Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ITV4_LEIDO

TriTrypDb:

LdBPK_330620.1 , LdCL_330011700 , LDHU3_33.0900

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8ITV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ITV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.718
CLV_C14_Caspase3-7	173	177	PF00656	0.727
CLV_C14_Caspase3-7	194	198	PF00656	0.761
CLV_C14_Caspase3-7	525	529	PF00656	0.762
CLV_C14_Caspase3-7	531	535	PF00656	0.681
CLV_C14_Caspase3-7	540	544	PF00656	0.573
CLV_C14_Caspase3-7	668	672	PF00656	0.766
CLV_NRD_NRD_1	119	121	PF00675	0.768
CLV_NRD_NRD_1	478	480	PF00675	0.793
CLV_NRD_NRD_1	548	550	PF00675	0.773
CLV_NRD_NRD_1	594	596	PF00675	0.780
CLV_NRD_NRD_1	639	641	PF00675	0.736
CLV_PCSK_FUR_1	478	482	PF00082	0.732
CLV_PCSK_KEX2_1	119	121	PF00082	0.768
CLV_PCSK_KEX2_1	478	480	PF00082	0.717
CLV_PCSK_KEX2_1	556	558	PF00082	0.798
CLV_PCSK_KEX2_1	593	595	PF00082	0.796
CLV_PCSK_KEX2_1	615	617	PF00082	0.739
CLV_PCSK_KEX2_1	639	641	PF00082	0.736
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.730
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.798
CLV_PCSK_PC1ET2_1	593	595	PF00082	0.796
CLV_PCSK_PC1ET2_1	615	617	PF00082	0.739
CLV_PCSK_SKI1_1	182	186	PF00082	0.717
CLV_PCSK_SKI1_1	590	594	PF00082	0.770
CLV_PCSK_SKI1_1	639	643	PF00082	0.735
DEG_APCC_DBOX_1	181	189	PF00400	0.654
DEG_Nend_Nbox_1	1	3	PF02207	0.801
DEG_SCF_FBW7_2	512	519	PF00400	0.771
DEG_SPOP_SBC_1	236	240	PF00917	0.645
DEG_SPOP_SBC_1	606	610	PF00917	0.725
DOC_ANK_TNKS_1	326	333	PF00023	0.650
DOC_CYCLIN_yClb5_NLxxxL_5	486	492	PF00134	0.755
DOC_MAPK_gen_1	613	620	PF00069	0.590
DOC_PP2B_LxvP_1	221	224	PF13499	0.763
DOC_PP2B_LxvP_1	492	495	PF13499	0.761
DOC_PP4_FxxP_1	165	168	PF00568	0.692
DOC_USP7_MATH_1	140	144	PF00917	0.751
DOC_USP7_MATH_1	224	228	PF00917	0.651
DOC_USP7_MATH_1	241	245	PF00917	0.540
DOC_USP7_MATH_1	258	262	PF00917	0.594
DOC_USP7_MATH_1	276	280	PF00917	0.519
DOC_USP7_MATH_1	347	351	PF00917	0.628
DOC_USP7_MATH_1	555	559	PF00917	0.787
DOC_USP7_MATH_1	599	603	PF00917	0.813
DOC_USP7_MATH_1	606	610	PF00917	0.701
DOC_USP7_MATH_1	670	674	PF00917	0.727
DOC_USP7_MATH_1	91	95	PF00917	0.735
DOC_WW_Pin1_4	118	123	PF00397	0.662
DOC_WW_Pin1_4	256	261	PF00397	0.821
DOC_WW_Pin1_4	274	279	PF00397	0.521
DOC_WW_Pin1_4	335	340	PF00397	0.594
DOC_WW_Pin1_4	497	502	PF00397	0.754
DOC_WW_Pin1_4	512	517	PF00397	0.580
DOC_WW_Pin1_4	607	612	PF00397	0.762
DOC_WW_Pin1_4	645	650	PF00397	0.695
DOC_WW_Pin1_4	656	661	PF00397	0.685
LIG_14-3-3_CanoR_1	342	347	PF00244	0.666
LIG_14-3-3_CanoR_1	395	400	PF00244	0.742
LIG_14-3-3_CanoR_1	557	563	PF00244	0.746
LIG_14-3-3_CanoR_1	582	588	PF00244	0.650
LIG_14-3-3_CanoR_1	607	611	PF00244	0.794
LIG_14-3-3_CanoR_1	619	626	PF00244	0.593
LIG_Actin_WH2_2	625	641	PF00022	0.739
LIG_BIR_III_2	543	547	PF00653	0.630
LIG_BIR_III_4	534	538	PF00653	0.759
LIG_Clathr_ClatBox_1	280	284	PF01394	0.828
LIG_deltaCOP1_diTrp_1	382	392	PF00928	0.825
LIG_FHA_1	111	117	PF00498	0.710
LIG_FHA_1	237	243	PF00498	0.607
LIG_FHA_1	440	446	PF00498	0.837
LIG_FHA_1	506	512	PF00498	0.782
LIG_FHA_1	583	589	PF00498	0.651
LIG_FHA_1	612	618	PF00498	0.787
LIG_FHA_1	646	652	PF00498	0.671
LIG_FHA_2	102	108	PF00498	0.649
LIG_FHA_2	458	464	PF00498	0.756
LIG_FHA_2	513	519	PF00498	0.769
LIG_FHA_2	573	579	PF00498	0.737
LIG_FHA_2	582	588	PF00498	0.720
LIG_FHA_2	599	605	PF00498	0.634
LIG_LIR_Apic_2	164	168	PF02991	0.693
LIG_MYND_1	278	282	PF01753	0.665
LIG_MYND_1	501	505	PF01753	0.616
LIG_PCNA_yPIPBox_3	615	629	PF02747	0.759
LIG_PDZ_Class_3	672	677	PF00595	0.643
LIG_Pex14_2	161	165	PF04695	0.690
LIG_SH2_CRK	141	145	PF00017	0.755
LIG_SH2_NCK_1	105	109	PF00017	0.653
LIG_SH2_NCK_1	532	536	PF00017	0.793
LIG_SH2_SRC	105	108	PF00017	0.734
LIG_SH2_SRC	532	535	PF00017	0.755
LIG_SH2_STAP1	301	305	PF00017	0.759
LIG_SH2_STAP1	532	536	PF00017	0.716
LIG_SH2_STAT5	141	144	PF00017	0.758
LIG_SH2_STAT5	301	304	PF00017	0.684
LIG_SH3_1	333	339	PF00018	0.581
LIG_SH3_3	217	223	PF00018	0.736
LIG_SH3_3	333	339	PF00018	0.581
LIG_SH3_3	435	441	PF00018	0.754
LIG_SH3_3	654	660	PF00018	0.740
LIG_TRAF2_1	326	329	PF00917	0.697
LIG_TRAF2_1	409	412	PF00917	0.764
LIG_TRAF2_1	621	624	PF00917	0.736
LIG_TRFH_1	219	223	PF08558	0.681
MOD_CDC14_SPxK_1	121	124	PF00782	0.696
MOD_CDK_SPxK_1	118	124	PF00069	0.671
MOD_CDK_SPxK_1	607	613	PF00069	0.626
MOD_CDK_SPxxK_3	335	342	PF00069	0.602
MOD_CK1_1	235	241	PF00069	0.804
MOD_CK1_1	244	250	PF00069	0.687
MOD_CK1_1	261	267	PF00069	0.568
MOD_CK1_1	349	355	PF00069	0.768
MOD_CK1_1	387	393	PF00069	0.835
MOD_CK1_1	394	400	PF00069	0.725
MOD_CK1_1	493	499	PF00069	0.745
MOD_CK1_1	506	512	PF00069	0.674
MOD_CK1_1	524	530	PF00069	0.579
MOD_CK1_1	558	564	PF00069	0.836
MOD_CK1_1	85	91	PF00069	0.803
MOD_CK1_1	99	105	PF00069	0.598
MOD_CK2_1	301	307	PF00069	0.750
MOD_CK2_1	323	329	PF00069	0.777
MOD_CK2_1	393	399	PF00069	0.847
MOD_CK2_1	572	578	PF00069	0.744
MOD_CK2_1	581	587	PF00069	0.721
MOD_CK2_1	598	604	PF00069	0.631
MOD_CK2_1	618	624	PF00069	0.427
MOD_Cter_Amidation	547	550	PF01082	0.774
MOD_GlcNHglycan	202	205	PF01048	0.665
MOD_GlcNHglycan	234	237	PF01048	0.639
MOD_GlcNHglycan	239	242	PF01048	0.635
MOD_GlcNHglycan	24	27	PF01048	0.782
MOD_GlcNHglycan	246	249	PF01048	0.646
MOD_GlcNHglycan	260	263	PF01048	0.632
MOD_GlcNHglycan	30	33	PF01048	0.720
MOD_GlcNHglycan	303	306	PF01048	0.743
MOD_GlcNHglycan	344	347	PF01048	0.819
MOD_GlcNHglycan	349	352	PF01048	0.781
MOD_GlcNHglycan	369	372	PF01048	0.647
MOD_GlcNHglycan	389	392	PF01048	0.505
MOD_GlcNHglycan	524	527	PF01048	0.793
MOD_GlcNHglycan	564	567	PF01048	0.827
MOD_GlcNHglycan	575	578	PF01048	0.682
MOD_GSK3_1	140	147	PF00069	0.825
MOD_GSK3_1	232	239	PF00069	0.790
MOD_GSK3_1	24	31	PF00069	0.757
MOD_GSK3_1	342	349	PF00069	0.746
MOD_GSK3_1	386	393	PF00069	0.835
MOD_GSK3_1	395	402	PF00069	0.693
MOD_GSK3_1	451	458	PF00069	0.761
MOD_GSK3_1	493	500	PF00069	0.783
MOD_GSK3_1	503	510	PF00069	0.703
MOD_GSK3_1	520	527	PF00069	0.562
MOD_GSK3_1	558	565	PF00069	0.825
MOD_GSK3_1	607	614	PF00069	0.794
MOD_GSK3_1	81	88	PF00069	0.793
MOD_GSK3_1	92	99	PF00069	0.595
MOD_N-GLC_1	28	33	PF02516	0.733
MOD_N-GLC_1	512	517	PF02516	0.769
MOD_NEK2_1	21	26	PF00069	0.773
MOD_NEK2_1	232	237	PF00069	0.671
MOD_NEK2_1	311	316	PF00069	0.766
MOD_NEK2_1	507	512	PF00069	0.775
MOD_NEK2_1	522	527	PF00069	0.595
MOD_NEK2_1	562	567	PF00069	0.755
MOD_NEK2_1	75	80	PF00069	0.804
MOD_PIKK_1	411	417	PF00454	0.700
MOD_PIKK_1	618	624	PF00454	0.757
MOD_PK_1	222	228	PF00069	0.793
MOD_PKA_2	170	176	PF00069	0.660
MOD_PKA_2	341	347	PF00069	0.627
MOD_PKA_2	394	400	PF00069	0.743
MOD_PKA_2	558	564	PF00069	0.836
MOD_PKA_2	581	587	PF00069	0.651
MOD_PKA_2	606	612	PF00069	0.791
MOD_PKA_2	618	624	PF00069	0.606
MOD_PKA_2	632	638	PF00069	0.539
MOD_Plk_2-3	665	671	PF00069	0.854
MOD_Plk_4	266	272	PF00069	0.825
MOD_Plk_4	276	282	PF00069	0.656
MOD_Plk_4	457	463	PF00069	0.621
MOD_Plk_4	46	52	PF00069	0.779
MOD_Plk_4	507	513	PF00069	0.794
MOD_ProDKin_1	118	124	PF00069	0.671
MOD_ProDKin_1	256	262	PF00069	0.821
MOD_ProDKin_1	274	280	PF00069	0.521
MOD_ProDKin_1	335	341	PF00069	0.599
MOD_ProDKin_1	497	503	PF00069	0.755
MOD_ProDKin_1	512	518	PF00069	0.581
MOD_ProDKin_1	607	613	PF00069	0.762
MOD_ProDKin_1	645	651	PF00069	0.701
MOD_ProDKin_1	656	662	PF00069	0.687
MOD_SUMO_for_1	409	412	PF00179	0.764
MOD_SUMO_rev_2	131	140	PF00179	0.750
MOD_SUMO_rev_2	659	668	PF00179	0.777
TRG_DiLeu_BaEn_1	307	312	PF01217	0.752
TRG_DiLeu_BaEn_3	623	629	PF01217	0.732
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.618
TRG_ENDOCYTIC_2	141	144	PF00928	0.758
TRG_ER_diArg_1	118	120	PF00400	0.754
TRG_ER_diArg_1	477	479	PF00400	0.708
TRG_ER_diArg_1	481	484	PF00400	0.704
TRG_ER_diArg_1	638	640	PF00400	0.737
TRG_NES_CRM1_1	623	636	PF08389	0.735
TRG_NLS_MonoExtC_3	478	483	PF00514	0.813
TRG_NLS_MonoExtN_4	478	484	PF00514	0.815
TRG_NLS_MonoExtN_4	590	597	PF00514	0.772
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.795

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HL97	Leishmania braziliensis	69%	100%
A4I8S3	Leishmania infantum	100%	100%
E9B3N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q4E8	Leishmania major	89%	100%