LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IVH8_LEIDO
TriTrypDb:
LdBPK_354100.1 , LdCL_350046100 , LDHU3_35.5320
Length:
115

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IVH8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IVH8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 77 79 PF00675 0.410
CLV_PCSK_KEX2_1 77 79 PF00082 0.525
CLV_PCSK_SKI1_1 64 68 PF00082 0.326
DOC_MAPK_gen_1 14 23 PF00069 0.495
DOC_MAPK_MEF2A_6 16 25 PF00069 0.369
DOC_PP4_FxxP_1 112 115 PF00568 0.377
DOC_USP7_MATH_1 106 110 PF00917 0.351
DOC_USP7_MATH_1 71 75 PF00917 0.419
DOC_WW_Pin1_4 2 7 PF00397 0.453
LIG_Actin_WH2_2 32 47 PF00022 0.284
LIG_BRCT_BRCA1_1 108 112 PF00533 0.426
LIG_BRCT_BRCA1_1 72 76 PF00533 0.518
LIG_FHA_1 49 55 PF00498 0.502
LIG_FHA_1 97 103 PF00498 0.360
LIG_FHA_2 15 21 PF00498 0.455
LIG_FHA_2 51 57 PF00498 0.401
LIG_FHA_2 95 101 PF00498 0.384
LIG_IRF3_LxIS_1 36 42 PF10401 0.272
LIG_LIR_Apic_2 109 115 PF02991 0.336
LIG_LIR_Gen_1 99 108 PF02991 0.369
LIG_LIR_Nem_3 99 104 PF02991 0.373
LIG_SH2_STAT3 87 90 PF00017 0.287
LIG_SH2_STAT5 38 41 PF00017 0.447
LIG_SH2_STAT5 88 91 PF00017 0.320
LIG_SH3_3 105 111 PF00018 0.479
LIG_TYR_ITIM 36 41 PF00017 0.264
MOD_CK1_1 4 10 PF00069 0.527
MOD_CK1_1 82 88 PF00069 0.348
MOD_CK2_1 50 56 PF00069 0.343
MOD_GlcNHglycan 6 9 PF01048 0.589
MOD_GlcNHglycan 73 76 PF01048 0.369
MOD_GlcNHglycan 81 84 PF01048 0.415
MOD_GSK3_1 90 97 PF00069 0.384
MOD_N-GLC_2 27 29 PF02516 0.336
MOD_NEK2_1 1 6 PF00069 0.553
MOD_NEK2_1 39 44 PF00069 0.366
MOD_Plk_4 50 56 PF00069 0.399
MOD_Plk_4 82 88 PF00069 0.403
MOD_ProDKin_1 2 8 PF00069 0.450
MOD_SUMO_rev_2 42 52 PF00179 0.353
TRG_ENDOCYTIC_2 38 41 PF00928 0.275
TRG_ER_diArg_1 76 78 PF00400 0.426

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5B2 Leptomonas seymouri 70% 100%
A0A1X0P535 Trypanosomatidae 51% 94%
A0A3R7MNW4 Trypanosoma rangeli 54% 100%
A4HN75 Leishmania braziliensis 83% 100%
A4IBU3 Leishmania infantum 99% 100%
C9ZYR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9AFN0 Leishmania major 88% 100%
E9B6T3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS