Dolichyl-diphosphooligosaccharide--protein glycotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oligosaccharyl transferase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IV37_LEIDO

TriTrypDb:

LdBPK_351160.1 , LdCL_350016500 , LDHU3_35.1540

Length:

836

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 26
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	27
GO:0110165	cellular anatomical entity	1	27
GO:0005635	nuclear envelope	4	4
GO:0005783	endoplasmic reticulum	5	4
GO:0031967	organelle envelope	3	4
GO:0031975	envelope	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4

Expansion

Sequence features

A0A3Q8IV37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IV37

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	27
GO:0006807	nitrogen compound metabolic process	2	27
GO:0008152	metabolic process	1	27
GO:0019538	protein metabolic process	3	27
GO:0036211	protein modification process	4	27
GO:0043170	macromolecule metabolic process	3	27
GO:0043412	macromolecule modification	4	27
GO:0043413	macromolecule glycosylation	3	27
GO:0044238	primary metabolic process	2	27
GO:0070085	glycosylation	2	27
GO:0071704	organic substance metabolic process	2	27
GO:1901564	organonitrogen compound metabolic process	3	27

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	27
GO:0004576	oligosaccharyl transferase activity	5	27
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	6	27
GO:0005488	binding	1	27
GO:0016740	transferase activity	2	27
GO:0016757	glycosyltransferase activity	3	27
GO:0016758	hexosyltransferase activity	4	27
GO:0043167	ion binding	2	27
GO:0043169	cation binding	3	27
GO:0046872	metal ion binding	4	27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	633	637	PF00656	0.276
CLV_NRD_NRD_1	491	493	PF00675	0.304
CLV_NRD_NRD_1	502	504	PF00675	0.294
CLV_NRD_NRD_1	815	817	PF00675	0.651
CLV_NRD_NRD_1	829	831	PF00675	0.614
CLV_PCSK_FUR_1	500	504	PF00082	0.163
CLV_PCSK_KEX2_1	502	504	PF00082	0.300
CLV_PCSK_KEX2_1	829	831	PF00082	0.548
CLV_PCSK_SKI1_1	377	381	PF00082	0.456
CLV_PCSK_SKI1_1	454	458	PF00082	0.416
CLV_PCSK_SKI1_1	537	541	PF00082	0.304
CLV_PCSK_SKI1_1	589	593	PF00082	0.425
CLV_PCSK_SKI1_1	650	654	PF00082	0.508
CLV_PCSK_SKI1_1	736	740	PF00082	0.603
CLV_PCSK_SKI1_1	757	761	PF00082	0.601
DEG_MDM2_SWIB_1	541	548	PF02201	0.364
DEG_ODPH_VHL_1	363	376	PF01847	0.367
DEG_SCF_FBW7_1	26	33	PF00400	0.535
DEG_SCF_TRCP1_1	10	16	PF00400	0.579
DEG_SPOP_SBC_1	120	124	PF00917	0.474
DOC_AGCK_PIF_2	105	110	PF00069	0.302
DOC_CKS1_1	27	32	PF01111	0.535
DOC_CYCLIN_RxL_1	374	384	PF00134	0.264
DOC_CYCLIN_RxL_1	451	459	PF00134	0.266
DOC_MAPK_FxFP_2	40	43	PF00069	0.490
DOC_MAPK_gen_1	225	234	PF00069	0.363
DOC_MAPK_gen_1	329	336	PF00069	0.491
DOC_MAPK_gen_1	337	346	PF00069	0.513
DOC_MAPK_HePTP_8	336	348	PF00069	0.457
DOC_MAPK_MEF2A_6	339	348	PF00069	0.507
DOC_MAPK_MEF2A_6	537	544	PF00069	0.498
DOC_PP1_RVXF_1	433	439	PF00149	0.505
DOC_PP1_RVXF_1	535	542	PF00149	0.364
DOC_PP1_RVXF_1	612	619	PF00149	0.289
DOC_PP4_FxxP_1	40	43	PF00568	0.495
DOC_SPAK_OSR1_1	48	52	PF12202	0.385
DOC_USP7_MATH_1	119	123	PF00917	0.338
DOC_USP7_MATH_1	174	178	PF00917	0.276
DOC_USP7_MATH_1	303	307	PF00917	0.277
DOC_USP7_MATH_1	561	565	PF00917	0.387
DOC_USP7_MATH_1	568	572	PF00917	0.312
DOC_USP7_MATH_1	674	678	PF00917	0.460
DOC_USP7_UBL2_3	813	817	PF12436	0.548
DOC_WW_Pin1_4	15	20	PF00397	0.589
DOC_WW_Pin1_4	26	31	PF00397	0.645
DOC_WW_Pin1_4	299	304	PF00397	0.289
DOC_WW_Pin1_4	527	532	PF00397	0.573
DOC_WW_Pin1_4	606	611	PF00397	0.277
DOC_WW_Pin1_4	651	656	PF00397	0.310
DOC_WW_Pin1_4	680	685	PF00397	0.352
DOC_WW_Pin1_4	715	720	PF00397	0.329
LIG_14-3-3_CanoR_1	225	231	PF00244	0.311
LIG_14-3-3_CanoR_1	271	275	PF00244	0.539
LIG_14-3-3_CanoR_1	280	285	PF00244	0.415
LIG_14-3-3_CanoR_1	347	352	PF00244	0.462
LIG_14-3-3_CanoR_1	48	54	PF00244	0.586
LIG_14-3-3_CanoR_1	631	635	PF00244	0.301
LIG_14-3-3_CanoR_1	688	694	PF00244	0.323
LIG_14-3-3_CanoR_1	70	75	PF00244	0.289
LIG_14-3-3_CanoR_1	722	726	PF00244	0.377
LIG_AP2alpha_2	85	87	PF02296	0.289
LIG_BRCT_BRCA1_1	101	105	PF00533	0.380
LIG_BRCT_BRCA1_1	40	44	PF00533	0.528
LIG_BRCT_BRCA1_1	433	437	PF00533	0.439
LIG_BRCT_BRCA1_1	556	560	PF00533	0.337
LIG_BRCT_BRCA1_1	563	567	PF00533	0.292
LIG_deltaCOP1_diTrp_1	403	408	PF00928	0.232
LIG_eIF4E_1	431	437	PF01652	0.385
LIG_FHA_1	162	168	PF00498	0.379
LIG_FHA_1	413	419	PF00498	0.386
LIG_FHA_1	548	554	PF00498	0.391
LIG_FHA_1	651	657	PF00498	0.315
LIG_FHA_1	733	739	PF00498	0.392
LIG_FHA_2	27	33	PF00498	0.571
LIG_FHA_2	471	477	PF00498	0.278
LIG_FHA_2	520	526	PF00498	0.431
LIG_FHA_2	564	570	PF00498	0.341
LIG_FHA_2	607	613	PF00498	0.266
LIG_LIR_Apic_2	366	371	PF02991	0.314
LIG_LIR_Apic_2	713	717	PF02991	0.379
LIG_LIR_Apic_2	785	789	PF02991	0.458
LIG_LIR_Gen_1	187	196	PF02991	0.440
LIG_LIR_Gen_1	216	224	PF02991	0.345
LIG_LIR_Gen_1	403	414	PF02991	0.236
LIG_LIR_Gen_1	601	610	PF02991	0.262
LIG_LIR_Gen_1	62	71	PF02991	0.427
LIG_LIR_Gen_1	668	674	PF02991	0.357
LIG_LIR_Gen_1	692	702	PF02991	0.439
LIG_LIR_Gen_1	743	753	PF02991	0.420
LIG_LIR_Gen_1	98	108	PF02991	0.347
LIG_LIR_Nem_3	106	110	PF02991	0.290
LIG_LIR_Nem_3	112	116	PF02991	0.272
LIG_LIR_Nem_3	122	128	PF02991	0.261
LIG_LIR_Nem_3	166	172	PF02991	0.356
LIG_LIR_Nem_3	187	191	PF02991	0.391
LIG_LIR_Nem_3	216	221	PF02991	0.330
LIG_LIR_Nem_3	283	288	PF02991	0.314
LIG_LIR_Nem_3	302	307	PF02991	0.283
LIG_LIR_Nem_3	33	39	PF02991	0.660
LIG_LIR_Nem_3	366	372	PF02991	0.287
LIG_LIR_Nem_3	403	409	PF02991	0.224
LIG_LIR_Nem_3	41	47	PF02991	0.659
LIG_LIR_Nem_3	426	431	PF02991	0.435
LIG_LIR_Nem_3	434	440	PF02991	0.401
LIG_LIR_Nem_3	601	605	PF02991	0.277
LIG_LIR_Nem_3	62	67	PF02991	0.382
LIG_LIR_Nem_3	668	672	PF02991	0.293
LIG_LIR_Nem_3	692	697	PF02991	0.317
LIG_LIR_Nem_3	743	748	PF02991	0.368
LIG_LIR_Nem_3	750	756	PF02991	0.314
LIG_LIR_Nem_3	85	90	PF02991	0.289
LIG_LIR_Nem_3	98	104	PF02991	0.287
LIG_LYPXL_yS_3	125	128	PF13949	0.387
LIG_MLH1_MIPbox_1	101	105	PF16413	0.380
LIG_NRBOX	309	315	PF00104	0.389
LIG_NRBOX	435	441	PF00104	0.369
LIG_Pex14_1	101	105	PF04695	0.289
LIG_Pex14_1	45	49	PF04695	0.488
LIG_Pex14_1	619	623	PF04695	0.277
LIG_Pex14_2	104	108	PF04695	0.215
LIG_Pex14_2	36	40	PF04695	0.642
LIG_Pex14_2	541	545	PF04695	0.500
LIG_Pex14_2	556	560	PF04695	0.232
LIG_Pex14_2	84	88	PF04695	0.267
LIG_PTB_Apo_2	688	695	PF02174	0.327
LIG_PTB_Phospho_1	688	694	PF10480	0.323
LIG_SH2_CRK	714	718	PF00017	0.370
LIG_SH2_CRK	753	757	PF00017	0.305
LIG_SH2_CRK	77	81	PF00017	0.302
LIG_SH2_NCK_1	714	718	PF00017	0.328
LIG_SH2_PTP2	250	253	PF00017	0.364
LIG_SH2_PTP2	602	605	PF00017	0.173
LIG_SH2_PTP2	669	672	PF00017	0.292
LIG_SH2_SRC	431	434	PF00017	0.364
LIG_SH2_SRC	79	82	PF00017	0.313
LIG_SH2_STAP1	282	286	PF00017	0.364
LIG_SH2_STAP1	749	753	PF00017	0.365
LIG_SH2_STAT3	621	624	PF00017	0.277
LIG_SH2_STAT5	218	221	PF00017	0.387
LIG_SH2_STAT5	250	253	PF00017	0.364
LIG_SH2_STAT5	282	285	PF00017	0.458
LIG_SH2_STAT5	286	289	PF00017	0.443
LIG_SH2_STAT5	368	371	PF00017	0.275
LIG_SH2_STAT5	447	450	PF00017	0.336
LIG_SH2_STAT5	598	601	PF00017	0.283
LIG_SH2_STAT5	602	605	PF00017	0.282
LIG_SH2_STAT5	669	672	PF00017	0.292
LIG_SH2_STAT5	79	82	PF00017	0.351
LIG_SH3_2	43	48	PF14604	0.480
LIG_SH3_3	150	156	PF00018	0.387
LIG_SH3_3	24	30	PF00018	0.567
LIG_SH3_3	291	297	PF00018	0.414
LIG_SH3_3	359	365	PF00018	0.444
LIG_SH3_3	396	402	PF00018	0.202
LIG_SH3_3	40	46	PF00018	0.489
LIG_SH3_3	696	702	PF00018	0.406
LIG_SH3_3	769	775	PF00018	0.372
LIG_SH3_3	776	782	PF00018	0.374
LIG_SUMO_SIM_par_1	420	427	PF11976	0.224
LIG_SUMO_SIM_par_1	454	459	PF11976	0.218
LIG_SxIP_EBH_1	184	197	PF03271	0.349
LIG_TYR_ITSM	214	221	PF00017	0.329
LIG_UBA3_1	23	28	PF00899	0.556
LIG_UBA3_1	725	734	PF00899	0.401
LIG_WRC_WIRS_1	214	219	PF05994	0.329
LIG_WRC_WIRS_1	405	410	PF05994	0.185
LIG_WRC_WIRS_1	425	430	PF05994	0.199
MOD_CDC14_SPxK_1	302	305	PF00782	0.380
MOD_CDK_SPxK_1	299	305	PF00069	0.289
MOD_CDK_SPxxK_3	715	722	PF00069	0.377
MOD_CK1_1	13	19	PF00069	0.720
MOD_CK1_1	147	153	PF00069	0.433
MOD_CK1_1	175	181	PF00069	0.307
MOD_CK1_1	223	229	PF00069	0.364
MOD_CK1_1	486	492	PF00069	0.498
MOD_CK1_1	516	522	PF00069	0.422
MOD_CK1_1	554	560	PF00069	0.350
MOD_CK1_1	562	568	PF00069	0.318
MOD_CK1_1	715	721	PF00069	0.334
MOD_CK1_1	765	771	PF00069	0.345
MOD_CK2_1	390	396	PF00069	0.256
MOD_CK2_1	470	476	PF00069	0.355
MOD_CK2_1	563	569	PF00069	0.341
MOD_CK2_1	819	825	PF00069	0.534
MOD_Cter_Amidation	1	4	PF01082	0.521
MOD_GlcNHglycan	10	13	PF01048	0.436
MOD_GlcNHglycan	101	104	PF01048	0.570
MOD_GlcNHglycan	173	177	PF01048	0.506
MOD_GlcNHglycan	441	444	PF01048	0.315
MOD_GlcNHglycan	458	461	PF01048	0.170
MOD_GlcNHglycan	515	518	PF01048	0.196
MOD_GlcNHglycan	676	679	PF01048	0.579
MOD_GSK3_1	168	175	PF00069	0.355
MOD_GSK3_1	26	33	PF00069	0.631
MOD_GSK3_1	270	277	PF00069	0.529
MOD_GSK3_1	299	306	PF00069	0.306
MOD_GSK3_1	479	486	PF00069	0.560
MOD_GSK3_1	515	522	PF00069	0.518
MOD_GSK3_1	547	554	PF00069	0.415
MOD_GSK3_1	555	562	PF00069	0.318
MOD_GSK3_1	65	72	PF00069	0.384
MOD_GSK3_1	95	102	PF00069	0.349
MOD_N-GLC_1	629	634	PF02516	0.476
MOD_N-GLC_1	762	767	PF02516	0.541
MOD_N-GLC_2	205	207	PF02516	0.289
MOD_NEK2_1	128	133	PF00069	0.345
MOD_NEK2_1	186	191	PF00069	0.375
MOD_NEK2_1	195	200	PF00069	0.368
MOD_NEK2_1	213	218	PF00069	0.222
MOD_NEK2_1	390	395	PF00069	0.258
MOD_NEK2_1	423	428	PF00069	0.310
MOD_NEK2_1	439	444	PF00069	0.337
MOD_NEK2_1	456	461	PF00069	0.214
MOD_NEK2_1	470	475	PF00069	0.400
MOD_NEK2_1	49	54	PF00069	0.419
MOD_NEK2_1	547	552	PF00069	0.183
MOD_NEK2_1	721	726	PF00069	0.327
MOD_NEK2_1	8	13	PF00069	0.578
MOD_NEK2_2	220	225	PF00069	0.329
MOD_PK_1	347	353	PF00069	0.426
MOD_PK_1	70	76	PF00069	0.322
MOD_PKA_2	226	232	PF00069	0.323
MOD_PKA_2	270	276	PF00069	0.539
MOD_PKA_2	584	590	PF00069	0.304
MOD_PKA_2	630	636	PF00069	0.277
MOD_PKA_2	69	75	PF00069	0.226
MOD_PKA_2	721	727	PF00069	0.372
MOD_PKB_1	345	353	PF00069	0.513
MOD_Plk_1	629	635	PF00069	0.276
MOD_Plk_4	109	115	PF00069	0.289
MOD_Plk_4	213	219	PF00069	0.329
MOD_Plk_4	262	268	PF00069	0.432
MOD_Plk_4	274	280	PF00069	0.432
MOD_Plk_4	417	423	PF00069	0.355
MOD_Plk_4	424	430	PF00069	0.331
MOD_Plk_4	470	476	PF00069	0.326
MOD_Plk_4	479	485	PF00069	0.494
MOD_Plk_4	49	55	PF00069	0.281
MOD_Plk_4	551	557	PF00069	0.272
MOD_Plk_4	658	664	PF00069	0.351
MOD_Plk_4	689	695	PF00069	0.313
MOD_Plk_4	721	727	PF00069	0.365
MOD_Plk_4	740	746	PF00069	0.271
MOD_Plk_4	782	788	PF00069	0.377
MOD_ProDKin_1	15	21	PF00069	0.589
MOD_ProDKin_1	26	32	PF00069	0.641
MOD_ProDKin_1	299	305	PF00069	0.289
MOD_ProDKin_1	527	533	PF00069	0.573
MOD_ProDKin_1	606	612	PF00069	0.277
MOD_ProDKin_1	651	657	PF00069	0.316
MOD_ProDKin_1	680	686	PF00069	0.348
MOD_ProDKin_1	715	721	PF00069	0.324
TRG_DiLeu_BaEn_1	658	663	PF01217	0.330
TRG_DiLeu_BaLyEn_6	451	456	PF01217	0.295
TRG_ENDOCYTIC_2	125	128	PF00928	0.428
TRG_ENDOCYTIC_2	218	221	PF00928	0.329
TRG_ENDOCYTIC_2	240	243	PF00928	0.329
TRG_ENDOCYTIC_2	250	253	PF00928	0.329
TRG_ENDOCYTIC_2	282	285	PF00928	0.329
TRG_ENDOCYTIC_2	602	605	PF00928	0.273
TRG_ENDOCYTIC_2	669	672	PF00928	0.292
TRG_ENDOCYTIC_2	694	697	PF00928	0.339
TRG_ENDOCYTIC_2	753	756	PF00928	0.300
TRG_ENDOCYTIC_2	77	80	PF00928	0.302
TRG_ER_diArg_1	224	227	PF00400	0.376
TRG_ER_diArg_1	328	331	PF00400	0.516
TRG_ER_diArg_1	336	339	PF00400	0.471
TRG_ER_diArg_1	344	347	PF00400	0.355
TRG_ER_diArg_1	374	377	PF00400	0.257
TRG_ER_diArg_1	500	503	PF00400	0.363
TRG_ER_diArg_1	828	830	PF00400	0.417
TRG_NES_CRM1_1	308	323	PF08389	0.380
TRG_Pf-PMV_PEXEL_1	377	382	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	521	525	PF00026	0.177

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IZ72	Bodo saltans	51%	100%
A0A1X0NFU7	Trypanosomatidae	55%	99%
A0A3Q8IHT0	Leishmania donovani	75%	100%
A0A3Q8II34	Leishmania donovani	57%	100%
A0A3Q8ILY7	Leishmania donovani	75%	99%
A0A422MX14	Trypanosoma rangeli	55%	100%
A4HFF9	Leishmania braziliensis	71%	100%
A4HMD5	Leishmania braziliensis	71%	100%
A4HMD6	Leishmania braziliensis	55%	100%
A4HMD7	Leishmania braziliensis	81%	100%
A4IB08	Leishmania infantum	75%	100%
A4IB09	Leishmania infantum	75%	99%
A4IB10	Leishmania infantum	58%	100%
C9ZNL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
C9ZQ40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E2RG47	Canis lupus familiaris	30%	100%
E9AET6	Leishmania major	74%	100%
E9AET7	Leishmania major	75%	100%
E9AET8	Leishmania major	57%	100%
E9AET9	Leishmania major	91%	100%
E9AHU4	Leishmania infantum	100%	100%
E9B5Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
E9B5Z3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
E9B5Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
E9B5Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
F1PJP5	Canis lupus familiaris	29%	100%
O94335	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
P39007	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P46975	Caenorhabditis elegans	30%	100%
P46977	Homo sapiens	29%	100%
P46978	Mus musculus	29%	100%
Q2KJI2	Bos taurus	29%	100%
Q3TDQ1	Mus musculus	30%	100%
Q54NM9	Dictyostelium discoideum	31%	100%
Q5RCE2	Pongo abelii	29%	100%
Q6F2Z1	Oryza sativa subsp. japonica	29%	100%
Q7XQ88	Oryza sativa subsp. japonica	32%	100%
Q8TCJ2	Homo sapiens	30%	100%
Q93ZY3	Arabidopsis thaliana	31%	100%
Q9FX21	Arabidopsis thaliana	32%	100%
V5BDM6	Trypanosoma cruzi	57%	100%