Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IV47_LEIDO

TriTrypDb:

LdBPK_351370.1 , LdCL_350018600 , LDHU3_35.1800

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IV47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IV47

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.717
CLV_C14_Caspase3-7	135	139	PF00656	0.763
CLV_C14_Caspase3-7	184	188	PF00656	0.798
CLV_C14_Caspase3-7	267	271	PF00656	0.793
CLV_C14_Caspase3-7	381	385	PF00656	0.601
CLV_NRD_NRD_1	29	31	PF00675	0.511
CLV_NRD_NRD_1	298	300	PF00675	0.686
CLV_NRD_NRD_1	387	389	PF00675	0.533
CLV_NRD_NRD_1	397	399	PF00675	0.513
CLV_NRD_NRD_1	417	419	PF00675	0.657
CLV_PCSK_FUR_1	426	430	PF00082	0.622
CLV_PCSK_FUR_1	445	449	PF00082	0.448
CLV_PCSK_KEX2_1	29	31	PF00082	0.511
CLV_PCSK_KEX2_1	298	300	PF00082	0.777
CLV_PCSK_KEX2_1	389	391	PF00082	0.604
CLV_PCSK_KEX2_1	396	398	PF00082	0.634
CLV_PCSK_KEX2_1	417	419	PF00082	0.637
CLV_PCSK_KEX2_1	428	430	PF00082	0.568
CLV_PCSK_KEX2_1	444	446	PF00082	0.445
CLV_PCSK_KEX2_1	447	449	PF00082	0.448
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.721
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.560
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.566
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.663
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.479
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.458
CLV_PCSK_PC7_1	392	398	PF00082	0.541
CLV_PCSK_SKI1_1	310	314	PF00082	0.773
CLV_PCSK_SKI1_1	397	401	PF00082	0.537
CLV_PCSK_SKI1_1	55	59	PF00082	0.783
DEG_Nend_UBRbox_3	1	3	PF02207	0.639
DEG_SCF_FBW7_1	361	367	PF00400	0.733
DEG_SCF_FBW7_2	84	89	PF00400	0.602
DEG_SPOP_SBC_1	201	205	PF00917	0.742
DOC_CKS1_1	245	250	PF01111	0.658
DOC_CKS1_1	361	366	PF01111	0.735
DOC_USP7_MATH_1	201	205	PF00917	0.777
DOC_USP7_MATH_1	226	230	PF00917	0.718
DOC_USP7_MATH_1	280	284	PF00917	0.739
DOC_USP7_MATH_1	294	298	PF00917	0.752
DOC_USP7_MATH_1	315	319	PF00917	0.768
DOC_USP7_MATH_1	336	340	PF00917	0.737
DOC_USP7_MATH_1	364	368	PF00917	0.797
DOC_USP7_UBL2_3	310	314	PF12436	0.763
DOC_USP7_UBL2_3	396	400	PF12436	0.587
DOC_USP7_UBL2_3	60	64	PF12436	0.695
DOC_WW_Pin1_4	112	117	PF00397	0.778
DOC_WW_Pin1_4	244	249	PF00397	0.650
DOC_WW_Pin1_4	257	262	PF00397	0.747
DOC_WW_Pin1_4	272	277	PF00397	0.629
DOC_WW_Pin1_4	298	303	PF00397	0.707
DOC_WW_Pin1_4	360	365	PF00397	0.797
DOC_WW_Pin1_4	82	87	PF00397	0.632
LIG_14-3-3_CanoR_1	19	24	PF00244	0.553
LIG_14-3-3_CanoR_1	365	371	PF00244	0.723
LIG_14-3-3_CanoR_1	42	50	PF00244	0.758
LIG_BIR_III_2	335	339	PF00653	0.695
LIG_eIF4E_1	323	329	PF01652	0.640
LIG_FHA_1	113	119	PF00498	0.754
LIG_FHA_1	258	264	PF00498	0.803
LIG_FHA_1	273	279	PF00498	0.674
LIG_FHA_1	319	325	PF00498	0.819
LIG_FHA_1	32	38	PF00498	0.632
LIG_FHA_2	104	110	PF00498	0.766
LIG_FHA_2	265	271	PF00498	0.825
LIG_FHA_2	341	347	PF00498	0.773
LIG_FHA_2	9	15	PF00498	0.591
LIG_LIR_Gen_1	376	386	PF02991	0.609
LIG_LIR_Nem_3	165	171	PF02991	0.645
LIG_LIR_Nem_3	177	182	PF02991	0.657
LIG_LIR_Nem_3	241	246	PF02991	0.735
LIG_LIR_Nem_3	376	382	PF02991	0.685
LIG_Pex14_2	58	62	PF04695	0.719
LIG_SH2_GRB2like	323	326	PF00017	0.738
LIG_SH2_STAT3	212	215	PF00017	0.775
LIG_SH2_STAT5	169	172	PF00017	0.639
LIG_SH2_STAT5	181	184	PF00017	0.683
LIG_SH2_STAT5	230	233	PF00017	0.630
LIG_SH2_STAT5	234	237	PF00017	0.630
LIG_SH2_STAT5	244	247	PF00017	0.654
LIG_SH2_STAT5	323	326	PF00017	0.738
LIG_SH3_3	188	194	PF00018	0.622
LIG_SH3_3	20	26	PF00018	0.690
LIG_SH3_3	309	315	PF00018	0.700
LIG_SH3_3	344	350	PF00018	0.767
LIG_SUMO_SIM_anti_2	375	384	PF11976	0.623
LIG_SUMO_SIM_par_1	123	129	PF11976	0.606
MOD_CDK_SPK_2	112	117	PF00069	0.619
MOD_CDK_SPK_2	360	365	PF00069	0.735
MOD_CK1_1	126	132	PF00069	0.729
MOD_CK1_1	205	211	PF00069	0.713
MOD_CK1_1	318	324	PF00069	0.774
MOD_CK1_1	440	446	PF00069	0.589
MOD_CK1_1	48	54	PF00069	0.704
MOD_CK2_1	126	132	PF00069	0.651
MOD_CK2_1	221	227	PF00069	0.662
MOD_CK2_1	342	348	PF00069	0.739
MOD_GlcNHglycan	128	131	PF01048	0.752
MOD_GlcNHglycan	138	141	PF01048	0.755
MOD_GlcNHglycan	150	154	PF01048	0.612
MOD_GlcNHglycan	39	42	PF01048	0.753
MOD_GlcNHglycan	51	54	PF01048	0.599
MOD_GSK3_1	15	22	PF00069	0.583
MOD_GSK3_1	201	208	PF00069	0.716
MOD_GSK3_1	257	264	PF00069	0.788
MOD_GSK3_1	280	287	PF00069	0.736
MOD_GSK3_1	294	301	PF00069	0.676
MOD_GSK3_1	336	343	PF00069	0.748
MOD_GSK3_1	360	367	PF00069	0.735
MOD_GSK3_1	45	52	PF00069	0.614
MOD_GSK3_1	99	106	PF00069	0.796
MOD_LATS_1	47	53	PF00433	0.673
MOD_N-GLC_1	369	374	PF02516	0.559
MOD_N-GLC_2	393	395	PF02516	0.434
MOD_NEK2_1	1	6	PF00069	0.644
MOD_NEK2_1	185	190	PF00069	0.731
MOD_NEK2_1	37	42	PF00069	0.766
MOD_PIKK_1	202	208	PF00454	0.770
MOD_PIKK_1	211	217	PF00454	0.585
MOD_PIKK_1	261	267	PF00454	0.789
MOD_PK_1	19	25	PF00069	0.583
MOD_PKA_2	18	24	PF00069	0.546
MOD_PKA_2	318	324	PF00069	0.717
MOD_PKA_2	364	370	PF00069	0.728
MOD_PKA_2	43	49	PF00069	0.779
MOD_Plk_4	1	7	PF00069	0.637
MOD_Plk_4	175	181	PF00069	0.622
MOD_Plk_4	206	212	PF00069	0.680
MOD_Plk_4	226	232	PF00069	0.473
MOD_Plk_4	238	244	PF00069	0.584
MOD_Plk_4	336	342	PF00069	0.652
MOD_Plk_4	352	358	PF00069	0.538
MOD_Plk_4	437	443	PF00069	0.648
MOD_ProDKin_1	112	118	PF00069	0.777
MOD_ProDKin_1	244	250	PF00069	0.656
MOD_ProDKin_1	257	263	PF00069	0.749
MOD_ProDKin_1	272	278	PF00069	0.630
MOD_ProDKin_1	298	304	PF00069	0.703
MOD_ProDKin_1	360	366	PF00069	0.798
MOD_ProDKin_1	82	88	PF00069	0.630
MOD_SUMO_rev_2	381	391	PF00179	0.544
TRG_DiLeu_BaEn_3	377	383	PF01217	0.643
TRG_ENDOCYTIC_2	179	182	PF00928	0.691
TRG_ER_diArg_1	388	391	PF00400	0.601
TRG_ER_diArg_1	397	399	PF00400	0.653
TRG_ER_diArg_1	42	45	PF00400	0.576
TRG_NLS_Bipartite_1	428	448	PF00514	0.571
TRG_NLS_MonoCore_2	443	448	PF00514	0.613
TRG_NLS_MonoExtC_3	297	302	PF00514	0.713
TRG_NLS_MonoExtC_3	388	394	PF00514	0.544
TRG_NLS_MonoExtC_3	395	400	PF00514	0.472
TRG_NLS_MonoExtC_3	443	448	PF00514	0.613
TRG_NLS_MonoExtN_4	296	302	PF00514	0.715
TRG_NLS_MonoExtN_4	388	393	PF00514	0.550
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5V5	Leptomonas seymouri	36%	88%
A4HMF8	Leishmania braziliensis	56%	100%
A4IB29	Leishmania infantum	99%	100%
E9AEV9	Leishmania major	89%	100%
E9B615	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%