Mitogen-activated protein kinase

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitogen-activated protein kinase 2

Species:

Leishmania donovani

UniProt:

A0A3Q8IVR8_LEIDO

TriTrypDb:

LdBPK_360780.1 , LdCL_360012700 , LDHU3_36.0980

Length:

456

Annotations

LeishMANIAdb annotations

Acyltransferase involved in GPI anchor remodelling (homologue of yeast GUP1)

Annotations by Jardim et al.

Protein kinase, Mitogen-activated kinase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

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Phosphorylation

Amastigote: 169, 176

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IVR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IVR8

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0000281	mitotic cytokinesis	4	1
GO:0000910	cytokinesis	3	1
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0004674	protein serine/threonine kinase activity	4	11
GO:0004707	MAP kinase activity	5	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	321	325	PF00656	0.556
CLV_NRD_NRD_1	261	263	PF00675	0.432
CLV_NRD_NRD_1	289	291	PF00675	0.381
CLV_NRD_NRD_1	32	34	PF00675	0.283
CLV_NRD_NRD_1	345	347	PF00675	0.457
CLV_NRD_NRD_1	367	369	PF00675	0.702
CLV_NRD_NRD_1	454	456	PF00675	0.709
CLV_PCSK_KEX2_1	261	263	PF00082	0.432
CLV_PCSK_KEX2_1	289	291	PF00082	0.392
CLV_PCSK_KEX2_1	345	347	PF00082	0.457

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Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E2	Leptomonas seymouri	38%	100%
A0A0N0P2S2	Leptomonas seymouri	32%	82%
A0A0N0P3Z9	Leptomonas seymouri	32%	100%
A0A0N0P407	Leptomonas seymouri	29%	100%
A0A0N0P4E3	Leptomonas seymouri	35%	68%
A0A0N0P4P4	Leptomonas seymouri	26%	100%
A0A0N1I0C1	Leptomonas seymouri	77%	100%
A0A0N1I304	Leptomonas seymouri	32%	78%
A0A0N1I3G0	Leptomonas seymouri	37%	100%
A0A0N1I9B7	Leptomonas seymouri	39%	100%

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