Calcineurin-like phosphoesterase superfamily domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IW24_LEIDO

TriTrypDb:

LdBPK_362800.1 , LdCL_360034400 , LDHU3_36.3900

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IW24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IW24

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.551
CLV_NRD_NRD_1	289	291	PF00675	0.457
CLV_NRD_NRD_1	312	314	PF00675	0.610
CLV_PCSK_KEX2_1	167	169	PF00082	0.551
CLV_PCSK_KEX2_1	289	291	PF00082	0.452
CLV_PCSK_SKI1_1	123	127	PF00082	0.524
CLV_PCSK_SKI1_1	167	171	PF00082	0.448
CLV_PCSK_SKI1_1	289	293	PF00082	0.486
CLV_PCSK_SKI1_1	317	321	PF00082	0.719
CLV_Separin_Metazoa	310	314	PF03568	0.570
DOC_CDC14_PxL_1	12	20	PF14671	0.492
DOC_CDC14_PxL_1	333	341	PF14671	0.547
DOC_CYCLIN_yCln2_LP_2	169	175	PF00134	0.462
DOC_CYCLIN_yCln2_LP_2	356	359	PF00134	0.448
DOC_CYCLIN_yCln2_LP_2	67	73	PF00134	0.500
DOC_MAPK_MEF2A_6	167	176	PF00069	0.459
DOC_MAPK_MEF2A_6	81	90	PF00069	0.475
DOC_PP2B_LxvP_1	306	309	PF13499	0.542
DOC_PP2B_LxvP_1	356	359	PF13499	0.462
DOC_USP7_MATH_1	159	163	PF00917	0.506
DOC_USP7_MATH_1	252	256	PF00917	0.515
DOC_USP7_MATH_1	270	274	PF00917	0.511
DOC_USP7_MATH_1	53	57	PF00917	0.610
DOC_USP7_MATH_1	82	86	PF00917	0.479
DOC_USP7_UBL2_3	211	215	PF12436	0.667
DOC_WW_Pin1_4	190	195	PF00397	0.392
DOC_WW_Pin1_4	200	205	PF00397	0.454
DOC_WW_Pin1_4	248	253	PF00397	0.575
DOC_WW_Pin1_4	261	266	PF00397	0.572
DOC_WW_Pin1_4	48	53	PF00397	0.664
LIG_14-3-3_CanoR_1	236	243	PF00244	0.652
LIG_14-3-3_CanoR_1	269	275	PF00244	0.561
LIG_14-3-3_CanoR_1	29	38	PF00244	0.678
LIG_14-3-3_CanoR_1	313	317	PF00244	0.598
LIG_Actin_WH2_2	71	89	PF00022	0.488
LIG_BRCT_BRCA1_1	132	136	PF00533	0.438
LIG_EH1_1	143	151	PF00400	0.460
LIG_FHA_1	161	167	PF00498	0.562
LIG_FHA_1	20	26	PF00498	0.654
LIG_FHA_1	281	287	PF00498	0.427
LIG_FHA_1	62	68	PF00498	0.539
LIG_LIR_LC3C_4	257	261	PF02991	0.477
LIG_LIR_Nem_3	10	15	PF02991	0.391
LIG_PDZ_Class_2	361	366	PF00595	0.454
LIG_Pex14_2	132	136	PF04695	0.518
LIG_SH2_CRK	12	16	PF00017	0.456
LIG_SH2_CRK	191	195	PF00017	0.468
LIG_SH2_NCK_1	73	77	PF00017	0.508
LIG_SH2_SRC	73	76	PF00017	0.500
LIG_SH2_STAP1	282	286	PF00017	0.596
LIG_SH2_STAT3	282	285	PF00017	0.527
LIG_SH2_STAT5	14	17	PF00017	0.473
LIG_SH2_STAT5	175	178	PF00017	0.444
LIG_SH2_STAT5	282	285	PF00017	0.468
LIG_SH3_2	50	55	PF14604	0.650
LIG_SH3_3	179	185	PF00018	0.499
LIG_SH3_3	262	268	PF00018	0.505
LIG_SH3_3	334	340	PF00018	0.553
LIG_SH3_3	352	358	PF00018	0.390
LIG_SH3_3	47	53	PF00018	0.687
LIG_SH3_3	56	62	PF00018	0.574
LIG_SH3_3	76	82	PF00018	0.470
LIG_SUMO_SIM_anti_2	255	260	PF11976	0.549
LIG_SUMO_SIM_par_1	360	365	PF11976	0.391
LIG_SUMO_SIM_par_1	87	94	PF11976	0.402
LIG_TRAF2_1	273	276	PF00917	0.569
LIG_WRPW_2	214	217	PF00400	0.569
MOD_CDK_SPK_2	190	195	PF00069	0.465
MOD_CDK_SPxxK_3	48	55	PF00069	0.653
MOD_CK1_1	193	199	PF00069	0.422
MOD_CK1_1	200	206	PF00069	0.474
MOD_CK1_1	232	238	PF00069	0.668
MOD_CK1_1	27	33	PF00069	0.650
MOD_CK1_1	63	69	PF00069	0.490
MOD_CK2_1	270	276	PF00069	0.613
MOD_CK2_1	41	47	PF00069	0.637
MOD_GlcNHglycan	131	135	PF01048	0.454
MOD_GlcNHglycan	138	141	PF01048	0.513
MOD_GlcNHglycan	220	223	PF01048	0.584
MOD_GlcNHglycan	55	58	PF01048	0.660
MOD_GSK3_1	130	137	PF00069	0.449
MOD_GSK3_1	193	200	PF00069	0.456
MOD_GSK3_1	232	239	PF00069	0.661
MOD_GSK3_1	24	31	PF00069	0.589
MOD_GSK3_1	248	255	PF00069	0.476
MOD_GSK3_1	32	39	PF00069	0.616
MOD_NEK2_1	136	141	PF00069	0.514
MOD_NEK2_1	218	223	PF00069	0.615
MOD_NEK2_1	41	46	PF00069	0.619
MOD_NEK2_2	82	87	PF00069	0.475
MOD_PIKK_1	280	286	PF00454	0.429
MOD_PK_1	99	105	PF00069	0.511
MOD_PKA_2	19	25	PF00069	0.617
MOD_PKA_2	235	241	PF00069	0.717
MOD_PKA_2	28	34	PF00069	0.638
MOD_PKA_2	312	318	PF00069	0.592
MOD_PKB_1	97	105	PF00069	0.503
MOD_Plk_1	130	136	PF00069	0.499
MOD_Plk_1	177	183	PF00069	0.438
MOD_Plk_1	99	105	PF00069	0.511
MOD_Plk_4	177	183	PF00069	0.510
MOD_Plk_4	357	363	PF00069	0.484
MOD_Plk_4	36	42	PF00069	0.646
MOD_ProDKin_1	190	196	PF00069	0.395
MOD_ProDKin_1	200	206	PF00069	0.451
MOD_ProDKin_1	248	254	PF00069	0.574
MOD_ProDKin_1	261	267	PF00069	0.581
MOD_ProDKin_1	48	54	PF00069	0.666
TRG_DiLeu_BaEn_2	116	122	PF01217	0.620
TRG_ENDOCYTIC_2	12	15	PF00928	0.396
TRG_ER_diArg_1	166	168	PF00400	0.543
TRG_ER_diArg_1	243	246	PF00400	0.510
TRG_ER_diArg_1	288	290	PF00400	0.471
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I7	Leptomonas seymouri	59%	100%
A0A0S4J6J0	Bodo saltans	30%	100%
A4HPD3	Leishmania braziliensis	83%	100%
A4ICH3	Leishmania infantum	100%	100%
E9AT44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O15442	Homo sapiens	25%	100%
Q4Q1F4	Leishmania major	93%	100%
Q91ZG2	Mus musculus	25%	100%