PCI domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3808), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IUJ9_LEIDO

TriTrypDb:

LdBPK_341600.1 , LdCL_340022300 , LDHU3_34.2440

Length:

803

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	2

Expansion

Sequence features

A0A3Q8IUJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IUJ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.508
CLV_C14_Caspase3-7	479	483	PF00656	0.480
CLV_C14_Caspase3-7	633	637	PF00656	0.431
CLV_NRD_NRD_1	512	514	PF00675	0.233
CLV_NRD_NRD_1	529	531	PF00675	0.321
CLV_NRD_NRD_1	607	609	PF00675	0.489
CLV_PCSK_KEX2_1	439	441	PF00082	0.298
CLV_PCSK_KEX2_1	548	550	PF00082	0.293
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.321
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.340
CLV_PCSK_SKI1_1	142	146	PF00082	0.202
CLV_PCSK_SKI1_1	291	295	PF00082	0.364
CLV_PCSK_SKI1_1	302	306	PF00082	0.304
CLV_PCSK_SKI1_1	531	535	PF00082	0.321
CLV_PCSK_SKI1_1	56	60	PF00082	0.434
CLV_PCSK_SKI1_1	697	701	PF00082	0.419
CLV_PCSK_SKI1_1	797	801	PF00082	0.605
DEG_APCC_DBOX_1	301	309	PF00400	0.540
DOC_CYCLIN_RxL_1	643	655	PF00134	0.506
DOC_CYCLIN_yCln2_LP_2	570	576	PF00134	0.587
DOC_MAPK_gen_1	373	381	PF00069	0.560
DOC_MAPK_gen_1	386	396	PF00069	0.512
DOC_MAPK_gen_1	439	447	PF00069	0.540
DOC_MAPK_gen_1	548	555	PF00069	0.575
DOC_MAPK_gen_1	608	615	PF00069	0.508
DOC_MAPK_gen_1	707	716	PF00069	0.551
DOC_MAPK_MEF2A_6	375	383	PF00069	0.502
DOC_MAPK_MEF2A_6	389	398	PF00069	0.462
DOC_PP1_RVXF_1	647	654	PF00149	0.526
DOC_USP7_MATH_1	205	209	PF00917	0.563
DOC_USP7_MATH_1	333	337	PF00917	0.480
DOC_USP7_MATH_1	347	351	PF00917	0.442
DOC_USP7_MATH_1	406	410	PF00917	0.508
DOC_USP7_MATH_1	5	9	PF00917	0.664
DOC_USP7_MATH_1	652	656	PF00917	0.666
DOC_USP7_MATH_1	680	684	PF00917	0.668
DOC_USP7_MATH_1	756	760	PF00917	0.459
DOC_USP7_UBL2_3	223	227	PF12436	0.464
DOC_USP7_UBL2_3	778	782	PF12436	0.525
DOC_WW_Pin1_4	246	251	PF00397	0.537
DOC_WW_Pin1_4	329	334	PF00397	0.490
DOC_WW_Pin1_4	557	562	PF00397	0.440
DOC_WW_Pin1_4	56	61	PF00397	0.571
DOC_WW_Pin1_4	626	631	PF00397	0.504
DOC_WW_Pin1_4	659	664	PF00397	0.690
DOC_WW_Pin1_4	667	672	PF00397	0.738
DOC_WW_Pin1_4	720	725	PF00397	0.496
LIG_14-3-3_CanoR_1	110	116	PF00244	0.521
LIG_14-3-3_CanoR_1	129	137	PF00244	0.362
LIG_14-3-3_CanoR_1	170	175	PF00244	0.521
LIG_14-3-3_CanoR_1	204	210	PF00244	0.563
LIG_14-3-3_CanoR_1	260	265	PF00244	0.540
LIG_14-3-3_CanoR_1	277	281	PF00244	0.469
LIG_14-3-3_CanoR_1	389	395	PF00244	0.542
LIG_14-3-3_CanoR_1	530	536	PF00244	0.536
LIG_14-3-3_CanoR_1	681	685	PF00244	0.637
LIG_14-3-3_CanoR_1	729	734	PF00244	0.400
LIG_14-3-3_CanoR_1	90	100	PF00244	0.532
LIG_Actin_WH2_2	290	308	PF00022	0.540
LIG_BIR_II_1	1	5	PF00653	0.736
LIG_BRCT_BRCA1_1	145	149	PF00533	0.527
LIG_BRCT_BRCA1_1	41	45	PF00533	0.442
LIG_BRCT_BRCA1_1	649	653	PF00533	0.533
LIG_BRCT_BRCA1_2	145	151	PF00533	0.563
LIG_deltaCOP1_diTrp_1	160	169	PF00928	0.496
LIG_DLG_GKlike_1	729	737	PF00625	0.510
LIG_FHA_1	270	276	PF00498	0.534
LIG_FHA_1	364	370	PF00498	0.512
LIG_FHA_1	389	395	PF00498	0.521
LIG_FHA_2	504	510	PF00498	0.509
LIG_HCF-1_HBM_1	217	220	PF13415	0.508
LIG_IRF3_LxIS_1	394	399	PF10401	0.480
LIG_LIR_Gen_1	146	153	PF02991	0.515
LIG_LIR_Gen_1	211	220	PF02991	0.509
LIG_LIR_Gen_1	506	515	PF02991	0.538
LIG_LIR_Nem_3	146	152	PF02991	0.544
LIG_LIR_Nem_3	207	212	PF02991	0.465
LIG_LIR_Nem_3	355	360	PF02991	0.503
LIG_LIR_Nem_3	422	426	PF02991	0.460
LIG_LIR_Nem_3	427	432	PF02991	0.460
LIG_LIR_Nem_3	506	510	PF02991	0.538
LIG_LIR_Nem_3	686	691	PF02991	0.389
LIG_LIR_Nem_3	743	749	PF02991	0.408
LIG_PCNA_yPIPBox_3	182	196	PF02747	0.553
LIG_PCNA_yPIPBox_3	622	635	PF02747	0.479
LIG_Pex14_1	731	735	PF04695	0.430
LIG_Pex14_2	149	153	PF04695	0.563
LIG_REV1ctd_RIR_1	75	85	PF16727	0.490
LIG_RPA_C_Fungi	44	56	PF08784	0.530
LIG_SH2_CRK	209	213	PF00017	0.364
LIG_SH2_CRK	343	347	PF00017	0.425
LIG_SH2_CRK	432	436	PF00017	0.380
LIG_SH2_CRK	688	692	PF00017	0.414
LIG_SH2_NCK_1	735	739	PF00017	0.404
LIG_SH2_NCK_1	742	746	PF00017	0.347
LIG_SH2_SRC	357	360	PF00017	0.425
LIG_SH2_SRC	432	435	PF00017	0.380
LIG_SH2_SRC	634	637	PF00017	0.422
LIG_SH2_STAP1	426	430	PF00017	0.356
LIG_SH2_STAP1	592	596	PF00017	0.449
LIG_SH2_STAP1	72	76	PF00017	0.380
LIG_SH2_STAP1	735	739	PF00017	0.423
LIG_SH2_STAP1	742	746	PF00017	0.388
LIG_SH2_STAT3	788	791	PF00017	0.386
LIG_SH2_STAT5	357	360	PF00017	0.422
LIG_SH2_STAT5	461	464	PF00017	0.379
LIG_SH2_STAT5	619	622	PF00017	0.475
LIG_SH2_STAT5	634	637	PF00017	0.525
LIG_SH2_STAT5	746	749	PF00017	0.431
LIG_SH3_3	244	250	PF00018	0.434
LIG_SH3_3	570	576	PF00018	0.517
LIG_SH3_3	584	590	PF00018	0.401
LIG_SH3_3	665	671	PF00018	0.771
LIG_SH3_3	674	680	PF00018	0.700
LIG_SH3_5	630	634	PF00018	0.550
LIG_SUMO_SIM_par_1	610	617	PF11976	0.514
LIG_TRAF2_1	23	26	PF00917	0.672
LIG_TRAF2_1	239	242	PF00917	0.380
LIG_TRAF2_1	498	501	PF00917	0.244
LIG_UBA3_1	690	697	PF00899	0.432
LIG_UBA3_1	760	766	PF00899	0.521
MOD_CDC14_SPxK_1	249	252	PF00782	0.341
MOD_CDK_SPxK_1	246	252	PF00069	0.341
MOD_CDK_SPxxK_3	659	666	PF00069	0.576
MOD_CDK_SPxxK_3	720	727	PF00069	0.522
MOD_CK1_1	143	149	PF00069	0.427
MOD_CK1_1	208	214	PF00069	0.466
MOD_CK1_1	255	261	PF00069	0.368
MOD_CK1_1	4	10	PF00069	0.722
MOD_CK1_1	449	455	PF00069	0.324
MOD_CK1_1	508	514	PF00069	0.441
MOD_CK1_1	659	665	PF00069	0.654
MOD_CK1_1	91	97	PF00069	0.446
MOD_CK2_1	162	168	PF00069	0.425
MOD_CK2_1	45	51	PF00069	0.522
MOD_CK2_1	495	501	PF00069	0.472
MOD_CK2_1	634	640	PF00069	0.570
MOD_CK2_1	65	71	PF00069	0.339
MOD_CK2_1	680	686	PF00069	0.595
MOD_CK2_1	7	13	PF00069	0.680
MOD_GlcNHglycan	130	133	PF01048	0.425
MOD_GlcNHglycan	164	167	PF01048	0.383
MOD_GlcNHglycan	192	195	PF01048	0.411
MOD_GlcNHglycan	265	269	PF01048	0.382
MOD_GlcNHglycan	3	6	PF01048	0.657
MOD_GlcNHglycan	335	338	PF01048	0.360
MOD_GlcNHglycan	349	352	PF01048	0.371
MOD_GlcNHglycan	7	10	PF01048	0.579
MOD_GlcNHglycan	769	772	PF01048	0.568
MOD_GSK3_1	1	8	PF00069	0.754
MOD_GSK3_1	128	135	PF00069	0.318
MOD_GSK3_1	136	143	PF00069	0.329
MOD_GSK3_1	204	211	PF00069	0.422
MOD_GSK3_1	226	233	PF00069	0.420
MOD_GSK3_1	242	249	PF00069	0.468
MOD_GSK3_1	260	267	PF00069	0.384
MOD_GSK3_1	329	336	PF00069	0.379
MOD_GSK3_1	390	397	PF00069	0.354
MOD_GSK3_1	505	512	PF00069	0.433
MOD_GSK3_1	553	560	PF00069	0.421
MOD_GSK3_1	647	654	PF00069	0.602
MOD_GSK3_1	667	674	PF00069	0.486
MOD_N-GLC_1	205	210	PF02516	0.347
MOD_N-GLC_1	45	50	PF02516	0.648
MOD_N-GLC_1	56	61	PF02516	0.440
MOD_N-GLC_2	402	404	PF02516	0.458
MOD_NEK2_1	127	132	PF00069	0.334
MOD_NEK2_1	188	193	PF00069	0.364
MOD_NEK2_1	264	269	PF00069	0.425
MOD_NEK2_1	292	297	PF00069	0.425
MOD_NEK2_1	353	358	PF00069	0.348
MOD_NEK2_1	374	379	PF00069	0.285
MOD_NEK2_1	396	401	PF00069	0.399
MOD_NEK2_1	448	453	PF00069	0.384
MOD_NEK2_1	45	50	PF00069	0.562
MOD_NEK2_1	651	656	PF00069	0.682
MOD_NEK2_2	226	231	PF00069	0.244
MOD_NEK2_2	634	639	PF00069	0.462
MOD_NEK2_2	85	90	PF00069	0.413
MOD_PIKK_1	132	138	PF00454	0.391
MOD_PIKK_1	175	181	PF00454	0.447
MOD_PIKK_1	230	236	PF00454	0.380
MOD_PIKK_1	408	414	PF00454	0.319
MOD_PIKK_1	459	465	PF00454	0.356
MOD_PIKK_1	518	524	PF00454	0.341
MOD_PKA_1	439	445	PF00069	0.425
MOD_PKA_2	128	134	PF00069	0.343
MOD_PKA_2	276	282	PF00069	0.356
MOD_PKA_2	374	380	PF00069	0.364
MOD_PKA_2	388	394	PF00069	0.265
MOD_PKA_2	439	445	PF00069	0.425
MOD_PKA_2	680	686	PF00069	0.563
MOD_PKA_2	91	97	PF00069	0.411
MOD_Plk_1	140	146	PF00069	0.410
MOD_Plk_1	205	211	PF00069	0.347
MOD_Plk_1	394	400	PF00069	0.386
MOD_Plk_1	750	756	PF00069	0.462
MOD_Plk_1	85	91	PF00069	0.321
MOD_Plk_4	140	146	PF00069	0.425
MOD_Plk_4	208	214	PF00069	0.416
MOD_Plk_4	252	258	PF00069	0.341
MOD_Plk_4	292	298	PF00069	0.379
MOD_Plk_4	326	332	PF00069	0.327
MOD_Plk_4	353	359	PF00069	0.347
MOD_Plk_4	374	380	PF00069	0.313
MOD_Plk_4	560	566	PF00069	0.554
MOD_Plk_4	695	701	PF00069	0.428
MOD_Plk_4	756	762	PF00069	0.502
MOD_ProDKin_1	246	252	PF00069	0.421
MOD_ProDKin_1	329	335	PF00069	0.356
MOD_ProDKin_1	557	563	PF00069	0.445
MOD_ProDKin_1	56	62	PF00069	0.571
MOD_ProDKin_1	626	632	PF00069	0.499
MOD_ProDKin_1	659	665	PF00069	0.692
MOD_ProDKin_1	667	673	PF00069	0.738
MOD_ProDKin_1	720	726	PF00069	0.491
MOD_SUMO_rev_2	498	503	PF00179	0.454
TRG_DiLeu_BaEn_1	316	321	PF01217	0.458
TRG_DiLeu_BaEn_1	686	691	PF01217	0.493
TRG_DiLeu_BaEn_4	500	506	PF01217	0.399
TRG_DiLeu_LyEn_5	686	691	PF01217	0.429
TRG_ENDOCYTIC_2	209	212	PF00928	0.324
TRG_ENDOCYTIC_2	213	216	PF00928	0.327
TRG_ENDOCYTIC_2	343	346	PF00928	0.425
TRG_ENDOCYTIC_2	357	360	PF00928	0.417
TRG_ENDOCYTIC_2	432	435	PF00928	0.398
TRG_ENDOCYTIC_2	688	691	PF00928	0.418
TRG_ENDOCYTIC_2	696	699	PF00928	0.390
TRG_ER_diArg_1	89	92	PF00400	0.425
TRG_NES_CRM1_1	20	34	PF08389	0.573
TRG_NES_CRM1_1	372	384	PF08389	0.380
TRG_NLS_MonoExtC_3	566	572	PF00514	0.589
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	568	572	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I210	Leptomonas seymouri	60%	100%
A0A1X0PAU9	Trypanosomatidae	30%	100%
A0A3R7K1I3	Trypanosoma rangeli	28%	100%
A4H7S4	Leishmania braziliensis	74%	100%
A4I9W2	Leishmania infantum	100%	100%
C9ZMS0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D3ZC96	Rattus norvegicus	22%	100%
E9B4X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q352	Leishmania major	91%	100%
V5B3F2	Trypanosoma cruzi	29%	100%