Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IUQ4_LEIDO

TriTrypDb:

LdBPK_342510.1 , LdCL_340032700 , LDHU3_34.4110

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3Q8IUQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IUQ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	234	240	PF00089	0.537
CLV_NRD_NRD_1	278	280	PF00675	0.522
CLV_NRD_NRD_1	420	422	PF00675	0.727
CLV_NRD_NRD_1	475	477	PF00675	0.492
CLV_NRD_NRD_1	522	524	PF00675	0.587
CLV_PCSK_KEX2_1	278	280	PF00082	0.638
CLV_PCSK_KEX2_1	475	477	PF00082	0.492
CLV_PCSK_KEX2_1	522	524	PF00082	0.587
CLV_PCSK_SKI1_1	199	203	PF00082	0.552
CLV_PCSK_SKI1_1	22	26	PF00082	0.584
CLV_PCSK_SKI1_1	27	31	PF00082	0.552
CLV_PCSK_SKI1_1	431	435	PF00082	0.532
CLV_PCSK_SKI1_1	475	479	PF00082	0.508
DEG_APCC_DBOX_1	39	47	PF00400	0.529
DEG_APCC_DBOX_1	430	438	PF00400	0.590
DEG_SPOP_SBC_1	296	300	PF00917	0.767
DOC_ANK_TNKS_1	420	427	PF00023	0.583
DOC_CKS1_1	64	69	PF01111	0.573
DOC_CYCLIN_yCln2_LP_2	64	70	PF00134	0.550
DOC_MAPK_gen_1	228	236	PF00069	0.424
DOC_MAPK_gen_1	421	429	PF00069	0.646
DOC_MAPK_gen_1	450	460	PF00069	0.653
DOC_MAPK_MEF2A_6	230	238	PF00069	0.439
DOC_MAPK_MEF2A_6	421	429	PF00069	0.556
DOC_MAPK_MEF2A_6	453	462	PF00069	0.695
DOC_MAPK_MEF2A_6	56	64	PF00069	0.583
DOC_MAPK_NFAT4_5	422	430	PF00069	0.542
DOC_USP7_MATH_1	15	19	PF00917	0.523
DOC_USP7_MATH_1	2	6	PF00917	0.607
DOC_USP7_MATH_1	287	291	PF00917	0.655
DOC_USP7_MATH_1	296	300	PF00917	0.700
DOC_USP7_MATH_1	340	344	PF00917	0.752
DOC_USP7_MATH_1	354	358	PF00917	0.686
DOC_USP7_MATH_1	530	534	PF00917	0.510
DOC_WW_Pin1_4	297	302	PF00397	0.799
DOC_WW_Pin1_4	377	382	PF00397	0.494
DOC_WW_Pin1_4	63	68	PF00397	0.571
DOC_WW_Pin1_4	93	98	PF00397	0.704
DOC_WW_Pin1_4	99	104	PF00397	0.700
LIG_14-3-3_CanoR_1	228	236	PF00244	0.435
LIG_14-3-3_CanoR_1	250	255	PF00244	0.459
LIG_14-3-3_CanoR_1	369	377	PF00244	0.551
LIG_14-3-3_CanoR_1	379	385	PF00244	0.447
LIG_14-3-3_CanoR_1	475	484	PF00244	0.457
LIG_APCC_ABBA_1	458	463	PF00400	0.717
LIG_BIR_II_1	1	5	PF00653	0.680
LIG_BIR_III_2	328	332	PF00653	0.707
LIG_BRCT_BRCA1_1	107	111	PF00533	0.452
LIG_BRCT_BRCA1_1	458	462	PF00533	0.631
LIG_CSL_BTD_1	540	543	PF09270	0.437
LIG_EH1_1	43	51	PF00400	0.579
LIG_eIF4E_1	44	50	PF01652	0.491
LIG_FHA_1	119	125	PF00498	0.487
LIG_FHA_1	184	190	PF00498	0.477
LIG_FHA_1	229	235	PF00498	0.415
LIG_FHA_1	392	398	PF00498	0.511
LIG_FHA_1	489	495	PF00498	0.439
LIG_FHA_1	535	541	PF00498	0.476
LIG_FHA_1	57	63	PF00498	0.573
LIG_FHA_1	73	79	PF00498	0.669
LIG_FHA_2	159	165	PF00498	0.445
LIG_FHA_2	195	201	PF00498	0.656
LIG_FHA_2	331	337	PF00498	0.773
LIG_FHA_2	369	375	PF00498	0.650
LIG_FHA_2	46	52	PF00498	0.573
LIG_FHA_2	476	482	PF00498	0.483
LIG_FHA_2	64	70	PF00498	0.654
LIG_HCF-1_HBM_1	246	249	PF13415	0.580
LIG_MLH1_MIPbox_1	458	462	PF16413	0.631
LIG_MYND_1	303	307	PF01753	0.594
LIG_Pex14_2	384	388	PF04695	0.562
LIG_SH2_CRK	90	94	PF00017	0.725
LIG_SH2_GRB2like	183	186	PF00017	0.562
LIG_SH2_NCK_1	256	260	PF00017	0.584
LIG_SH2_NCK_1	90	94	PF00017	0.687
LIG_SH2_SRC	256	259	PF00017	0.517
LIG_SH2_STAP1	183	187	PF00017	0.550
LIG_SH2_STAP1	256	260	PF00017	0.529
LIG_SH2_STAT5	151	154	PF00017	0.526
LIG_SH2_STAT5	205	208	PF00017	0.502
LIG_SH2_STAT5	428	431	PF00017	0.547
LIG_SH3_3	213	219	PF00018	0.489
LIG_SH3_3	298	304	PF00018	0.764
LIG_SH3_3	358	364	PF00018	0.686
LIG_SH3_3	467	473	PF00018	0.693
LIG_SUMO_SIM_par_1	270	276	PF11976	0.428
LIG_TRAF2_1	162	165	PF00917	0.562
LIG_UBA3_1	49	56	PF00899	0.481
LIG_WW_2	303	306	PF00397	0.593
LIG_WW_3	363	367	PF00397	0.740
LIG_WW_3	472	476	PF00397	0.653
MOD_CK1_1	357	363	PF00069	0.700
MOD_CK1_1	380	386	PF00069	0.470
MOD_CK1_1	414	420	PF00069	0.687
MOD_CK1_1	5	11	PF00069	0.650
MOD_CK1_1	533	539	PF00069	0.514
MOD_CK1_1	63	69	PF00069	0.658
MOD_CK1_1	96	102	PF00069	0.692
MOD_CK2_1	127	133	PF00069	0.559
MOD_CK2_1	158	164	PF00069	0.427
MOD_CK2_1	252	258	PF00069	0.514
MOD_CK2_1	330	336	PF00069	0.748
MOD_CK2_1	368	374	PF00069	0.582
MOD_Cter_Amidation	419	422	PF01082	0.730
MOD_GlcNHglycan	15	18	PF01048	0.520
MOD_GlcNHglycan	152	155	PF01048	0.571
MOD_GlcNHglycan	179	182	PF01048	0.290
MOD_GlcNHglycan	212	215	PF01048	0.442
MOD_GlcNHglycan	3	7	PF01048	0.635
MOD_GlcNHglycan	349	352	PF01048	0.689
MOD_GlcNHglycan	354	357	PF01048	0.659
MOD_GlcNHglycan	400	403	PF01048	0.422
MOD_GlcNHglycan	413	416	PF01048	0.562
MOD_GlcNHglycan	532	535	PF01048	0.410
MOD_GlcNHglycan	98	101	PF01048	0.715
MOD_GSK3_1	179	186	PF00069	0.470
MOD_GSK3_1	224	231	PF00069	0.408
MOD_GSK3_1	282	289	PF00069	0.662
MOD_GSK3_1	387	394	PF00069	0.563
MOD_GSK3_1	4	11	PF00069	0.608
MOD_GSK3_1	517	524	PF00069	0.495
MOD_GSK3_1	52	59	PF00069	0.466
MOD_GSK3_1	530	537	PF00069	0.370
MOD_LATS_1	312	318	PF00433	0.727
MOD_N-GLC_1	287	292	PF02516	0.728
MOD_NEK2_1	136	141	PF00069	0.515
MOD_NEK2_1	210	215	PF00069	0.382
MOD_NEK2_1	265	270	PF00069	0.524
MOD_NEK2_1	34	39	PF00069	0.573
MOD_NEK2_1	352	357	PF00069	0.770
MOD_NEK2_1	482	487	PF00069	0.484
MOD_NEK2_2	183	188	PF00069	0.562
MOD_NEK2_2	534	539	PF00069	0.410
MOD_PIKK_1	15	21	PF00454	0.583
MOD_PIKK_1	8	14	PF00454	0.630
MOD_PK_1	314	320	PF00069	0.620
MOD_PKA_1	475	481	PF00069	0.493
MOD_PKA_2	365	371	PF00069	0.649
MOD_PKA_2	475	481	PF00069	0.482
MOD_PKA_2	514	520	PF00069	0.546
MOD_PKA_2	521	527	PF00069	0.584
MOD_Plk_1	183	189	PF00069	0.519
MOD_Plk_1	287	293	PF00069	0.698
MOD_Plk_1	34	40	PF00069	0.506
MOD_Plk_1	456	462	PF00069	0.628
MOD_Plk_1	534	540	PF00069	0.393
MOD_Plk_4	217	223	PF00069	0.437
MOD_Plk_4	270	276	PF00069	0.512
MOD_Plk_4	34	40	PF00069	0.565
MOD_Plk_4	45	51	PF00069	0.530
MOD_Plk_4	456	462	PF00069	0.697
MOD_ProDKin_1	297	303	PF00069	0.799
MOD_ProDKin_1	377	383	PF00069	0.488
MOD_ProDKin_1	63	69	PF00069	0.567
MOD_ProDKin_1	93	99	PF00069	0.704
TRG_DiLeu_BaEn_1	479	484	PF01217	0.464
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.562
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.482
TRG_ENDOCYTIC_2	90	93	PF00928	0.680
TRG_ER_diArg_1	277	279	PF00400	0.612
TRG_ER_diArg_1	474	476	PF00400	0.530
TRG_ER_diArg_1	521	523	PF00400	0.531
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	71	76	PF00026	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E9	Leptomonas seymouri	68%	96%
A0A0S4JQH6	Bodo saltans	34%	100%
A0A1X0P9Q5	Trypanosomatidae	42%	100%
A0A3R7L5W7	Trypanosoma rangeli	40%	100%
A4HAY5	Leishmania braziliensis	85%	99%
A4IA44	Leishmania infantum	99%	100%
C9ZM56	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B558	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
Q4Q2S7	Leishmania major	93%	99%
V5BKS0	Trypanosoma cruzi	44%	100%