Vesicular, overexpressed in cancer, prosurvival protein 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IU97_LEIDO

TriTrypDb:

LdCL_330037600

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IU97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IU97

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	30	32	PF00675	0.543
CLV_NRD_NRD_1	68	70	PF00675	0.317
CLV_PCSK_KEX2_1	15	17	PF00082	0.533
CLV_PCSK_KEX2_1	30	32	PF00082	0.543
CLV_PCSK_KEX2_1	67	69	PF00082	0.309
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.533
DOC_CYCLIN_yClb3_PxF_3	96	102	PF00134	0.596
DOC_PP2B_LxvP_1	118	121	PF13499	0.587
DOC_USP7_MATH_1	191	195	PF00917	0.605
DOC_USP7_MATH_1	33	37	PF00917	0.336
DOC_WW_Pin1_4	29	34	PF00397	0.346
LIG_14-3-3_CanoR_1	115	119	PF00244	0.594
LIG_14-3-3_CanoR_1	16	22	PF00244	0.329
LIG_14-3-3_CanoR_1	5	11	PF00244	0.341
LIG_14-3-3_CanoR_1	67	75	PF00244	0.544
LIG_BRCT_BRCA1_1	33	37	PF00533	0.336
LIG_EVH1_1	118	122	PF00568	0.590
LIG_FHA_1	163	169	PF00498	0.596
LIG_FHA_1	39	45	PF00498	0.291
LIG_LIR_Apic_2	193	199	PF02991	0.609
LIG_LIR_Apic_2	20	24	PF02991	0.343
LIG_LIR_Nem_3	34	40	PF02991	0.324
LIG_SH2_NCK_1	113	117	PF00017	0.597
LIG_SH2_PTP2	21	24	PF00017	0.341
LIG_SH2_SRC	139	142	PF00017	0.593
LIG_SH2_STAP1	8	12	PF00017	0.341
LIG_SH2_STAT3	146	149	PF00017	0.600
LIG_SH2_STAT3	151	154	PF00017	0.598
LIG_SH2_STAT5	139	142	PF00017	0.593
LIG_SH2_STAT5	169	172	PF00017	0.597
LIG_SH2_STAT5	21	24	PF00017	0.341
LIG_SH2_STAT5	27	30	PF00017	0.340
LIG_SH2_STAT5	8	11	PF00017	0.336
LIG_SH3_3	116	122	PF00018	0.590
LIG_SH3_3	137	143	PF00018	0.594
LIG_SH3_3	147	153	PF00018	0.595
LIG_SH3_3	91	97	PF00018	0.605
MOD_CK1_1	190	196	PF00069	0.607
MOD_GlcNHglycan	11	15	PF01048	0.547
MOD_GlcNHglycan	189	192	PF01048	0.405
MOD_GlcNHglycan	193	196	PF01048	0.409
MOD_GlcNHglycan	33	36	PF01048	0.536
MOD_GSK3_1	158	165	PF00069	0.601
MOD_GSK3_1	187	194	PF00069	0.600
MOD_GSK3_1	29	36	PF00069	0.341
MOD_GSK3_1	6	13	PF00069	0.343
MOD_GSK3_1	69	76	PF00069	0.558
MOD_NEK2_1	159	164	PF00069	0.602
MOD_NEK2_1	189	194	PF00069	0.605
MOD_NEK2_2	38	43	PF00069	0.300
MOD_PIKK_1	159	165	PF00454	0.600
MOD_PIKK_1	69	75	PF00454	0.556
MOD_PKA_1	68	74	PF00069	0.545
MOD_PKA_2	114	120	PF00069	0.594
MOD_PKA_2	68	74	PF00069	0.545
MOD_PKB_1	67	75	PF00069	0.544
MOD_Plk_4	135	141	PF00069	0.595
MOD_Plk_4	17	23	PF00069	0.328
MOD_Plk_4	171	177	PF00069	0.594
MOD_Plk_4	45	51	PF00069	0.199
MOD_ProDKin_1	29	35	PF00069	0.344
TRG_ER_diArg_1	29	31	PF00400	0.350
TRG_ER_diArg_1	66	69	PF00400	0.502