Aminotransferase class IV, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Aminotransferase class IV, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IUN5_LEIDO

TriTrypDb:

LdBPK_342180.1 , LdCL_340029500 , LDHU3_34.3640

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IUN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IUN5

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008483	transaminase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016769	transferase activity, transferring nitrogenous groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.587
CLV_NRD_NRD_1	335	337	PF00675	0.499
CLV_NRD_NRD_1	40	42	PF00675	0.512
CLV_PCSK_KEX2_1	335	337	PF00082	0.504
CLV_PCSK_KEX2_1	40	42	PF00082	0.486
CLV_PCSK_SKI1_1	155	159	PF00082	0.341
CLV_PCSK_SKI1_1	303	307	PF00082	0.339
CLV_PCSK_SKI1_1	309	313	PF00082	0.332
DEG_Nend_UBRbox_1	1	4	PF02207	0.509
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.526
DOC_CYCLIN_yCln2_LP_2	362	368	PF00134	0.449
DOC_MAPK_DCC_7	359	368	PF00069	0.444
DOC_MAPK_gen_1	97	105	PF00069	0.496
DOC_MAPK_MEF2A_6	196	205	PF00069	0.526
DOC_PP1_RVXF_1	156	163	PF00149	0.482
DOC_PP1_RVXF_1	307	313	PF00149	0.573
DOC_PP2B_LxvP_1	119	122	PF13499	0.534
DOC_PP2B_LxvP_1	124	127	PF13499	0.534
DOC_PP4_FxxP_1	176	179	PF00568	0.512
DOC_USP7_MATH_1	10	14	PF00917	0.670
DOC_USP7_MATH_1	185	189	PF00917	0.559
DOC_USP7_MATH_1	190	194	PF00917	0.566
DOC_USP7_MATH_1	250	254	PF00917	0.482
DOC_USP7_MATH_1	322	326	PF00917	0.562
DOC_USP7_MATH_1	59	63	PF00917	0.502
DOC_USP7_MATH_1	72	76	PF00917	0.482
DOC_USP7_MATH_2	127	133	PF00917	0.467
DOC_USP7_UBL2_3	299	303	PF12436	0.562
DOC_WW_Pin1_4	141	146	PF00397	0.526
DOC_WW_Pin1_4	314	319	PF00397	0.482
LIG_14-3-3_CanoR_1	112	118	PF00244	0.562
LIG_14-3-3_CanoR_1	27	33	PF00244	0.549
LIG_14-3-3_CanoR_1	41	51	PF00244	0.386
LIG_Actin_WH2_2	288	305	PF00022	0.562
LIG_APCC_ABBA_1	326	331	PF00400	0.420
LIG_BIR_III_2	84	88	PF00653	0.635
LIG_EH1_1	36	44	PF00400	0.257
LIG_FHA_1	112	118	PF00498	0.530
LIG_FHA_1	281	287	PF00498	0.496
LIG_FHA_2	299	305	PF00498	0.575
LIG_LIR_Apic_2	174	179	PF02991	0.559
LIG_LIR_Apic_2	245	250	PF02991	0.535
LIG_LIR_Gen_1	57	66	PF02991	0.505
LIG_LIR_Gen_1	86	96	PF02991	0.518
LIG_LIR_Nem_3	282	287	PF02991	0.560
LIG_LIR_Nem_3	57	61	PF02991	0.463
LIG_LIR_Nem_3	86	92	PF02991	0.474
LIG_PCNA_yPIPBox_3	155	163	PF02747	0.593
LIG_Pex14_2	51	55	PF04695	0.506
LIG_SH2_CRK	284	288	PF00017	0.585
LIG_SH2_CRK	89	93	PF00017	0.474
LIG_SH2_SRC	141	144	PF00017	0.544
LIG_SH2_SRC	148	151	PF00017	0.550
LIG_SH2_SRC	338	341	PF00017	0.522
LIG_SH2_STAP1	109	113	PF00017	0.523
LIG_SH2_STAP1	235	239	PF00017	0.562
LIG_SH2_STAP1	338	342	PF00017	0.525
LIG_SH2_STAT3	257	260	PF00017	0.534
LIG_SH2_STAT5	141	144	PF00017	0.494
LIG_SH2_STAT5	148	151	PF00017	0.481
LIG_SH2_STAT5	228	231	PF00017	0.570
LIG_SH2_STAT5	247	250	PF00017	0.364
LIG_SH2_STAT5	257	260	PF00017	0.446
LIG_SH2_STAT5	378	381	PF00017	0.492
LIG_SH2_STAT5	5	8	PF00017	0.516
LIG_SUMO_SIM_anti_2	236	242	PF11976	0.496
LIG_SUMO_SIM_par_1	236	242	PF11976	0.496
LIG_SUMO_SIM_par_1	64	70	PF11976	0.461
LIG_SxIP_EBH_1	155	169	PF03271	0.526
LIG_TRAF2_1	269	272	PF00917	0.513
LIG_UBA3_1	181	186	PF00899	0.519
LIG_UBA3_1	274	281	PF00899	0.575
LIG_WRC_WIRS_1	55	60	PF05994	0.481
MOD_CK1_1	188	194	PF00069	0.536
MOD_CK1_1	262	268	PF00069	0.568
MOD_CK2_1	105	111	PF00069	0.585
MOD_CK2_1	266	272	PF00069	0.522
MOD_GlcNHglycan	268	271	PF01048	0.356
MOD_GlcNHglycan	371	374	PF01048	0.321
MOD_GlcNHglycan	60	64	PF01048	0.498
MOD_GlcNHglycan	74	77	PF01048	0.408
MOD_GSK3_1	111	118	PF00069	0.489
MOD_GSK3_1	163	170	PF00069	0.476
MOD_GSK3_1	184	191	PF00069	0.552
MOD_GSK3_1	19	26	PF00069	0.632
MOD_GSK3_1	262	269	PF00069	0.540
MOD_GSK3_1	276	283	PF00069	0.557
MOD_GSK3_1	369	376	PF00069	0.333
MOD_NEK2_1	105	110	PF00069	0.556
MOD_NEK2_1	113	118	PF00069	0.496
MOD_NEK2_1	184	189	PF00069	0.504
MOD_NEK2_1	23	28	PF00069	0.687
MOD_NEK2_1	280	285	PF00069	0.532
MOD_NEK2_1	345	350	PF00069	0.558
MOD_NEK2_1	54	59	PF00069	0.486
MOD_NEK2_2	190	195	PF00069	0.542
MOD_NEK2_2	298	303	PF00069	0.585
MOD_PIKK_1	373	379	PF00454	0.360
MOD_PKA_2	111	117	PF00069	0.544
MOD_Plk_1	19	25	PF00069	0.507
MOD_Plk_4	129	135	PF00069	0.560
MOD_Plk_4	158	164	PF00069	0.496
MOD_Plk_4	190	196	PF00069	0.499
MOD_Plk_4	262	268	PF00069	0.547
MOD_Plk_4	316	322	PF00069	0.546
MOD_Plk_4	4	10	PF00069	0.598
MOD_ProDKin_1	141	147	PF00069	0.526
MOD_ProDKin_1	314	320	PF00069	0.482
MOD_SUMO_for_1	358	361	PF00179	0.320
MOD_SUMO_rev_2	304	311	PF00179	0.585
MOD_SUMO_rev_2	356	360	PF00179	0.513
TRG_DiLeu_BaEn_1	129	134	PF01217	0.526
TRG_DiLeu_BaEn_1	271	276	PF01217	0.513
TRG_DiLeu_BaEn_2	32	38	PF01217	0.298
TRG_ENDOCYTIC_2	235	238	PF00928	0.543
TRG_ENDOCYTIC_2	284	287	PF00928	0.562
TRG_ENDOCYTIC_2	5	8	PF00928	0.516
TRG_ENDOCYTIC_2	89	92	PF00928	0.417
TRG_ENDOCYTIC_2	93	96	PF00928	0.473
TRG_ER_diArg_1	335	337	PF00400	0.484
TRG_ER_diArg_1	39	41	PF00400	0.516
TRG_ER_diArg_1	96	99	PF00400	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDK5	Leptomonas seymouri	63%	100%
A0A1X0PAI4	Trypanosomatidae	38%	100%
A0A3R7NT31	Trypanosoma rangeli	36%	100%
A4HAV2	Leishmania braziliensis	82%	100%
A4I9Z9	Leishmania infantum	98%	100%
C9ZML4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	99%
E9B527	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q2V9	Leishmania major	88%	100%
V5B0F3	Trypanosoma cruzi	33%	82%