Peroxisomal biogenesis factor 11 (PEX11) family protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Gim5A protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IVG4_LEIDO

TriTrypDb:

LdBPK_353750.1 , LdCL_350042500 , LDHU3_35.4910

Length:

225

Annotations

LeishMANIAdb annotations

Publication identifier(s): 11260462
A known glcosomal (peroxisomal) kinetoplastid protein. Known to be a dimeric, essential component of glycosomes (PMID: 11260462). Localization: Peroxisomal (experimental)

Annotations by Jardim et al.

Glycosome membrane, Gim5A

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IVG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IVG4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	16
GO:0009987	cellular process	1	16
GO:0016043	cellular component organization	3	16
GO:0016559	peroxisome fission	6	16
GO:0048285	organelle fission	5	16
GO:0071840	cellular component organization or biogenesis	2	16

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	50	54	PF00656	0.369
CLV_PCSK_KEX2_1	155	157	PF00082	0.316
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.276
CLV_PCSK_SKI1_1	212	216	PF00082	0.476
CLV_PCSK_SKI1_1	43	47	PF00082	0.513
CLV_PCSK_SKI1_1	56	60	PF00082	0.463
DEG_APCC_DBOX_1	211	219	PF00400	0.316
DOC_CYCLIN_RxL_1	200	210	PF00134	0.385
DOC_MAPK_gen_1	15	24	PF00069	0.289
DOC_MAPK_gen_1	78	85	PF00069	0.281
DOC_MAPK_MEF2A_6	56	65	PF00069	0.272
DOC_PP2B_LxvP_1	199	202	PF13499	0.459
DOC_WW_Pin1_4	147	152	PF00397	0.531
LIG_14-3-3_CanoR_1	156	164	PF00244	0.554
LIG_BIR_II_1	1	5	PF00653	0.405
LIG_BRCT_BRCA1_1	91	95	PF00533	0.296
LIG_FHA_1	103	109	PF00498	0.292
LIG_FHA_1	130	136	PF00498	0.302
LIG_FHA_1	159	165	PF00498	0.430
LIG_FHA_1	194	200	PF00498	0.419
LIG_FHA_2	148	154	PF00498	0.565
LIG_LIR_Nem_3	127	133	PF02991	0.443
LIG_LIR_Nem_3	53	58	PF02991	0.259
LIG_LIR_Nem_3	92	97	PF02991	0.395
LIG_MLH1_MIPbox_1	91	95	PF16413	0.281
LIG_PALB2_WD40_1	125	133	PF16756	0.391
LIG_Pex14_2	95	99	PF04695	0.301
LIG_SH2_CRK	131	135	PF00017	0.279
LIG_SH2_CRK	55	59	PF00017	0.289
LIG_SH2_STAP1	131	135	PF00017	0.305
LIG_SH2_STAT5	131	134	PF00017	0.326
LIG_SH2_STAT5	142	145	PF00017	0.526
LIG_SH2_STAT5	8	11	PF00017	0.299
LIG_SH3_3	183	189	PF00018	0.423
LIG_SUMO_SIM_anti_2	59	65	PF11976	0.258
LIG_TRAF2_1	150	153	PF00917	0.501
LIG_UBA3_1	168	177	PF00899	0.290
LIG_UBA3_1	64	70	PF00899	0.301
MOD_CK1_1	44	50	PF00069	0.336
MOD_CK1_1	69	75	PF00069	0.281
MOD_CK2_1	147	153	PF00069	0.570
MOD_GlcNHglycan	1	4	PF01048	0.608
MOD_GlcNHglycan	184	189	PF01048	0.630
MOD_GSK3_1	102	109	PF00069	0.327
MOD_GSK3_1	37	44	PF00069	0.273
MOD_N-GLC_1	207	212	PF02516	0.575
MOD_NEK2_1	102	107	PF00069	0.329
MOD_NEK2_1	158	163	PF00069	0.375
MOD_NEK2_1	168	173	PF00069	0.324
MOD_NEK2_1	193	198	PF00069	0.386
MOD_NEK2_1	207	212	PF00069	0.299
MOD_NEK2_1	217	222	PF00069	0.338
MOD_NEK2_1	41	46	PF00069	0.261
MOD_PIKK_1	142	148	PF00454	0.558
MOD_Plk_1	102	108	PF00069	0.266
MOD_Plk_1	207	213	PF00069	0.406
MOD_Plk_4	129	135	PF00069	0.311
MOD_ProDKin_1	147	153	PF00069	0.531
TRG_ENDOCYTIC_2	131	134	PF00928	0.314
TRG_ENDOCYTIC_2	55	58	PF00928	0.289

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJQ7	Leptomonas seymouri	76%	100%
A0A1X0P5I2	Trypanosomatidae	53%	91%
A0A3R7K892	Trypanosoma rangeli	23%	91%
A0A3R7MWK0	Trypanosoma rangeli	50%	92%
A0A3S7X9W6	Leishmania donovani	26%	89%
A4HN40	Leishmania braziliensis	26%	100%
A4HN41	Leishmania braziliensis	93%	100%
A4IBQ9	Leishmania infantum	100%	100%
C9ZYW5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	93%
C9ZYW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	93%
E9AFJ3	Leishmania major	27%	100%
E9AFJ4	Leishmania major	99%	100%
E9B6P7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	89%
E9B6P8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BTC6	Trypanosoma cruzi	54%	92%