Histidine phosphatase (Branch 1) family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerolphosphate mutase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IU44_LEIDO

TriTrypDb:

LdBPK_332220.1 , LdCL_330029200 , LDHU3_33.3200

Length:

502

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IU44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IU44

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.668
CLV_C14_Caspase3-7	447	451	PF00656	0.742
CLV_MEL_PAP_1	160	166	PF00089	0.411
CLV_NRD_NRD_1	103	105	PF00675	0.355
CLV_NRD_NRD_1	23	25	PF00675	0.633
CLV_NRD_NRD_1	255	257	PF00675	0.833
CLV_NRD_NRD_1	259	261	PF00675	0.612
CLV_NRD_NRD_1	32	34	PF00675	0.474
CLV_NRD_NRD_1	419	421	PF00675	0.717
CLV_NRD_NRD_1	8	10	PF00675	0.639
CLV_PCSK_KEX2_1	103	105	PF00082	0.353
CLV_PCSK_KEX2_1	23	25	PF00082	0.633
CLV_PCSK_KEX2_1	255	257	PF00082	0.833
CLV_PCSK_KEX2_1	259	261	PF00082	0.612
CLV_PCSK_KEX2_1	32	34	PF00082	0.474
CLV_PCSK_KEX2_1	7	9	PF00082	0.648
CLV_PCSK_KEX2_1	74	76	PF00082	0.411
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.411
CLV_PCSK_PC7_1	255	261	PF00082	0.715
CLV_PCSK_SKI1_1	141	145	PF00082	0.411
CLV_PCSK_SKI1_1	278	282	PF00082	0.338
CLV_PCSK_SKI1_1	32	36	PF00082	0.397
CLV_PCSK_SKI1_1	350	354	PF00082	0.483
DEG_APCC_DBOX_1	191	199	PF00400	0.585
DEG_APCC_DBOX_1	95	103	PF00400	0.383
DEG_MDM2_SWIB_1	308	315	PF02201	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.762
DEG_SPOP_SBC_1	227	231	PF00917	0.715
DEG_SPOP_SBC_1	247	251	PF00917	0.822
DOC_CYCLIN_RxL_1	347	356	PF00134	0.506
DOC_MAPK_gen_1	311	319	PF00069	0.411
DOC_MAPK_gen_1	371	380	PF00069	0.510
DOC_MAPK_MEF2A_6	173	180	PF00069	0.598
DOC_MAPK_NFAT4_5	173	181	PF00069	0.605
DOC_PP2B_LxvP_1	178	181	PF13499	0.655
DOC_PP4_FxxP_1	313	316	PF00568	0.411
DOC_USP7_MATH_1	211	215	PF00917	0.698
DOC_USP7_MATH_1	219	223	PF00917	0.692
DOC_USP7_MATH_1	226	230	PF00917	0.597
DOC_USP7_MATH_1	247	251	PF00917	0.718
DOC_USP7_MATH_1	405	409	PF00917	0.712
DOC_USP7_MATH_1	422	426	PF00917	0.849
DOC_USP7_MATH_1	427	431	PF00917	0.767
DOC_USP7_MATH_1	432	436	PF00917	0.681
DOC_USP7_MATH_1	449	453	PF00917	0.755
DOC_WW_Pin1_4	238	243	PF00397	0.815
DOC_WW_Pin1_4	259	264	PF00397	0.695
DOC_WW_Pin1_4	428	433	PF00397	0.848
DOC_WW_Pin1_4	477	482	PF00397	0.772
DOC_WW_Pin1_4	492	497	PF00397	0.565
DOC_WW_Pin1_4	51	56	PF00397	0.411
DOC_WW_Pin1_4	87	92	PF00397	0.411
LIG_14-3-3_CanoR_1	103	107	PF00244	0.411
LIG_14-3-3_CanoR_1	259	263	PF00244	0.763
LIG_14-3-3_CanoR_1	342	352	PF00244	0.502
LIG_14-3-3_CanoR_1	466	473	PF00244	0.700
LIG_14-3-3_CanoR_1	94	100	PF00244	0.411
LIG_Actin_WH2_2	157	175	PF00022	0.513
LIG_BRCT_BRCA1_1	164	168	PF00533	0.378
LIG_deltaCOP1_diTrp_1	135	144	PF00928	0.389
LIG_deltaCOP1_diTrp_1	368	377	PF00928	0.581
LIG_FHA_2	203	209	PF00498	0.710
LIG_FHA_2	229	235	PF00498	0.719
LIG_FHA_2	96	102	PF00498	0.411
LIG_GBD_Chelix_1	299	307	PF00786	0.411
LIG_LIR_Apic_2	54	60	PF02991	0.353
LIG_LIR_Gen_1	165	176	PF02991	0.411
LIG_LIR_Gen_1	318	327	PF02991	0.411
LIG_LIR_Gen_1	484	492	PF02991	0.634
LIG_LIR_Nem_3	165	171	PF02991	0.411
LIG_LIR_Nem_3	375	380	PF02991	0.708
LIG_LIR_Nem_3	484	488	PF02991	0.726
LIG_LIR_Nem_3	83	89	PF02991	0.411
LIG_MLH1_MIPbox_1	164	168	PF16413	0.411
LIG_Pex14_2	308	312	PF04695	0.381
LIG_PTB_Apo_2	11	18	PF02174	0.618
LIG_SH2_CRK	128	132	PF00017	0.513
LIG_SH2_CRK	149	153	PF00017	0.411
LIG_SH2_GRB2like	51	54	PF00017	0.513
LIG_SH2_STAT3	12	15	PF00017	0.619
LIG_SH2_STAT5	86	89	PF00017	0.360
LIG_SH3_1	260	266	PF00018	0.691
LIG_SH3_2	413	418	PF14604	0.798
LIG_SH3_3	260	266	PF00018	0.728
LIG_SH3_3	407	413	PF00018	0.625
LIG_SH3_5	481	485	PF00018	0.712
LIG_SH3_CIN85_PxpxPR_1	413	418	PF14604	0.798
LIG_SUMO_SIM_par_1	330	335	PF11976	0.411
LIG_TRAF2_1	386	389	PF00917	0.710
LIG_TRAF2_2	130	135	PF00917	0.436
LIG_WW_3	415	419	PF00397	0.812
MOD_CDK_SPxK_1	477	483	PF00069	0.717
MOD_CDK_SPxxK_3	51	58	PF00069	0.411
MOD_CDK_SPxxK_3	87	94	PF00069	0.411
MOD_CK1_1	218	224	PF00069	0.774
MOD_CK1_1	230	236	PF00069	0.654
MOD_CK1_1	425	431	PF00069	0.835
MOD_CK1_1	439	445	PF00069	0.566
MOD_CK1_1	452	458	PF00069	0.755
MOD_CK2_1	102	108	PF00069	0.411
MOD_CK2_1	228	234	PF00069	0.840
MOD_CK2_1	286	292	PF00069	0.332
MOD_CK2_1	441	447	PF00069	0.842
MOD_CK2_1	95	101	PF00069	0.411
MOD_Cter_Amidation	72	75	PF01082	0.411
MOD_GlcNHglycan	155	158	PF01048	0.357
MOD_GlcNHglycan	164	167	PF01048	0.361
MOD_GlcNHglycan	217	220	PF01048	0.632
MOD_GlcNHglycan	234	237	PF01048	0.817
MOD_GlcNHglycan	269	272	PF01048	0.594
MOD_GlcNHglycan	288	291	PF01048	0.286
MOD_GlcNHglycan	407	410	PF01048	0.629
MOD_GlcNHglycan	424	427	PF01048	0.742
MOD_GlcNHglycan	434	437	PF01048	0.784
MOD_GlcNHglycan	438	441	PF01048	0.638
MOD_GlcNHglycan	444	447	PF01048	0.593
MOD_GlcNHglycan	450	454	PF01048	0.731
MOD_GSK3_1	102	109	PF00069	0.375
MOD_GSK3_1	172	179	PF00069	0.623
MOD_GSK3_1	211	218	PF00069	0.729
MOD_GSK3_1	226	233	PF00069	0.728
MOD_GSK3_1	236	243	PF00069	0.759
MOD_GSK3_1	245	252	PF00069	0.731
MOD_GSK3_1	254	261	PF00069	0.583
MOD_GSK3_1	348	355	PF00069	0.485
MOD_GSK3_1	421	428	PF00069	0.800
MOD_GSK3_1	432	439	PF00069	0.686
MOD_GSK3_1	441	448	PF00069	0.699
MOD_N-GLC_2	184	186	PF02516	0.768
MOD_NEK2_1	1	6	PF00069	0.751
MOD_NEK2_1	106	111	PF00069	0.411
MOD_NEK2_1	134	139	PF00069	0.402
MOD_NEK2_1	153	158	PF00069	0.483
MOD_NEK2_1	167	172	PF00069	0.333
MOD_NEK2_1	202	207	PF00069	0.622
MOD_NEK2_1	254	259	PF00069	0.735
MOD_PIKK_1	106	112	PF00454	0.411
MOD_PIKK_1	219	225	PF00454	0.821
MOD_PIKK_1	465	471	PF00454	0.778
MOD_PKA_1	420	426	PF00069	0.850
MOD_PKA_2	102	108	PF00069	0.411
MOD_PKA_2	162	168	PF00069	0.411
MOD_PKA_2	172	178	PF00069	0.411
MOD_PKA_2	254	260	PF00069	0.732
MOD_PKA_2	465	471	PF00069	0.700
MOD_PKA_2	95	101	PF00069	0.411
MOD_PKB_1	418	426	PF00069	0.846
MOD_Plk_1	106	112	PF00069	0.411
MOD_Plk_1	134	140	PF00069	0.411
MOD_Plk_1	25	31	PF00069	0.450
MOD_Plk_1	367	373	PF00069	0.569
MOD_Plk_4	167	173	PF00069	0.429
MOD_Plk_4	25	31	PF00069	0.644
MOD_Plk_4	348	354	PF00069	0.476
MOD_ProDKin_1	238	244	PF00069	0.808
MOD_ProDKin_1	259	265	PF00069	0.696
MOD_ProDKin_1	428	434	PF00069	0.848
MOD_ProDKin_1	477	483	PF00069	0.772
MOD_ProDKin_1	492	498	PF00069	0.548
MOD_ProDKin_1	51	57	PF00069	0.411
MOD_ProDKin_1	87	93	PF00069	0.411
MOD_SUMO_rev_2	52	60	PF00179	0.411
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.471
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.521
TRG_ENDOCYTIC_2	128	131	PF00928	0.353
TRG_ENDOCYTIC_2	148	151	PF00928	0.183
TRG_ENDOCYTIC_2	485	488	PF00928	0.732
TRG_ER_diArg_1	102	104	PF00400	0.357
TRG_ER_diArg_1	23	25	PF00400	0.637
TRG_ER_diArg_1	254	256	PF00400	0.844
TRG_ER_diArg_1	258	260	PF00400	0.617
TRG_ER_diArg_1	31	33	PF00400	0.489
TRG_ER_diArg_1	417	420	PF00400	0.743
TRG_ER_diArg_1	7	9	PF00400	0.648
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHK5	Leptomonas seymouri	68%	100%
A4HLS2	Leishmania braziliensis	81%	100%
A4I981	Leishmania infantum	100%	100%
E9B448	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q3X7	Leishmania major	93%	100%