Ubiquinol-cytochrome c reductase, iron-sulfur subunit

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rieske iron-sulfur protein, mitochondrial precursor, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IV54_LEIDO

TriTrypDb:

LdBPK_351540.1 , LdCL_350020300 , LDHU3_35.2060

Length:

297

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), reiske iron-sulfur

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005739	mitochondrion	5	1
GO:0005743	mitochondrial inner membrane	5	2
GO:0005750	mitochondrial respiratory chain complex III	4	1
GO:0019866	organelle inner membrane	4	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045275	respiratory chain complex III	4	1
GO:0070069	cytochrome complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1
GO:0070469	respirasome	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IV54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IV54

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	7	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0019646	aerobic electron transport chain	6	1
GO:0022900	electron transport chain	4	1
GO:0022904	respiratory electron transport chain	5	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005215	transporter activity	1	12
GO:0005488	binding	1	12
GO:0008121	ubiquinol-cytochrome-c reductase activity	4	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0009055	electron transfer activity	3	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015078	proton transmembrane transporter activity	5	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0015399	primary active transmembrane transporter activity	4	12
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	5	12
GO:0016491	oxidoreductase activity	2	12
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	3	12
GO:0022804	active transmembrane transporter activity	3	12
GO:0022853	active monoatomic ion transmembrane transporter activity	4	12
GO:0022857	transmembrane transporter activity	2	12
GO:0022890	inorganic cation transmembrane transporter activity	4	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0051536	iron-sulfur cluster binding	3	12
GO:0051537	2 iron, 2 sulfur cluster binding	4	12
GO:0051540	metal cluster binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.353
CLV_NRD_NRD_1	198	200	PF00675	0.465
CLV_NRD_NRD_1	228	230	PF00675	0.435
CLV_NRD_NRD_1	3	5	PF00675	0.398
CLV_PCSK_KEX2_1	198	200	PF00082	0.440
CLV_PCSK_KEX2_1	228	230	PF00082	0.435
CLV_PCSK_KEX2_1	3	5	PF00082	0.398
CLV_PCSK_PC7_1	224	230	PF00082	0.435
CLV_PCSK_SKI1_1	115	119	PF00082	0.381
CLV_PCSK_SKI1_1	192	196	PF00082	0.444
CLV_PCSK_SKI1_1	202	206	PF00082	0.434
CLV_PCSK_SKI1_1	60	64	PF00082	0.438
DEG_Nend_Nbox_1	1	3	PF02207	0.620
DOC_CKS1_1	208	213	PF01111	0.283
DOC_MAPK_DCC_7	269	279	PF00069	0.240
DOC_MAPK_gen_1	14	22	PF00069	0.641
DOC_MAPK_gen_1	228	237	PF00069	0.289
DOC_MAPK_MEF2A_6	14	22	PF00069	0.635
DOC_MAPK_MEF2A_6	228	237	PF00069	0.257
DOC_PP2B_LxvP_1	279	282	PF13499	0.240
DOC_PP4_FxxP_1	255	258	PF00568	0.240
DOC_PP4_FxxP_1	45	48	PF00568	0.600
DOC_PP4_MxPP_1	46	49	PF00568	0.673
DOC_USP7_MATH_1	136	140	PF00917	0.278
DOC_USP7_MATH_1	16	20	PF00917	0.706
DOC_USP7_MATH_1	162	166	PF00917	0.353
DOC_USP7_MATH_1	37	41	PF00917	0.589
DOC_USP7_UBL2_3	115	119	PF12436	0.581
DOC_WW_Pin1_4	207	212	PF00397	0.266
LIG_14-3-3_CanoR_1	129	137	PF00244	0.553
LIG_14-3-3_CanoR_1	17	21	PF00244	0.679
LIG_14-3-3_CanoR_1	182	188	PF00244	0.351
LIG_14-3-3_CanoR_1	198	204	PF00244	0.184
LIG_14-3-3_CanoR_1	3	7	PF00244	0.616
LIG_BRCT_BRCA1_1	18	22	PF00533	0.640
LIG_BRCT_BRCA1_1	41	45	PF00533	0.604
LIG_BRCT_BRCA1_2	41	47	PF00533	0.608
LIG_deltaCOP1_diTrp_1	39	45	PF00928	0.593
LIG_FHA_1	183	189	PF00498	0.314
LIG_FHA_1	93	99	PF00498	0.622
LIG_FHA_2	30	36	PF00498	0.612
LIG_FHA_2	72	78	PF00498	0.618
LIG_FHA_2	80	86	PF00498	0.621
LIG_GBD_Chelix_1	233	241	PF00786	0.451
LIG_LIR_Apic_2	42	48	PF02991	0.599
LIG_LIR_Nem_3	19	25	PF02991	0.655
LIG_LIR_Nem_3	249	255	PF02991	0.265
LIG_LIR_Nem_3	55	61	PF02991	0.635
LIG_PCNA_yPIPBox_3	131	145	PF02747	0.475
LIG_Pex14_1	108	112	PF04695	0.541
LIG_Pex14_1	41	45	PF04695	0.604
LIG_Pex14_2	2	6	PF04695	0.716
LIG_Pex14_2	252	256	PF04695	0.265
LIG_PTB_Apo_2	250	257	PF02174	0.283
LIG_REV1ctd_RIR_1	110	119	PF16727	0.561
LIG_SH2_CRK	151	155	PF00017	0.278
LIG_SH2_NCK_1	64	68	PF00017	0.578
LIG_SH2_SRC	264	267	PF00017	0.342
LIG_SH2_STAP1	103	107	PF00017	0.576
LIG_SH2_STAT3	158	161	PF00017	0.343
LIG_SH2_STAT5	158	161	PF00017	0.331
LIG_SH3_3	156	162	PF00018	0.330
LIG_SH3_3	241	247	PF00018	0.319
LIG_SUMO_SIM_par_1	233	239	PF11976	0.251
MOD_CK1_1	5	11	PF00069	0.647
MOD_CK2_1	71	77	PF00069	0.607
MOD_CK2_1	79	85	PF00069	0.610
MOD_GlcNHglycan	138	141	PF01048	0.293
MOD_GlcNHglycan	199	202	PF01048	0.479
MOD_GlcNHglycan	212	215	PF01048	0.406
MOD_GlcNHglycan	265	269	PF01048	0.447
MOD_GlcNHglycan	50	53	PF01048	0.483
MOD_GlcNHglycan	7	10	PF01048	0.447
MOD_GSK3_1	48	55	PF00069	0.699
MOD_NEK2_1	10	15	PF00069	0.618
MOD_NEK2_1	2	7	PF00069	0.632
MOD_PKA_2	130	136	PF00069	0.569
MOD_PKA_2	16	22	PF00069	0.680
MOD_PKA_2	197	203	PF00069	0.265
MOD_PKA_2	2	8	PF00069	0.607
MOD_Plk_1	103	109	PF00069	0.548
MOD_Plk_1	288	294	PF00069	0.299
MOD_Plk_2-3	217	223	PF00069	0.342
MOD_Plk_2-3	39	45	PF00069	0.593
MOD_Plk_4	103	109	PF00069	0.558
MOD_Plk_4	16	22	PF00069	0.624
MOD_Plk_4	162	168	PF00069	0.335
MOD_Plk_4	183	189	PF00069	0.267
MOD_Plk_4	288	294	PF00069	0.314
MOD_ProDKin_1	207	213	PF00069	0.266
TRG_ENDOCYTIC_2	151	154	PF00928	0.308
TRG_ENDOCYTIC_2	284	287	PF00928	0.313
TRG_ER_diArg_1	129	132	PF00400	0.554
TRG_ER_diArg_1	197	199	PF00400	0.262
TRG_ER_diArg_1	2	4	PF00400	0.603
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.578
TRG_PTS2	1	25	PF00400	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P592	Leptomonas seymouri	90%	100%
A0A0S4J243	Bodo saltans	72%	100%
A0A1X0P5Z9	Trypanosomatidae	84%	100%
A0A422NQ65	Trypanosoma rangeli	84%	100%
A4HMH5	Leishmania braziliensis	97%	100%
A4IB55	Leishmania infantum	100%	100%
C9ZZG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	84%	100%
E9AEX6	Leishmania major	99%	100%
E9B632	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q69BJ6	Symphalangus syndactylus	37%	100%
Q69BK5	Pan troglodytes	36%	100%
Q69BK6	Pan paniscus	36%	100%
V5DKE1	Trypanosoma cruzi	84%	100%