Pteridine transporter, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

biopterin transporter, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IVN0_LEIDO

TriTrypDb:

LdBPK_355120.1 , LdCL_350056900 , LDHU3_35.6810

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A0A3Q8IVN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IVN0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	237	239	PF00675	0.311
CLV_NRD_NRD_1	599	601	PF00675	0.283
CLV_PCSK_KEX2_1	116	118	PF00082	0.300
CLV_PCSK_KEX2_1	237	239	PF00082	0.259
CLV_PCSK_KEX2_1	474	476	PF00082	0.529
CLV_PCSK_KEX2_1	624	626	PF00082	0.512
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.300
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.529
CLV_PCSK_PC1ET2_1	624	626	PF00082	0.407
CLV_PCSK_SKI1_1	322	326	PF00082	0.259
CLV_PCSK_SKI1_1	330	334	PF00082	0.273
CLV_PCSK_SKI1_1	46	50	PF00082	0.256
DEG_APCC_DBOX_1	329	337	PF00400	0.399
DEG_ODPH_VHL_1	514	526	PF01847	0.528
DOC_CDC14_PxL_1	24	32	PF14671	0.545
DOC_CDC14_PxL_1	560	568	PF14671	0.338
DOC_CYCLIN_RxL_1	405	414	PF00134	0.180
DOC_CYCLIN_yClb5_NLxxxL_5	392	401	PF00134	0.273
DOC_CYCLIN_yCln2_LP_2	461	467	PF00134	0.208
DOC_CYCLIN_yCln2_LP_2	503	509	PF00134	0.407
DOC_MAPK_gen_1	474	482	PF00069	0.330
DOC_MAPK_MEF2A_6	354	362	PF00069	0.184
DOC_MAPK_MEF2A_6	41	49	PF00069	0.558
DOC_MAPK_MEF2A_6	474	482	PF00069	0.363
DOC_PP1_RVXF_1	380	387	PF00149	0.485
DOC_PP2B_LxvP_1	395	398	PF13499	0.385
DOC_PP2B_LxvP_1	410	413	PF13499	0.325
DOC_PP2B_LxvP_1	503	506	PF13499	0.348
DOC_PP4_FxxP_1	305	308	PF00568	0.464
DOC_PP4_FxxP_1	374	377	PF00568	0.326
DOC_PP4_FxxP_1	577	580	PF00568	0.266
DOC_USP7_MATH_1	139	143	PF00917	0.272
DOC_USP7_MATH_1	182	186	PF00917	0.333
DOC_USP7_MATH_1	39	43	PF00917	0.552
DOC_USP7_MATH_1	447	451	PF00917	0.532
DOC_USP7_MATH_1	463	467	PF00917	0.333
DOC_USP7_MATH_1	516	520	PF00917	0.493
DOC_WW_Pin1_4	266	271	PF00397	0.527
DOC_WW_Pin1_4	4	9	PF00397	0.752
LIG_14-3-3_CanoR_1	67	71	PF00244	0.432
LIG_14-3-3_CanoR_1	87	92	PF00244	0.498
LIG_Actin_WH2_2	9	27	PF00022	0.496
LIG_APCC_ABBA_1	166	171	PF00400	0.528
LIG_APCC_ABBA_1	231	236	PF00400	0.415
LIG_BIR_III_4	301	305	PF00653	0.551
LIG_BRCT_BRCA1_1	370	374	PF00533	0.266
LIG_BRCT_BRCA1_1	418	422	PF00533	0.325
LIG_BRCT_BRCA1_1	449	453	PF00533	0.467
LIG_BRCT_BRCA1_1	520	524	PF00533	0.500
LIG_EH1_1	495	503	PF00400	0.379
LIG_FHA_1	106	112	PF00498	0.536
LIG_FHA_1	188	194	PF00498	0.345
LIG_FHA_1	216	222	PF00498	0.436
LIG_FHA_1	337	343	PF00498	0.360
LIG_FHA_1	373	379	PF00498	0.365
LIG_FHA_1	401	407	PF00498	0.388
LIG_FHA_1	567	573	PF00498	0.425
LIG_FHA_2	351	357	PF00498	0.210
LIG_FHA_2	608	614	PF00498	0.696
LIG_GBD_Chelix_1	343	351	PF00786	0.325
LIG_LIR_Apic_2	371	377	PF02991	0.411
LIG_LIR_Gen_1	107	114	PF02991	0.522
LIG_LIR_Gen_1	353	363	PF02991	0.302
LIG_LIR_Gen_1	421	430	PF02991	0.331
LIG_LIR_Gen_1	439	447	PF02991	0.394
LIG_LIR_Gen_1	466	473	PF02991	0.345
LIG_LIR_Gen_1	521	531	PF02991	0.518
LIG_LIR_Nem_3	107	112	PF02991	0.498
LIG_LIR_Nem_3	115	121	PF02991	0.498
LIG_LIR_Nem_3	356	362	PF02991	0.292
LIG_LIR_Nem_3	371	376	PF02991	0.378
LIG_LIR_Nem_3	419	425	PF02991	0.304
LIG_LIR_Nem_3	439	445	PF02991	0.264
LIG_LIR_Nem_3	450	454	PF02991	0.474
LIG_LIR_Nem_3	466	471	PF02991	0.346
LIG_LIR_Nem_3	521	527	PF02991	0.480
LIG_LIR_Nem_3	547	553	PF02991	0.299
LIG_MLH1_MIPbox_1	370	374	PF16413	0.408
LIG_NRBOX	223	229	PF00104	0.343
LIG_PCNA_TLS_4	307	314	PF02747	0.393
LIG_Pex14_1	355	359	PF04695	0.293
LIG_Pex14_2	418	422	PF04695	0.313
LIG_Pex14_2	442	446	PF04695	0.375
LIG_PTB_Apo_2	399	406	PF02174	0.401
LIG_PTB_Phospho_1	399	405	PF10480	0.411
LIG_SH2_CRK	119	123	PF00017	0.378
LIG_SH2_CRK	134	138	PF00017	0.332
LIG_SH2_CRK	451	455	PF00017	0.503
LIG_SH2_CRK	85	89	PF00017	0.515
LIG_SH2_GRB2like	388	391	PF00017	0.392
LIG_SH2_GRB2like	394	397	PF00017	0.415
LIG_SH2_GRB2like	560	563	PF00017	0.357
LIG_SH2_NCK_1	560	564	PF00017	0.303
LIG_SH2_PTP2	15	18	PF00017	0.638
LIG_SH2_PTP2	359	362	PF00017	0.198
LIG_SH2_PTP2	583	586	PF00017	0.208
LIG_SH2_SRC	15	18	PF00017	0.644
LIG_SH2_STAP1	114	118	PF00017	0.508
LIG_SH2_STAP1	169	173	PF00017	0.494
LIG_SH2_STAT5	114	117	PF00017	0.506
LIG_SH2_STAT5	119	122	PF00017	0.351
LIG_SH2_STAT5	15	18	PF00017	0.633
LIG_SH2_STAT5	216	219	PF00017	0.360
LIG_SH2_STAT5	313	316	PF00017	0.555
LIG_SH2_STAT5	359	362	PF00017	0.229
LIG_SH2_STAT5	388	391	PF00017	0.361
LIG_SH2_STAT5	394	397	PF00017	0.351
LIG_SH2_STAT5	405	408	PF00017	0.287
LIG_SH2_STAT5	420	423	PF00017	0.268
LIG_SH2_STAT5	488	491	PF00017	0.302
LIG_SH2_STAT5	543	546	PF00017	0.264
LIG_SH2_STAT5	583	586	PF00017	0.507
LIG_SH2_STAT5	92	95	PF00017	0.399
LIG_SH3_3	2	8	PF00018	0.695
LIG_SH3_3	267	273	PF00018	0.548
LIG_SH3_3	403	409	PF00018	0.339
LIG_SH3_3	410	416	PF00018	0.287
LIG_SH3_3	457	463	PF00018	0.208
LIG_SH3_3	581	587	PF00018	0.401
LIG_SUMO_SIM_anti_2	469	474	PF11976	0.326
LIG_SUMO_SIM_par_1	220	225	PF11976	0.208
LIG_TRAF2_1	614	617	PF00917	0.627
LIG_TRFH_1	134	138	PF08558	0.372
LIG_TRFH_1	583	587	PF08558	0.301
LIG_TYR_ITIM	132	137	PF00017	0.388
LIG_TYR_ITIM	357	362	PF00017	0.385
LIG_TYR_ITIM	392	397	PF00017	0.344
LIG_TYR_ITIM	581	586	PF00017	0.507
LIG_UBA3_1	132	140	PF00899	0.359
LIG_UBA3_1	248	256	PF00899	0.624
LIG_UBA3_1	467	474	PF00899	0.334
LIG_WRC_WIRS_1	370	375	PF05994	0.296
LIG_WRC_WIRS_1	40	45	PF05994	0.566
LIG_WRC_WIRS_1	401	406	PF05994	0.346
MOD_CDC14_SPxK_1	269	272	PF00782	0.399
MOD_CDK_SPxK_1	266	272	PF00069	0.399
MOD_CK1_1	257	263	PF00069	0.393
MOD_CK1_1	266	272	PF00069	0.562
MOD_CK1_1	372	378	PF00069	0.208
MOD_CK1_1	536	542	PF00069	0.368
MOD_CK2_1	278	284	PF00069	0.517
MOD_CK2_1	607	613	PF00069	0.723
MOD_Cter_Amidation	598	601	PF01082	0.328
MOD_GlcNHglycan	122	125	PF01048	0.387
MOD_GlcNHglycan	141	145	PF01048	0.506
MOD_GlcNHglycan	19	22	PF01048	0.290
MOD_GlcNHglycan	224	227	PF01048	0.397
MOD_GlcNHglycan	256	259	PF01048	0.325
MOD_GlcNHglycan	457	460	PF01048	0.389
MOD_GlcNHglycan	538	541	PF01048	0.401
MOD_GlcNHglycan	587	590	PF01048	0.402
MOD_GSK3_1	252	259	PF00069	0.496
MOD_GSK3_1	368	375	PF00069	0.303
MOD_GSK3_1	436	443	PF00069	0.322
MOD_GSK3_1	532	539	PF00069	0.385
MOD_GSK3_1	554	561	PF00069	0.403
MOD_GSK3_1	585	592	PF00069	0.521
MOD_GSK3_1	86	93	PF00069	0.550
MOD_NEK2_1	105	110	PF00069	0.493
MOD_NEK2_1	112	117	PF00069	0.432
MOD_NEK2_1	156	161	PF00069	0.361
MOD_NEK2_1	187	192	PF00069	0.334
MOD_NEK2_1	196	201	PF00069	0.337
MOD_NEK2_1	222	227	PF00069	0.296
MOD_NEK2_1	252	257	PF00069	0.546
MOD_NEK2_1	336	341	PF00069	0.364
MOD_NEK2_1	418	423	PF00069	0.312
MOD_NEK2_1	440	445	PF00069	0.387
MOD_NEK2_1	455	460	PF00069	0.374
MOD_NEK2_1	526	531	PF00069	0.357
MOD_NEK2_1	533	538	PF00069	0.364
MOD_NEK2_1	545	550	PF00069	0.309
MOD_NEK2_1	566	571	PF00069	0.464
MOD_NEK2_1	66	71	PF00069	0.486
MOD_NEK2_2	369	374	PF00069	0.468
MOD_NEK2_2	39	44	PF00069	0.424
MOD_NEK2_2	463	468	PF00069	0.379
MOD_PIKK_1	551	557	PF00454	0.411
MOD_PKA_2	436	442	PF00069	0.355
MOD_PKA_2	516	522	PF00069	0.497
MOD_PKA_2	589	595	PF00069	0.401
MOD_PKA_2	66	72	PF00069	0.411
MOD_PKA_2	86	92	PF00069	0.490
MOD_PKB_1	307	315	PF00069	0.395
MOD_Plk_4	182	188	PF00069	0.349
MOD_Plk_4	196	202	PF00069	0.336
MOD_Plk_4	309	315	PF00069	0.508
MOD_Plk_4	369	375	PF00069	0.402
MOD_Plk_4	400	406	PF00069	0.349
MOD_Plk_4	418	424	PF00069	0.369
MOD_Plk_4	436	442	PF00069	0.236
MOD_Plk_4	463	469	PF00069	0.331
MOD_Plk_4	518	524	PF00069	0.523
MOD_Plk_4	526	532	PF00069	0.369
MOD_Plk_4	545	551	PF00069	0.307
MOD_Plk_4	87	93	PF00069	0.455
MOD_ProDKin_1	266	272	PF00069	0.527
MOD_ProDKin_1	4	10	PF00069	0.750
MOD_SUMO_rev_2	288	298	PF00179	0.389
TRG_ENDOCYTIC_2	119	122	PF00928	0.357
TRG_ENDOCYTIC_2	134	137	PF00928	0.347
TRG_ENDOCYTIC_2	359	362	PF00928	0.369
TRG_ENDOCYTIC_2	394	397	PF00928	0.362
TRG_ENDOCYTIC_2	423	426	PF00928	0.309
TRG_ENDOCYTIC_2	451	454	PF00928	0.503
TRG_ENDOCYTIC_2	543	546	PF00928	0.334
TRG_ENDOCYTIC_2	583	586	PF00928	0.498
TRG_ENDOCYTIC_2	85	88	PF00928	0.499
TRG_ER_diArg_1	173	176	PF00400	0.443
TRG_ER_diArg_1	237	240	PF00400	0.418
TRG_ER_diArg_1	306	309	PF00400	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	42%	89%
A0A0N1HY49	Leptomonas seymouri	40%	93%
A0A0N1HZ06	Leptomonas seymouri	59%	100%
A0A0N1IHL1	Leptomonas seymouri	39%	88%
A0A0N1PAY4	Leptomonas seymouri	39%	71%
A0A0N1PB77	Leptomonas seymouri	70%	97%
A0A0N1PBZ2	Leptomonas seymouri	38%	93%
A0A0N1PCC1	Leptomonas seymouri	38%	94%
A0A0S4INN8	Bodo saltans	28%	97%
A0A381MBI0	Leishmania infantum	40%	100%
A0A3Q8I8X7	Leishmania donovani	40%	100%
A0A3Q8IAZ0	Leishmania donovani	36%	100%
A0A3Q8IH50	Leishmania donovani	40%	100%
A0A3R7M4J1	Trypanosoma rangeli	37%	98%
A0A3S5H5P4	Leishmania donovani	41%	93%
A0A3S5H5V2	Leishmania donovani	45%	96%
A0A3S5H6F6	Leishmania donovani	37%	90%
A0A3S5H763	Leishmania donovani	42%	93%
A0A3S7WR10	Leishmania donovani	40%	84%
A0A3S7WR14	Leishmania donovani	37%	91%
A0A3S7WR15	Leishmania donovani	37%	74%
A0A3S7WR24	Leishmania donovani	38%	89%
A4H4T8	Leishmania braziliensis	45%	100%
A4H5Y4	Leishmania braziliensis	39%	100%
A4H617	Leishmania braziliensis	38%	100%
A4H618	Leishmania braziliensis	37%	100%
A4H619	Leishmania braziliensis	38%	100%
A4H620	Leishmania braziliensis	41%	100%
A4H6C3	Leishmania braziliensis	40%	100%
A4HNH7	Leishmania braziliensis	85%	100%
A4HSS2	Leishmania infantum	40%	100%
A4HUE4	Leishmania infantum	40%	100%
A4HUE5	Leishmania infantum	38%	100%
A4HUE6	Leishmania infantum	37%	100%
A4HUE7	Leishmania infantum	36%	100%
A4HUE8	Leishmania infantum	38%	100%
A4HUF4	Leishmania infantum	36%	100%
A4HUF5	Leishmania infantum	40%	100%
A4HYA9	Leishmania infantum	42%	100%
A4IC33	Leishmania infantum	97%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	99%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	99%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	99%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	98%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AG72	Leishmania infantum	45%	100%
E9AI40	Leishmania braziliensis	38%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QDC4	Leishmania major	42%	100%
Q4QH81	Leishmania major	39%	100%
Q4QHH7	Leishmania major	39%	100%
Q4QHH8	Leishmania major	37%	100%
Q4QHH9	Leishmania major	37%	100%
Q4QHI0	Leishmania major	37%	100%
Q4QHI1	Leishmania major	37%	100%
Q4QHI2	Leishmania major	37%	100%
Q4QIU9	Leishmania major	45%	100%
Q4QJ48	Leishmania major	40%	100%
Q7KIP2	Leishmania major	91%	100%