Histidine_phosphatase_superfamily_(Branch_1)_puta tive/Pfam:PF00300

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histidine phosphatase superfamily (branch 1), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IVL2_LEIDO

TriTrypDb:

LdBPK_354880.1 , LdCL_350053800 , LDHU3_35.6400

Length:

335

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 4
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IVL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IVL2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	58	62	PF00656	0.529
CLV_NRD_NRD_1	158	160	PF00675	0.301
CLV_NRD_NRD_1	285	287	PF00675	0.401
CLV_PCSK_KEX2_1	126	128	PF00082	0.410
CLV_PCSK_KEX2_1	158	160	PF00082	0.301
CLV_PCSK_KEX2_1	285	287	PF00082	0.341
CLV_PCSK_KEX2_1	66	68	PF00082	0.370
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.379
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.389
CLV_PCSK_PC7_1	281	287	PF00082	0.332
CLV_PCSK_SKI1_1	102	106	PF00082	0.354
CLV_PCSK_SKI1_1	137	141	PF00082	0.446
CLV_PCSK_SKI1_1	281	285	PF00082	0.300
CLV_PCSK_SKI1_1	70	74	PF00082	0.291
CLV_PCSK_SKI1_1	95	99	PF00082	0.365
DEG_Nend_Nbox_1	1	3	PF02207	0.409
DOC_CKS1_1	16	21	PF01111	0.512
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.516
DOC_MAPK_gen_1	137	145	PF00069	0.462
DOC_MAPK_gen_1	66	74	PF00069	0.331
DOC_MAPK_MEF2A_6	66	73	PF00069	0.332
DOC_PP1_RVXF_1	140	146	PF00149	0.419
DOC_PP1_RVXF_1	68	74	PF00149	0.301
DOC_PP2B_LxvP_1	90	93	PF13499	0.523
DOC_PP4_FxxP_1	108	111	PF00568	0.372
DOC_PP4_FxxP_1	287	290	PF00568	0.425
DOC_USP7_MATH_1	111	115	PF00917	0.346
DOC_USP7_MATH_1	120	124	PF00917	0.350
DOC_USP7_MATH_1	147	151	PF00917	0.397
DOC_USP7_MATH_1	261	265	PF00917	0.501
DOC_USP7_UBL2_3	328	332	PF12436	0.471
DOC_WW_Pin1_4	116	121	PF00397	0.327
DOC_WW_Pin1_4	15	20	PF00397	0.511
DOC_WW_Pin1_4	166	171	PF00397	0.465
LIG_14-3-3_CanoR_1	148	152	PF00244	0.391
LIG_14-3-3_CanoR_1	171	181	PF00244	0.354
LIG_14-3-3_CanoR_1	55	60	PF00244	0.589
LIG_14-3-3_CanoR_1	75	81	PF00244	0.336
LIG_AP2alpha_1	104	108	PF02296	0.449
LIG_BRCT_BRCA1_1	276	280	PF00533	0.280
LIG_CtBP_PxDLS_1	215	219	PF00389	0.405
LIG_EH_1	109	113	PF12763	0.381
LIG_FHA_1	147	153	PF00498	0.350
LIG_FHA_1	161	167	PF00498	0.265
LIG_FHA_1	211	217	PF00498	0.453
LIG_FHA_1	324	330	PF00498	0.418
LIG_FHA_1	49	55	PF00498	0.548
LIG_FHA_2	310	316	PF00498	0.459
LIG_FHA_2	56	62	PF00498	0.666
LIG_LIR_Apic_2	105	111	PF02991	0.495
LIG_LIR_Gen_1	103	112	PF02991	0.373
LIG_LIR_Gen_1	236	246	PF02991	0.425
LIG_LIR_Gen_1	51	59	PF02991	0.453
LIG_LIR_Gen_1	79	85	PF02991	0.367
LIG_LIR_Nem_3	103	107	PF02991	0.462
LIG_LIR_Nem_3	277	283	PF02991	0.286
LIG_LIR_Nem_3	79	84	PF02991	0.359
LIG_MLH1_MIPbox_1	276	280	PF16413	0.295
LIG_Pex14_1	81	85	PF04695	0.333
LIG_Pex14_2	104	108	PF04695	0.470
LIG_Pex14_2	280	284	PF04695	0.292
LIG_PTB_Apo_2	79	86	PF02174	0.361
LIG_REV1ctd_RIR_1	281	288	PF16727	0.350
LIG_SH2_GRB2like	225	228	PF00017	0.469
LIG_SH2_SRC	225	228	PF00017	0.469
LIG_SH2_SRC	31	34	PF00017	0.431
LIG_SH2_STAT5	225	228	PF00017	0.412
LIG_SH2_STAT5	279	282	PF00017	0.346
LIG_SH2_STAT5	53	56	PF00017	0.519
LIG_SH3_3	13	19	PF00018	0.542
LIG_SH3_3	218	224	PF00018	0.468
LIG_SUMO_SIM_anti_2	217	223	PF11976	0.381
LIG_SUMO_SIM_anti_2	270	275	PF11976	0.284
LIG_TRAF2_1	184	187	PF00917	0.329
LIG_TRAF2_1	321	324	PF00917	0.338
LIG_WRC_WIRS_1	132	137	PF05994	0.405
LIG_WRC_WIRS_1	280	285	PF05994	0.241
MOD_CDK_SPK_2	166	171	PF00069	0.465
MOD_CDK_SPxxK_3	15	22	PF00069	0.513
MOD_CK1_1	119	125	PF00069	0.340
MOD_CK1_1	196	202	PF00069	0.468
MOD_CK1_1	296	302	PF00069	0.432
MOD_CK2_1	181	187	PF00069	0.377
MOD_CK2_1	309	315	PF00069	0.365
MOD_Cter_Amidation	124	127	PF01082	0.503
MOD_Cter_Amidation	64	67	PF01082	0.471
MOD_GlcNHglycan	251	254	PF01048	0.505
MOD_GlcNHglycan	276	279	PF01048	0.332
MOD_GSK3_1	102	109	PF00069	0.473
MOD_GSK3_1	116	123	PF00069	0.323
MOD_GSK3_1	131	138	PF00069	0.441
MOD_GSK3_1	147	154	PF00069	0.462
MOD_GSK3_1	166	173	PF00069	0.544
MOD_GSK3_1	289	296	PF00069	0.448
MOD_GSK3_1	309	316	PF00069	0.213
MOD_GSK3_1	76	83	PF00069	0.300
MOD_N-GLC_2	86	88	PF02516	0.432
MOD_NEK2_1	135	140	PF00069	0.384
MOD_NEK2_1	181	186	PF00069	0.363
MOD_NEK2_1	84	89	PF00069	0.445
MOD_NEK2_2	279	284	PF00069	0.230
MOD_PIKK_1	172	178	PF00454	0.556
MOD_PIKK_1	186	192	PF00454	0.410
MOD_PKA_2	147	153	PF00069	0.458
MOD_PKA_2	170	176	PF00069	0.369
MOD_PKA_2	48	54	PF00069	0.472
MOD_Plk_1	181	187	PF00069	0.319
MOD_Plk_1	322	328	PF00069	0.344
MOD_Plk_2-3	314	320	PF00069	0.474
MOD_Plk_4	131	137	PF00069	0.389
MOD_Plk_4	147	153	PF00069	0.291
MOD_Plk_4	76	82	PF00069	0.326
MOD_ProDKin_1	116	122	PF00069	0.327
MOD_ProDKin_1	15	21	PF00069	0.503
MOD_ProDKin_1	166	172	PF00069	0.465
MOD_SUMO_for_1	39	42	PF00179	0.388
TRG_ENDOCYTIC_2	238	241	PF00928	0.355
TRG_ENDOCYTIC_2	331	334	PF00928	0.344
TRG_ENDOCYTIC_2	53	56	PF00928	0.427
TRG_ER_diArg_1	157	159	PF00400	0.304
TRG_ER_diArg_1	284	286	PF00400	0.400
TRG_NLS_Bipartite_1	285	301	PF00514	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P956	Leptomonas seymouri	76%	100%
A0A0S4J7E1	Bodo saltans	56%	100%
A0A1X0P4X0	Trypanosomatidae	58%	100%
A0A422P1A4	Trypanosoma rangeli	60%	99%
A4HNE6	Leishmania braziliensis	89%	100%
A4IC18	Leishmania infantum	100%	100%
C9ZYI2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AFV7	Leishmania major	96%	100%
E9B710	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BG29	Trypanosoma cruzi	56%	100%