AAA domain (Dynein-related subfamily)/ATPase family associated with various cellular activities (AAA)/AAA domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase family associated with various cellular activities (AAA), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IUC9_LEIDO

TriTrypDb:

LdBPK_340360.1 , LdCL_340008700 , LDHU3_34.0530

Length:

803

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3Q8IUC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IUC9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0016887	ATP hydrolysis activity	7	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	608	612	PF00656	0.716
CLV_C14_Caspase3-7	643	647	PF00656	0.707
CLV_C14_Caspase3-7	792	796	PF00656	0.597
CLV_NRD_NRD_1	169	171	PF00675	0.452
CLV_NRD_NRD_1	215	217	PF00675	0.448
CLV_NRD_NRD_1	290	292	PF00675	0.449
CLV_NRD_NRD_1	511	513	PF00675	0.275
CLV_NRD_NRD_1	584	586	PF00675	0.448
CLV_NRD_NRD_1	744	746	PF00675	0.427
CLV_PCSK_KEX2_1	169	171	PF00082	0.452
CLV_PCSK_KEX2_1	191	193	PF00082	0.546
CLV_PCSK_KEX2_1	215	217	PF00082	0.466
CLV_PCSK_KEX2_1	290	292	PF00082	0.449
CLV_PCSK_KEX2_1	343	345	PF00082	0.518
CLV_PCSK_KEX2_1	511	513	PF00082	0.275
CLV_PCSK_KEX2_1	744	746	PF00082	0.427
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.512
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.518
CLV_PCSK_SKI1_1	126	130	PF00082	0.396
CLV_PCSK_SKI1_1	344	348	PF00082	0.476
CLV_PCSK_SKI1_1	43	47	PF00082	0.379
CLV_PCSK_SKI1_1	756	760	PF00082	0.376
DEG_APCC_DBOX_1	343	351	PF00400	0.684
DEG_APCC_DBOX_1	510	518	PF00400	0.475
DEG_COP1_1	135	145	PF00400	0.602
DEG_Nend_UBRbox_2	1	3	PF02207	0.496
DEG_SPOP_SBC_1	427	431	PF00917	0.667
DOC_ANK_TNKS_1	476	483	PF00023	0.585
DOC_CDC14_PxL_1	348	356	PF14671	0.678
DOC_MAPK_gen_1	343	350	PF00069	0.665
DOC_MAPK_gen_1	449	458	PF00069	0.610
DOC_MAPK_gen_1	508	517	PF00069	0.485
DOC_MAPK_gen_1	546	555	PF00069	0.665
DOC_MAPK_MEF2A_6	511	519	PF00069	0.475
DOC_PP1_RVXF_1	484	490	PF00149	0.530
DOC_PP2B_LxvP_1	680	683	PF13499	0.592
DOC_PP4_FxxP_1	273	276	PF00568	0.722
DOC_PP4_FxxP_1	478	481	PF00568	0.609
DOC_SPAK_OSR1_1	477	481	PF12202	0.576
DOC_USP7_MATH_1	195	199	PF00917	0.705
DOC_USP7_MATH_1	316	320	PF00917	0.747
DOC_USP7_MATH_1	389	393	PF00917	0.675
DOC_USP7_MATH_1	399	403	PF00917	0.695
DOC_USP7_MATH_1	414	418	PF00917	0.720
DOC_USP7_MATH_1	557	561	PF00917	0.573
DOC_USP7_MATH_1	618	622	PF00917	0.735
DOC_USP7_MATH_1	703	707	PF00917	0.610
DOC_WD40_RPTOR_TOS_1	535	541	PF00400	0.634
DOC_WW_Pin1_4	616	621	PF00397	0.745
LIG_14-3-3_CanoR_1	124	129	PF00244	0.667
LIG_14-3-3_CanoR_1	131	141	PF00244	0.607
LIG_14-3-3_CanoR_1	330	335	PF00244	0.618
LIG_14-3-3_CanoR_1	43	53	PF00244	0.619
LIG_14-3-3_CanoR_1	449	454	PF00244	0.630
LIG_14-3-3_CanoR_1	463	468	PF00244	0.481
LIG_14-3-3_CanoR_1	486	490	PF00244	0.577
LIG_14-3-3_CanoR_1	556	562	PF00244	0.525
LIG_14-3-3_CanoR_1	744	752	PF00244	0.622
LIG_14-3-3_CanoR_1	790	795	PF00244	0.610
LIG_Actin_WH2_2	524	542	PF00022	0.608
LIG_AP2alpha_1	673	677	PF02296	0.530
LIG_APCC_ABBA_1	372	377	PF00400	0.669
LIG_APCC_ABBA_1	561	566	PF00400	0.525
LIG_APCC_ABBAyCdc20_2	110	116	PF00400	0.667
LIG_BIR_III_4	568	572	PF00653	0.536
LIG_BRCT_BRCA1_1	104	108	PF00533	0.645
LIG_BRCT_BRCA1_1	110	114	PF00533	0.649
LIG_BRCT_BRCA1_1	121	125	PF00533	0.576
LIG_BRCT_BRCA1_1	269	273	PF00533	0.767
LIG_BRCT_BRCA1_1	402	406	PF00533	0.674
LIG_BRCT_BRCA1_1	454	458	PF00533	0.537
LIG_BRCT_BRCA1_2	104	110	PF00533	0.625
LIG_CaM_IQ_9	577	593	PF13499	0.619
LIG_CAP-Gly_1	795	803	PF01302	0.648
LIG_CtBP_PxDLS_1	660	664	PF00389	0.618
LIG_deltaCOP1_diTrp_1	115	125	PF00928	0.678
LIG_eIF4E_1	102	108	PF01652	0.663
LIG_FHA_1	12	18	PF00498	0.262
LIG_FHA_1	331	337	PF00498	0.613
LIG_FHA_1	460	466	PF00498	0.543
LIG_FHA_1	486	492	PF00498	0.579
LIG_FHA_1	498	504	PF00498	0.430
LIG_FHA_1	548	554	PF00498	0.658
LIG_FHA_1	650	656	PF00498	0.677
LIG_FHA_1	721	727	PF00498	0.526
LIG_FHA_1	747	753	PF00498	0.578
LIG_FHA_1	786	792	PF00498	0.527
LIG_FHA_2	264	270	PF00498	0.707
LIG_FHA_2	522	528	PF00498	0.490
LIG_FXI_DFP_1	564	568	PF00024	0.327
LIG_GBD_Chelix_1	506	514	PF00786	0.275
LIG_HCF-1_HBM_1	727	730	PF13415	0.593
LIG_LIR_Apic_2	270	276	PF02991	0.820
LIG_LIR_Apic_2	288	292	PF02991	0.588
LIG_LIR_Gen_1	101	108	PF02991	0.609
LIG_LIR_Gen_1	452	459	PF02991	0.594
LIG_LIR_Gen_1	565	573	PF02991	0.537
LIG_LIR_Gen_1	671	680	PF02991	0.545
LIG_LIR_Gen_1	684	690	PF02991	0.530
LIG_LIR_Gen_1	795	803	PF02991	0.590
LIG_LIR_Nem_3	101	107	PF02991	0.610
LIG_LIR_Nem_3	115	121	PF02991	0.627
LIG_LIR_Nem_3	122	128	PF02991	0.598
LIG_LIR_Nem_3	379	385	PF02991	0.654
LIG_LIR_Nem_3	452	456	PF02991	0.544
LIG_LIR_Nem_3	565	570	PF02991	0.557
LIG_LIR_Nem_3	572	577	PF02991	0.596
LIG_LIR_Nem_3	671	676	PF02991	0.538
LIG_LIR_Nem_3	684	689	PF02991	0.532
LIG_LIR_Nem_3	795	800	PF02991	0.581
LIG_LYPXL_S_1	350	354	PF13949	0.481
LIG_LYPXL_yS_3	351	354	PF13949	0.679
LIG_MLH1_MIPbox_1	269	273	PF16413	0.733
LIG_MLH1_MIPbox_1	454	458	PF16413	0.537
LIG_NRBOX	12	18	PF00104	0.340
LIG_PDZ_Class_3	798	803	PF00595	0.688
LIG_Pex14_2	114	118	PF04695	0.629
LIG_Pex14_2	125	129	PF04695	0.615
LIG_Pex14_2	30	34	PF04695	0.304
LIG_Pex14_2	40	44	PF04695	0.585
LIG_Pex14_2	453	457	PF04695	0.551
LIG_Pex14_2	673	677	PF04695	0.530
LIG_Pex14_2	686	690	PF04695	0.517
LIG_SH2_CRK	104	108	PF00017	0.616
LIG_SH2_CRK	289	293	PF00017	0.640
LIG_SH2_SRC	102	105	PF00017	0.606
LIG_SH2_SRC	217	220	PF00017	0.625
LIG_SH2_STAP1	102	106	PF00017	0.604
LIG_SH2_STAP1	121	125	PF00017	0.621
LIG_SH2_STAP1	217	221	PF00017	0.651
LIG_SH2_STAP1	730	734	PF00017	0.601
LIG_SH2_STAT5	335	338	PF00017	0.628
LIG_SH2_STAT5	383	386	PF00017	0.583
LIG_SH2_STAT5	562	565	PF00017	0.522
LIG_SH2_STAT5	78	81	PF00017	0.587
LIG_SH2_STAT5	83	86	PF00017	0.582
LIG_SH3_3	239	245	PF00018	0.750
LIG_SH3_3	273	279	PF00018	0.716
LIG_SH3_3	346	352	PF00018	0.682
LIG_SH3_3	528	534	PF00018	0.578
LIG_SUMO_SIM_anti_2	138	144	PF11976	0.617
LIG_SUMO_SIM_anti_2	281	288	PF11976	0.704
LIG_SUMO_SIM_par_1	281	288	PF11976	0.704
LIG_SUMO_SIM_par_1	513	518	PF11976	0.499
LIG_SUMO_SIM_par_1	520	527	PF11976	0.514
LIG_TYR_ITIM	349	354	PF00017	0.679
LIG_WRC_WIRS_1	794	799	PF05994	0.586
MOD_CK1_1	177	183	PF00069	0.731
MOD_CK1_1	261	267	PF00069	0.760
MOD_CK1_1	268	274	PF00069	0.715
MOD_CK1_1	304	310	PF00069	0.730
MOD_CK1_1	402	408	PF00069	0.700
MOD_CK1_1	445	451	PF00069	0.695
MOD_CK1_1	547	553	PF00069	0.688
MOD_CK1_1	6	12	PF00069	0.426
MOD_CK1_1	619	625	PF00069	0.736
MOD_CK1_1	628	634	PF00069	0.694
MOD_CK1_1	793	799	PF00069	0.623
MOD_CK2_1	132	138	PF00069	0.573
MOD_CK2_1	263	269	PF00069	0.719
MOD_CK2_1	515	521	PF00069	0.479
MOD_CK2_1	655	661	PF00069	0.664
MOD_Cter_Amidation	167	170	PF01082	0.447
MOD_Cter_Amidation	189	192	PF01082	0.546
MOD_Cter_Amidation	742	745	PF01082	0.406
MOD_GlcNHglycan	318	321	PF01048	0.513
MOD_GlcNHglycan	377	381	PF01048	0.447
MOD_GlcNHglycan	386	389	PF01048	0.454
MOD_GlcNHglycan	402	405	PF01048	0.439
MOD_GlcNHglycan	445	448	PF01048	0.465
MOD_GlcNHglycan	599	602	PF01048	0.471
MOD_GlcNHglycan	622	625	PF01048	0.637
MOD_GlcNHglycan	627	630	PF01048	0.591
MOD_GlcNHglycan	769	772	PF01048	0.319
MOD_GlcNHglycan	8	11	PF01048	0.629
MOD_GSK3_1	120	127	PF00069	0.626
MOD_GSK3_1	137	144	PF00069	0.730
MOD_GSK3_1	177	184	PF00069	0.700
MOD_GSK3_1	258	265	PF00069	0.808
MOD_GSK3_1	357	364	PF00069	0.688
MOD_GSK3_1	389	396	PF00069	0.715
MOD_GSK3_1	400	407	PF00069	0.753
MOD_GSK3_1	414	421	PF00069	0.709
MOD_GSK3_1	425	432	PF00069	0.710
MOD_GSK3_1	445	452	PF00069	0.659
MOD_GSK3_1	459	466	PF00069	0.484
MOD_GSK3_1	494	501	PF00069	0.485
MOD_GSK3_1	517	524	PF00069	0.547
MOD_GSK3_1	547	554	PF00069	0.688
MOD_GSK3_1	612	619	PF00069	0.726
MOD_GSK3_1	763	770	PF00069	0.534
MOD_GSK3_1	785	792	PF00069	0.574
MOD_GSK3_1	8	15	PF00069	0.394
MOD_N-GLC_1	302	307	PF02516	0.466
MOD_N-GLC_1	762	767	PF02516	0.307
MOD_NEK2_1	137	142	PF00069	0.627
MOD_NEK2_1	210	215	PF00069	0.686
MOD_NEK2_1	301	306	PF00069	0.673
MOD_NEK2_1	426	431	PF00069	0.683
MOD_NEK2_1	655	660	PF00069	0.634
MOD_NEK2_1	701	706	PF00069	0.592
MOD_NEK2_1	708	713	PF00069	0.544
MOD_NEK2_1	71	76	PF00069	0.612
MOD_NEK2_1	747	752	PF00069	0.535
MOD_NEK2_1	762	767	PF00069	0.542
MOD_NEK2_2	44	49	PF00069	0.567
MOD_NEK2_2	485	490	PF00069	0.579
MOD_NEK2_2	557	562	PF00069	0.540
MOD_PIKK_1	177	183	PF00454	0.731
MOD_PIKK_1	244	250	PF00454	0.659
MOD_PIKK_1	263	269	PF00454	0.730
MOD_PIKK_1	295	301	PF00454	0.649
MOD_PIKK_1	314	320	PF00454	0.559
MOD_PIKK_1	612	618	PF00454	0.738
MOD_PIKK_1	720	726	PF00454	0.668
MOD_PIKK_1	747	753	PF00454	0.532
MOD_PK_1	790	796	PF00069	0.618
MOD_PKA_2	174	180	PF00069	0.732
MOD_PKA_2	485	491	PF00069	0.577
MOD_PKA_2	547	553	PF00069	0.720
MOD_PKA_2	604	610	PF00069	0.815
MOD_PKA_2	649	655	PF00069	0.732
MOD_PKA_2	789	795	PF00069	0.566
MOD_Plk_1	102	108	PF00069	0.594
MOD_Plk_1	137	143	PF00069	0.620
MOD_Plk_1	268	274	PF00069	0.704
MOD_Plk_1	415	421	PF00069	0.698
MOD_Plk_1	708	714	PF00069	0.557
MOD_Plk_1	735	741	PF00069	0.694
MOD_Plk_2-3	521	527	PF00069	0.460
MOD_Plk_2-3	637	643	PF00069	0.687
MOD_Plk_2-3	666	672	PF00069	0.613
MOD_Plk_4	102	108	PF00069	0.594
MOD_Plk_4	12	18	PF00069	0.322
MOD_Plk_4	137	143	PF00069	0.680
MOD_Plk_4	268	274	PF00069	0.697
MOD_Plk_4	330	336	PF00069	0.620
MOD_Plk_4	350	356	PF00069	0.623
MOD_Plk_4	452	458	PF00069	0.553
MOD_Plk_4	463	469	PF00069	0.549
MOD_Plk_4	485	491	PF00069	0.587
MOD_Plk_4	498	504	PF00069	0.425
MOD_Plk_4	557	563	PF00069	0.538
MOD_Plk_4	649	655	PF00069	0.680
MOD_Plk_4	682	688	PF00069	0.544
MOD_Plk_4	703	709	PF00069	0.633
MOD_ProDKin_1	616	622	PF00069	0.744
MOD_SUMO_rev_2	269	279	PF00179	0.705
TRG_DiLeu_BaEn_2	151	157	PF01217	0.629
TRG_DiLeu_BaLyEn_6	697	702	PF01217	0.550
TRG_ENDOCYTIC_2	104	107	PF00928	0.619
TRG_ENDOCYTIC_2	351	354	PF00928	0.679
TRG_ENDOCYTIC_2	382	385	PF00928	0.644
TRG_ENDOCYTIC_2	42	45	PF00928	0.608
TRG_ER_diArg_1	214	216	PF00400	0.662
TRG_ER_diArg_1	289	291	PF00400	0.644
TRG_ER_diArg_1	475	478	PF00400	0.574
TRG_ER_diArg_1	510	512	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	291	296	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	585	590	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDZ4	Leptomonas seymouri	51%	97%
A4HAE8	Leishmania braziliensis	69%	99%
A4I9K4	Leishmania infantum	99%	100%
E9B4K2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q3H4	Leishmania major	91%	100%