Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IVC2_LEIDO

TriTrypDb:

LdBPK_352920.1 , LdCL_350034100 , LDHU3_35.3760

Length:

740

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IVC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IVC2

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.505
CLV_C14_Caspase3-7	203	207	PF00656	0.557
CLV_C14_Caspase3-7	464	468	PF00656	0.809
CLV_C14_Caspase3-7	643	647	PF00656	0.529
CLV_NRD_NRD_1	102	104	PF00675	0.488
CLV_NRD_NRD_1	444	446	PF00675	0.614
CLV_NRD_NRD_1	682	684	PF00675	0.656
CLV_NRD_NRD_1	727	729	PF00675	0.636
CLV_NRD_NRD_1	730	732	PF00675	0.606
CLV_PCSK_FUR_1	100	104	PF00082	0.534
CLV_PCSK_KEX2_1	102	104	PF00082	0.488
CLV_PCSK_KEX2_1	405	407	PF00082	0.499
CLV_PCSK_KEX2_1	444	446	PF00082	0.614
CLV_PCSK_KEX2_1	682	684	PF00082	0.612
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.477
CLV_PCSK_SKI1_1	211	215	PF00082	0.521
CLV_PCSK_SKI1_1	422	426	PF00082	0.633
CLV_PCSK_SKI1_1	496	500	PF00082	0.655
CLV_PCSK_SKI1_1	545	549	PF00082	0.601
CLV_PCSK_SKI1_1	596	600	PF00082	0.775
CLV_PCSK_SKI1_1	733	737	PF00082	0.662
DEG_APCC_DBOX_1	405	413	PF00400	0.549
DEG_SPOP_SBC_1	126	130	PF00917	0.723
DEG_SPOP_SBC_1	293	297	PF00917	0.671
DEG_SPOP_SBC_1	571	575	PF00917	0.504
DEG_SPOP_SBC_1	716	720	PF00917	0.655
DEG_SPOP_SBC_1	75	79	PF00917	0.617
DOC_CKS1_1	489	494	PF01111	0.742
DOC_CYCLIN_yCln2_LP_2	376	382	PF00134	0.561
DOC_MAPK_gen_1	211	220	PF00069	0.622
DOC_MAPK_gen_1	405	413	PF00069	0.568
DOC_MAPK_MEF2A_6	260	269	PF00069	0.397
DOC_MAPK_RevD_3	90	103	PF00069	0.619
DOC_MIT_MIM_1	619	629	PF04212	0.653
DOC_PP1_RVXF_1	619	625	PF00149	0.605
DOC_USP7_MATH_1	163	167	PF00917	0.781
DOC_USP7_MATH_1	179	183	PF00917	0.584
DOC_USP7_MATH_1	316	320	PF00917	0.475
DOC_USP7_MATH_1	572	576	PF00917	0.643
DOC_USP7_MATH_1	716	720	PF00917	0.711
DOC_USP7_UBL2_3	729	733	PF12436	0.631
DOC_WW_Pin1_4	122	127	PF00397	0.755
DOC_WW_Pin1_4	142	147	PF00397	0.752
DOC_WW_Pin1_4	289	294	PF00397	0.666
DOC_WW_Pin1_4	399	404	PF00397	0.525
DOC_WW_Pin1_4	488	493	PF00397	0.648
DOC_WW_Pin1_4	502	507	PF00397	0.685
DOC_WW_Pin1_4	83	88	PF00397	0.540
LIG_14-3-3_CanoR_1	266	275	PF00244	0.481
LIG_14-3-3_CanoR_1	406	412	PF00244	0.493
LIG_14-3-3_CanoR_1	422	427	PF00244	0.468
LIG_14-3-3_CanoR_1	431	437	PF00244	0.432
LIG_14-3-3_CanoR_1	445	455	PF00244	0.580
LIG_14-3-3_CanoR_1	461	470	PF00244	0.676
LIG_14-3-3_CanoR_1	682	686	PF00244	0.685
LIG_14-3-3_CanoR_1	714	723	PF00244	0.636
LIG_AP2alpha_1	495	499	PF02296	0.744
LIG_APCC_ABBA_1	335	340	PF00400	0.474
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_BRCT_BRCA1_1	302	306	PF00533	0.664
LIG_BRCT_BRCA1_1	414	418	PF00533	0.502
LIG_BRCT_BRCA1_2	414	420	PF00533	0.585
LIG_Clathr_ClatBox_1	189	193	PF01394	0.453
LIG_CtBP_PxDLS_1	537	541	PF00389	0.753
LIG_FHA_1	185	191	PF00498	0.424
LIG_FHA_1	293	299	PF00498	0.683
LIG_FHA_1	364	370	PF00498	0.521
LIG_FHA_1	44	50	PF00498	0.748
LIG_FHA_1	589	595	PF00498	0.703
LIG_FHA_1	599	605	PF00498	0.576
LIG_FHA_1	607	613	PF00498	0.412
LIG_FHA_1	696	702	PF00498	0.760
LIG_FHA_1	716	722	PF00498	0.405
LIG_FHA_1	75	81	PF00498	0.622
LIG_FHA_2	110	116	PF00498	0.515
LIG_FHA_2	160	166	PF00498	0.726
LIG_FHA_2	423	429	PF00498	0.604
LIG_GBD_Chelix_1	227	235	PF00786	0.424
LIG_HCF-1_HBM_1	106	109	PF13415	0.535
LIG_LIR_Gen_1	322	331	PF02991	0.600
LIG_LIR_LC3C_4	187	191	PF02991	0.499
LIG_LIR_Nem_3	25	29	PF02991	0.455
LIG_LIR_Nem_3	322	327	PF02991	0.614
LIG_LIR_Nem_3	494	498	PF02991	0.637
LIG_LIR_Nem_3	556	561	PF02991	0.639
LIG_LIR_Nem_3	72	76	PF02991	0.487
LIG_NRBOX	408	414	PF00104	0.559
LIG_PCNA_PIPBox_1	605	614	PF02747	0.711
LIG_Pex14_2	495	499	PF04695	0.744
LIG_SH2_CRK	26	30	PF00017	0.509
LIG_SH2_GRB2like	118	121	PF00017	0.585
LIG_SH2_PTP2	73	76	PF00017	0.492
LIG_SH2_SRC	195	198	PF00017	0.516
LIG_SH2_SRC	204	207	PF00017	0.420
LIG_SH2_SRC	338	341	PF00017	0.436
LIG_SH2_STAP1	204	208	PF00017	0.471
LIG_SH2_STAP1	338	342	PF00017	0.434
LIG_SH2_STAP1	581	585	PF00017	0.530
LIG_SH2_STAT3	118	121	PF00017	0.560
LIG_SH2_STAT3	36	39	PF00017	0.599
LIG_SH2_STAT5	109	112	PF00017	0.511
LIG_SH2_STAT5	195	198	PF00017	0.576
LIG_SH2_STAT5	73	76	PF00017	0.492
LIG_SH3_1	700	706	PF00018	0.664
LIG_SH3_3	102	108	PF00018	0.430
LIG_SH3_3	120	126	PF00018	0.694
LIG_SH3_3	143	149	PF00018	0.700
LIG_SH3_3	15	21	PF00018	0.401
LIG_SH3_3	262	268	PF00018	0.448
LIG_SH3_3	310	316	PF00018	0.664
LIG_SH3_3	452	458	PF00018	0.659
LIG_SH3_3	495	501	PF00018	0.635
LIG_SH3_3	700	706	PF00018	0.656
LIG_SUMO_SIM_anti_2	187	194	PF11976	0.461
LIG_SUMO_SIM_anti_2	273	279	PF11976	0.439
LIG_SUMO_SIM_anti_2	366	374	PF11976	0.592
LIG_SUMO_SIM_anti_2	550	556	PF11976	0.676
LIG_SUMO_SIM_par_1	187	194	PF11976	0.466
LIG_SUMO_SIM_par_1	273	279	PF11976	0.439
LIG_SUMO_SIM_par_1	366	374	PF11976	0.592
LIG_SUMO_SIM_par_1	432	438	PF11976	0.427
LIG_SUMO_SIM_par_1	476	483	PF11976	0.646
LIG_SUMO_SIM_par_1	500	505	PF11976	0.683
LIG_TRAF2_1	79	82	PF00917	0.608
LIG_TYR_ITIM	71	76	PF00017	0.483
LIG_WW_3	150	154	PF00397	0.789
MOD_CDC14_SPxK_1	150	153	PF00782	0.707
MOD_CDC14_SPxK_1	402	405	PF00782	0.538
MOD_CDK_SPK_2	289	294	PF00069	0.627
MOD_CDK_SPxK_1	147	153	PF00069	0.716
MOD_CDK_SPxK_1	399	405	PF00069	0.528
MOD_CDK_SPxxK_3	399	406	PF00069	0.521
MOD_CK1_1	124	130	PF00069	0.756
MOD_CK1_1	166	172	PF00069	0.789
MOD_CK1_1	184	190	PF00069	0.454
MOD_CK1_1	270	276	PF00069	0.397
MOD_CK1_1	292	298	PF00069	0.667
MOD_CK1_1	319	325	PF00069	0.631
MOD_CK1_1	360	366	PF00069	0.650
MOD_CK1_1	478	484	PF00069	0.677
MOD_CK1_1	64	70	PF00069	0.628
MOD_CK1_1	83	89	PF00069	0.403
MOD_CK2_1	294	300	PF00069	0.669
MOD_CK2_1	394	400	PF00069	0.471
MOD_CK2_1	422	428	PF00069	0.612
MOD_CK2_1	432	438	PF00069	0.548
MOD_CK2_1	502	508	PF00069	0.587
MOD_CK2_1	681	687	PF00069	0.719
MOD_CK2_1	76	82	PF00069	0.606
MOD_GlcNHglycan	1	4	PF01048	0.682
MOD_GlcNHglycan	129	132	PF01048	0.733
MOD_GlcNHglycan	164	168	PF01048	0.780
MOD_GlcNHglycan	183	186	PF01048	0.709
MOD_GlcNHglycan	269	272	PF01048	0.475
MOD_GlcNHglycan	283	286	PF01048	0.433
MOD_GlcNHglycan	328	331	PF01048	0.646
MOD_GlcNHglycan	359	362	PF01048	0.556
MOD_GlcNHglycan	415	418	PF01048	0.482
MOD_GlcNHglycan	449	452	PF01048	0.691
MOD_GlcNHglycan	57	60	PF01048	0.740
MOD_GlcNHglycan	574	577	PF01048	0.625
MOD_GlcNHglycan	657	660	PF01048	0.668
MOD_GlcNHglycan	66	69	PF01048	0.524
MOD_GSK3_1	121	128	PF00069	0.682
MOD_GSK3_1	132	139	PF00069	0.628
MOD_GSK3_1	159	166	PF00069	0.826
MOD_GSK3_1	180	187	PF00069	0.657
MOD_GSK3_1	289	296	PF00069	0.720
MOD_GSK3_1	401	408	PF00069	0.499
MOD_GSK3_1	457	464	PF00069	0.787
MOD_GSK3_1	487	494	PF00069	0.748
MOD_GSK3_1	502	509	PF00069	0.552
MOD_GSK3_1	518	525	PF00069	0.584
MOD_GSK3_1	566	573	PF00069	0.723
MOD_GSK3_1	636	643	PF00069	0.574
MOD_GSK3_1	655	662	PF00069	0.550
MOD_GSK3_1	76	83	PF00069	0.647
MOD_LATS_1	459	465	PF00433	0.752
MOD_N-GLC_1	357	362	PF02516	0.560
MOD_N-GLC_1	363	368	PF02516	0.453
MOD_N-GLC_1	55	60	PF02516	0.715
MOD_N-GLC_1	716	721	PF02516	0.632
MOD_NEK2_1	180	185	PF00069	0.655
MOD_NEK2_1	394	399	PF00069	0.483
MOD_NEK2_1	412	417	PF00069	0.560
MOD_NEK2_1	487	492	PF00069	0.745
MOD_NEK2_1	5	10	PF00069	0.559
MOD_NEK2_1	650	655	PF00069	0.674
MOD_NEK2_1	722	727	PF00069	0.731
MOD_NEK2_1	76	81	PF00069	0.579
MOD_PIKK_1	136	142	PF00454	0.639
MOD_PIKK_1	527	533	PF00454	0.734
MOD_PIKK_1	563	569	PF00454	0.662
MOD_PK_1	294	300	PF00069	0.628
MOD_PKA_1	405	411	PF00069	0.511
MOD_PKA_2	22	28	PF00069	0.618
MOD_PKA_2	293	299	PF00069	0.619
MOD_PKA_2	405	411	PF00069	0.511
MOD_PKA_2	447	453	PF00069	0.715
MOD_PKA_2	681	687	PF00069	0.601
MOD_Plk_1	475	481	PF00069	0.662
MOD_Plk_1	716	722	PF00069	0.634
MOD_Plk_2-3	197	203	PF00069	0.465
MOD_Plk_2-3	640	646	PF00069	0.578
MOD_Plk_4	132	138	PF00069	0.693
MOD_Plk_4	270	276	PF00069	0.397
MOD_Plk_4	407	413	PF00069	0.507
MOD_Plk_4	475	481	PF00069	0.655
MOD_Plk_4	650	656	PF00069	0.580
MOD_Plk_4	69	75	PF00069	0.486
MOD_Plk_4	717	723	PF00069	0.718
MOD_ProDKin_1	122	128	PF00069	0.762
MOD_ProDKin_1	142	148	PF00069	0.753
MOD_ProDKin_1	289	295	PF00069	0.664
MOD_ProDKin_1	399	405	PF00069	0.528
MOD_ProDKin_1	488	494	PF00069	0.649
MOD_ProDKin_1	502	508	PF00069	0.686
MOD_ProDKin_1	83	89	PF00069	0.531
MOD_SUMO_for_1	613	616	PF00179	0.659
MOD_SUMO_rev_2	303	312	PF00179	0.646
MOD_SUMO_rev_2	616	622	PF00179	0.632
MOD_SUMO_rev_2	684	691	PF00179	0.624
TRG_DiLeu_BaEn_2	307	313	PF01217	0.656
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.523
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.566
TRG_ENDOCYTIC_2	26	29	PF00928	0.512
TRG_ENDOCYTIC_2	338	341	PF00928	0.436
TRG_ENDOCYTIC_2	558	561	PF00928	0.625
TRG_ENDOCYTIC_2	581	584	PF00928	0.608
TRG_ENDOCYTIC_2	73	76	PF00928	0.492
TRG_ER_diArg_1	443	445	PF00400	0.587
TRG_ER_diArg_1	533	536	PF00400	0.763
TRG_ER_diArg_1	99	102	PF00400	0.451
TRG_NES_CRM1_1	640	652	PF08389	0.615
TRG_NLS_MonoExtC_3	727	732	PF00514	0.723
TRG_NLS_MonoExtN_4	728	735	PF00514	0.737
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	247	252	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	592	597	PF00026	0.685

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFG5	Leptomonas seymouri	37%	98%
A4HMV4	Leishmania braziliensis	62%	100%
A4IBH5	Leishmania infantum	99%	100%
E9AFB1	Leishmania major	88%	100%
E9B6G6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%