Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IUX8_LEIDO

TriTrypDb:

LdBPK_343840.1 , LdCL_340047800 , LDHU3_34.6140

Length:

104

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IUX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IUX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	35	37	PF00675	0.514
CLV_NRD_NRD_1	4	6	PF00675	0.510
CLV_PCSK_KEX2_1	35	37	PF00082	0.515
CLV_PCSK_KEX2_1	4	6	PF00082	0.549
DOC_PP4_FxxP_1	30	33	PF00568	0.494
DOC_WW_Pin1_4	37	42	PF00397	0.606
DOC_WW_Pin1_4	67	72	PF00397	0.453
LIG_APCC_ABBA_1	27	32	PF00400	0.538
LIG_deltaCOP1_diTrp_1	53	58	PF00928	0.482
LIG_LIR_Gen_1	22	33	PF02991	0.508
LIG_LIR_Gen_1	78	87	PF02991	0.415
LIG_LIR_Nem_3	22	28	PF02991	0.504
LIG_LIR_Nem_3	56	61	PF02991	0.468
LIG_LIR_Nem_3	78	83	PF02991	0.418
LIG_MYND_1	37	41	PF01753	0.536
LIG_Pex14_1	54	58	PF04695	0.454
LIG_Pex14_2	91	95	PF04695	0.429
LIG_SH2_NCK_1	96	100	PF00017	0.479
LIG_SH2_STAP1	96	100	PF00017	0.479
LIG_SH3_2	63	68	PF14604	0.491
LIG_SH3_3	31	37	PF00018	0.622
LIG_SH3_3	60	66	PF00018	0.487
LIG_SH3_3	95	101	PF00018	0.531
LIG_TRAF2_1	40	43	PF00917	0.462
MOD_CDK_SPxxK_3	37	44	PF00069	0.564
MOD_CK2_1	37	43	PF00069	0.463
MOD_NEK2_1	18	23	PF00069	0.505
MOD_ProDKin_1	37	43	PF00069	0.604
MOD_ProDKin_1	67	73	PF00069	0.454
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.510
TRG_ENDOCYTIC_2	25	28	PF00928	0.506
TRG_ENDOCYTIC_2	96	99	PF00928	0.514
TRG_ER_diArg_1	3	5	PF00400	0.531
TRG_ER_diArg_1	34	36	PF00400	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF74	Leptomonas seymouri	87%	100%
A0A0S4KIS5	Bodo saltans	63%	100%
A0A1X0PBI1	Trypanosomatidae	77%	99%
A0A422NVD7	Trypanosoma rangeli	76%	99%
A4HBC4	Leishmania braziliensis	89%	100%
A4IAH2	Leishmania infantum	100%	100%
E9B5J6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4Q2E0	Leishmania major	99%	100%