Peroxin-13

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Peroxin-13

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IVL9_LEIDO

TriTrypDb:

LdBPK_355010.1 , LdCL_350055100 , LDHU3_35.6570

Length:

208

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005777	peroxisome	6	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A0A3Q8IVL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IVL9

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0016560	protein import into peroxisome matrix, docking	5	2
GO:0033036	macromolecule localization	2	2
GO:0051179	localization	1	2
GO:0051641	cellular localization	2	2
GO:0070727	cellular macromolecule localization	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.648
CLV_NRD_NRD_1	124	126	PF00675	0.627
CLV_NRD_NRD_1	144	146	PF00675	0.512
CLV_NRD_NRD_1	186	188	PF00675	0.472
CLV_PCSK_KEX2_1	140	142	PF00082	0.678
CLV_PCSK_KEX2_1	175	177	PF00082	0.456
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.665
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.476
CLV_PCSK_PC7_1	136	142	PF00082	0.717
CLV_PCSK_SKI1_1	125	129	PF00082	0.664
CLV_PCSK_SKI1_1	187	191	PF00082	0.499
DEG_APCC_DBOX_1	124	132	PF00400	0.487
DOC_USP7_MATH_1	139	143	PF00917	0.514
DOC_USP7_MATH_1	197	201	PF00917	0.664
DOC_WW_Pin1_4	52	57	PF00397	0.704
LIG_14-3-3_CanoR_1	176	181	PF00244	0.659
LIG_deltaCOP1_diTrp_1	73	78	PF00928	0.580
LIG_FHA_1	66	72	PF00498	0.598
LIG_LIR_Nem_3	73	78	PF02991	0.509
LIG_LIR_Nem_3	95	99	PF02991	0.393
LIG_NRBOX	168	174	PF00104	0.393
LIG_PDZ_Class_1	203	208	PF00595	0.656
LIG_Pex14_2	152	156	PF04695	0.449
LIG_SH2_CRK	36	40	PF00017	0.461
LIG_SH2_PTP2	96	99	PF00017	0.424
LIG_SH2_STAT5	137	140	PF00017	0.489
LIG_SH2_STAT5	171	174	PF00017	0.353
LIG_SH2_STAT5	96	99	PF00017	0.387
LIG_SH3_3	141	147	PF00018	0.470
LIG_SxIP_EBH_1	124	133	PF03271	0.509
LIG_WRC_WIRS_1	153	158	PF05994	0.457
MOD_CK2_1	190	196	PF00069	0.705
MOD_Cter_Amidation	185	188	PF01082	0.485
MOD_GlcNHglycan	184	187	PF01048	0.488
MOD_GlcNHglycan	191	195	PF01048	0.502
MOD_GlcNHglycan	199	202	PF01048	0.511
MOD_GlcNHglycan	8	11	PF01048	0.680
MOD_GlcNHglycan	87	90	PF01048	0.406
MOD_GSK3_1	148	155	PF00069	0.426
MOD_GSK3_1	197	204	PF00069	0.716
MOD_NEK2_1	152	157	PF00069	0.399
MOD_NEK2_1	182	187	PF00069	0.683
MOD_NEK2_1	189	194	PF00069	0.706
MOD_NEK2_1	65	70	PF00069	0.636
MOD_NEK2_1	82	87	PF00069	0.405
MOD_NMyristoyl	1	7	PF02799	0.485
MOD_PIKK_1	76	82	PF00454	0.371
MOD_Plk_4	148	154	PF00069	0.461
MOD_ProDKin_1	52	58	PF00069	0.699
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.361
TRG_ENDOCYTIC_2	27	30	PF00928	0.471
TRG_ENDOCYTIC_2	36	39	PF00928	0.407
TRG_ENDOCYTIC_2	96	99	PF00928	0.393
TRG_ER_diArg_1	141	144	PF00400	0.475
TRG_NLS_Bipartite_1	125	144	PF00514	0.521
TRG_NLS_MonoCore_2	144	149	PF00514	0.521
TRG_NLS_MonoExtN_4	139	144	PF00514	0.474
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.485
TRG_PTS1	205	208	PF00515	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2X3	Leptomonas seymouri	73%	72%
A0A0S4J7P3	Bodo saltans	31%	69%
A0A0S4J8A4	Bodo saltans	30%	69%
A0A1X0P507	Trypanosomatidae	34%	73%
A4HNF9	Leishmania braziliensis	81%	100%
A4IC72	Leishmania infantum	99%	100%
E9AFX0	Leishmania major	93%	100%
E9B723	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5D0D7	Trypanosoma cruzi	27%	75%