Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IVE9_LEIDO

TriTrypDb:

LdBPK_353480.1 , LdCL_350039800 , LDHU3_35.4560

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IVE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IVE9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	489	493	PF00656	0.747
CLV_C14_Caspase3-7	539	543	PF00656	0.601
CLV_C14_Caspase3-7	81	85	PF00656	0.721
CLV_NRD_NRD_1	190	192	PF00675	0.663
CLV_NRD_NRD_1	284	286	PF00675	0.532
CLV_NRD_NRD_1	378	380	PF00675	0.567
CLV_NRD_NRD_1	516	518	PF00675	0.790
CLV_NRD_NRD_1	534	536	PF00675	0.431
CLV_PCSK_KEX2_1	164	166	PF00082	0.704
CLV_PCSK_KEX2_1	240	242	PF00082	0.681
CLV_PCSK_KEX2_1	284	286	PF00082	0.532
CLV_PCSK_KEX2_1	378	380	PF00082	0.567
CLV_PCSK_KEX2_1	516	518	PF00082	0.790
CLV_PCSK_KEX2_1	534	536	PF00082	0.431
CLV_PCSK_KEX2_1	56	58	PF00082	0.684
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.643
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.769
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.618
CLV_PCSK_SKI1_1	353	357	PF00082	0.689
CLV_PCSK_SKI1_1	402	406	PF00082	0.660
CLV_PCSK_SKI1_1	486	490	PF00082	0.797
CLV_PCSK_SKI1_1	508	512	PF00082	0.635
DEG_APCC_DBOX_1	362	370	PF00400	0.520
DEG_Nend_UBRbox_3	1	3	PF02207	0.772
DEG_SPOP_SBC_1	181	185	PF00917	0.615
DOC_CDC14_PxL_1	322	330	PF14671	0.484
DOC_CYCLIN_RxL_1	503	515	PF00134	0.628
DOC_MAPK_gen_1	133	141	PF00069	0.678
DOC_MAPK_gen_1	213	221	PF00069	0.721
DOC_MAPK_gen_1	378	386	PF00069	0.423
DOC_MAPK_gen_1	534	540	PF00069	0.601
DOC_MAPK_gen_1	99	108	PF00069	0.546
DOC_MAPK_HePTP_8	96	108	PF00069	0.423
DOC_MAPK_MEF2A_6	357	366	PF00069	0.641
DOC_MAPK_MEF2A_6	99	108	PF00069	0.550
DOC_PP1_RVXF_1	218	224	PF00149	0.645
DOC_PP1_SILK_1	359	364	PF00149	0.644
DOC_PP2B_LxvP_1	434	437	PF13499	0.675
DOC_USP7_MATH_1	167	171	PF00917	0.664
DOC_USP7_MATH_1	181	185	PF00917	0.686
DOC_USP7_MATH_1	39	43	PF00917	0.730
DOC_USP7_MATH_1	392	396	PF00917	0.665
DOC_USP7_MATH_1	525	529	PF00917	0.696
DOC_USP7_MATH_1	553	557	PF00917	0.626
DOC_WW_Pin1_4	254	259	PF00397	0.678
DOC_WW_Pin1_4	397	402	PF00397	0.662
DOC_WW_Pin1_4	408	413	PF00397	0.693
DOC_WW_Pin1_4	496	501	PF00397	0.692
DOC_WW_Pin1_4	509	514	PF00397	0.783
LIG_14-3-3_CanoR_1	153	161	PF00244	0.563
LIG_14-3-3_CanoR_1	220	224	PF00244	0.653
LIG_14-3-3_CanoR_1	241	245	PF00244	0.607
LIG_14-3-3_CanoR_1	284	293	PF00244	0.545
LIG_14-3-3_CanoR_1	314	318	PF00244	0.680
LIG_14-3-3_CanoR_1	363	367	PF00244	0.532
LIG_14-3-3_CanoR_1	394	401	PF00244	0.615
LIG_14-3-3_CanoR_1	453	457	PF00244	0.563
LIG_14-3-3_CanoR_1	527	533	PF00244	0.635
LIG_BRCT_BRCA1_1	50	54	PF00533	0.634
LIG_BRCT_BRCA1_2	50	56	PF00533	0.628
LIG_eIF4E_1	323	329	PF01652	0.537
LIG_eIF4E_1	331	337	PF01652	0.430
LIG_FHA_1	209	215	PF00498	0.601
LIG_FHA_1	263	269	PF00498	0.602
LIG_FHA_1	356	362	PF00498	0.592
LIG_FHA_1	398	404	PF00498	0.726
LIG_FHA_1	405	411	PF00498	0.642
LIG_FHA_1	467	473	PF00498	0.541
LIG_FHA_1	483	489	PF00498	0.680
LIG_FHA_1	91	97	PF00498	0.666
LIG_FHA_1	99	105	PF00498	0.469
LIG_FHA_2	122	128	PF00498	0.578
LIG_FHA_2	158	164	PF00498	0.489
LIG_FHA_2	339	345	PF00498	0.529
LIG_FHA_2	487	493	PF00498	0.740
LIG_FHA_2	502	508	PF00498	0.596
LIG_FHA_2	527	533	PF00498	0.678
LIG_FHA_2	6	12	PF00498	0.696
LIG_LIR_Gen_1	222	231	PF02991	0.709
LIG_LIR_Gen_1	291	302	PF02991	0.507
LIG_LIR_Gen_1	456	466	PF02991	0.586
LIG_LIR_Gen_1	479	488	PF02991	0.706
LIG_LIR_Nem_3	140	146	PF02991	0.422
LIG_LIR_Nem_3	222	226	PF02991	0.709
LIG_LIR_Nem_3	25	30	PF02991	0.696
LIG_LIR_Nem_3	291	297	PF02991	0.526
LIG_LIR_Nem_3	319	325	PF02991	0.532
LIG_LIR_Nem_3	4	9	PF02991	0.709
LIG_LIR_Nem_3	456	462	PF02991	0.585
LIG_LIR_Nem_3	479	483	PF02991	0.752
LIG_NRBOX	267	273	PF00104	0.645
LIG_NRBOX	365	371	PF00104	0.519
LIG_PDZ_Wminus1_1	584	586	PF00595	0.662
LIG_SH2_CRK	307	311	PF00017	0.556
LIG_SH2_CRK	377	381	PF00017	0.411
LIG_SH2_SRC	323	326	PF00017	0.605
LIG_SH2_STAP1	15	19	PF00017	0.603
LIG_SH2_STAP1	331	335	PF00017	0.593
LIG_SH2_STAT5	137	140	PF00017	0.676
LIG_SH2_STAT5	323	326	PF00017	0.508
LIG_SH2_STAT5	572	575	PF00017	0.584
LIG_SH2_STAT5	577	580	PF00017	0.527
LIG_SH3_3	18	24	PF00018	0.657
LIG_SH3_3	403	409	PF00018	0.668
LIG_SH3_3	430	436	PF00018	0.784
LIG_SH3_3	462	468	PF00018	0.548
LIG_SH3_3	55	61	PF00018	0.682
LIG_SUMO_SIM_anti_2	18	23	PF11976	0.715
LIG_SUMO_SIM_par_1	121	128	PF11976	0.623
LIG_SUMO_SIM_par_1	259	265	PF11976	0.703
LIG_SUMO_SIM_par_1	460	467	PF11976	0.548
LIG_TRAF2_1	124	127	PF00917	0.590
LIG_TRFH_1	278	282	PF08558	0.637
LIG_TRFH_1	322	326	PF08558	0.508
LIG_TYR_ITIM	305	310	PF00017	0.539
LIG_WRC_WIRS_1	537	542	PF05994	0.628
MOD_CDK_SPK_2	254	259	PF00069	0.678
MOD_CDK_SPK_2	397	402	PF00069	0.759
MOD_CDK_SPxxK_3	509	516	PF00069	0.778
MOD_CK1_1	175	181	PF00069	0.651
MOD_CK1_1	185	191	PF00069	0.612
MOD_CK1_1	25	31	PF00069	0.672
MOD_CK1_1	32	38	PF00069	0.710
MOD_CK1_1	396	402	PF00069	0.678
MOD_CK1_1	41	47	PF00069	0.588
MOD_CK1_1	447	453	PF00069	0.559
MOD_CK1_1	48	54	PF00069	0.634
MOD_CK1_1	484	490	PF00069	0.645
MOD_CK1_1	512	518	PF00069	0.820
MOD_CK2_1	121	127	PF00069	0.600
MOD_CK2_1	146	152	PF00069	0.574
MOD_CK2_1	157	163	PF00069	0.488
MOD_CK2_1	313	319	PF00069	0.670
MOD_CK2_1	338	344	PF00069	0.476
MOD_CK2_1	5	11	PF00069	0.630
MOD_CK2_1	501	507	PF00069	0.622
MOD_GlcNHglycan	27	30	PF01048	0.668
MOD_GlcNHglycan	290	293	PF01048	0.643
MOD_GlcNHglycan	33	37	PF01048	0.774
MOD_GlcNHglycan	344	347	PF01048	0.640
MOD_GlcNHglycan	371	374	PF01048	0.569
MOD_GlcNHglycan	390	393	PF01048	0.447
MOD_GlcNHglycan	395	398	PF01048	0.652
MOD_GlcNHglycan	446	449	PF01048	0.720
MOD_GlcNHglycan	555	558	PF01048	0.642
MOD_GlcNHglycan	80	83	PF01048	0.745
MOD_GSK3_1	153	160	PF00069	0.508
MOD_GSK3_1	167	174	PF00069	0.608
MOD_GSK3_1	181	188	PF00069	0.631
MOD_GSK3_1	227	234	PF00069	0.724
MOD_GSK3_1	240	247	PF00069	0.559
MOD_GSK3_1	249	256	PF00069	0.670
MOD_GSK3_1	25	32	PF00069	0.435
MOD_GSK3_1	284	291	PF00069	0.652
MOD_GSK3_1	308	315	PF00069	0.604
MOD_GSK3_1	338	345	PF00069	0.498
MOD_GSK3_1	34	41	PF00069	0.762
MOD_GSK3_1	353	360	PF00069	0.672
MOD_GSK3_1	365	372	PF00069	0.458
MOD_GSK3_1	388	395	PF00069	0.684
MOD_GSK3_1	404	411	PF00069	0.509
MOD_GSK3_1	44	51	PF00069	0.597
MOD_GSK3_1	482	489	PF00069	0.717
MOD_GSK3_1	5	12	PF00069	0.667
MOD_GSK3_1	536	543	PF00069	0.599
MOD_GSK3_1	553	560	PF00069	0.594
MOD_GSK3_1	573	580	PF00069	0.550
MOD_GSK3_1	61	68	PF00069	0.490
MOD_GSK3_1	73	80	PF00069	0.674
MOD_LATS_1	351	357	PF00433	0.697
MOD_N-GLC_1	295	300	PF02516	0.405
MOD_NEK2_1	115	120	PF00069	0.565
MOD_NEK2_1	146	151	PF00069	0.572
MOD_NEK2_1	171	176	PF00069	0.794
MOD_NEK2_1	180	185	PF00069	0.630
MOD_NEK2_1	208	213	PF00069	0.562
MOD_NEK2_1	295	300	PF00069	0.559
MOD_NEK2_1	342	347	PF00069	0.559
MOD_NEK2_1	355	360	PF00069	0.657
MOD_NEK2_1	362	367	PF00069	0.501
MOD_NEK2_1	369	374	PF00069	0.454
MOD_NEK2_1	43	48	PF00069	0.700
MOD_NEK2_1	446	451	PF00069	0.783
MOD_NEK2_1	573	578	PF00069	0.645
MOD_NEK2_2	338	343	PF00069	0.408
MOD_PIKK_1	165	171	PF00454	0.695
MOD_PIKK_1	208	214	PF00454	0.605
MOD_PIKK_1	295	301	PF00454	0.609
MOD_PIKK_1	355	361	PF00454	0.595
MOD_PIKK_1	519	525	PF00454	0.780
MOD_PIKK_1	61	67	PF00454	0.633
MOD_PK_1	240	246	PF00069	0.587
MOD_PK_1	357	363	PF00069	0.585
MOD_PKA_1	240	246	PF00069	0.772
MOD_PKA_1	284	290	PF00069	0.532
MOD_PKA_2	219	225	PF00069	0.640
MOD_PKA_2	240	246	PF00069	0.746
MOD_PKA_2	284	290	PF00069	0.532
MOD_PKA_2	313	319	PF00069	0.670
MOD_PKA_2	362	368	PF00069	0.529
MOD_PKA_2	393	399	PF00069	0.596
MOD_PKA_2	452	458	PF00069	0.667
MOD_PKA_2	526	532	PF00069	0.707
MOD_PKA_2	9	15	PF00069	0.661
MOD_PKA_2	98	104	PF00069	0.558
MOD_PKB_1	151	159	PF00069	0.539
MOD_Plk_1	146	152	PF00069	0.574
MOD_Plk_1	338	344	PF00069	0.476
MOD_Plk_2-3	5	11	PF00069	0.705
MOD_Plk_2-3	536	542	PF00069	0.632
MOD_Plk_4	185	191	PF00069	0.732
MOD_Plk_4	313	319	PF00069	0.670
MOD_Plk_4	357	363	PF00069	0.622
MOD_Plk_4	365	371	PF00069	0.513
MOD_Plk_4	447	453	PF00069	0.559
MOD_Plk_4	536	542	PF00069	0.632
MOD_Plk_4	573	579	PF00069	0.650
MOD_Plk_4	9	15	PF00069	0.696
MOD_ProDKin_1	254	260	PF00069	0.675
MOD_ProDKin_1	397	403	PF00069	0.662
MOD_ProDKin_1	408	414	PF00069	0.694
MOD_ProDKin_1	496	502	PF00069	0.691
MOD_ProDKin_1	509	515	PF00069	0.782
MOD_SUMO_rev_2	382	391	PF00179	0.553
TRG_DiLeu_BaEn_1	18	23	PF01217	0.653
TRG_DiLeu_BaEn_2	535	541	PF01217	0.639
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.632
TRG_ENDOCYTIC_2	307	310	PF00928	0.552
TRG_ENDOCYTIC_2	322	325	PF00928	0.510
TRG_ENDOCYTIC_2	377	380	PF00928	0.522
TRG_ER_diArg_1	278	281	PF00400	0.628
TRG_ER_diArg_1	377	379	PF00400	0.551
TRG_ER_diArg_1	533	535	PF00400	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V6	Leptomonas seymouri	32%	99%
A4HN10	Leishmania braziliensis	68%	99%
A4IBN3	Leishmania infantum	99%	100%
E9AFG7	Leishmania major	89%	100%
E9B6M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%