Ciliary BBSome complex subunit 1 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bardet-biedl syndrome 1 protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IVI7_LEIDO

TriTrypDb:

LdBPK_354250.1 , LdCL_350047600 , LDHU3_35.5470

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0034464	BBSome	2	12
GO:0005737	cytoplasm	2	1
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0036064	ciliary basal body	3	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IVI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IVI7

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	12
GO:0030031	cell projection assembly	5	12
GO:0044782	cilium organization	5	12
GO:0060271	cilium assembly	6	12
GO:0070925	organelle assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0120031	plasma membrane bounded cell projection assembly	6	12
GO:0120036	plasma membrane bounded cell projection organization	5	12
GO:1905515	non-motile cilium assembly	7	12
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006826	iron ion transport	8	1
GO:0006897	endocytosis	5	1
GO:0006907	pinocytosis	6	1
GO:0008104	protein localization	4	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0030001	metal ion transport	6	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0033572	transferrin transport	5	1
GO:0045184	establishment of protein localization	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0061512	protein localization to cilium	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0001664	G protein-coupled receptor binding	4	1
GO:0005102	signaling receptor binding	3	1
GO:0005113	patched binding	4	1
GO:0005119	smoothened binding	5	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.411
CLV_C14_Caspase3-7	324	328	PF00656	0.399
CLV_C14_Caspase3-7	84	88	PF00656	0.336
CLV_NRD_NRD_1	432	434	PF00675	0.431
CLV_PCSK_KEX2_1	55	57	PF00082	0.304
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.340
CLV_PCSK_SKI1_1	206	210	PF00082	0.306
CLV_PCSK_SKI1_1	231	235	PF00082	0.387
CLV_PCSK_SKI1_1	517	521	PF00082	0.393
CLV_PCSK_SKI1_1	55	59	PF00082	0.264
DEG_APCC_DBOX_1	21	29	PF00400	0.257
DEG_SCF_TRCP1_1	151	157	PF00400	0.306
DEG_SPOP_SBC_1	154	158	PF00917	0.263
DOC_CDC14_PxL_1	534	542	PF14671	0.346
DOC_CKS1_1	235	240	PF01111	0.306
DOC_MAPK_DCC_7	113	121	PF00069	0.247
DOC_MAPK_DCC_7	178	187	PF00069	0.306
DOC_MAPK_gen_1	306	315	PF00069	0.346
DOC_MAPK_gen_1	370	380	PF00069	0.297
DOC_MAPK_MEF2A_6	113	121	PF00069	0.265
DOC_MAPK_MEF2A_6	178	187	PF00069	0.387
DOC_MAPK_MEF2A_6	373	382	PF00069	0.292
DOC_PP1_RVXF_1	515	521	PF00149	0.451
DOC_PP4_FxxP_1	114	117	PF00568	0.301
DOC_PP4_FxxP_1	535	538	PF00568	0.413
DOC_PP4_FxxP_1	72	75	PF00568	0.336
DOC_PP4_FxxP_1	89	92	PF00568	0.336
DOC_PP4_MxPP_1	115	118	PF00568	0.387
DOC_SPAK_OSR1_1	113	117	PF12202	0.301
DOC_USP7_MATH_1	123	127	PF00917	0.356
DOC_USP7_MATH_1	197	201	PF00917	0.408
DOC_USP7_MATH_1	426	430	PF00917	0.431
DOC_USP7_MATH_1	463	467	PF00917	0.456
DOC_USP7_MATH_1	482	486	PF00917	0.314
DOC_USP7_MATH_1	51	55	PF00917	0.296
DOC_USP7_MATH_1	61	65	PF00917	0.298
DOC_USP7_MATH_1	77	81	PF00917	0.206
DOC_WW_Pin1_4	165	170	PF00397	0.393
DOC_WW_Pin1_4	234	239	PF00397	0.340
DOC_WW_Pin1_4	572	577	PF00397	0.524
LIG_14-3-3_CanoR_1	178	183	PF00244	0.365
LIG_14-3-3_CanoR_1	370	380	PF00244	0.457
LIG_14-3-3_CanoR_1	451	459	PF00244	0.373
LIG_Actin_WH2_2	435	453	PF00022	0.428
LIG_BIR_II_1	1	5	PF00653	0.631
LIG_BIR_III_2	278	282	PF00653	0.405
LIG_BRCT_BRCA1_1	421	425	PF00533	0.523
LIG_Clathr_ClatBox_1	184	188	PF01394	0.387
LIG_deltaCOP1_diTrp_1	14	21	PF00928	0.302
LIG_FHA_1	132	138	PF00498	0.317
LIG_FHA_1	158	164	PF00498	0.262
LIG_FHA_1	35	41	PF00498	0.356
LIG_FHA_2	136	142	PF00498	0.336
LIG_FHA_2	166	172	PF00498	0.374
LIG_FHA_2	322	328	PF00498	0.323
LIG_FHA_2	551	557	PF00498	0.437
LIG_FHA_2	578	584	PF00498	0.496
LIG_LIR_Apic_2	525	531	PF02991	0.501
LIG_LIR_Apic_2	87	92	PF02991	0.372
LIG_LIR_Gen_1	126	137	PF02991	0.303
LIG_LIR_Gen_1	214	225	PF02991	0.255
LIG_LIR_Gen_1	438	447	PF02991	0.442
LIG_LIR_Gen_1	45	51	PF02991	0.387
LIG_LIR_Gen_1	98	105	PF02991	0.387
LIG_LIR_LC3C_4	386	389	PF02991	0.295
LIG_LIR_Nem_3	126	132	PF02991	0.241
LIG_LIR_Nem_3	14	19	PF02991	0.383
LIG_LIR_Nem_3	214	220	PF02991	0.247
LIG_LIR_Nem_3	248	254	PF02991	0.248
LIG_LIR_Nem_3	299	305	PF02991	0.303
LIG_LIR_Nem_3	357	363	PF02991	0.329
LIG_LIR_Nem_3	438	443	PF02991	0.453
LIG_LIR_Nem_3	45	49	PF02991	0.262
LIG_MYND_1	538	542	PF01753	0.345
LIG_NRBOX	145	151	PF00104	0.387
LIG_NRBOX	160	166	PF00104	0.387
LIG_PCNA_yPIPBox_3	106	115	PF02747	0.306
LIG_Pex14_1	17	21	PF04695	0.242
LIG_SH2_CRK	251	255	PF00017	0.242
LIG_SH2_CRK	287	291	PF00017	0.329
LIG_SH2_CRK	360	364	PF00017	0.320
LIG_SH2_CRK	46	50	PF00017	0.257
LIG_SH2_CRK	528	532	PF00017	0.406
LIG_SH2_GRB2like	302	305	PF00017	0.374
LIG_SH2_STAT5	101	104	PF00017	0.336
LIG_SH2_STAT5	219	222	PF00017	0.307
LIG_SH2_STAT5	348	351	PF00017	0.335
LIG_SH2_STAT5	458	461	PF00017	0.370
LIG_SH3_3	114	120	PF00018	0.317
LIG_SH3_3	229	235	PF00018	0.292
LIG_SH3_3	271	277	PF00018	0.426
LIG_SH3_3	310	316	PF00018	0.336
LIG_SH3_3	411	417	PF00018	0.458
LIG_SH3_3	539	545	PF00018	0.436
LIG_SH3_3	579	585	PF00018	0.407
LIG_SUMO_SIM_anti_2	160	165	PF11976	0.313
LIG_SUMO_SIM_anti_2	207	214	PF11976	0.284
LIG_SUMO_SIM_par_1	134	141	PF11976	0.295
LIG_SUMO_SIM_par_1	207	214	PF11976	0.284
LIG_SUMO_SIM_par_1	289	296	PF11976	0.292
LIG_SUMO_SIM_par_1	336	341	PF11976	0.366
LIG_SUMO_SIM_par_1	563	569	PF11976	0.508
LIG_SUMO_SIM_par_1	580	586	PF11976	0.292
LIG_SUMO_SIM_par_1	92	98	PF11976	0.336
LIG_TRAF2_1	138	141	PF00917	0.241
LIG_TRAF2_1	168	171	PF00917	0.369
LIG_TYR_ITIM	249	254	PF00017	0.276
LIG_TYR_ITIM	300	305	PF00017	0.306
LIG_TYR_ITIM	358	363	PF00017	0.464
LIG_WRC_WIRS_1	78	83	PF05994	0.301
MOD_CDK_SPxxK_3	165	172	PF00069	0.304
MOD_CDK_SPxxK_3	572	579	PF00069	0.395
MOD_CK1_1	157	163	PF00069	0.242
MOD_CK1_1	320	326	PF00069	0.381
MOD_CK1_1	466	472	PF00069	0.454
MOD_CK1_1	536	542	PF00069	0.337
MOD_CK1_1	76	82	PF00069	0.287
MOD_CK2_1	135	141	PF00069	0.252
MOD_CK2_1	165	171	PF00069	0.355
MOD_CK2_1	197	203	PF00069	0.389
MOD_CK2_1	338	344	PF00069	0.369
MOD_CK2_1	426	432	PF00069	0.458
MOD_CK2_1	550	556	PF00069	0.451
MOD_Cter_Amidation	306	309	PF01082	0.363
MOD_GlcNHglycan	1	4	PF01048	0.793
MOD_GlcNHglycan	151	154	PF01048	0.415
MOD_GlcNHglycan	319	322	PF01048	0.347
MOD_GlcNHglycan	75	78	PF01048	0.260
MOD_GSK3_1	131	138	PF00069	0.261
MOD_GSK3_1	145	152	PF00069	0.298
MOD_GSK3_1	153	160	PF00069	0.260
MOD_GSK3_1	174	181	PF00069	0.307
MOD_GSK3_1	292	299	PF00069	0.296
MOD_GSK3_1	317	324	PF00069	0.288
MOD_GSK3_1	420	427	PF00069	0.530
MOD_GSK3_1	536	543	PF00069	0.388
MOD_GSK3_1	566	573	PF00069	0.373
MOD_GSK3_1	73	80	PF00069	0.266
MOD_N-GLC_1	383	388	PF02516	0.301
MOD_N-GLC_1	396	401	PF02516	0.401
MOD_N-GLC_1	463	468	PF02516	0.520
MOD_NEK2_1	104	109	PF00069	0.263
MOD_NEK2_1	149	154	PF00069	0.407
MOD_NEK2_1	398	403	PF00069	0.529
MOD_NEK2_1	450	455	PF00069	0.372
MOD_NEK2_1	577	582	PF00069	0.454
MOD_NEK2_2	482	487	PF00069	0.501
MOD_NEK2_2	77	82	PF00069	0.301
MOD_PIKK_1	348	354	PF00454	0.390
MOD_PIKK_1	424	430	PF00454	0.431
MOD_PIKK_1	445	451	PF00454	0.468
MOD_PK_1	178	184	PF00069	0.263
MOD_PK_1	261	267	PF00069	0.336
MOD_PK_1	309	315	PF00069	0.412
MOD_PKA_2	450	456	PF00069	0.422
MOD_Plk_1	445	451	PF00069	0.404
MOD_Plk_1	482	488	PF00069	0.407
MOD_Plk_2-3	135	141	PF00069	0.288
MOD_Plk_4	123	129	PF00069	0.235
MOD_Plk_4	145	151	PF00069	0.423
MOD_Plk_4	298	304	PF00069	0.275
MOD_Plk_4	309	315	PF00069	0.329
MOD_Plk_4	383	389	PF00069	0.308
MOD_Plk_4	420	426	PF00069	0.416
MOD_Plk_4	536	542	PF00069	0.357
MOD_Plk_4	77	83	PF00069	0.344
MOD_ProDKin_1	165	171	PF00069	0.393
MOD_ProDKin_1	234	240	PF00069	0.340
MOD_ProDKin_1	572	578	PF00069	0.516
TRG_DiLeu_BaEn_1	332	337	PF01217	0.460
TRG_DiLeu_BaEn_3	170	176	PF01217	0.313
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.387
TRG_ENDOCYTIC_2	101	104	PF00928	0.254
TRG_ENDOCYTIC_2	112	115	PF00928	0.222
TRG_ENDOCYTIC_2	251	254	PF00928	0.242
TRG_ENDOCYTIC_2	287	290	PF00928	0.347
TRG_ENDOCYTIC_2	302	305	PF00928	0.297
TRG_ENDOCYTIC_2	360	363	PF00928	0.323
TRG_ENDOCYTIC_2	440	443	PF00928	0.463
TRG_ENDOCYTIC_2	458	461	PF00928	0.269
TRG_ENDOCYTIC_2	46	49	PF00928	0.265
TRG_Pf-PMV_PEXEL_1	579	583	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJK5	Leptomonas seymouri	74%	100%
A0A0S4KEX6	Bodo saltans	41%	97%
A0A1X0P534	Trypanosomatidae	47%	97%
A0A3R7KG84	Trypanosoma rangeli	47%	100%
A4HN90	Leishmania braziliensis	85%	100%
A4IBV8	Leishmania infantum	99%	100%
C9ZYQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	97%
E9AFP5	Leishmania major	95%	100%
E9B6U8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q3V3N7	Mus musculus	32%	100%
Q8NFJ9	Homo sapiens	31%	100%
Q9NEZ7	Caenorhabditis elegans	24%	100%
V5DUI8	Trypanosoma cruzi	48%	100%