Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ITW3_LEIDO

TriTrypDb:

LdBPK_330820.1 , LdCL_330013700 , LDHU3_33.1180

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ITW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ITW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.663
CLV_C14_Caspase3-7	284	288	PF00656	0.604
CLV_NRD_NRD_1	178	180	PF00675	0.680
CLV_NRD_NRD_1	233	235	PF00675	0.586
CLV_NRD_NRD_1	291	293	PF00675	0.610
CLV_NRD_NRD_1	316	318	PF00675	0.775
CLV_NRD_NRD_1	371	373	PF00675	0.601
CLV_NRD_NRD_1	66	68	PF00675	0.663
CLV_PCSK_FUR_1	176	180	PF00082	0.675
CLV_PCSK_KEX2_1	178	180	PF00082	0.680
CLV_PCSK_KEX2_1	233	235	PF00082	0.586
CLV_PCSK_KEX2_1	290	292	PF00082	0.588
CLV_PCSK_KEX2_1	316	318	PF00082	0.650
CLV_PCSK_KEX2_1	65	67	PF00082	0.663
CLV_PCSK_SKI1_1	332	336	PF00082	0.442
DEG_Nend_Nbox_1	1	3	PF02207	0.593
DEG_SCF_FBW7_1	210	216	PF00400	0.606
DEG_SCF_FBW7_1	217	224	PF00400	0.620
DEG_SCF_FBW7_1	41	47	PF00400	0.630
DEG_SPOP_SBC_1	320	324	PF00917	0.666
DEG_SPOP_SBC_1	44	48	PF00917	0.654
DOC_CKS1_1	210	215	PF01111	0.656
DOC_CKS1_1	218	223	PF01111	0.510
DOC_CKS1_1	226	231	PF01111	0.590
DOC_CKS1_1	272	277	PF01111	0.565
DOC_CKS1_1	41	46	PF01111	0.629
DOC_MAPK_gen_1	233	240	PF00069	0.553
DOC_PP4_FxxP_1	2	5	PF00568	0.653
DOC_PP4_FxxP_1	202	205	PF00568	0.603
DOC_PP4_FxxP_1	38	41	PF00568	0.740
DOC_USP7_MATH_1	116	120	PF00917	0.641
DOC_USP7_MATH_1	145	149	PF00917	0.701
DOC_USP7_MATH_1	160	164	PF00917	0.578
DOC_USP7_MATH_1	193	197	PF00917	0.697
DOC_USP7_MATH_1	211	215	PF00917	0.649
DOC_USP7_MATH_1	221	225	PF00917	0.693
DOC_USP7_MATH_1	315	319	PF00917	0.791
DOC_USP7_MATH_1	320	324	PF00917	0.749
DOC_USP7_MATH_1	359	363	PF00917	0.459
DOC_USP7_MATH_1	393	397	PF00917	0.636
DOC_USP7_MATH_1	408	412	PF00917	0.725
DOC_USP7_MATH_1	68	72	PF00917	0.673
DOC_USP7_MATH_1	98	102	PF00917	0.629
DOC_WW_Pin1_4	100	105	PF00397	0.710
DOC_WW_Pin1_4	109	114	PF00397	0.626
DOC_WW_Pin1_4	167	172	PF00397	0.753
DOC_WW_Pin1_4	184	189	PF00397	0.516
DOC_WW_Pin1_4	203	208	PF00397	0.772
DOC_WW_Pin1_4	209	214	PF00397	0.626
DOC_WW_Pin1_4	217	222	PF00397	0.628
DOC_WW_Pin1_4	225	230	PF00397	0.629
DOC_WW_Pin1_4	25	30	PF00397	0.700
DOC_WW_Pin1_4	271	276	PF00397	0.580
DOC_WW_Pin1_4	391	396	PF00397	0.587
DOC_WW_Pin1_4	40	45	PF00397	0.664
DOC_WW_Pin1_4	54	59	PF00397	0.542
LIG_14-3-3_CanoR_1	118	122	PF00244	0.653
LIG_14-3-3_CanoR_1	134	140	PF00244	0.639
LIG_14-3-3_CanoR_1	254	260	PF00244	0.614
LIG_14-3-3_CanoR_1	316	320	PF00244	0.643
LIG_14-3-3_CanoR_1	387	395	PF00244	0.592
LIG_14-3-3_CanoR_1	65	74	PF00244	0.642
LIG_FHA_1	1	7	PF00498	0.617
LIG_FHA_1	134	140	PF00498	0.615
LIG_FHA_2	154	160	PF00498	0.662
LIG_FHA_2	256	262	PF00498	0.614
LIG_FHA_2	376	382	PF00498	0.575
LIG_LIR_Apic_2	200	205	PF02991	0.609
LIG_LIR_Apic_2	212	218	PF02991	0.577
LIG_LIR_Apic_2	35	41	PF02991	0.727
LIG_LIR_Gen_1	236	245	PF02991	0.567
LIG_LIR_Nem_3	236	240	PF02991	0.633
LIG_LIR_Nem_3	303	309	PF02991	0.623
LIG_LIR_Nem_3	88	94	PF02991	0.555
LIG_LYPXL_yS_3	91	94	PF13949	0.566
LIG_PCNA_yPIPBox_3	31	42	PF02747	0.614
LIG_SH2_STAT5	280	283	PF00017	0.572
LIG_SH3_3	207	213	PF00018	0.664
LIG_SH3_3	215	221	PF00018	0.613
LIG_SH3_3	269	275	PF00018	0.579
LIG_SH3_3	38	44	PF00018	0.651
LIG_SUMO_SIM_anti_2	135	143	PF11976	0.612
LIG_SUMO_SIM_par_1	77	83	PF11976	0.611
LIG_TRAF2_1	198	201	PF00917	0.747
LIG_TYR_ITIM	89	94	PF00017	0.556
MOD_CDK_SPK_2	217	222	PF00069	0.601
MOD_CK1_1	103	109	PF00069	0.647
MOD_CK1_1	111	117	PF00069	0.640
MOD_CK1_1	130	136	PF00069	0.621
MOD_CK1_1	137	143	PF00069	0.608
MOD_CK1_1	167	173	PF00069	0.621
MOD_CK1_1	17	23	PF00069	0.786
MOD_CK1_1	181	187	PF00069	0.556
MOD_CK1_1	216	222	PF00069	0.677
MOD_CK1_1	255	261	PF00069	0.693
MOD_CK1_1	376	382	PF00069	0.627
MOD_CK1_1	389	395	PF00069	0.551
MOD_CK1_1	403	409	PF00069	0.617
MOD_CK1_1	45	51	PF00069	0.623
MOD_CK1_1	57	63	PF00069	0.684
MOD_CK1_1	80	86	PF00069	0.581
MOD_CK2_1	21	27	PF00069	0.665
MOD_CK2_1	255	261	PF00069	0.661
MOD_CK2_1	270	276	PF00069	0.573
MOD_CK2_1	30	36	PF00069	0.588
MOD_CK2_1	315	321	PF00069	0.749
MOD_Cter_Amidation	231	234	PF01082	0.588
MOD_Cter_Amidation	63	66	PF01082	0.661
MOD_DYRK1A_RPxSP_1	54	58	PF00069	0.633
MOD_GlcNHglycan	107	110	PF01048	0.730
MOD_GlcNHglycan	147	150	PF01048	0.759
MOD_GlcNHglycan	155	159	PF01048	0.721
MOD_GlcNHglycan	16	19	PF01048	0.650
MOD_GlcNHglycan	180	183	PF01048	0.643
MOD_GlcNHglycan	230	233	PF01048	0.714
MOD_GlcNHglycan	248	251	PF01048	0.533
MOD_GlcNHglycan	283	286	PF01048	0.768
MOD_GlcNHglycan	293	297	PF01048	0.634
MOD_GlcNHglycan	302	305	PF01048	0.697
MOD_GlcNHglycan	344	349	PF01048	0.522
MOD_GlcNHglycan	377	381	PF01048	0.594
MOD_GlcNHglycan	388	391	PF01048	0.531
MOD_GlcNHglycan	405	408	PF01048	0.691
MOD_GlcNHglycan	59	62	PF01048	0.656
MOD_GSK3_1	105	112	PF00069	0.665
MOD_GSK3_1	126	133	PF00069	0.772
MOD_GSK3_1	160	167	PF00069	0.548
MOD_GSK3_1	17	24	PF00069	0.739
MOD_GSK3_1	178	185	PF00069	0.751
MOD_GSK3_1	205	212	PF00069	0.662
MOD_GSK3_1	213	220	PF00069	0.738
MOD_GSK3_1	221	228	PF00069	0.579
MOD_GSK3_1	292	299	PF00069	0.672
MOD_GSK3_1	315	322	PF00069	0.631
MOD_GSK3_1	359	366	PF00069	0.445
MOD_GSK3_1	389	396	PF00069	0.604
MOD_GSK3_1	40	47	PF00069	0.595
MOD_GSK3_1	409	416	PF00069	0.481
MOD_NEK2_1	117	122	PF00069	0.592
MOD_NEK2_1	270	275	PF00069	0.668
MOD_NEK2_1	281	286	PF00069	0.544
MOD_NEK2_1	298	303	PF00069	0.638
MOD_NEK2_1	360	365	PF00069	0.456
MOD_PIKK_1	205	211	PF00454	0.566
MOD_PIKK_1	252	258	PF00454	0.663
MOD_PK_1	127	133	PF00069	0.638
MOD_PKA_1	178	184	PF00069	0.680
MOD_PKA_1	291	297	PF00069	0.671
MOD_PKA_1	66	72	PF00069	0.654
MOD_PKA_2	117	123	PF00069	0.667
MOD_PKA_2	126	132	PF00069	0.610
MOD_PKA_2	133	139	PF00069	0.638
MOD_PKA_2	160	166	PF00069	0.620
MOD_PKA_2	178	184	PF00069	0.607
MOD_PKA_2	221	227	PF00069	0.602
MOD_PKA_2	291	297	PF00069	0.657
MOD_PKA_2	315	321	PF00069	0.784
MOD_PKA_2	386	392	PF00069	0.599
MOD_PKA_2	398	404	PF00069	0.616
MOD_PKA_2	408	414	PF00069	0.608
MOD_PKA_2	66	72	PF00069	0.643
MOD_PKB_1	176	184	PF00069	0.625
MOD_PKB_1	290	298	PF00069	0.671
MOD_PKB_1	65	73	PF00069	0.655
MOD_Plk_4	137	143	PF00069	0.744
MOD_Plk_4	363	369	PF00069	0.441
MOD_ProDKin_1	100	106	PF00069	0.708
MOD_ProDKin_1	109	115	PF00069	0.625
MOD_ProDKin_1	167	173	PF00069	0.752
MOD_ProDKin_1	184	190	PF00069	0.517
MOD_ProDKin_1	203	209	PF00069	0.773
MOD_ProDKin_1	217	223	PF00069	0.816
MOD_ProDKin_1	225	231	PF00069	0.628
MOD_ProDKin_1	25	31	PF00069	0.701
MOD_ProDKin_1	271	277	PF00069	0.578
MOD_ProDKin_1	391	397	PF00069	0.587
MOD_ProDKin_1	40	46	PF00069	0.665
MOD_ProDKin_1	54	60	PF00069	0.543
TRG_ENDOCYTIC_2	91	94	PF00928	0.566
TRG_ER_diArg_1	176	179	PF00400	0.674
TRG_ER_diArg_1	290	292	PF00400	0.668
TRG_ER_diArg_1	315	317	PF00400	0.646
TRG_ER_diArg_1	65	67	PF00400	0.663
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.657

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S8	Leptomonas seymouri	41%	98%
A4HLB7	Leishmania braziliensis	65%	96%
E9AEH0	Leishmania major	90%	100%
E9AHN3	Leishmania infantum	100%	100%
E9B3Q9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%