Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IUS4_LEIDO

TriTrypDb:

LdBPK_342790.1 , LdCL_340036000 , LDHU3_34.4790

Length:

230

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IUS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IUS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	70	72	PF00675	0.421
CLV_PCSK_KEX2_1	70	72	PF00082	0.421
CLV_PCSK_SKI1_1	124	128	PF00082	0.437
CLV_PCSK_SKI1_1	71	75	PF00082	0.396
DEG_APCC_DBOX_1	123	131	PF00400	0.602
DEG_Nend_Nbox_1	1	3	PF02207	0.703
DOC_CYCLIN_yCln2_LP_2	9	15	PF00134	0.649
DOC_MAPK_MEF2A_6	120	129	PF00069	0.635
DOC_SPAK_OSR1_1	89	93	PF12202	0.673
DOC_USP7_MATH_1	35	39	PF00917	0.376
DOC_USP7_MATH_1	63	67	PF00917	0.670
DOC_USP7_UBL2_3	74	78	PF12436	0.594
LIG_14-3-3_CanoR_1	132	139	PF00244	0.620
LIG_14-3-3_CanoR_1	188	193	PF00244	0.678
LIG_14-3-3_CanoR_1	207	211	PF00244	0.565
LIG_14-3-3_CanoR_1	89	93	PF00244	0.737
LIG_Actin_RPEL_3	82	101	PF02755	0.647
LIG_Clathr_ClatBox_1	100	104	PF01394	0.658
LIG_DCNL_PONY_1	1	4	PF03556	0.668
LIG_EH1_1	89	97	PF00400	0.671
LIG_eIF4E_1	146	152	PF01652	0.633
LIG_eIF4E_1	21	27	PF01652	0.358
LIG_eIF4E_1	45	51	PF01652	0.411
LIG_FHA_1	114	120	PF00498	0.640
LIG_FHA_1	29	35	PF00498	0.351
LIG_FHA_1	8	14	PF00498	0.674
LIG_FHA_2	207	213	PF00498	0.686
LIG_GBD_Chelix_1	46	54	PF00786	0.336
LIG_GBD_Chelix_1	92	100	PF00786	0.411
LIG_IRF3_LxIS_1	9	16	PF10401	0.648
LIG_NRBOX	22	28	PF00104	0.411
LIG_PTB_Apo_2	144	151	PF02174	0.578
LIG_PTB_Phospho_1	144	150	PF10480	0.578
LIG_SH2_NCK_1	146	150	PF00017	0.665
LIG_SH2_PTP2	128	131	PF00017	0.589
LIG_SH2_STAT5	113	116	PF00017	0.605
LIG_SH2_STAT5	128	131	PF00017	0.589
LIG_SH2_STAT5	150	153	PF00017	0.651
LIG_SH2_STAT5	45	48	PF00017	0.417
LIG_SH2_STAT5	81	84	PF00017	0.631
LIG_SH3_3	119	125	PF00018	0.671
LIG_SUMO_SIM_par_1	25	31	PF11976	0.411
LIG_TYR_ITIM	126	131	PF00017	0.622
MOD_CK1_1	134	140	PF00069	0.626
MOD_CK2_1	88	94	PF00069	0.631
MOD_GlcNHglycan	133	136	PF01048	0.444
MOD_GlcNHglycan	164	167	PF01048	0.472
MOD_GlcNHglycan	175	178	PF01048	0.522
MOD_GlcNHglycan	183	186	PF01048	0.372
MOD_GlcNHglycan	199	202	PF01048	0.478
MOD_GlcNHglycan	67	70	PF01048	0.443
MOD_GSK3_1	134	141	PF00069	0.688
MOD_GSK3_1	158	165	PF00069	0.714
MOD_GSK3_1	188	195	PF00069	0.678
MOD_N-GLC_1	158	163	PF02516	0.404
MOD_N-GLC_1	217	222	PF02516	0.445
MOD_N-GLC_2	206	208	PF02516	0.488
MOD_NEK2_1	13	18	PF00069	0.486
MOD_NEK2_1	131	136	PF00069	0.646
MOD_NEK2_1	151	156	PF00069	0.677
MOD_NEK2_1	217	222	PF00069	0.656
MOD_NEK2_1	27	32	PF00069	0.346
MOD_NEK2_1	88	93	PF00069	0.631
MOD_PIKK_1	63	69	PF00454	0.599
MOD_PIKK_1	7	13	PF00454	0.637
MOD_PKA_2	131	137	PF00069	0.630
MOD_PKA_2	141	147	PF00069	0.560
MOD_PKA_2	187	193	PF00069	0.673
MOD_PKA_2	206	212	PF00069	0.660
MOD_PKA_2	218	224	PF00069	0.604
MOD_PKA_2	88	94	PF00069	0.734
MOD_Plk_4	206	212	PF00069	0.717
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.608
TRG_ENDOCYTIC_2	128	131	PF00928	0.671
TRG_ENDOCYTIC_2	45	48	PF00928	0.411
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS2	Leptomonas seymouri	51%	100%
A4HB15	Leishmania braziliensis	69%	100%
A4IA72	Leishmania infantum	100%	100%
E9B585	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q2P8	Leishmania major	95%	100%