Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IV80_LEIDO

TriTrypDb:

LdBPK_351990.1 , LdCL_350025100 , LDHU3_35.2600

Length:

914

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IV80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IV80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.571
CLV_C14_Caspase3-7	621	625	PF00656	0.632
CLV_NRD_NRD_1	15	17	PF00675	0.655
CLV_NRD_NRD_1	3	5	PF00675	0.665
CLV_NRD_NRD_1	436	438	PF00675	0.734
CLV_NRD_NRD_1	565	567	PF00675	0.799
CLV_NRD_NRD_1	643	645	PF00675	0.594
CLV_NRD_NRD_1	658	660	PF00675	0.629
CLV_NRD_NRD_1	777	779	PF00675	0.570
CLV_NRD_NRD_1	800	802	PF00675	0.615
CLV_NRD_NRD_1	871	873	PF00675	0.672
CLV_PCSK_FUR_1	352	356	PF00082	0.688
CLV_PCSK_FUR_1	434	438	PF00082	0.730
CLV_PCSK_FUR_1	798	802	PF00082	0.614
CLV_PCSK_KEX2_1	15	17	PF00082	0.709
CLV_PCSK_KEX2_1	354	356	PF00082	0.689
CLV_PCSK_KEX2_1	436	438	PF00082	0.734
CLV_PCSK_KEX2_1	565	567	PF00082	0.725
CLV_PCSK_KEX2_1	585	587	PF00082	0.576
CLV_PCSK_KEX2_1	658	660	PF00082	0.629
CLV_PCSK_KEX2_1	776	778	PF00082	0.571
CLV_PCSK_KEX2_1	800	802	PF00082	0.615
CLV_PCSK_KEX2_1	871	873	PF00082	0.672
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.650
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.697
CLV_PCSK_PC7_1	773	779	PF00082	0.673
CLV_PCSK_SKI1_1	18	22	PF00082	0.726
CLV_PCSK_SKI1_1	241	245	PF00082	0.670
CLV_PCSK_SKI1_1	256	260	PF00082	0.410
CLV_PCSK_SKI1_1	388	392	PF00082	0.545
CLV_PCSK_SKI1_1	565	569	PF00082	0.802
CLV_PCSK_SKI1_1	589	593	PF00082	0.604
CLV_PCSK_SKI1_1	597	601	PF00082	0.529
CLV_PCSK_SKI1_1	632	636	PF00082	0.463
CLV_PCSK_SKI1_1	685	689	PF00082	0.456
CLV_PCSK_SKI1_1	851	855	PF00082	0.683
CLV_PCSK_SKI1_1	87	91	PF00082	0.775
CLV_PCSK_SKI1_1	97	101	PF00082	0.629
DEG_APCC_DBOX_1	684	692	PF00400	0.493
DEG_COP1_1	442	452	PF00400	0.632
DEG_Nend_Nbox_1	1	3	PF02207	0.679
DEG_SCF_FBW7_2	88	94	PF00400	0.713
DEG_SPOP_SBC_1	743	747	PF00917	0.751
DOC_ANK_TNKS_1	289	296	PF00023	0.564
DOC_CDC14_PxL_1	717	725	PF14671	0.514
DOC_CKS1_1	834	839	PF01111	0.661
DOC_CKS1_1	88	93	PF01111	0.749
DOC_CYCLIN_yClb3_PxF_3	322	328	PF00134	0.690
DOC_CYCLIN_yCln2_LP_2	85	91	PF00134	0.485
DOC_MAPK_gen_1	385	394	PF00069	0.512
DOC_MAPK_gen_1	644	652	PF00069	0.658
DOC_MAPK_gen_1	668	676	PF00069	0.556
DOC_MAPK_gen_1	773	781	PF00069	0.678
DOC_MAPK_MEF2A_6	230	239	PF00069	0.650
DOC_MAPK_MEF2A_6	644	652	PF00069	0.686
DOC_MAPK_MEF2A_6	698	707	PF00069	0.495
DOC_MAPK_NFAT4_5	645	653	PF00069	0.693
DOC_PP1_RVXF_1	352	359	PF00149	0.685
DOC_PP1_SILK_1	213	218	PF00149	0.579
DOC_PP2B_LxvP_1	547	550	PF13499	0.714
DOC_PP2B_LxvP_1	74	77	PF13499	0.689
DOC_PP4_FxxP_1	752	755	PF00568	0.662
DOC_USP7_MATH_1	160	164	PF00917	0.699
DOC_USP7_MATH_1	228	232	PF00917	0.635
DOC_USP7_MATH_1	263	267	PF00917	0.676
DOC_USP7_MATH_1	282	286	PF00917	0.361
DOC_USP7_MATH_1	288	292	PF00917	0.659
DOC_USP7_MATH_1	48	52	PF00917	0.685
DOC_USP7_MATH_1	573	577	PF00917	0.727
DOC_USP7_MATH_1	604	608	PF00917	0.738
DOC_USP7_MATH_1	75	79	PF00917	0.750
DOC_USP7_UBL2_3	585	589	PF12436	0.779
DOC_WW_Pin1_4	151	156	PF00397	0.582
DOC_WW_Pin1_4	203	208	PF00397	0.618
DOC_WW_Pin1_4	231	236	PF00397	0.695
DOC_WW_Pin1_4	24	29	PF00397	0.718
DOC_WW_Pin1_4	333	338	PF00397	0.743
DOC_WW_Pin1_4	439	444	PF00397	0.679
DOC_WW_Pin1_4	52	57	PF00397	0.681
DOC_WW_Pin1_4	735	740	PF00397	0.711
DOC_WW_Pin1_4	746	751	PF00397	0.600
DOC_WW_Pin1_4	833	838	PF00397	0.650
DOC_WW_Pin1_4	87	92	PF00397	0.750
LIG_14-3-3_CanoR_1	209	216	PF00244	0.690
LIG_14-3-3_CanoR_1	230	235	PF00244	0.665
LIG_14-3-3_CanoR_1	355	359	PF00244	0.579
LIG_14-3-3_CanoR_1	632	638	PF00244	0.530
LIG_14-3-3_CanoR_1	644	649	PF00244	0.586
LIG_14-3-3_CanoR_1	716	721	PF00244	0.514
LIG_14-3-3_CanoR_1	851	857	PF00244	0.641
LIG_Actin_WH2_2	194	211	PF00022	0.734
LIG_Actin_WH2_2	495	512	PF00022	0.658
LIG_Actin_WH2_2	669	687	PF00022	0.543
LIG_BIR_III_4	271	275	PF00653	0.560
LIG_BIR_III_4	98	102	PF00653	0.525
LIG_BRCT_BRCA1_1	162	166	PF00533	0.681
LIG_BRCT_BRCA1_1	444	448	PF00533	0.650
LIG_BRCT_BRCA1_1	748	752	PF00533	0.647
LIG_CaM_NSCaTE_8	342	349	PF13499	0.565
LIG_CtBP_PxDLS_1	704	709	PF00389	0.600
LIG_deltaCOP1_diTrp_1	157	161	PF00928	0.686
LIG_deltaCOP1_diTrp_1	305	312	PF00928	0.579
LIG_eIF4E_1	717	723	PF01652	0.510
LIG_FHA_1	304	310	PF00498	0.688
LIG_FHA_1	389	395	PF00498	0.615
LIG_FHA_1	509	515	PF00498	0.580
LIG_FHA_1	551	557	PF00498	0.715
LIG_FHA_1	633	639	PF00498	0.453
LIG_FHA_1	65	71	PF00498	0.649
LIG_FHA_1	717	723	PF00498	0.510
LIG_FHA_1	828	834	PF00498	0.684
LIG_FHA_1	859	865	PF00498	0.729
LIG_FHA_1	897	903	PF00498	0.781
LIG_FHA_1	907	913	PF00498	0.622
LIG_FHA_2	396	402	PF00498	0.524
LIG_FHA_2	517	523	PF00498	0.642
LIG_FHA_2	762	768	PF00498	0.608
LIG_FHA_2	816	822	PF00498	0.771
LIG_GBD_Chelix_1	420	428	PF00786	0.620
LIG_LIR_Apic_2	749	755	PF02991	0.658
LIG_LIR_Gen_1	305	315	PF02991	0.583
LIG_LIR_Gen_1	725	734	PF02991	0.550
LIG_LIR_Nem_3	104	109	PF02991	0.588
LIG_LIR_Nem_3	305	311	PF02991	0.580
LIG_LIR_Nem_3	477	482	PF02991	0.552
LIG_LIR_Nem_3	714	720	PF02991	0.520
LIG_LIR_Nem_3	725	730	PF02991	0.523
LIG_MAD2	80	88	PF02301	0.482
LIG_MYND_1	323	327	PF01753	0.657
LIG_NRBOX	126	132	PF00104	0.726
LIG_NRBOX	462	468	PF00104	0.582
LIG_NRBOX	485	491	PF00104	0.472
LIG_NRBOX	633	639	PF00104	0.475
LIG_NRBOX	687	693	PF00104	0.510
LIG_PCNA_yPIPBox_3	835	846	PF02747	0.649
LIG_SH2_CRK	718	722	PF00017	0.508
LIG_SH2_NCK_1	496	500	PF00017	0.627
LIG_SH2_NCK_1	859	863	PF00017	0.656
LIG_SH2_SRC	794	797	PF00017	0.699
LIG_SH2_STAP1	459	463	PF00017	0.460
LIG_SH2_STAP1	496	500	PF00017	0.627
LIG_SH2_STAT5	465	468	PF00017	0.489
LIG_SH2_STAT5	479	482	PF00017	0.510
LIG_SH2_STAT5	696	699	PF00017	0.619
LIG_SH2_STAT5	718	721	PF00017	0.512
LIG_SH2_STAT5	727	730	PF00017	0.527
LIG_SH3_3	117	123	PF00018	0.550
LIG_SH3_3	23	29	PF00018	0.642
LIG_SH3_3	232	238	PF00018	0.723
LIG_SH3_3	320	326	PF00018	0.686
LIG_SH3_3	432	438	PF00018	0.723
LIG_SH3_3	576	582	PF00018	0.587
LIG_SH3_3	649	655	PF00018	0.688
LIG_SH3_3	727	733	PF00018	0.648
LIG_SH3_3	786	792	PF00018	0.592
LIG_SH3_3	811	817	PF00018	0.836
LIG_SH3_3	831	837	PF00018	0.465
LIG_SH3_3	85	91	PF00018	0.719
LIG_SH3_3	899	905	PF00018	0.697
LIG_SUMO_SIM_anti_2	60	69	PF11976	0.730
LIG_SUMO_SIM_par_1	635	643	PF11976	0.497
LIG_SUMO_SIM_par_1	880	886	PF11976	0.794
LIG_TRAF2_1	91	94	PF00917	0.708
LIG_TYR_ITIM	715	720	PF00017	0.522
LIG_UBA3_1	637	645	PF00899	0.533
MOD_CDC14_SPxK_1	206	209	PF00782	0.707
MOD_CDK_SPxK_1	203	209	PF00069	0.715
MOD_CDK_SPxxK_3	833	840	PF00069	0.615
MOD_CK1_1	231	237	PF00069	0.689
MOD_CK1_1	254	260	PF00069	0.651
MOD_CK1_1	266	272	PF00069	0.480
MOD_CK1_1	27	33	PF00069	0.713
MOD_CK1_1	310	316	PF00069	0.628
MOD_CK1_1	442	448	PF00069	0.663
MOD_CK1_1	475	481	PF00069	0.644
MOD_CK1_1	491	497	PF00069	0.366
MOD_CK1_1	66	72	PF00069	0.723
MOD_CK1_1	745	751	PF00069	0.725
MOD_CK1_1	822	828	PF00069	0.783
MOD_CK1_1	858	864	PF00069	0.701
MOD_CK2_1	122	128	PF00069	0.645
MOD_CK2_1	129	135	PF00069	0.620
MOD_CK2_1	395	401	PF00069	0.535
MOD_CK2_1	516	522	PF00069	0.653
MOD_CK2_1	535	541	PF00069	0.303
MOD_CK2_1	633	639	PF00069	0.475
MOD_CK2_1	761	767	PF00069	0.622
MOD_CMANNOS	158	161	PF00535	0.599
MOD_Cter_Amidation	2	5	PF01082	0.716
MOD_Cter_Amidation	583	586	PF01082	0.705
MOD_GlcNHglycan	162	165	PF01048	0.635
MOD_GlcNHglycan	230	233	PF01048	0.749
MOD_GlcNHglycan	333	336	PF01048	0.694
MOD_GlcNHglycan	343	346	PF01048	0.661
MOD_GlcNHglycan	347	350	PF01048	0.655
MOD_GlcNHglycan	370	373	PF01048	0.649
MOD_GlcNHglycan	41	44	PF01048	0.615
MOD_GlcNHglycan	439	442	PF01048	0.803
MOD_GlcNHglycan	469	472	PF01048	0.552
MOD_GlcNHglycan	575	578	PF01048	0.800
MOD_GlcNHglycan	607	610	PF01048	0.611
MOD_GlcNHglycan	752	755	PF01048	0.798
MOD_GlcNHglycan	77	80	PF01048	0.752
MOD_GlcNHglycan	823	827	PF01048	0.787
MOD_GlcNHglycan	885	888	PF01048	0.748
MOD_GSK3_1	182	189	PF00069	0.753
MOD_GSK3_1	24	31	PF00069	0.766
MOD_GSK3_1	280	287	PF00069	0.664
MOD_GSK3_1	303	310	PF00069	0.615
MOD_GSK3_1	313	320	PF00069	0.651
MOD_GSK3_1	341	348	PF00069	0.686
MOD_GSK3_1	39	46	PF00069	0.506
MOD_GSK3_1	444	451	PF00069	0.727
MOD_GSK3_1	48	55	PF00069	0.687
MOD_GSK3_1	484	491	PF00069	0.519
MOD_GSK3_1	550	557	PF00069	0.691
MOD_GSK3_1	605	612	PF00069	0.613
MOD_GSK3_1	640	647	PF00069	0.587
MOD_GSK3_1	742	749	PF00069	0.753
MOD_GSK3_1	815	822	PF00069	0.799
MOD_GSK3_1	83	90	PF00069	0.737
MOD_GSK3_1	847	854	PF00069	0.632
MOD_GSK3_1	883	890	PF00069	0.708
MOD_GSK3_1	892	899	PF00069	0.721
MOD_GSK3_1	906	913	PF00069	0.567
MOD_N-GLC_1	484	489	PF02516	0.538
MOD_N-GLC_1	605	610	PF02516	0.615
MOD_N-GLC_1	787	792	PF02516	0.608
MOD_NEK2_1	166	171	PF00069	0.629
MOD_NEK2_1	208	213	PF00069	0.693
MOD_NEK2_1	280	285	PF00069	0.640
MOD_NEK2_1	395	400	PF00069	0.563
MOD_NEK2_1	402	407	PF00069	0.489
MOD_NEK2_1	466	471	PF00069	0.508
MOD_NEK2_1	488	493	PF00069	0.490
MOD_NEK2_1	498	503	PF00069	0.513
MOD_NEK2_1	633	638	PF00069	0.467
MOD_NEK2_1	640	645	PF00069	0.557
MOD_NEK2_1	703	708	PF00069	0.485
MOD_NEK2_1	722	727	PF00069	0.509
MOD_NEK2_1	847	852	PF00069	0.592
MOD_PIKK_1	222	228	PF00454	0.728
MOD_PIKK_1	310	316	PF00454	0.579
MOD_PIKK_1	317	323	PF00454	0.677
MOD_PIKK_1	395	401	PF00454	0.535
MOD_PIKK_1	488	494	PF00454	0.520
MOD_PIKK_1	698	704	PF00454	0.477
MOD_PIKK_1	733	739	PF00454	0.533
MOD_PIKK_1	887	893	PF00454	0.618
MOD_PIKK_1	89	95	PF00454	0.668
MOD_PKA_1	354	360	PF00069	0.677
MOD_PKA_1	644	650	PF00069	0.655
MOD_PKA_2	208	214	PF00069	0.679
MOD_PKA_2	303	309	PF00069	0.688
MOD_PKA_2	354	360	PF00069	0.575
MOD_PKA_2	380	386	PF00069	0.551
MOD_PKA_2	475	481	PF00069	0.566
MOD_PKA_2	896	902	PF00069	0.685
MOD_PKB_1	16	24	PF00069	0.768
MOD_Plk_1	263	269	PF00069	0.682
MOD_Plk_1	484	490	PF00069	0.508
MOD_Plk_1	662	668	PF00069	0.606
MOD_Plk_2-3	618	624	PF00069	0.649
MOD_Plk_2-3	761	767	PF00069	0.622
MOD_Plk_4	241	247	PF00069	0.668
MOD_Plk_4	303	309	PF00069	0.604
MOD_Plk_4	444	450	PF00069	0.699
MOD_Plk_4	475	481	PF00069	0.644
MOD_Plk_4	484	490	PF00069	0.515
MOD_Plk_4	491	497	PF00069	0.429
MOD_Plk_4	498	504	PF00069	0.411
MOD_Plk_4	508	514	PF00069	0.494
MOD_Plk_4	633	639	PF00069	0.471
MOD_Plk_4	687	693	PF00069	0.471
MOD_Plk_4	703	709	PF00069	0.495
MOD_Plk_4	722	728	PF00069	0.515
MOD_ProDKin_1	151	157	PF00069	0.584
MOD_ProDKin_1	203	209	PF00069	0.613
MOD_ProDKin_1	231	237	PF00069	0.689
MOD_ProDKin_1	24	30	PF00069	0.717
MOD_ProDKin_1	333	339	PF00069	0.742
MOD_ProDKin_1	439	445	PF00069	0.674
MOD_ProDKin_1	52	58	PF00069	0.682
MOD_ProDKin_1	735	741	PF00069	0.718
MOD_ProDKin_1	746	752	PF00069	0.600
MOD_ProDKin_1	833	839	PF00069	0.647
MOD_ProDKin_1	87	93	PF00069	0.751
TRG_DiLeu_BaEn_1	126	131	PF01217	0.641
TRG_DiLeu_BaEn_1	595	600	PF01217	0.692
TRG_DiLeu_BaEn_4	595	601	PF01217	0.654
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.606
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.547
TRG_DiLeu_BaLyEn_6	629	634	PF01217	0.532
TRG_DiLeu_BaLyEn_6	718	723	PF01217	0.504
TRG_DiLeu_LyEn_5	126	131	PF01217	0.728
TRG_ENDOCYTIC_2	106	109	PF00928	0.679
TRG_ENDOCYTIC_2	459	462	PF00928	0.461
TRG_ENDOCYTIC_2	717	720	PF00928	0.512
TRG_ENDOCYTIC_2	727	730	PF00928	0.527
TRG_ER_diArg_1	14	16	PF00400	0.658
TRG_ER_diArg_1	434	437	PF00400	0.731
TRG_ER_diArg_1	473	476	PF00400	0.549
TRG_ER_diArg_1	657	659	PF00400	0.629
TRG_ER_diArg_1	775	778	PF00400	0.570
TRG_ER_diArg_1	871	873	PF00400	0.672
TRG_Pf-PMV_PEXEL_1	659	663	PF00026	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA60	Leptomonas seymouri	48%	99%
A4HMM0	Leishmania braziliensis	74%	100%
A4IB98	Leishmania infantum	99%	100%
E9AF22	Leishmania major	93%	100%
E9B678	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%