3	293	299	PF02991	0.575
LIG_LIR_Nem_3	313	319	PF02991	0.499
LIG_LIR_Nem_3	367	372	PF02991	0.636
LIG_LIR_Nem_3	39	45	PF02991	0.341
LIG_MLH1_MIPbox_1	515	519	PF16413	0.687
LIG_NRBOX	109	115	PF00104	0.351
LIG_Pex14_2	108	112	PF04695	0.377
LIG_Pex14_2	370	374	PF04695	0.674
LIG_PTB_Apo_2	329	336	PF02174	0.638
LIG_PTB_Apo_2	368	375	PF02174	0.649
LIG_PTB_Apo_2	67	74	PF02174	0.338
LIG_PTB_Phospho_1	67	73	PF10480	0.335
LIG_SH2_CRK	288	292	PF00017	0.558
LIG_SH2_CRK	42	46	PF00017	0.314
LIG_SH2_CRK	449	453	PF00017	0.794
LIG_SH2_CRK	512	516	PF00017	0.651
LIG_SH2_GRB2like	53	56	PF00017	0.358
LIG_SH2_NCK_1	449	453	PF00017	0.794
LIG_SH2_NCK_1	512	516	PF00017	0.651
LIG_SH2_SRC	449	452	PF00017	0.743
LIG_SH2_STAP1	152	156	PF00017	0.351
LIG_SH2_STAP1	186	190	PF00017	0.371
LIG_SH2_STAT5	103	106	PF00017	0.351
LIG_SH2_STAT5	125	128	PF00017	0.583
LIG_SH2_STAT5	197	200	PF00017	0.307
LIG_SH2_STAT5	218	221	PF00017	0.335
LIG_SH2_STAT5	227	230	PF00017	0.591
LIG_SH2_STAT5	377	380	PF00017	0.680
LIG_SH2_STAT5	42	45	PF00017	0.314
LIG_SH2_STAT5	512	515	PF00017	0.736
LIG_SH2_STAT5	518	521	PF00017	0.692
LIG_SH2_STAT5	527	530	PF00017	0.632
LIG_SH2_STAT5	53	56	PF00017	0.338
LIG_SH3_1	5	11	PF00018	0.620
LIG_SH3_2	8	13	PF14604	0.639
LIG_SH3_3	134	140	PF00018	0.545
LIG_SH3_3	201	207	PF00018	0.333
LIG_SH3_3	448	454	PF00018	0.710
LIG_SH3_3	487	493	PF00018	0.741
LIG_SH3_3	5	11	PF00018	0.605
LIG_SH3_4	255	262	PF00018	0.604
LIG_SH3_5	373	377	PF00018	0.677
LIG_Sin3_3	296	303	PF02671	0.593
LIG_SUMO_SIM_anti_2	111	117	PF11976	0.334
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.357
LIG_SUMO_SIM_anti_2	220	226	PF11976	0.280
LIG_SUMO_SIM_anti_2	33	40	PF11976	0.277
LIG_SUMO_SIM_anti_2	61	69	PF11976	0.337
LIG_SUMO_SIM_par_1	33	40	PF11976	0.277
LIG_SUMO_SIM_par_1	395	401	PF11976	0.743
LIG_SUMO_SIM_par_1	61	69	PF11976	0.417
LIG_SUMO_SIM_par_1	84	89	PF11976	0.360
LIG_TRAF2_1	398	401	PF00917	0.688
LIG_TRAF2_1	434	437	PF00917	0.777
LIG_TRFH_1	418	422	PF08558	0.723
LIG_Vh1_VBS_1	17	35	PF01044	0.472
MOD_CK1_1	48	54	PF00069	0.363
MOD_CK2_1	181	187	PF00069	0.373
MOD_CK2_1	226	232	PF00069	0.481
MOD_CK2_1	395	401	PF00069	0.715
MOD_CK2_1	431	437	PF00069	0.766
MOD_CK2_1	441	447	PF00069	0.839
MOD_CK2_1	556	562	PF00069	0.733
MOD_GlcNHglycan	219	222	PF01048	0.319
MOD_GlcNHglycan	534	537	PF01048	0.547
MOD_GlcNHglycan	540	543	PF01048	0.565
MOD_GSK3_1	142	149	PF00069	0.513
MOD_GSK3_1	195	202	PF00069	0.337
MOD_GSK3_1	36	43	PF00069	0.313
MOD_GSK3_1	455	462	PF00069	0.747
MOD_GSK3_1	556	563	PF00069	0.731
MOD_GSK3_1	69	76	PF00069	0.390
MOD_GSK3_1	82	89	PF00069	0.310
MOD_N-GLC_1	123	128	PF02516	0.331
MOD_N-GLC_1	251	256	PF02516	0.404
MOD_N-GLC_1	325	330	PF02516	0.460
MOD_N-GLC_1	69	74	PF02516	0.540
MOD_NEK2_1	123	128	PF00069	0.564
MOD_NEK2_1	181	186	PF00069	0.371
MOD_NEK2_1	208	213	PF00069	0.386
MOD_NEK2_1	25	30	PF00069	0.313
MOD_NEK2_1	250	255	PF00069	0.597
MOD_NEK2_1	319	324	PF00069	0.702
MOD_NEK2_1	341	346	PF00069	0.636
MOD_NEK2_1	441	446	PF00069	0.711
MOD_NEK2_1	45	50	PF00069	0.258
MOD_NEK2_1	532	537	PF00069	0.741
MOD_NEK2_1	549	554	PF00069	0.670
MOD_NEK2_1	97	102	PF00069	0.311
MOD_PIKK_1	146	152	PF00454	0.351
MOD_PIKK_1	325	331	PF00454	0.652
MOD_PIKK_1	455	461	PF00454	0.745
MOD_PKA_1	182	188	PF00069	0.293
MOD_PKA_2	181	187	PF00069	0.373
MOD_PKA_2	43	49	PF00069	0.291
MOD_PKA_2	560	566	PF00069	0.725
MOD_PKA_2	82	88	PF00069	0.336
MOD_PKB_1	564	572	PF00069	0.697
MOD_Plk_1	325	331	PF00069	0.659
MOD_Plk_1	69	75	PF00069	0.415
MOD_Plk_2-3	395	401	PF00069	0.715
MOD_Plk_2-3	584	590	PF00069	0.731
MOD_Plk_4	18	24	PF00069	0.483
MOD_Plk_4	195	201	PF00069	0.311
MOD_Plk_4	30	36	PF00069	0.303
MOD_Plk_4	48	54	PF00069	0.299
MOD_ProDKin_1	4	10	PF00069	0.656
MOD_ProDKin_1	431	437	PF00069	0.730
MOD_ProDKin_1	511	517	PF00069	0.702
MOD_SUMO_for_1	190	193	PF00179	0.328
TRG_DiLeu_BaEn_1	111	116	PF01217	0.334
TRG_DiLeu_BaEn_2	244	250	PF01217	0.562
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.604
TRG_ENDOCYTIC_2	186	189	PF00928	0.401
TRG_ENDOCYTIC_2	197	200	PF00928	0.200
TRG_ENDOCYTIC_2	205	208	PF00928	0.311
TRG_ENDOCYTIC_2	288	291	PF00928	0.530
TRG_ENDOCYTIC_2	42	45	PF00928	0.311
TRG_ENDOCYTIC_2	95	98	PF00928	0.340
TRG_ER_diArg_1	11	13	PF00400	0.615
TRG_ER_diArg_1	467	470	PF00400	0.701
TRG_ER_diArg_1	471	474	PF00400	0.704
TRG_ER_diArg_1	545	548	PF00400	0.656
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7M6	Leptomonas seymouri	58%	98%
A4HPE8	Leishmania braziliensis	74%	99%
A4ICI9	Leishmania infantum	100%	100%
E9AT59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q1D8	Leishmania major	93%	100%
V5BFT0	Trypanosoma cruzi	36%	100%