TFIIS central domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IVQ2_LEIDO

TriTrypDb:

LdBPK_360300.1 , LdCL_360008000 , LDHU3_36.0420

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IVQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IVQ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.714
CLV_NRD_NRD_1	198	200	PF00675	0.722
CLV_NRD_NRD_1	222	224	PF00675	0.640
CLV_NRD_NRD_1	39	41	PF00675	0.436
CLV_NRD_NRD_1	9	11	PF00675	0.496
CLV_PCSK_KEX2_1	11	13	PF00082	0.488
CLV_PCSK_KEX2_1	191	193	PF00082	0.711
CLV_PCSK_KEX2_1	200	202	PF00082	0.575
CLV_PCSK_KEX2_1	222	224	PF00082	0.640
CLV_PCSK_KEX2_1	39	41	PF00082	0.436
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.488
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.711
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.575
DEG_SPOP_SBC_1	91	95	PF00917	0.738
DOC_ANK_TNKS_1	11	18	PF00023	0.488
DOC_CDC14_PxL_1	49	57	PF14671	0.399
DOC_CYCLIN_yClb5_NLxxxL_5	155	161	PF00134	0.659
DOC_CYCLIN_yCln2_LP_2	50	56	PF00134	0.399
DOC_MAPK_gen_1	222	228	PF00069	0.636
DOC_MAPK_MEF2A_6	100	109	PF00069	0.480
DOC_MAPK_MEF2A_6	45	54	PF00069	0.398
DOC_PP2B_LxvP_1	50	53	PF13499	0.394
DOC_USP7_MATH_1	184	188	PF00917	0.588
DOC_USP7_MATH_1	232	236	PF00917	0.735
DOC_USP7_MATH_1	279	283	PF00917	0.784
DOC_USP7_MATH_1	59	63	PF00917	0.428
DOC_USP7_MATH_1	91	95	PF00917	0.738
LIG_14-3-3_CanoR_1	123	133	PF00244	0.440
LIG_14-3-3_CanoR_1	39	45	PF00244	0.422
LIG_14-3-3_CterR_2	284	287	PF00244	0.578
LIG_BRCT_BRCA1_1	78	82	PF00533	0.497
LIG_DLG_GKlike_1	40	47	PF00625	0.413
LIG_FHA_1	75	81	PF00498	0.494
LIG_FHA_2	137	143	PF00498	0.600
LIG_FHA_2	204	210	PF00498	0.745
LIG_FHA_2	278	284	PF00498	0.799
LIG_FHA_2	73	79	PF00498	0.643
LIG_GBD_Chelix_1	101	109	PF00786	0.597
LIG_NRBOX	46	52	PF00104	0.395
LIG_Pex14_2	242	246	PF04695	0.726
LIG_SH2_NCK_1	56	60	PF00017	0.395
LIG_SH2_STAP1	125	129	PF00017	0.613
LIG_SH2_STAP1	56	60	PF00017	0.395
LIG_SH2_STAT3	125	128	PF00017	0.617
LIG_SUMO_SIM_anti_2	46	51	PF11976	0.394
LIG_TRAF2_1	139	142	PF00917	0.644
LIG_UBA3_1	104	111	PF00899	0.490
LIG_UBA3_1	147	155	PF00899	0.616
MOD_CK1_1	235	241	PF00069	0.733
MOD_CK1_1	253	259	PF00069	0.506
MOD_CK1_1	274	280	PF00069	0.652
MOD_CK1_1	43	49	PF00069	0.405
MOD_CK1_1	67	73	PF00069	0.454
MOD_CK1_1	90	96	PF00069	0.732
MOD_CK2_1	136	142	PF00069	0.648
MOD_CK2_1	170	176	PF00069	0.688
MOD_CK2_1	253	259	PF00069	0.762
MOD_CK2_1	260	266	PF00069	0.717
MOD_CK2_1	72	78	PF00069	0.640
MOD_GlcNHglycan	118	121	PF01048	0.553
MOD_GlcNHglycan	172	175	PF01048	0.484
MOD_GlcNHglycan	236	240	PF01048	0.694
MOD_GlcNHglycan	262	265	PF01048	0.762
MOD_GlcNHglycan	89	92	PF01048	0.760
MOD_GSK3_1	190	197	PF00069	0.651
MOD_GSK3_1	20	27	PF00069	0.456
MOD_GSK3_1	209	216	PF00069	0.649
MOD_GSK3_1	246	253	PF00069	0.540
MOD_GSK3_1	270	277	PF00069	0.808
MOD_GSK3_1	279	286	PF00069	0.703
MOD_GSK3_1	35	42	PF00069	0.471
MOD_GSK3_1	59	66	PF00069	0.407
MOD_GSK3_1	70	77	PF00069	0.707
MOD_GSK3_1	87	94	PF00069	0.729
MOD_N-GLC_1	136	141	PF02516	0.614
MOD_N-GLC_2	248	250	PF02516	0.705
MOD_NEK2_1	194	199	PF00069	0.629
MOD_NEK2_1	213	218	PF00069	0.376
MOD_NEK2_1	246	251	PF00069	0.701
MOD_NEK2_1	54	59	PF00069	0.411
MOD_NEK2_1	65	70	PF00069	0.454
MOD_NEK2_1	87	92	PF00069	0.694
MOD_OFUCOSY	18	25	PF10250	0.468
MOD_PIKK_1	124	130	PF00454	0.539
MOD_PKA_1	39	45	PF00069	0.422
MOD_PKA_2	259	265	PF00069	0.684
MOD_PKA_2	39	45	PF00069	0.422
MOD_PKB_1	201	209	PF00069	0.741
MOD_Plk_1	208	214	PF00069	0.691
MOD_Plk_2-3	176	182	PF00069	0.671
MOD_Plk_4	28	34	PF00069	0.432
MOD_SUMO_rev_2	93	102	PF00179	0.662
TRG_ER_diArg_1	185	188	PF00400	0.587
TRG_ER_diArg_1	198	201	PF00400	0.624
TRG_ER_diArg_1	221	223	PF00400	0.629
TRG_ER_diArg_1	39	41	PF00400	0.436
TRG_NLS_MonoExtC_3	198	203	PF00514	0.727

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HNN6	Leishmania braziliensis	78%	100%
A4ICV9	Leishmania infantum	99%	100%
E9ASE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q250	Leishmania major	93%	100%