Rho-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ITZ0_LEIDO

TriTrypDb:

LdBPK_331310.1 , LdCL_330019300 , LDHU3_33.1960

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ITZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ITZ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.454
CLV_NRD_NRD_1	23	25	PF00675	0.498
CLV_NRD_NRD_1	238	240	PF00675	0.781
CLV_NRD_NRD_1	289	291	PF00675	0.783
CLV_NRD_NRD_1	34	36	PF00675	0.485
CLV_NRD_NRD_1	41	43	PF00675	0.471
CLV_NRD_NRD_1	476	478	PF00675	0.816
CLV_NRD_NRD_1	49	51	PF00675	0.493
CLV_NRD_NRD_1	524	526	PF00675	0.804
CLV_NRD_NRD_1	558	560	PF00675	0.714
CLV_NRD_NRD_1	76	78	PF00675	0.487
CLV_PCSK_KEX2_1	33	35	PF00082	0.517
CLV_PCSK_KEX2_1	40	42	PF00082	0.502
CLV_PCSK_KEX2_1	476	478	PF00082	0.816
CLV_PCSK_KEX2_1	49	51	PF00082	0.490
CLV_PCSK_KEX2_1	524	526	PF00082	0.804
CLV_PCSK_KEX2_1	558	560	PF00082	0.714
CLV_PCSK_KEX2_1	76	78	PF00082	0.487
CLV_PCSK_PC1ET2_1	476	478	PF00082	0.816
CLV_PCSK_PC7_1	554	560	PF00082	0.704
CLV_PCSK_SKI1_1	122	126	PF00082	0.377
CLV_PCSK_SKI1_1	17	21	PF00082	0.513
CLV_PCSK_SKI1_1	241	245	PF00082	0.628
CLV_Separin_Metazoa	119	123	PF03568	0.376
DEG_SPOP_SBC_1	518	522	PF00917	0.769
DOC_CKS1_1	242	247	PF01111	0.777
DOC_CYCLIN_RxL_1	119	128	PF00134	0.371
DOC_CYCLIN_yCln2_LP_2	143	146	PF00134	0.447
DOC_CYCLIN_yCln2_LP_2	377	383	PF00134	0.843
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.441
DOC_MAPK_DCC_7	76	86	PF00069	0.458
DOC_MAPK_gen_1	113	120	PF00069	0.395
DOC_MAPK_gen_1	22	31	PF00069	0.502
DOC_MAPK_gen_1	76	84	PF00069	0.469
DOC_MAPK_HePTP_8	74	86	PF00069	0.461
DOC_MAPK_MEF2A_6	211	219	PF00069	0.801
DOC_MAPK_MEF2A_6	22	31	PF00069	0.512
DOC_MAPK_MEF2A_6	76	84	PF00069	0.469
DOC_PP1_RVXF_1	120	126	PF00149	0.372
DOC_PP2B_LxvP_1	143	146	PF13499	0.447
DOC_PP2B_LxvP_1	377	380	PF13499	0.843
DOC_PP2B_LxvP_1	390	393	PF13499	0.617
DOC_PP2B_LxvP_1	80	83	PF13499	0.454
DOC_PP4_FxxP_1	168	171	PF00568	0.761
DOC_PP4_FxxP_1	561	564	PF00568	0.733
DOC_USP7_MATH_1	230	234	PF00917	0.795
DOC_USP7_MATH_1	253	257	PF00917	0.859
DOC_USP7_MATH_1	313	317	PF00917	0.754
DOC_USP7_MATH_1	328	332	PF00917	0.632
DOC_USP7_MATH_1	345	349	PF00917	0.674
DOC_USP7_MATH_1	358	362	PF00917	0.611
DOC_USP7_MATH_1	393	397	PF00917	0.684
DOC_USP7_MATH_1	484	488	PF00917	0.715
DOC_USP7_MATH_1	499	503	PF00917	0.545
DOC_USP7_MATH_1	518	522	PF00917	0.516
DOC_USP7_UBL2_3	227	231	PF12436	0.803
DOC_WW_Pin1_4	195	200	PF00397	0.672
DOC_WW_Pin1_4	241	246	PF00397	0.805
DOC_WW_Pin1_4	247	252	PF00397	0.775
DOC_WW_Pin1_4	254	259	PF00397	0.660
DOC_WW_Pin1_4	268	273	PF00397	0.609
DOC_WW_Pin1_4	367	372	PF00397	0.740
DOC_WW_Pin1_4	391	396	PF00397	0.820
DOC_WW_Pin1_4	418	423	PF00397	0.796
DOC_WW_Pin1_4	442	447	PF00397	0.764
DOC_WW_Pin1_4	497	502	PF00397	0.778
DOC_WW_Pin1_4	7	12	PF00397	0.513
DOC_WW_Pin1_4	75	80	PF00397	0.481
LIG_14-3-3_CanoR_1	159	165	PF00244	0.474
LIG_14-3-3_CanoR_1	290	298	PF00244	0.780
LIG_14-3-3_CanoR_1	49	55	PF00244	0.519
LIG_14-3-3_CanoR_1	524	533	PF00244	0.788
LIG_14-3-3_CanoR_1	60	70	PF00244	0.437
LIG_BIR_II_1	1	5	PF00653	0.538
LIG_BRCT_BRCA1_1	219	223	PF00533	0.799
LIG_BRCT_BRCA1_1	499	503	PF00533	0.787
LIG_FHA_1	159	165	PF00498	0.474
LIG_FHA_1	293	299	PF00498	0.830
LIG_FHA_1	387	393	PF00498	0.800
LIG_FHA_1	426	432	PF00498	0.743
LIG_FHA_1	8	14	PF00498	0.519
LIG_FHA_2	49	55	PF00498	0.519
LIG_LIR_Apic_2	166	171	PF02991	0.764
LIG_LIR_Apic_2	461	467	PF02991	0.792
LIG_LIR_Gen_1	131	139	PF02991	0.388
LIG_LIR_Nem_3	131	135	PF02991	0.404
LIG_LIR_Nem_3	544	550	PF02991	0.717
LIG_MYND_1	467	471	PF01753	0.792
LIG_NRBOX	90	96	PF00104	0.392
LIG_Pex14_1	491	495	PF04695	0.773
LIG_Pex14_1	542	546	PF04695	0.731
LIG_SH2_STAP1	310	314	PF00017	0.701
LIG_SH2_STAT3	305	308	PF00017	0.581
LIG_SH2_STAT3	495	498	PF00017	0.631
LIG_SH2_STAT5	310	313	PF00017	0.698
LIG_SH2_STAT5	442	445	PF00017	0.629
LIG_SH2_STAT5	555	558	PF00017	0.693
LIG_SH2_STAT5	560	563	PF00017	0.661
LIG_SH3_3	167	173	PF00018	0.760
LIG_SH3_3	175	181	PF00018	0.656
LIG_SH3_3	186	192	PF00018	0.480
LIG_SH3_3	193	199	PF00018	0.511
LIG_SH3_3	206	212	PF00018	0.504
LIG_SH3_3	256	262	PF00018	0.848
LIG_SH3_3	266	272	PF00018	0.676
LIG_SH3_3	279	285	PF00018	0.614
LIG_SH3_3	301	307	PF00018	0.684
LIG_SH3_3	321	327	PF00018	0.646
LIG_SH3_3	329	335	PF00018	0.691
LIG_SH3_3	363	369	PF00018	0.808
LIG_SH3_3	447	453	PF00018	0.778
LIG_SH3_3	462	468	PF00018	0.551
LIG_SUMO_SIM_anti_2	115	122	PF11976	0.379
LIG_TRFH_1	442	446	PF08558	0.628
LIG_TRFH_1	495	499	PF08558	0.766
LIG_WRC_WIRS_1	129	134	PF05994	0.384
LIG_WRC_WIRS_1	165	170	PF05994	0.632
LIG_WW_3	365	369	PF00397	0.787
MOD_CDK_SPK_2	247	252	PF00069	0.856
MOD_CK1_1	128	134	PF00069	0.378
MOD_CK1_1	163	169	PF00069	0.501
MOD_CK1_1	247	253	PF00069	0.856
MOD_CK1_1	292	298	PF00069	0.831
MOD_CK1_1	309	315	PF00069	0.559
MOD_CK1_1	316	322	PF00069	0.730
MOD_CK1_1	349	355	PF00069	0.823
MOD_CK1_1	382	388	PF00069	0.707
MOD_CK1_1	418	424	PF00069	0.656
MOD_CK1_1	487	493	PF00069	0.731
MOD_CK1_1	517	523	PF00069	0.633
MOD_CK1_1	61	67	PF00069	0.459
MOD_CK1_1	7	13	PF00069	0.516
MOD_CK2_1	113	119	PF00069	0.400
MOD_CK2_1	145	151	PF00069	0.454
MOD_CK2_1	200	206	PF00069	0.765
MOD_GlcNHglycan	115	118	PF01048	0.384
MOD_GlcNHglycan	132	135	PF01048	0.343
MOD_GlcNHglycan	202	205	PF01048	0.807
MOD_GlcNHglycan	246	249	PF01048	0.843
MOD_GlcNHglycan	311	314	PF01048	0.833
MOD_GlcNHglycan	315	318	PF01048	0.779
MOD_GlcNHglycan	348	351	PF01048	0.829
MOD_GlcNHglycan	362	365	PF01048	0.614
MOD_GlcNHglycan	381	384	PF01048	0.573
MOD_GlcNHglycan	399	402	PF01048	0.532
MOD_GlcNHglycan	417	420	PF01048	0.515
MOD_GlcNHglycan	481	484	PF01048	0.808
MOD_GlcNHglycan	486	489	PF01048	0.723
MOD_GlcNHglycan	516	519	PF01048	0.700
MOD_GlcNHglycan	534	537	PF01048	0.618
MOD_GSK3_1	160	167	PF00069	0.498
MOD_GSK3_1	264	271	PF00069	0.794
MOD_GSK3_1	292	299	PF00069	0.830
MOD_GSK3_1	308	315	PF00069	0.575
MOD_GSK3_1	345	352	PF00069	0.822
MOD_GSK3_1	381	388	PF00069	0.708
MOD_GSK3_1	391	398	PF00069	0.602
MOD_GSK3_1	409	416	PF00069	0.665
MOD_GSK3_1	442	449	PF00069	0.768
MOD_GSK3_1	513	520	PF00069	0.830
MOD_GSK3_1	58	65	PF00069	0.469
MOD_LATS_1	58	64	PF00433	0.473
MOD_N-GLC_1	254	259	PF02516	0.854
MOD_NEK2_1	125	130	PF00069	0.375
MOD_NEK2_1	160	165	PF00069	0.575
MOD_NEK2_1	217	222	PF00069	0.798
MOD_NEK2_1	298	303	PF00069	0.561
MOD_NEK2_1	359	364	PF00069	0.792
MOD_NEK2_1	417	422	PF00069	0.670
MOD_NEK2_1	514	519	PF00069	0.643
MOD_NEK2_1	62	67	PF00069	0.463
MOD_NEK2_1	70	75	PF00069	0.445
MOD_NEK2_1	99	104	PF00069	0.406
MOD_NEK2_2	12	17	PF00069	0.534
MOD_OFUCOSY	136	142	PF10250	0.397
MOD_PIKK_1	395	401	PF00454	0.627
MOD_PIKK_1	41	47	PF00454	0.522
MOD_PIKK_1	48	54	PF00454	0.504
MOD_PKA_1	113	119	PF00069	0.400
MOD_PKA_1	34	40	PF00069	0.513
MOD_PKA_1	41	47	PF00069	0.504
MOD_PKA_2	158	164	PF00069	0.467
MOD_PKA_2	289	295	PF00069	0.833
MOD_PKA_2	34	40	PF00069	0.513
MOD_PKA_2	4	10	PF00069	0.515
MOD_PKA_2	41	47	PF00069	0.504
MOD_PKA_2	48	54	PF00069	0.485
MOD_PKA_2	542	548	PF00069	0.735
MOD_Plk_4	160	166	PF00069	0.478
MOD_Plk_4	446	452	PF00069	0.737
MOD_Plk_4	542	548	PF00069	0.698
MOD_ProDKin_1	195	201	PF00069	0.673
MOD_ProDKin_1	241	247	PF00069	0.811
MOD_ProDKin_1	254	260	PF00069	0.660
MOD_ProDKin_1	268	274	PF00069	0.609
MOD_ProDKin_1	367	373	PF00069	0.740
MOD_ProDKin_1	391	397	PF00069	0.820
MOD_ProDKin_1	418	424	PF00069	0.791
MOD_ProDKin_1	442	448	PF00069	0.766
MOD_ProDKin_1	497	503	PF00069	0.778
MOD_ProDKin_1	7	13	PF00069	0.516
MOD_ProDKin_1	75	81	PF00069	0.478
MOD_SUMO_rev_2	109	116	PF00179	0.434
MOD_SUMO_rev_2	233	242	PF00179	0.783
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.455
TRG_ER_diArg_1	21	24	PF00400	0.485
TRG_ER_diArg_1	32	35	PF00400	0.488
TRG_ER_diArg_1	40	42	PF00400	0.469
TRG_ER_diArg_1	558	560	PF00400	0.711
TRG_NLS_MonoCore_2	475	480	PF00514	0.811
TRG_NLS_MonoExtC_3	476	481	PF00514	0.678
TRG_NLS_MonoExtN_4	473	480	PF00514	0.809

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I8Z0	Leishmania infantum	99%	100%
E9B3V9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q465	Leishmania major	89%	100%