Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ITX1_LEIDO

TriTrypDb:

LdBPK_330910.1 , LdCL_330015200 , LDHU3_33.1440

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ITX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ITX1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.559
CLV_C14_Caspase3-7	366	370	PF00656	0.639
CLV_C14_Caspase3-7	69	73	PF00656	0.702
CLV_MEL_PAP_1	259	265	PF00089	0.537
CLV_NRD_NRD_1	19	21	PF00675	0.448
CLV_NRD_NRD_1	281	283	PF00675	0.556
CLV_NRD_NRD_1	332	334	PF00675	0.697
CLV_NRD_NRD_1	40	42	PF00675	0.455
CLV_NRD_NRD_1	433	435	PF00675	0.413
CLV_NRD_NRD_1	474	476	PF00675	0.399
CLV_PCSK_KEX2_1	119	121	PF00082	0.681
CLV_PCSK_KEX2_1	261	263	PF00082	0.542
CLV_PCSK_KEX2_1	281	283	PF00082	0.349
CLV_PCSK_KEX2_1	326	328	PF00082	0.636
CLV_PCSK_KEX2_1	39	41	PF00082	0.453
CLV_PCSK_KEX2_1	474	476	PF00082	0.399
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.662
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.542
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.611
CLV_PCSK_SKI1_1	206	210	PF00082	0.417
CLV_PCSK_SKI1_1	21	25	PF00082	0.440
CLV_PCSK_SKI1_1	255	259	PF00082	0.565
CLV_PCSK_SKI1_1	334	338	PF00082	0.650
CLV_PCSK_SKI1_1	346	350	PF00082	0.610
CLV_PCSK_SKI1_1	47	51	PF00082	0.524
CLV_PCSK_SKI1_1	59	63	PF00082	0.530
CLV_PCSK_SKI1_1	9	13	PF00082	0.692
DEG_APCC_DBOX_1	205	213	PF00400	0.413
DEG_Nend_UBRbox_2	1	3	PF02207	0.549
DEG_SPOP_SBC_1	157	161	PF00917	0.614
DOC_CKS1_1	97	102	PF01111	0.715
DOC_CYCLIN_RxL_1	203	210	PF00134	0.408
DOC_CYCLIN_RxL_1	474	485	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	442	448	PF00134	0.361
DOC_MAPK_gen_1	434	442	PF00069	0.368
DOC_MAPK_MEF2A_6	226	234	PF00069	0.502
DOC_MAPK_RevD_3	440	454	PF00069	0.361
DOC_PP1_RVXF_1	477	484	PF00149	0.523
DOC_PP2B_LxvP_1	220	223	PF13499	0.400
DOC_PP4_FxxP_1	337	340	PF00568	0.654
DOC_USP7_MATH_1	105	109	PF00917	0.569
DOC_USP7_MATH_1	11	15	PF00917	0.690
DOC_USP7_MATH_1	150	154	PF00917	0.672
DOC_USP7_MATH_1	183	187	PF00917	0.731
DOC_USP7_MATH_1	286	290	PF00917	0.528
DOC_USP7_MATH_1	310	314	PF00917	0.562
DOC_USP7_MATH_1	342	346	PF00917	0.640
DOC_USP7_MATH_1	399	403	PF00917	0.578
DOC_USP7_MATH_1	406	410	PF00917	0.595
DOC_USP7_MATH_1	88	92	PF00917	0.652
DOC_USP7_MATH_1	98	102	PF00917	0.712
DOC_USP7_UBL2_3	322	326	PF12436	0.654
DOC_USP7_UBL2_3	349	353	PF12436	0.601
DOC_USP7_UBL2_3	56	60	PF12436	0.712
DOC_WW_Pin1_4	125	130	PF00397	0.767
DOC_WW_Pin1_4	164	169	PF00397	0.592
DOC_WW_Pin1_4	79	84	PF00397	0.670
DOC_WW_Pin1_4	93	98	PF00397	0.582
LIG_14-3-3_CanoR_1	120	129	PF00244	0.618
LIG_Actin_WH2_2	266	283	PF00022	0.478
LIG_APCC_ABBA_1	232	237	PF00400	0.536
LIG_APCC_ABBAyCdc20_2	479	485	PF00400	0.401
LIG_EH_1	2	6	PF12763	0.560
LIG_FHA_1	167	173	PF00498	0.747
LIG_FHA_1	445	451	PF00498	0.373
LIG_FHA_2	153	159	PF00498	0.749
LIG_FHA_2	213	219	PF00498	0.551
LIG_FHA_2	265	271	PF00498	0.634
LIG_FHA_2	369	375	PF00498	0.640
LIG_LIR_Apic_2	390	396	PF02991	0.574
LIG_LIR_Apic_2	424	430	PF02991	0.479
LIG_LIR_Gen_1	2	12	PF02991	0.643
LIG_LIR_Nem_3	2	8	PF02991	0.553
LIG_LIR_Nem_3	358	364	PF02991	0.713
LIG_MYND_3	429	433	PF01753	0.413
LIG_Rb_pABgroove_1	437	445	PF01858	0.515
LIG_SH2_CRK	245	249	PF00017	0.381
LIG_SH2_CRK	393	397	PF00017	0.690
LIG_SH2_CRK	443	447	PF00017	0.508
LIG_SH2_GRB2like	484	487	PF00017	0.401
LIG_SH2_NCK_1	443	447	PF00017	0.508
LIG_SH2_SRC	385	388	PF00017	0.592
LIG_SH2_SRC	443	446	PF00017	0.507
LIG_SH2_SRC	484	487	PF00017	0.401
LIG_SH2_STAP1	245	249	PF00017	0.381
LIG_SH2_STAT5	252	255	PF00017	0.416
LIG_SH2_STAT5	361	364	PF00017	0.601
LIG_SH3_3	375	381	PF00018	0.709
LIG_SH3_3	94	100	PF00018	0.635
LIG_SH3_5	381	385	PF00018	0.597
LIG_SUMO_SIM_anti_2	447	452	PF11976	0.382
LIG_TRAF2_1	108	111	PF00917	0.765
LIG_TRAF2_1	189	192	PF00917	0.526
LIG_TRAF2_1	35	38	PF00917	0.575
MOD_CDK_SPxxK_3	79	86	PF00069	0.676
MOD_CK1_1	101	107	PF00069	0.740
MOD_CK1_1	125	131	PF00069	0.613
MOD_CK1_1	164	170	PF00069	0.733
MOD_CK1_1	264	270	PF00069	0.550
MOD_CK1_1	402	408	PF00069	0.682
MOD_CK1_1	91	97	PF00069	0.669
MOD_CK2_1	105	111	PF00069	0.735
MOD_CK2_1	120	126	PF00069	0.590
MOD_CK2_1	152	158	PF00069	0.747
MOD_CK2_1	193	199	PF00069	0.545
MOD_CK2_1	264	270	PF00069	0.648
MOD_CK2_1	32	38	PF00069	0.578
MOD_CK2_1	464	470	PF00069	0.545
MOD_Cter_Amidation	259	262	PF01082	0.519
MOD_GlcNHglycan	100	103	PF01048	0.714
MOD_GlcNHglycan	284	287	PF01048	0.633
MOD_GlcNHglycan	288	291	PF01048	0.613
MOD_GlcNHglycan	312	315	PF01048	0.714
MOD_GlcNHglycan	337	340	PF01048	0.644
MOD_GlcNHglycan	415	419	PF01048	0.650
MOD_GlcNHglycan	62	65	PF01048	0.677
MOD_GlcNHglycan	90	93	PF01048	0.750
MOD_GSK3_1	101	108	PF00069	0.749
MOD_GSK3_1	152	159	PF00069	0.686
MOD_GSK3_1	179	186	PF00069	0.660
MOD_GSK3_1	282	289	PF00069	0.543
MOD_GSK3_1	305	312	PF00069	0.756
MOD_GSK3_1	398	405	PF00069	0.619
MOD_GSK3_1	74	81	PF00069	0.716
MOD_GSK3_1	84	91	PF00069	0.583
MOD_NEK2_1	251	256	PF00069	0.439
MOD_PIKK_1	150	156	PF00454	0.696
MOD_PIKK_1	161	167	PF00454	0.654
MOD_PIKK_1	22	28	PF00454	0.552
MOD_PIKK_1	453	459	PF00454	0.415
MOD_PK_1	435	441	PF00069	0.388
MOD_PKA_1	261	267	PF00069	0.549
MOD_PKA_1	453	459	PF00069	0.415
MOD_PKA_1	59	65	PF00069	0.579
MOD_PKA_2	261	267	PF00069	0.549
MOD_PKA_2	399	405	PF00069	0.680
MOD_PKB_1	120	128	PF00069	0.712
MOD_Plk_1	112	118	PF00069	0.703
MOD_Plk_1	157	163	PF00069	0.677
MOD_Plk_1	193	199	PF00069	0.570
MOD_Plk_1	275	281	PF00069	0.525
MOD_Plk_1	368	374	PF00069	0.611
MOD_Plk_1	423	429	PF00069	0.506
MOD_Plk_4	243	249	PF00069	0.407
MOD_Plk_4	264	270	PF00069	0.686
MOD_Plk_4	275	281	PF00069	0.488
MOD_Plk_4	435	441	PF00069	0.388
MOD_ProDKin_1	125	131	PF00069	0.767
MOD_ProDKin_1	164	170	PF00069	0.593
MOD_ProDKin_1	79	85	PF00069	0.672
MOD_ProDKin_1	93	99	PF00069	0.581
MOD_SUMO_for_1	325	328	PF00179	0.696
MOD_SUMO_for_1	362	365	PF00179	0.595
MOD_SUMO_for_1	412	415	PF00179	0.671
MOD_SUMO_rev_2	289	298	PF00179	0.547
MOD_SUMO_rev_2	428	437	PF00179	0.378
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.546
TRG_ENDOCYTIC_2	245	248	PF00928	0.384
TRG_ENDOCYTIC_2	443	446	PF00928	0.507
TRG_ER_diArg_1	280	282	PF00400	0.550
TRG_ER_diArg_1	39	41	PF00400	0.571
TRG_ER_diArg_1	473	475	PF00400	0.402
TRG_NLS_Bipartite_1	40	62	PF00514	0.628
TRG_NLS_MonoExtC_3	118	124	PF00514	0.776
TRG_NLS_MonoExtN_4	56	62	PF00514	0.712
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA2	Leptomonas seymouri	46%	100%
A4HLE1	Leishmania braziliensis	76%	99%
A4I8V0	Leishmania infantum	99%	100%
E9B3R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q4A5	Leishmania major	93%	100%