Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IUB2_LEIDO

TriTrypDb:

LdBPK_333400.1 , LdCL_330041700 , LDHU3_33.4910

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IUB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IUB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.635
CLV_C14_Caspase3-7	268	272	PF00656	0.492
CLV_C14_Caspase3-7	80	84	PF00656	0.515
CLV_NRD_NRD_1	111	113	PF00675	0.632
CLV_NRD_NRD_1	13	15	PF00675	0.623
CLV_NRD_NRD_1	154	156	PF00675	0.585
CLV_NRD_NRD_1	206	208	PF00675	0.609
CLV_NRD_NRD_1	290	292	PF00675	0.830
CLV_NRD_NRD_1	318	320	PF00675	0.750
CLV_NRD_NRD_1	341	343	PF00675	0.771
CLV_NRD_NRD_1	37	39	PF00675	0.556
CLV_NRD_NRD_1	392	394	PF00675	0.712
CLV_NRD_NRD_1	58	60	PF00675	0.471
CLV_NRD_NRD_1	68	70	PF00675	0.542
CLV_NRD_NRD_1	89	91	PF00675	0.605
CLV_PCSK_FUR_1	11	15	PF00082	0.605
CLV_PCSK_FUR_1	56	60	PF00082	0.467
CLV_PCSK_KEX2_1	13	15	PF00082	0.623
CLV_PCSK_KEX2_1	142	144	PF00082	0.628
CLV_PCSK_KEX2_1	154	156	PF00082	0.585
CLV_PCSK_KEX2_1	205	207	PF00082	0.609
CLV_PCSK_KEX2_1	221	223	PF00082	0.400
CLV_PCSK_KEX2_1	340	342	PF00082	0.772
CLV_PCSK_KEX2_1	37	39	PF00082	0.556
CLV_PCSK_KEX2_1	392	394	PF00082	0.712
CLV_PCSK_KEX2_1	58	60	PF00082	0.471
CLV_PCSK_KEX2_1	68	70	PF00082	0.542
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.595
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.583
CLV_PCSK_SKI1_1	118	122	PF00082	0.651
CLV_PCSK_SKI1_1	142	146	PF00082	0.588
CLV_PCSK_SKI1_1	165	169	PF00082	0.540
CLV_PCSK_SKI1_1	3	7	PF00082	0.600
CLV_PCSK_SKI1_1	68	72	PF00082	0.542
DEG_APCC_DBOX_1	93	101	PF00400	0.510
DEG_Nend_Nbox_1	1	3	PF02207	0.589
DEG_SPOP_SBC_1	286	290	PF00917	0.812
DOC_CKS1_1	314	319	PF01111	0.686
DOC_CKS1_1	336	341	PF01111	0.760
DOC_MAPK_gen_1	211	219	PF00069	0.580
DOC_MAPK_MEF2A_6	211	219	PF00069	0.543
DOC_USP7_MATH_1	233	237	PF00917	0.609
DOC_USP7_MATH_1	285	289	PF00917	0.830
DOC_USP7_MATH_1	370	374	PF00917	0.813
DOC_USP7_MATH_1	386	390	PF00917	0.594
DOC_USP7_MATH_1	430	434	PF00917	0.787
DOC_USP7_MATH_1	436	440	PF00917	0.676
DOC_USP7_MATH_1	72	76	PF00917	0.616
DOC_USP7_UBL2_3	173	177	PF12436	0.595
DOC_USP7_UBL2_3	179	183	PF12436	0.519
DOC_USP7_UBL2_3	46	50	PF12436	0.503
DOC_WW_Pin1_4	12	17	PF00397	0.549
DOC_WW_Pin1_4	275	280	PF00397	0.752
DOC_WW_Pin1_4	313	318	PF00397	0.683
DOC_WW_Pin1_4	335	340	PF00397	0.769
DOC_WW_Pin1_4	384	389	PF00397	0.796
DOC_WW_Pin1_4	426	431	PF00397	0.723
LIG_14-3-3_CanoR_1	143	149	PF00244	0.634
LIG_14-3-3_CanoR_1	291	297	PF00244	0.798
LIG_14-3-3_CanoR_1	419	423	PF00244	0.656
LIG_Actin_WH2_2	5	21	PF00022	0.607
LIG_FHA_1	2	8	PF00498	0.612
LIG_FHA_1	240	246	PF00498	0.639
LIG_FHA_1	449	455	PF00498	0.646
LIG_FHA_2	305	311	PF00498	0.700
LIG_FHA_2	78	84	PF00498	0.594
LIG_GBD_Chelix_1	63	71	PF00786	0.472
LIG_LIR_Gen_1	45	55	PF02991	0.450
LIG_LIR_Nem_3	45	51	PF02991	0.455
LIG_MYND_1	16	20	PF01753	0.620
LIG_NRBOX	1	7	PF00104	0.585
LIG_PDZ_Class_2	452	457	PF00595	0.736
LIG_RPA_C_Fungi	97	109	PF08784	0.517
LIG_SH2_STAT5	86	89	PF00017	0.490
LIG_SH3_2	314	319	PF14604	0.661
LIG_SH3_2	336	341	PF14604	0.760
LIG_SH3_2	388	393	PF14604	0.650
LIG_SH3_3	122	128	PF00018	0.715
LIG_SH3_3	14	20	PF00018	0.602
LIG_SH3_3	311	317	PF00018	0.656
LIG_SH3_3	326	332	PF00018	0.770
LIG_SH3_3	333	339	PF00018	0.675
LIG_SH3_3	385	391	PF00018	0.731
LIG_TRAF2_1	235	238	PF00917	0.617
LIG_TRAF2_1	328	331	PF00917	0.682
LIG_TRAF2_1	374	377	PF00917	0.765
LIG_TRAF2_1	380	383	PF00917	0.691
LIG_WW_3	316	320	PF00397	0.592
MOD_CDK_SPK_2	335	340	PF00069	0.761
MOD_CDK_SPxK_1	313	319	PF00069	0.630
MOD_CDK_SPxK_1	335	341	PF00069	0.761
MOD_CDK_SPxxK_3	12	19	PF00069	0.553
MOD_CDK_SPxxK_3	313	320	PF00069	0.660
MOD_CDK_SPxxK_3	335	342	PF00069	0.763
MOD_CK1_1	290	296	PF00069	0.795
MOD_CK2_1	304	310	PF00069	0.763
MOD_CK2_1	401	407	PF00069	0.703
MOD_CK2_1	434	440	PF00069	0.609
MOD_GlcNHglycan	299	302	PF01048	0.703
MOD_GlcNHglycan	357	360	PF01048	0.743
MOD_GlcNHglycan	372	375	PF01048	0.709
MOD_GlcNHglycan	403	406	PF01048	0.697
MOD_GlcNHglycan	432	435	PF01048	0.794
MOD_GSK3_1	286	293	PF00069	0.790
MOD_GSK3_1	305	312	PF00069	0.734
MOD_GSK3_1	351	358	PF00069	0.805
MOD_GSK3_1	417	424	PF00069	0.735
MOD_GSK3_1	426	433	PF00069	0.723
MOD_N-GLC_1	297	302	PF02516	0.740
MOD_N-GLC_1	449	454	PF02516	0.603
MOD_NEK2_1	1	6	PF00069	0.602
MOD_NEK2_1	144	149	PF00069	0.631
MOD_NEK2_1	200	205	PF00069	0.521
MOD_NEK2_1	51	56	PF00069	0.520
MOD_PIKK_1	233	239	PF00454	0.582
MOD_PIKK_1	290	296	PF00454	0.740
MOD_PIKK_1	386	392	PF00454	0.740
MOD_PKA_1	334	340	PF00069	0.725
MOD_PKA_2	290	296	PF00069	0.826
MOD_PKA_2	418	424	PF00069	0.746
MOD_PKB_1	342	350	PF00069	0.721
MOD_Plk_1	200	206	PF00069	0.551
MOD_ProDKin_1	12	18	PF00069	0.551
MOD_ProDKin_1	275	281	PF00069	0.749
MOD_ProDKin_1	313	319	PF00069	0.686
MOD_ProDKin_1	335	341	PF00069	0.768
MOD_ProDKin_1	384	390	PF00069	0.797
MOD_ProDKin_1	426	432	PF00069	0.722
MOD_SUMO_for_1	167	170	PF00179	0.582
MOD_SUMO_for_1	178	181	PF00179	0.535
MOD_SUMO_for_1	182	185	PF00179	0.472
MOD_SUMO_for_1	188	191	PF00179	0.479
MOD_SUMO_for_1	194	197	PF00179	0.333
MOD_SUMO_rev_2	170	174	PF00179	0.494
TRG_DiLeu_BaEn_1	244	249	PF01217	0.597
TRG_ER_diArg_1	11	14	PF00400	0.626
TRG_ER_diArg_1	204	207	PF00400	0.602
TRG_ER_diArg_1	339	342	PF00400	0.764
TRG_ER_diArg_1	36	38	PF00400	0.559
TRG_ER_diArg_1	391	393	PF00400	0.710
TRG_ER_diArg_1	56	59	PF00400	0.466
TRG_ER_diArg_1	67	69	PF00400	0.541
TRG_ER_diArg_1	87	90	PF00400	0.484
TRG_NLS_Bipartite_1	142	159	PF00514	0.573
TRG_NLS_MonoExtN_4	154	159	PF00514	0.624
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HM33	Leishmania braziliensis	53%	98%
A4I9G6	Leishmania infantum	99%	100%
E9B4G4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q3L1	Leishmania major	88%	100%