LeishMANIAdb
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Protein_kinase_putative/GeneDB:LmjF.33.1710

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein_kinase_putative/GeneDB:LmjF.33.1710
Gene product:
protein kinase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IU22_LEIDO
TriTrypDb:
LdBPK_331810.1 , LdCL_330024900 , LDHU3_33.2700
Length:
640

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 3
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 308, 311

Expansion

Sequence features

A0A3Q8IU22
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IU22

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016310 phosphorylation 5 12
GO:0019538 protein metabolic process 3 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004672 protein kinase activity 3 12
GO:0005488 binding 1 12
GO:0005509 calcium ion binding 5 12
GO:0005524 ATP binding 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0004674 protein serine/threonine kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 238 242 PF00656 0.376
CLV_C14_Caspase3-7 365 369 PF00656 0.357
CLV_C14_Caspase3-7 445 449 PF00656 0.581
CLV_C14_Caspase3-7 468 472 PF00656 0.410
CLV_C14_Caspase3-7 561 565 PF00656 0.683
CLV_NRD_NRD_1 16 18 PF00675 0.801
CLV_NRD_NRD_1 244 246 PF00675 0.362
CLV_NRD_NRD_1 514 516 PF00675 0.435
CLV_NRD_NRD_1 617 619 PF00675 0.403
CLV_NRD_NRD_1 84 86 PF00675 0.343
CLV_PCSK_FUR_1 512 516 PF00082 0.460
CLV_PCSK_KEX2_1 125 127 PF00082 0.468
CLV_PCSK_KEX2_1 246 248 PF00082 0.388
CLV_PCSK_KEX2_1 514 516 PF00082 0.435
CLV_PCSK_KEX2_1 617 619 PF00082 0.467
CLV_PCSK_PC1ET2_1 125 127 PF00082 0.468
CLV_PCSK_PC1ET2_1 246 248 PF00082 0.388
CLV_PCSK_SKI1_1 154 158 PF00082 0.342
CLV_PCSK_SKI1_1 321 325 PF00082 0.724
CLV_PCSK_SKI1_1 367 371 PF00082 0.342
CLV_PCSK_SKI1_1 434 438 PF00082 0.517
CLV_PCSK_SKI1_1 441 445 PF00082 0.411
CLV_PCSK_SKI1_1 546 550 PF00082 0.520
CLV_PCSK_SKI1_1 578 582 PF00082 0.462
CLV_PCSK_SKI1_1 611 615 PF00082 0.432
CLV_PCSK_SKI1_1 618 622 PF00082 0.384
CLV_PCSK_SKI1_1 85 89 PF00082 0.410
CLV_Separin_Metazoa 623 627 PF03568 0.451
CLV_Separin_Metazoa 82 86 PF03568 0.329
DEG_APCC_DBOX_1 366 374 PF00400 0.342
DEG_COP1_1 302 309 PF00400 0.563
DEG_SCF_FBW7_1 322 328 PF00400 0.736
DOC_CKS1_1 306 311 PF01111 0.693
DOC_CKS1_1 322 327 PF01111 0.665
DOC_CYCLIN_RxL_1 457 469 PF00134 0.410
DOC_CYCLIN_RxL_1 542 554 PF00134 0.570
DOC_CYCLIN_yClb5_NLxxxL_5 103 111 PF00134 0.435
DOC_MAPK_gen_1 154 163 PF00069 0.342
DOC_MAPK_gen_1 457 465 PF00069 0.514
DOC_MAPK_gen_1 54 60 PF00069 0.348
DOC_MAPK_gen_1 578 585 PF00069 0.450
DOC_MAPK_gen_1 85 95 PF00069 0.342
DOC_MAPK_MEF2A_6 459 467 PF00069 0.410
DOC_MAPK_MEF2A_6 505 513 PF00069 0.555
DOC_MAPK_MEF2A_6 54 62 PF00069 0.347
DOC_MAPK_MEF2A_6 578 587 PF00069 0.422
DOC_PP1_RVXF_1 603 610 PF00149 0.473
DOC_PP2B_LxvP_1 271 274 PF13499 0.365
DOC_USP7_MATH_1 274 278 PF00917 0.550
DOC_USP7_MATH_1 325 329 PF00917 0.763
DOC_USP7_MATH_1 338 342 PF00917 0.610
DOC_USP7_MATH_1 349 353 PF00917 0.351
DOC_USP7_MATH_1 475 479 PF00917 0.365
DOC_USP7_UBL2_3 18 22 PF12436 0.701
DOC_USP7_UBL2_3 3 7 PF12436 0.728
DOC_USP7_UBL2_3 457 461 PF12436 0.486
DOC_USP7_UBL2_3 61 65 PF12436 0.350
DOC_WW_Pin1_4 305 310 PF00397 0.616
DOC_WW_Pin1_4 321 326 PF00397 0.706
DOC_WW_Pin1_4 334 339 PF00397 0.653
DOC_WW_Pin1_4 5 10 PF00397 0.812
LIG_14-3-3_CanoR_1 279 289 PF00244 0.365
LIG_14-3-3_CanoR_1 398 406 PF00244 0.358
LIG_14-3-3_CanoR_1 484 490 PF00244 0.362
LIG_14-3-3_CanoR_1 529 533 PF00244 0.553
LIG_BIR_II_1 1 5 PF00653 0.735
LIG_BRCT_BRCA1_1 123 127 PF00533 0.346
LIG_BRCT_BRCA1_1 328 332 PF00533 0.706
LIG_BRCT_BRCA1_1 487 491 PF00533 0.410
LIG_BRCT_BRCA1_1 556 560 PF00533 0.429
LIG_deltaCOP1_diTrp_1 218 227 PF00928 0.351
LIG_FHA_1 280 286 PF00498 0.420
LIG_FHA_1 51 57 PF00498 0.365
LIG_FHA_1 593 599 PF00498 0.462
LIG_FHA_2 279 285 PF00498 0.463
LIG_FHA_2 378 384 PF00498 0.486
LIG_FHA_2 398 404 PF00498 0.434
LIG_FHA_2 466 472 PF00498 0.407
LIG_FHA_2 556 562 PF00498 0.443
LIG_FHA_2 6 12 PF00498 0.679
LIG_LIR_Apic_2 198 204 PF02991 0.342
LIG_LIR_Gen_1 102 113 PF02991 0.353
LIG_LIR_Gen_1 116 122 PF02991 0.316
LIG_LIR_Gen_1 189 199 PF02991 0.498
LIG_LIR_Gen_1 433 444 PF02991 0.592
LIG_LIR_Gen_1 473 482 PF02991 0.355
LIG_LIR_Nem_3 102 108 PF02991 0.353
LIG_LIR_Nem_3 116 121 PF02991 0.316
LIG_LIR_Nem_3 189 195 PF02991 0.498
LIG_LIR_Nem_3 433 439 PF02991 0.614
LIG_LIR_Nem_3 442 447 PF02991 0.575
LIG_LIR_Nem_3 488 494 PF02991 0.391
LIG_PALB2_WD40_1 608 616 PF16756 0.436
LIG_Pex14_2 387 391 PF04695 0.342
LIG_Pex14_2 404 408 PF04695 0.479
LIG_Pex14_2 609 613 PF04695 0.417
LIG_PTB_Apo_2 312 319 PF02174 0.641
LIG_Rb_LxCxE_1 622 640 PF01857 0.523
LIG_REV1ctd_RIR_1 501 507 PF16727 0.613
LIG_SH2_CRK 105 109 PF00017 0.342
LIG_SH2_CRK 594 598 PF00017 0.394
LIG_SH2_NCK_1 536 540 PF00017 0.546
LIG_SH2_STAP1 594 598 PF00017 0.428
LIG_SH2_STAT3 135 138 PF00017 0.342
LIG_SH2_STAT5 135 138 PF00017 0.367
LIG_SH2_STAT5 145 148 PF00017 0.417
LIG_SH2_STAT5 179 182 PF00017 0.342
LIG_SH2_STAT5 233 236 PF00017 0.387
LIG_SH2_STAT5 259 262 PF00017 0.357
LIG_SH2_STAT5 280 283 PF00017 0.486
LIG_SH2_STAT5 536 539 PF00017 0.476
LIG_SH2_STAT5 573 576 PF00017 0.493
LIG_SH2_STAT5 594 597 PF00017 0.398
LIG_SH2_STAT5 76 79 PF00017 0.342
LIG_SH3_3 270 276 PF00018 0.534
LIG_SH3_3 303 309 PF00018 0.676
LIG_SH3_3 319 325 PF00018 0.669
LIG_TRAF2_1 380 383 PF00917 0.376
LIG_TRAF2_1 400 403 PF00917 0.401
LIG_TRAF2_1 551 554 PF00917 0.625
LIG_TRAF2_1 559 562 PF00917 0.554
LIG_TRAF2_2 261 266 PF00917 0.410
LIG_UBA3_1 117 125 PF00899 0.468
LIG_UBA3_1 83 88 PF00899 0.431
LIG_UBA3_1 95 103 PF00899 0.435
MOD_CDK_SPK_2 5 10 PF00069 0.676
MOD_CK1_1 177 183 PF00069 0.369
MOD_CK1_1 328 334 PF00069 0.749
MOD_CK1_1 337 343 PF00069 0.708
MOD_CK1_1 449 455 PF00069 0.449
MOD_CK1_1 474 480 PF00069 0.444
MOD_CK1_1 487 493 PF00069 0.285
MOD_CK1_1 531 537 PF00069 0.607
MOD_CK1_1 555 561 PF00069 0.556
MOD_CK2_1 377 383 PF00069 0.373
MOD_CK2_1 397 403 PF00069 0.403
MOD_CK2_1 5 11 PF00069 0.677
MOD_CK2_1 548 554 PF00069 0.487
MOD_CK2_1 555 561 PF00069 0.401
MOD_CK2_1 72 78 PF00069 0.401
MOD_DYRK1A_RPxSP_1 321 325 PF00069 0.647
MOD_GlcNHglycan 276 279 PF01048 0.442
MOD_GlcNHglycan 328 331 PF01048 0.781
MOD_GlcNHglycan 450 454 PF01048 0.438
MOD_GlcNHglycan 473 476 PF01048 0.365
MOD_GlcNHglycan 70 73 PF01048 0.487
MOD_GSK3_1 191 198 PF00069 0.342
MOD_GSK3_1 237 244 PF00069 0.368
MOD_GSK3_1 274 281 PF00069 0.468
MOD_GSK3_1 321 328 PF00069 0.644
MOD_GSK3_1 334 341 PF00069 0.679
MOD_GSK3_1 349 356 PF00069 0.284
MOD_GSK3_1 449 456 PF00069 0.385
MOD_GSK3_1 471 478 PF00069 0.447
MOD_GSK3_1 548 555 PF00069 0.506
MOD_GSK3_1 68 75 PF00069 0.513
MOD_N-GLC_1 253 258 PF02516 0.494
MOD_N-GLC_1 353 358 PF02516 0.404
MOD_NEK2_1 174 179 PF00069 0.435
MOD_NEK2_1 191 196 PF00069 0.357
MOD_NEK2_1 406 411 PF00069 0.527
MOD_NEK2_1 528 533 PF00069 0.634
MOD_NEK2_1 548 553 PF00069 0.295
MOD_NEK2_1 569 574 PF00069 0.461
MOD_NEK2_1 67 72 PF00069 0.507
MOD_OFUCOSY 217 222 PF10250 0.342
MOD_PIKK_1 571 577 PF00454 0.618
MOD_PKA_2 177 183 PF00069 0.342
MOD_PKA_2 278 284 PF00069 0.422
MOD_PKA_2 397 403 PF00069 0.364
MOD_PKA_2 528 534 PF00069 0.623
MOD_PKA_2 68 74 PF00069 0.477
MOD_PKB_1 245 253 PF00069 0.461
MOD_Plk_1 523 529 PF00069 0.416
MOD_Plk_1 628 634 PF00069 0.501
MOD_Plk_4 295 301 PF00069 0.518
MOD_Plk_4 72 78 PF00069 0.368
MOD_ProDKin_1 305 311 PF00069 0.616
MOD_ProDKin_1 321 327 PF00069 0.705
MOD_ProDKin_1 334 340 PF00069 0.644
MOD_ProDKin_1 5 11 PF00069 0.813
MOD_SUMO_for_1 156 159 PF00179 0.342
MOD_SUMO_for_1 620 623 PF00179 0.525
MOD_SUMO_for_1 633 636 PF00179 0.561
MOD_SUMO_rev_2 119 127 PF00179 0.395
MOD_SUMO_rev_2 381 387 PF00179 0.499
TRG_DiLeu_BaEn_1 442 447 PF01217 0.430
TRG_DiLeu_BaEn_2 382 388 PF01217 0.486
TRG_DiLeu_BaLyEn_6 583 588 PF01217 0.428
TRG_DiLeu_BaLyEn_6 91 96 PF01217 0.435
TRG_ENDOCYTIC_2 105 108 PF00928 0.342
TRG_ENDOCYTIC_2 233 236 PF00928 0.342
TRG_ENDOCYTIC_2 501 504 PF00928 0.507
TRG_ENDOCYTIC_2 594 597 PF00928 0.398
TRG_ER_diArg_1 245 248 PF00400 0.352
TRG_ER_diArg_1 511 514 PF00400 0.416
TRG_ER_diArg_1 616 618 PF00400 0.457
TRG_NES_CRM1_1 435 450 PF08389 0.578
TRG_Pf-PMV_PEXEL_1 154 159 PF00026 0.357
TRG_Pf-PMV_PEXEL_1 258 262 PF00026 0.384
TRG_Pf-PMV_PEXEL_1 617 622 PF00026 0.437

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMD1 Leptomonas seymouri 82% 100%
A0A0S4IPB3 Bodo saltans 31% 95%
A0A0S4JIY0 Bodo saltans 53% 99%
A0A1X0NJJ7 Trypanosomatidae 29% 85%
A0A1X0P150 Trypanosomatidae 56% 100%
A0A2I0BVG8 Plasmodium falciparum (isolate NF54) 27% 100%
A0A3S5H5G0 Leishmania donovani 25% 100%
A0A3S5H5U5 Leishmania donovani 27% 100%
A0A3S5IQS7 Trypanosoma rangeli 30% 87%
A0A422N215 Trypanosoma rangeli 54% 100%
A0A509AHB6 Plasmodium berghei (strain Anka) 28% 100%
A0A509AQE6 Plasmodium berghei (strain Anka) 28% 100%
A0A5K1K8H0 Plasmodium falciparum (isolate 3D7) 27% 100%
A2ZVI7 Oryza sativa subsp. japonica 30% 100%
A4H459 Leishmania braziliensis 25% 100%
A4H4S9 Leishmania braziliensis 27% 100%
A4HCD7 Leishmania braziliensis 29% 100%
A4HFF3 Leishmania braziliensis 28% 100%
A4HLN2 Leishmania braziliensis 92% 100%
A4HSE2 Leishmania infantum 25% 100%
A4I967 Leishmania infantum 100% 100%
A5A7I7 Solanum tuberosum 28% 100%
A5A7I8 Solanum tuberosum 28% 100%
B9FKW9 Oryza sativa subsp. japonica 30% 100%
C9ZIW2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
D0A2A6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 86%
E9AG71 Leishmania infantum 27% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B408 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O49717 Arabidopsis thaliana 30% 100%
O80673 Arabidopsis thaliana 28% 100%
P28582 Daucus carota 30% 100%
P28583 Glycine max 29% 100%
P49101 Zea mays 30% 100%
P53681 Daucus carota 28% 100%
P53683 Oryza sativa subsp. japonica 30% 100%
P53684 Oryza sativa subsp. japonica 28% 100%
P62343 Plasmodium falciparum (isolate K1 / Thailand) 27% 100%
P62344 Plasmodium falciparum (isolate 3D7) 27% 100%
P93759 Arabidopsis thaliana 31% 100%
Q06850 Arabidopsis thaliana 28% 100%
Q0D715 Oryza sativa subsp. japonica 29% 100%
Q0DYK7 Oryza sativa subsp. japonica 29% 100%
Q10KY3 Oryza sativa subsp. japonica 29% 100%
Q1PE17 Arabidopsis thaliana 31% 100%
Q1PFH8 Arabidopsis thaliana 29% 100%
Q2QQR2 Oryza sativa subsp. japonica 28% 100%
Q2QVG8 Oryza sativa subsp. japonica 31% 100%
Q2QX45 Oryza sativa subsp. japonica 28% 100%
Q2QY37 Oryza sativa subsp. japonica 31% 100%
Q2RAV0 Oryza sativa subsp. japonica 31% 100%
Q38868 Arabidopsis thaliana 31% 100%
Q38869 Arabidopsis thaliana 29% 100%
Q38870 Arabidopsis thaliana 28% 99%
Q38871 Arabidopsis thaliana 29% 100%
Q38872 Arabidopsis thaliana 28% 100%
Q38873 Arabidopsis thaliana 30% 100%
Q39016 Arabidopsis thaliana 29% 100%
Q3E9C0 Arabidopsis thaliana 31% 100%
Q42396 Arabidopsis thaliana 30% 100%
Q42438 Arabidopsis thaliana 29% 100%
Q42479 Arabidopsis thaliana 32% 100%
Q4Q416 Leishmania major 98% 100%
Q4QIV8 Leishmania major 27% 100%
Q4QJJ0 Leishmania major 25% 100%
Q53P85 Oryza sativa subsp. japonica 29% 100%
Q5VQQ5 Oryza sativa subsp. japonica 30% 100%
Q69IM9 Oryza sativa subsp. japonica 30% 100%
Q6AVI8 Oryza sativa subsp. japonica 28% 100%
Q6F3A6 Oryza sativa subsp. japonica 29% 100%
Q6I587 Oryza sativa subsp. japonica 29% 100%
Q6I5I8 Oryza sativa subsp. japonica 29% 100%
Q6K968 Oryza sativa subsp. japonica 29% 100%
Q6NLQ6 Arabidopsis thaliana 30% 100%
Q6Z2M9 Oryza sativa subsp. japonica 30% 100%
Q75GE8 Oryza sativa subsp. japonica 30% 100%
Q7RAH3 Plasmodium yoelii yoelii 28% 100%
Q7XIM0 Oryza sativa subsp. japonica 28% 100%
Q7XJR9 Arabidopsis thaliana 31% 100%
Q7XSQ5 Oryza sativa subsp. japonica 30% 100%
Q84SL0 Oryza sativa subsp. japonica 29% 100%
Q852N6 Oryza sativa subsp. japonica 28% 100%
Q8IBS5 Plasmodium falciparum (isolate 3D7) 27% 100%
Q8LPZ7 Oryza sativa subsp. japonica 29% 100%
Q8RWL2 Arabidopsis thaliana 31% 100%
Q8W4I7 Arabidopsis thaliana 29% 100%
Q9C6P3 Arabidopsis thaliana 31% 100%
Q9FKW4 Arabidopsis thaliana 29% 100%
Q9FMP5 Arabidopsis thaliana 30% 100%
Q9FX86 Arabidopsis thaliana 27% 100%
Q9FXQ3 Oryza sativa subsp. japonica 29% 100%
Q9LET1 Arabidopsis thaliana 27% 100%
Q9M101 Arabidopsis thaliana 28% 100%
Q9S9V0 Arabidopsis thaliana 28% 100%
Q9SIQ7 Arabidopsis thaliana 31% 100%
Q9SSF8 Arabidopsis thaliana 31% 100%
Q9SZM3 Arabidopsis thaliana 28% 100%
Q9ZSA2 Arabidopsis thaliana 30% 100%
Q9ZSA3 Arabidopsis thaliana 30% 100%
Q9ZSA4 Arabidopsis thaliana 28% 100%
Q9ZV15 Arabidopsis thaliana 27% 100%
V5BCN4 Trypanosoma cruzi 60% 100%
V5BN97 Trypanosoma cruzi 30% 87%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS