Acyl-CoA dehydrogenase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyl-CoA dehydrogenase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IVB5_LEIDO

TriTrypDb:

LdBPK_352780.1 , LdCL_350032700 , LDHU3_35.3530

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IVB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IVB5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0003995	acyl-CoA dehydrogenase activity	5	10
GO:0005488	binding	1	10
GO:0016491	oxidoreductase activity	2	10
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0050660	flavin adenine dinucleotide binding	4	10
GO:0052890	oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor	4	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.387
CLV_NRD_NRD_1	127	129	PF00675	0.504
CLV_NRD_NRD_1	2	4	PF00675	0.654
CLV_NRD_NRD_1	287	289	PF00675	0.386
CLV_NRD_NRD_1	323	325	PF00675	0.386
CLV_PCSK_KEX2_1	127	129	PF00082	0.504
CLV_PCSK_KEX2_1	2	4	PF00082	0.654
CLV_PCSK_SKI1_1	133	137	PF00082	0.478
CLV_PCSK_SKI1_1	198	202	PF00082	0.386
CLV_PCSK_SKI1_1	374	378	PF00082	0.386
CLV_PCSK_SKI1_1	395	399	PF00082	0.483
CLV_PCSK_SKI1_1	63	67	PF00082	0.442
DEG_APCC_DBOX_1	127	135	PF00400	0.504
DEG_Nend_UBRbox_1	1	4	PF02207	0.627
DOC_CKS1_1	73	78	PF01111	0.447
DOC_MAPK_gen_1	2	8	PF00069	0.726
DOC_MAPK_gen_1	250	258	PF00069	0.447
DOC_MAPK_gen_1	324	333	PF00069	0.409
DOC_MAPK_MEF2A_6	250	258	PF00069	0.412
DOC_MAPK_MEF2A_6	98	107	PF00069	0.386
DOC_PP1_RVXF_1	351	358	PF00149	0.386
DOC_USP7_MATH_1	101	105	PF00917	0.409
DOC_USP7_MATH_1	211	215	PF00917	0.393
DOC_USP7_MATH_1	274	278	PF00917	0.498
DOC_USP7_MATH_1	7	11	PF00917	0.727
DOC_USP7_UBL2_3	129	133	PF12436	0.498
DOC_USP7_UBL2_3	159	163	PF12436	0.506
DOC_USP7_UBL2_3	289	293	PF12436	0.498
DOC_WW_Pin1_4	207	212	PF00397	0.425
DOC_WW_Pin1_4	403	408	PF00397	0.709
DOC_WW_Pin1_4	72	77	PF00397	0.447
LIG_14-3-3_CanoR_1	2	8	PF00244	0.654
LIG_14-3-3_CanoR_1	225	234	PF00244	0.435
LIG_14-3-3_CanoR_1	37	42	PF00244	0.447
LIG_BRCT_BRCA1_1	150	154	PF00533	0.386
LIG_CaM_IQ_9	387	402	PF13499	0.504
LIG_Clathr_ClatBox_1	70	74	PF01394	0.386
LIG_deltaCOP1_diTrp_1	356	363	PF00928	0.412
LIG_FHA_1	104	110	PF00498	0.498
LIG_FHA_1	199	205	PF00498	0.386
LIG_FHA_1	208	214	PF00498	0.386
LIG_FHA_1	227	233	PF00498	0.251
LIG_FHA_1	383	389	PF00498	0.386
LIG_FHA_1	40	46	PF00498	0.505
LIG_FHA_2	156	162	PF00498	0.379
LIG_FHA_2	24	30	PF00498	0.447
LIG_FHA_2	73	79	PF00498	0.447
LIG_LIR_Gen_1	85	93	PF02991	0.386
LIG_LIR_Nem_3	194	200	PF02991	0.386
LIG_LIR_Nem_3	85	90	PF02991	0.386
LIG_Pex14_1	181	185	PF04695	0.504
LIG_Pex14_2	294	298	PF04695	0.361
LIG_Pex14_2	363	367	PF04695	0.447
LIG_PTB_Apo_2	112	119	PF02174	0.386
LIG_SH2_CRK	197	201	PF00017	0.386
LIG_SH2_STAP1	305	309	PF00017	0.412
LIG_SH2_STAT3	284	287	PF00017	0.386
LIG_SH2_STAT5	130	133	PF00017	0.447
LIG_SH2_STAT5	175	178	PF00017	0.455
LIG_SH2_STAT5	24	27	PF00017	0.600
LIG_SH2_STAT5	284	287	PF00017	0.386
LIG_SH2_STAT5	341	344	PF00017	0.498
LIG_SH3_3	15	21	PF00018	0.651
LIG_SH3_3	234	240	PF00018	0.366
LIG_SUMO_SIM_anti_2	277	282	PF11976	0.498
LIG_SUMO_SIM_par_1	58	64	PF11976	0.556
LIG_SUMO_SIM_par_1	88	95	PF11976	0.402
LIG_TRAF2_1	92	95	PF00917	0.386
LIG_UBA3_1	387	395	PF00899	0.412
MOD_CK1_1	207	213	PF00069	0.498
MOD_CK1_1	405	411	PF00069	0.770
MOD_CK1_1	85	91	PF00069	0.393
MOD_CK2_1	155	161	PF00069	0.379
MOD_CK2_1	225	231	PF00069	0.386
MOD_CK2_1	23	29	PF00069	0.386
MOD_GlcNHglycan	148	151	PF01048	0.386
MOD_GlcNHglycan	407	410	PF01048	0.783
MOD_GlcNHglycan	9	12	PF01048	0.729
MOD_GSK3_1	142	149	PF00069	0.386
MOD_GSK3_1	187	194	PF00069	0.447
MOD_GSK3_1	207	214	PF00069	0.234
MOD_GSK3_1	401	408	PF00069	0.681
MOD_GSK3_1	82	89	PF00069	0.386
MOD_N-GLC_1	169	174	PF02516	0.386
MOD_N-GLC_1	320	325	PF02516	0.479
MOD_NEK2_1	1	6	PF00069	0.618
MOD_NEK2_1	174	179	PF00069	0.457
MOD_NEK2_1	32	37	PF00069	0.386
MOD_NEK2_1	39	44	PF00069	0.386
MOD_NEK2_1	86	91	PF00069	0.394
MOD_NEK2_2	82	87	PF00069	0.412
MOD_PKA_1	162	168	PF00069	0.498
MOD_PKA_2	1	7	PF00069	0.629
MOD_PKA_2	224	230	PF00069	0.435
MOD_Plk_4	109	115	PF00069	0.406
MOD_Plk_4	20	26	PF00069	0.489
MOD_Plk_4	211	217	PF00069	0.498
MOD_Plk_4	341	347	PF00069	0.510
MOD_Plk_4	383	389	PF00069	0.421
MOD_Plk_4	82	88	PF00069	0.386
MOD_ProDKin_1	207	213	PF00069	0.425
MOD_ProDKin_1	403	409	PF00069	0.714
MOD_ProDKin_1	72	78	PF00069	0.447
MOD_SUMO_rev_2	214	222	PF00179	0.464
MOD_SUMO_rev_2	27	32	PF00179	0.490
MOD_SUMO_rev_2	370	378	PF00179	0.386
MOD_SUMO_rev_2	48	57	PF00179	0.441
TRG_ENDOCYTIC_2	197	200	PF00928	0.411
TRG_ER_diArg_1	1	3	PF00400	0.657
TRG_ER_diArg_1	46	49	PF00400	0.448
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXP9	Leptomonas seymouri	35%	99%
A0A0N1I6H4	Leptomonas seymouri	31%	100%
A0A0N1IMF9	Leptomonas seymouri	86%	100%
A0A0S4IM43	Bodo saltans	34%	100%
A0A0S4IY66	Bodo saltans	30%	100%
A0A0S4J7W1	Bodo saltans	33%	100%
A0A0S4JFP0	Bodo saltans	72%	100%
A0A0S4KIH4	Bodo saltans	36%	100%
A0A1X0NL04	Trypanosomatidae	33%	100%
A0A1X0P4C4	Trypanosomatidae	34%	100%
A0A1X0P5J1	Trypanosomatidae	68%	97%
A0A3R7LB59	Trypanosoma rangeli	32%	100%
A0A3R7LXK2	Trypanosoma rangeli	28%	100%
A0A3S5H5T1	Leishmania donovani	36%	99%
A0A3S7X0K3	Leishmania donovani	34%	100%
A0A422N1U9	Trypanosoma rangeli	32%	100%
A0A422NKY7	Trypanosoma rangeli	24%	66%
A4H4Q0	Leishmania braziliensis	35%	100%
A4H4Q2	Leishmania braziliensis	35%	100%
A4HFL6	Leishmania braziliensis	33%	100%
A4HMU0	Leishmania braziliensis	92%	100%
A4HSY0	Leishmania infantum	36%	100%
A4I353	Leishmania infantum	34%	100%
A4IBE1	Leishmania infantum	100%	100%
A5A6I0	Pan troglodytes	35%	98%
A8WP91	Caenorhabditis briggsae	33%	100%
A8XNF0	Caenorhabditis briggsae	35%	99%
B2AM55	Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)	23%	96%
B9U6P5	Variovorax paradoxus	29%	100%
C3UVB0	Desulfococcus multivorans	34%	100%
D0A5U7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D3JV03	Cereibacter sphaeroides	30%	75%
E9AD70	Leishmania major	34%	100%
E9AF97	Leishmania major	98%	100%
E9AKW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AYZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B6F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
F8GVD3	Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)	27%	100%
G3KIM8	Anaerotignum propionicum	37%	100%
H6LGM6	Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1)	36%	100%
I6Y3Q0	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	22%	100%
J7TF92	Clostridium sporogenes (strain ATCC 15579)	37%	100%
K4L7X3	Advenella mimigardefordensis (strain DSM 17166 / LMG 22922 / DPN7)	31%	100%
O32176	Bacillus subtilis (strain 168)	33%	69%
O34421	Bacillus subtilis (strain 168)	38%	100%
O53666	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	25%	67%
O54143	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	31%	100%
P08503	Rattus norvegicus	35%	98%
P0A9U8	Escherichia coli (strain K12)	27%	100%
P0A9U9	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	27%	100%
P0A9V0	Escherichia coli O157:H7	27%	100%
P11310	Homo sapiens	35%	98%
P12007	Rattus norvegicus	33%	97%
P15650	Rattus norvegicus	28%	96%
P15651	Rattus norvegicus	39%	100%
P16219	Homo sapiens	38%	100%
P26440	Homo sapiens	32%	97%
P28330	Homo sapiens	29%	96%
P34275	Caenorhabditis elegans	31%	100%
P41367	Sus scrofa	36%	98%
P45857	Bacillus subtilis (strain 168)	42%	100%
P45867	Bacillus subtilis (strain 168)	40%	100%
P45952	Mus musculus	36%	98%
P45954	Homo sapiens	52%	95%
P46703	Mycobacterium leprae (strain TN)	37%	100%
P51174	Mus musculus	29%	96%
P52042	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	40%	100%
P63428	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	37%	100%
P70584	Rattus norvegicus	53%	95%
P71857	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	22%	100%
P79273	Sus scrofa	39%	100%
P79274	Sus scrofa	29%	96%
P81140	Sus scrofa	28%	100%
P96608	Bacillus subtilis (strain 168)	24%	100%
P96831	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
P9WQG0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	37%	100%
P9WQG1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	37%	100%
P9WQG2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	28%	100%
P9WQG3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
Q06319	Megasphaera elsdenii	40%	100%
Q07417	Mus musculus	39%	100%
Q0AVA8	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	27%	68%
Q0AVM4	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	26%	68%
Q0NXR6	Bos taurus	32%	99%
Q13PC1	Paraburkholderia xenovorans (strain LB400)	29%	100%
Q1BBA3	Mycobacterium sp. (strain MCS)	23%	100%
Q20772	Caenorhabditis elegans	28%	100%
Q22347	Caenorhabditis elegans	34%	99%
Q2KHZ9	Bos taurus	29%	94%
Q2LQN9	Syntrophus aciditrophicus (strain SB)	37%	100%
Q2LQP0	Syntrophus aciditrophicus (strain SB)	31%	100%
Q3SZB4	Bos taurus	36%	98%
Q3SZI8	Bos taurus	34%	97%
Q3ZBF6	Bos taurus	38%	100%
Q4KCY6	Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)	29%	100%
Q4QIY9	Leishmania major	36%	100%
Q50LG2	Alternaria alternata	25%	95%
Q54IM8	Dictyostelium discoideum	36%	99%
Q54R47	Dictyostelium discoideum	30%	98%
Q54RR5	Dictyostelium discoideum	54%	100%
Q5EAD4	Bos taurus	51%	95%
Q5LLW7	Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)	26%	70%
Q5RAS0	Pongo abelii	38%	100%
Q5RBD5	Pongo abelii	32%	97%
Q5RF40	Pongo abelii	52%	95%
Q5W271	Serratia sp. (strain ATCC 39006)	25%	100%
Q60759	Mus musculus	29%	94%
Q60HI0	Macaca fascicularis	29%	96%
Q73ZP8	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	22%	100%
Q75IM9	Oryza sativa subsp. japonica	34%	100%
Q7U0Y2	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	28%	100%
Q8HXX8	Macaca fascicularis	28%	94%
Q8HXY8	Macaca fascicularis	34%	98%
Q8X1D8	Fusarium oxysporum	21%	94%
Q92947	Homo sapiens	29%	94%
Q96329	Arabidopsis thaliana	29%	94%
Q9D7B6	Mus musculus	32%	100%
Q9DBL1	Mus musculus	54%	95%
Q9FS87	Solanum tuberosum	33%	100%
Q9FS88	Solanum tuberosum	34%	100%
Q9H845	Homo sapiens	36%	66%
Q9JHI5	Mus musculus	33%	97%
Q9KJE8	Thauera aromatica	29%	100%
Q9NUZ1	Homo sapiens	24%	75%
Q9SWG0	Arabidopsis thaliana	33%	100%
Q9UKU7	Homo sapiens	33%	99%
Q9VSA3	Drosophila melanogaster	36%	98%
V5B8K6	Trypanosoma cruzi	33%	100%
V5BKL8	Trypanosoma cruzi	31%	98%
V5BY79	Trypanosoma cruzi	69%	100%
V5DCV2	Trypanosoma cruzi	25%	66%
V5DPQ5	Trypanosoma cruzi	33%	100%