Carboxypeptidase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MA(E) Family M32

Species:

Leishmania donovani

UniProt:

A0A3Q8IU74_LEIDO

TriTrypDb:

LdBPK_332670.1 , LdCL_330033800 , LDHU3_33.3790

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 3
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 9

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IU74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IU74

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	25
GO:0006807	nitrogen compound metabolic process	2	25
GO:0008152	metabolic process	1	25
GO:0019538	protein metabolic process	3	25
GO:0043170	macromolecule metabolic process	3	25
GO:0044238	primary metabolic process	2	25
GO:0071704	organic substance metabolic process	2	25
GO:1901564	organonitrogen compound metabolic process	3	25
GO:0006518	peptide metabolic process	4	1
GO:0043603	amide metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	25
GO:0004180	carboxypeptidase activity	5	25
GO:0004181	metallocarboxypeptidase activity	6	25
GO:0008233	peptidase activity	3	25
GO:0008235	metalloexopeptidase activity	5	25
GO:0008237	metallopeptidase activity	4	25
GO:0008238	exopeptidase activity	4	25
GO:0016787	hydrolase activity	2	25
GO:0140096	catalytic activity, acting on a protein	2	25
GO:0016853	isomerase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.412
CLV_NRD_NRD_1	117	119	PF00675	0.397
CLV_NRD_NRD_1	333	335	PF00675	0.484
CLV_NRD_NRD_1	433	435	PF00675	0.335
CLV_NRD_NRD_1	489	491	PF00675	0.350
CLV_NRD_NRD_1	86	88	PF00675	0.400
CLV_PCSK_KEX2_1	489	491	PF00082	0.402
CLV_PCSK_KEX2_1	86	88	PF00082	0.396
CLV_PCSK_SKI1_1	90	94	PF00082	0.401
DEG_APCC_DBOX_1	333	341	PF00400	0.319
DEG_APCC_DBOX_1	78	86	PF00400	0.363
DEG_Nend_UBRbox_2	1	3	PF02207	0.544
DOC_MAPK_gen_1	13	23	PF00069	0.368
DOC_USP7_MATH_1	146	150	PF00917	0.381
DOC_USP7_MATH_1	88	92	PF00917	0.501
DOC_USP7_UBL2_3	213	217	PF12436	0.298
DOC_USP7_UBL2_3	457	461	PF12436	0.369
DOC_WW_Pin1_4	148	153	PF00397	0.420
DOC_WW_Pin1_4	228	233	PF00397	0.358
DOC_WW_Pin1_4	305	310	PF00397	0.471
LIG_14-3-3_CanoR_1	105	114	PF00244	0.485
LIG_14-3-3_CanoR_1	244	250	PF00244	0.535
LIG_14-3-3_CanoR_1	334	338	PF00244	0.318
LIG_14-3-3_CanoR_1	87	96	PF00244	0.434
LIG_Actin_WH2_2	169	187	PF00022	0.332
LIG_BRCT_BRCA1_1	199	203	PF00533	0.319
LIG_eIF4E_1	469	475	PF01652	0.513
LIG_FHA_1	164	170	PF00498	0.482
LIG_FHA_1	245	251	PF00498	0.545
LIG_FHA_1	279	285	PF00498	0.341
LIG_FHA_1	306	312	PF00498	0.496
LIG_FHA_1	313	319	PF00498	0.457
LIG_FHA_1	416	422	PF00498	0.369
LIG_FHA_1	446	452	PF00498	0.346
LIG_FHA_1	469	475	PF00498	0.385
LIG_FHA_2	237	243	PF00498	0.458
LIG_FHA_2	54	60	PF00498	0.513
LIG_LIR_Gen_1	122	130	PF02991	0.528
LIG_LIR_Gen_1	151	160	PF02991	0.506
LIG_LIR_Gen_1	170	181	PF02991	0.308
LIG_LIR_Gen_1	214	221	PF02991	0.319
LIG_LIR_Gen_1	297	307	PF02991	0.387
LIG_LIR_Gen_1	8	17	PF02991	0.317
LIG_LIR_Nem_3	122	126	PF02991	0.375
LIG_LIR_Nem_3	151	156	PF02991	0.525
LIG_LIR_Nem_3	170	176	PF02991	0.270
LIG_LIR_Nem_3	18	23	PF02991	0.324
LIG_LIR_Nem_3	2	7	PF02991	0.391
LIG_LIR_Nem_3	214	218	PF02991	0.319
LIG_LIR_Nem_3	257	262	PF02991	0.466
LIG_LIR_Nem_3	297	302	PF02991	0.404
LIG_LIR_Nem_3	308	313	PF02991	0.424
LIG_LIR_Nem_3	388	392	PF02991	0.369
LIG_LIR_Nem_3	49	55	PF02991	0.351
LIG_LIR_Nem_3	8	14	PF02991	0.323
LIG_PCNA_yPIPBox_3	380	390	PF02747	0.390
LIG_PDZ_Class_2	494	499	PF00595	0.390
LIG_Pex14_2	199	203	PF04695	0.513
LIG_Pex14_2	215	219	PF04695	0.332
LIG_PTB_Apo_2	481	488	PF02174	0.395
LIG_PTB_Phospho_1	481	487	PF10480	0.395
LIG_SH2_CRK	173	177	PF00017	0.319
LIG_SH2_CRK	259	263	PF00017	0.319
LIG_SH2_GRB2like	173	176	PF00017	0.298
LIG_SH2_GRB2like	496	499	PF00017	0.366
LIG_SH2_PTP2	344	347	PF00017	0.407
LIG_SH2_SRC	160	163	PF00017	0.320
LIG_SH2_SRC	173	176	PF00017	0.421
LIG_SH2_SRC	496	499	PF00017	0.366
LIG_SH2_STAP1	153	157	PF00017	0.380
LIG_SH2_STAP1	425	429	PF00017	0.319
LIG_SH2_STAT3	425	428	PF00017	0.319
LIG_SH2_STAT5	143	146	PF00017	0.465
LIG_SH2_STAT5	249	252	PF00017	0.508
LIG_SH2_STAT5	313	316	PF00017	0.518
LIG_SH2_STAT5	344	347	PF00017	0.431
LIG_SH2_STAT5	389	392	PF00017	0.348
LIG_SH2_STAT5	415	418	PF00017	0.390
LIG_SH2_STAT5	487	490	PF00017	0.500
LIG_SH2_STAT5	496	499	PF00017	0.404
LIG_SH3_3	349	355	PF00018	0.383
LIG_SH3_5	309	313	PF00018	0.298
LIG_TRAF2_1	137	140	PF00917	0.419
LIG_UBA3_1	183	190	PF00899	0.351
LIG_UBA3_1	429	435	PF00899	0.513
MOD_CK1_1	192	198	PF00069	0.282
MOD_CK2_1	148	154	PF00069	0.322
MOD_CK2_1	36	42	PF00069	0.310
MOD_CK2_1	53	59	PF00069	0.420
MOD_Cter_Amidation	100	103	PF01082	0.319
MOD_GlcNHglycan	191	194	PF01048	0.319
MOD_GlcNHglycan	264	267	PF01048	0.298
MOD_GlcNHglycan	65	68	PF01048	0.455
MOD_GlcNHglycan	90	93	PF01048	0.458
MOD_GSK3_1	105	112	PF00069	0.400
MOD_GSK3_1	250	257	PF00069	0.539
MOD_GSK3_1	59	66	PF00069	0.486
MOD_NEK2_1	104	109	PF00069	0.484
MOD_NEK2_1	254	259	PF00069	0.390
MOD_NEK2_1	292	297	PF00069	0.378
MOD_NEK2_1	333	338	PF00069	0.494
MOD_NEK2_1	63	68	PF00069	0.515
MOD_PIKK_1	163	169	PF00454	0.319
MOD_PIKK_1	197	203	PF00454	0.505
MOD_PIKK_1	278	284	PF00454	0.341
MOD_PIKK_1	292	298	PF00454	0.447
MOD_PIKK_1	326	332	PF00454	0.403
MOD_PKA_2	104	110	PF00069	0.485
MOD_PKA_2	114	120	PF00069	0.381
MOD_PKA_2	243	249	PF00069	0.385
MOD_PKA_2	333	339	PF00069	0.298
MOD_PKA_2	476	482	PF00069	0.465
MOD_Plk_1	250	256	PF00069	0.426
MOD_Plk_2-3	59	65	PF00069	0.287
MOD_Plk_4	109	115	PF00069	0.454
MOD_Plk_4	139	145	PF00069	0.498
MOD_Plk_4	175	181	PF00069	0.402
MOD_Plk_4	192	198	PF00069	0.437
MOD_Plk_4	250	256	PF00069	0.378
MOD_Plk_4	294	300	PF00069	0.366
MOD_Plk_4	59	65	PF00069	0.385
MOD_Plk_4	6	12	PF00069	0.575
MOD_ProDKin_1	148	154	PF00069	0.420
MOD_ProDKin_1	228	234	PF00069	0.358
MOD_ProDKin_1	305	311	PF00069	0.471
MOD_SUMO_for_1	34	37	PF00179	0.319
MOD_SUMO_rev_2	365	373	PF00179	0.323
MOD_SUMO_rev_2	436	442	PF00179	0.319
TRG_DiLeu_BaEn_1	470	475	PF01217	0.372
TRG_DiLeu_BaEn_1	59	64	PF01217	0.543
TRG_DiLeu_BaEn_4	139	145	PF01217	0.465
TRG_DiLeu_LyEn_5	450	455	PF01217	0.271
TRG_ENDOCYTIC_2	153	156	PF00928	0.387
TRG_ENDOCYTIC_2	173	176	PF00928	0.234
TRG_ENDOCYTIC_2	259	262	PF00928	0.323
TRG_ENDOCYTIC_2	344	347	PF00928	0.448
TRG_ENDOCYTIC_2	389	392	PF00928	0.389
TRG_ENDOCYTIC_2	4	7	PF00928	0.430
TRG_ER_diArg_1	488	490	PF00400	0.393
TRG_ER_diArg_1	85	87	PF00400	0.391
TRG_NLS_Bipartite_1	86	106	PF00514	0.482
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IZ28	Bodo saltans	45%	100%
A0A1X0NY67	Trypanosomatidae	52%	99%
A0A1X0P441	Trypanosomatidae	57%	99%
A0A1X0P598	Trypanosomatidae	59%	99%
A0A3Q8IBW2	Leishmania donovani	52%	100%
A0A3Q8IJY8	Leishmania donovani	46%	100%
A0A3S7WSA3	Leishmania donovani	55%	99%
A0A422P042	Trypanosoma rangeli	57%	99%
A0A422P4R1	Trypanosoma rangeli	53%	99%
A4H716	Leishmania braziliensis	55%	100%
A4HLW4	Leishmania braziliensis	86%	100%
A4HVE5	Leishmania infantum	55%	100%
A4HVW0	Leishmania infantum	52%	100%
A4I993	Leishmania infantum	100%	100%
A4IC85	Leishmania infantum	46%	100%
D0A656	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	99%
E9AP43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9B493	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P42663	Thermus aquaticus	35%	98%
P50848	Bacillus subtilis (strain 168)	34%	100%
Q4Q0D4	Leishmania major	51%	100%
Q4Q3T3	Leishmania major	97%	100%
Q4QFW7	Leishmania major	52%	100%
Q4QGE5	Leishmania major	55%	100%
Q5SLM3	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	33%	98%
Q8U3L0	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	32%	100%
V5DQA0	Trypanosoma cruzi	60%	99%