Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8ITR9_LEIDO

TriTrypDb:

LdBPK_324100.1 , LdCL_320047000 , LDHU3_32.5270

Length:

994

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8ITR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8ITR9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0031123	RNA 3'-end processing	7	11
GO:0031124	mRNA 3'-end processing	8	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.546
CLV_NRD_NRD_1	315	317	PF00675	0.511
CLV_NRD_NRD_1	345	347	PF00675	0.394
CLV_NRD_NRD_1	348	350	PF00675	0.365
CLV_NRD_NRD_1	472	474	PF00675	0.477
CLV_NRD_NRD_1	51	53	PF00675	0.445
CLV_NRD_NRD_1	542	544	PF00675	0.539
CLV_NRD_NRD_1	644	646	PF00675	0.368
CLV_NRD_NRD_1	881	883	PF00675	0.748
CLV_NRD_NRD_1	9	11	PF00675	0.602
CLV_PCSK_FUR_1	470	474	PF00082	0.377
CLV_PCSK_KEX2_1	130	132	PF00082	0.504
CLV_PCSK_KEX2_1	190	192	PF00082	0.536
CLV_PCSK_KEX2_1	315	317	PF00082	0.511
CLV_PCSK_KEX2_1	344	346	PF00082	0.400
CLV_PCSK_KEX2_1	350	352	PF00082	0.370
CLV_PCSK_KEX2_1	393	395	PF00082	0.562
CLV_PCSK_KEX2_1	472	474	PF00082	0.477
CLV_PCSK_KEX2_1	51	53	PF00082	0.420
CLV_PCSK_KEX2_1	542	544	PF00082	0.539
CLV_PCSK_KEX2_1	881	883	PF00082	0.730
CLV_PCSK_KEX2_1	9	11	PF00082	0.602
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.555
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.477
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.557
CLV_PCSK_PC7_1	311	317	PF00082	0.486
CLV_PCSK_PC7_1	340	346	PF00082	0.535
CLV_PCSK_SKI1_1	111	115	PF00082	0.575
CLV_PCSK_SKI1_1	12	16	PF00082	0.501
CLV_PCSK_SKI1_1	435	439	PF00082	0.477
CLV_PCSK_SKI1_1	473	477	PF00082	0.522
CLV_PCSK_SKI1_1	567	571	PF00082	0.368
CLV_PCSK_SKI1_1	645	649	PF00082	0.433
CLV_PCSK_SKI1_1	682	686	PF00082	0.512
CLV_PCSK_SKI1_1	696	700	PF00082	0.347
CLV_PCSK_SKI1_1	767	771	PF00082	0.509
CLV_PCSK_SKI1_1	788	792	PF00082	0.589
CLV_PCSK_SKI1_1	811	815	PF00082	0.722
CLV_PCSK_SKI1_1	943	947	PF00082	0.682
DEG_APCC_DBOX_1	681	689	PF00400	0.469
DEG_MDM2_SWIB_1	666	673	PF02201	0.337
DEG_SCF_FBW7_1	18	25	PF00400	0.510
DOC_CKS1_1	19	24	PF01111	0.678
DOC_CKS1_1	653	658	PF01111	0.487
DOC_CYCLIN_RxL_1	274	284	PF00134	0.352
DOC_CYCLIN_RxL_1	642	650	PF00134	0.523
DOC_CYCLIN_RxL_1	805	819	PF00134	0.685
DOC_CYCLIN_yClb5_NLxxxL_5	540	549	PF00134	0.319
DOC_CYCLIN_yCln2_LP_2	433	439	PF00134	0.417
DOC_MAPK_DCC_7	355	364	PF00069	0.453
DOC_MAPK_FxFP_2	411	414	PF00069	0.523
DOC_MAPK_gen_1	542	549	PF00069	0.356
DOC_MAPK_gen_1	567	576	PF00069	0.469
DOC_MAPK_gen_1	679	688	PF00069	0.493
DOC_MAPK_MEF2A_6	355	364	PF00069	0.477
DOC_MAPK_MEF2A_6	542	551	PF00069	0.480
DOC_MIT_MIM_1	5	14	PF04212	0.606
DOC_PIKK_1	710	717	PF02985	0.505
DOC_PP2B_LxvP_1	176	179	PF13499	0.525
DOC_PP2B_LxvP_1	357	360	PF13499	0.445
DOC_PP2B_LxvP_1	789	792	PF13499	0.664
DOC_PP4_FxxP_1	411	414	PF00568	0.523
DOC_PP4_FxxP_1	659	662	PF00568	0.453
DOC_PP4_FxxP_1	768	771	PF00568	0.580
DOC_PP4_FxxP_1	804	807	PF00568	0.684
DOC_USP7_MATH_1	181	185	PF00917	0.417
DOC_USP7_MATH_1	254	258	PF00917	0.523
DOC_USP7_MATH_1	419	423	PF00917	0.598
DOC_USP7_MATH_1	442	446	PF00917	0.629
DOC_USP7_MATH_1	728	732	PF00917	0.538
DOC_USP7_MATH_1	884	888	PF00917	0.711
DOC_USP7_MATH_1	906	910	PF00917	0.755
DOC_USP7_MATH_1	912	916	PF00917	0.604
DOC_USP7_UBL2_3	943	947	PF12436	0.682
DOC_WW_Pin1_4	18	23	PF00397	0.676
DOC_WW_Pin1_4	24	29	PF00397	0.604
DOC_WW_Pin1_4	652	657	PF00397	0.420
DOC_WW_Pin1_4	820	825	PF00397	0.761
DOC_WW_Pin1_4	843	848	PF00397	0.736
LIG_14-3-3_CanoR_1	270	276	PF00244	0.430
LIG_14-3-3_CanoR_1	335	340	PF00244	0.530
LIG_14-3-3_CanoR_1	435	440	PF00244	0.519
LIG_14-3-3_CanoR_1	490	496	PF00244	0.375
LIG_14-3-3_CanoR_1	526	531	PF00244	0.484
LIG_14-3-3_CanoR_1	679	688	PF00244	0.493
LIG_14-3-3_CanoR_1	867	872	PF00244	0.677
LIG_14-3-3_CanoR_1	9	15	PF00244	0.612
LIG_Actin_WH2_2	634	651	PF00022	0.474
LIG_Actin_WH2_2	681	698	PF00022	0.421
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BRCT_BRCA1_1	288	292	PF00533	0.409
LIG_BRCT_BRCA1_1	335	339	PF00533	0.487
LIG_BRCT_BRCA1_1	753	757	PF00533	0.510
LIG_Clathr_ClatBox_1	361	365	PF01394	0.489
LIG_deltaCOP1_diTrp_1	459	464	PF00928	0.369
LIG_deltaCOP1_diTrp_1	981	984	PF00928	0.490
LIG_FHA_1	105	111	PF00498	0.418
LIG_FHA_1	123	129	PF00498	0.352
LIG_FHA_1	13	19	PF00498	0.629
LIG_FHA_1	180	186	PF00498	0.489
LIG_FHA_1	187	193	PF00498	0.416
LIG_FHA_1	259	265	PF00498	0.447
LIG_FHA_1	428	434	PF00498	0.452
LIG_FHA_1	441	447	PF00498	0.483
LIG_FHA_1	778	784	PF00498	0.616
LIG_FHA_1	785	791	PF00498	0.524
LIG_FHA_1	820	826	PF00498	0.764
LIG_FHA_1	91	97	PF00498	0.480
LIG_FHA_1	978	984	PF00498	0.560
LIG_FHA_2	153	159	PF00498	0.426
LIG_FHA_2	248	254	PF00498	0.469
LIG_FHA_2	737	743	PF00498	0.510
LIG_FHA_2	771	777	PF00498	0.703
LIG_FHA_2	830	836	PF00498	0.656
LIG_FHA_2	920	926	PF00498	0.640
LIG_FHA_2	936	942	PF00498	0.595
LIG_LIR_Apic_2	145	150	PF02991	0.500
LIG_LIR_Apic_2	297	301	PF02991	0.361
LIG_LIR_Apic_2	801	807	PF02991	0.682
LIG_LIR_Gen_1	196	205	PF02991	0.359
LIG_LIR_Gen_1	286	296	PF02991	0.437
LIG_LIR_Gen_1	369	379	PF02991	0.384
LIG_LIR_Gen_1	462	471	PF02991	0.440
LIG_LIR_Gen_1	505	515	PF02991	0.373
LIG_LIR_Gen_1	525	534	PF02991	0.228
LIG_LIR_Gen_1	635	644	PF02991	0.393
LIG_LIR_Gen_1	979	988	PF02991	0.636
LIG_LIR_Nem_3	126	132	PF02991	0.464
LIG_LIR_Nem_3	199	205	PF02991	0.350
LIG_LIR_Nem_3	274	279	PF02991	0.371
LIG_LIR_Nem_3	286	291	PF02991	0.312
LIG_LIR_Nem_3	325	331	PF02991	0.348
LIG_LIR_Nem_3	369	374	PF02991	0.372
LIG_LIR_Nem_3	462	467	PF02991	0.409
LIG_LIR_Nem_3	505	510	PF02991	0.372
LIG_LIR_Nem_3	525	530	PF02991	0.241
LIG_LIR_Nem_3	563	569	PF02991	0.510
LIG_LIR_Nem_3	635	639	PF02991	0.400
LIG_LIR_Nem_3	93	97	PF02991	0.565
LIG_LIR_Nem_3	979	985	PF02991	0.605
LIG_MLH1_MIPbox_1	288	292	PF16413	0.409
LIG_MYND_1	658	662	PF01753	0.413
LIG_NRBOX	643	649	PF00104	0.480
LIG_PCNA_PIPBox_1	493	502	PF02747	0.367
LIG_Pex14_1	579	583	PF04695	0.474
LIG_Pex14_2	659	663	PF04695	0.372
LIG_Pex14_2	666	670	PF04695	0.298
LIG_PTB_Apo_2	156	163	PF02174	0.327
LIG_PTB_Apo_2	270	277	PF02174	0.322
LIG_PTB_Phospho_1	270	276	PF10480	0.446
LIG_SH2_CRK	226	230	PF00017	0.462
LIG_SH2_CRK	353	357	PF00017	0.383
LIG_SH2_CRK	799	803	PF00017	0.690
LIG_SH2_GRB2like	193	196	PF00017	0.475
LIG_SH2_GRB2like	331	334	PF00017	0.463
LIG_SH2_NCK_1	799	803	PF00017	0.690
LIG_SH2_PTP2	238	241	PF00017	0.435
LIG_SH2_PTP2	298	301	PF00017	0.396
LIG_SH2_SRC	732	735	PF00017	0.356
LIG_SH2_STAP1	288	292	PF00017	0.409
LIG_SH2_STAP1	371	375	PF00017	0.365
LIG_SH2_STAP1	429	433	PF00017	0.476
LIG_SH2_STAP1	732	736	PF00017	0.347
LIG_SH2_STAT5	17	20	PF00017	0.677
LIG_SH2_STAT5	193	196	PF00017	0.495
LIG_SH2_STAT5	238	241	PF00017	0.304
LIG_SH2_STAT5	298	301	PF00017	0.374
LIG_SH2_STAT5	331	334	PF00017	0.404
LIG_SH2_STAT5	410	413	PF00017	0.528
LIG_SH2_STAT5	429	432	PF00017	0.275
LIG_SH2_STAT5	583	586	PF00017	0.382
LIG_SH3_1	844	850	PF00018	0.803
LIG_SH3_1	898	904	PF00018	0.738
LIG_SH3_3	16	22	PF00018	0.631
LIG_SH3_3	422	428	PF00018	0.529
LIG_SH3_3	436	442	PF00018	0.623
LIG_SH3_3	468	474	PF00018	0.524
LIG_SH3_3	75	81	PF00018	0.406
LIG_SH3_3	806	812	PF00018	0.681
LIG_SH3_3	837	843	PF00018	0.770
LIG_SH3_3	844	850	PF00018	0.778
LIG_SH3_3	898	904	PF00018	0.732
LIG_SH3_3	915	921	PF00018	0.592
LIG_SUMO_SIM_anti_2	305	310	PF11976	0.479
LIG_SUMO_SIM_anti_2	40	47	PF11976	0.476
LIG_SUMO_SIM_anti_2	683	689	PF11976	0.413
LIG_SUMO_SIM_anti_2	780	787	PF11976	0.579
LIG_SUMO_SIM_anti_2	909	916	PF11976	0.672
LIG_SUMO_SIM_par_1	152	158	PF11976	0.385
LIG_SUMO_SIM_par_1	435	440	PF11976	0.536
LIG_TRAF2_1	101	104	PF00917	0.428
LIG_TRAF2_1	586	589	PF00917	0.573
LIG_TRAF2_1	592	595	PF00917	0.462
LIG_TRAF2_1	708	711	PF00917	0.508
LIG_UBA3_1	70	79	PF00899	0.497
LIG_UBA3_1	783	788	PF00899	0.480
LIG_WRC_WIRS_1	194	199	PF05994	0.321
LIG_WRC_WIRS_1	272	277	PF05994	0.433
LIG_WRC_WIRS_1	291	296	PF05994	0.344
MOD_CK1_1	451	457	PF00069	0.544
MOD_CK1_1	462	468	PF00069	0.333
MOD_CK1_1	701	707	PF00069	0.581
MOD_CK2_1	152	158	PF00069	0.421
MOD_CK2_1	247	253	PF00069	0.464
MOD_CK2_1	444	450	PF00069	0.519
MOD_CK2_1	451	457	PF00069	0.408
MOD_CK2_1	519	525	PF00069	0.439
MOD_CK2_1	583	589	PF00069	0.564
MOD_CK2_1	59	65	PF00069	0.393
MOD_CK2_1	705	711	PF00069	0.521
MOD_CK2_1	728	734	PF00069	0.533
MOD_CK2_1	770	776	PF00069	0.684
MOD_CK2_1	829	835	PF00069	0.786
MOD_CK2_1	926	932	PF00069	0.595
MOD_CK2_1	935	941	PF00069	0.652
MOD_CK2_1	960	966	PF00069	0.537
MOD_CMANNOS	461	464	PF00535	0.365
MOD_GlcNHglycan	144	147	PF01048	0.578
MOD_GlcNHglycan	214	217	PF01048	0.430
MOD_GlcNHglycan	302	305	PF01048	0.506
MOD_GlcNHglycan	335	338	PF01048	0.460
MOD_GlcNHglycan	421	424	PF01048	0.566
MOD_GlcNHglycan	649	652	PF01048	0.533
MOD_GlcNHglycan	682	685	PF01048	0.467
MOD_GlcNHglycan	700	703	PF01048	0.321
MOD_GlcNHglycan	862	865	PF01048	0.667
MOD_GlcNHglycan	869	872	PF01048	0.616
MOD_GSK3_1	18	25	PF00069	0.590
MOD_GSK3_1	208	215	PF00069	0.434
MOD_GSK3_1	254	261	PF00069	0.384
MOD_GSK3_1	286	293	PF00069	0.328
MOD_GSK3_1	440	447	PF00069	0.591
MOD_GSK3_1	459	466	PF00069	0.448
MOD_GSK3_1	579	586	PF00069	0.497
MOD_GSK3_1	701	708	PF00069	0.538
MOD_GSK3_1	724	731	PF00069	0.499
MOD_GSK3_1	855	862	PF00069	0.666
MOD_GSK3_1	902	909	PF00069	0.712
MOD_N-GLC_1	179	184	PF02516	0.524
MOD_N-GLC_1	778	783	PF02516	0.432
MOD_N-GLC_1	867	872	PF02516	0.689
MOD_N-GLC_2	544	546	PF02516	0.450
MOD_N-GLC_2	678	680	PF02516	0.338
MOD_NEK2_1	186	191	PF00069	0.567
MOD_NEK2_1	271	276	PF00069	0.512
MOD_NEK2_1	290	295	PF00069	0.330
MOD_NEK2_1	309	314	PF00069	0.242
MOD_NEK2_1	448	453	PF00069	0.586
MOD_NEK2_1	46	51	PF00069	0.487
MOD_NEK2_1	463	468	PF00069	0.319
MOD_NEK2_1	484	489	PF00069	0.451
MOD_NEK2_1	59	64	PF00069	0.468
MOD_NEK2_1	637	642	PF00069	0.473
MOD_NEK2_1	647	652	PF00069	0.521
MOD_NEK2_1	784	789	PF00069	0.488
MOD_NEK2_1	826	831	PF00069	0.790
MOD_NEK2_1	859	864	PF00069	0.690
MOD_NEK2_2	444	449	PF00069	0.484
MOD_NEK2_2	926	931	PF00069	0.656
MOD_PIKK_1	751	757	PF00454	0.625
MOD_PIKK_1	829	835	PF00454	0.764
MOD_PK_1	355	361	PF00069	0.326
MOD_PKA_2	866	872	PF00069	0.722
MOD_PKB_1	10	18	PF00069	0.509
MOD_Plk_1	39	45	PF00069	0.422
MOD_Plk_1	403	409	PF00069	0.494
MOD_Plk_1	855	861	PF00069	0.718
MOD_Plk_1	935	941	PF00069	0.754
MOD_Plk_2-3	302	308	PF00069	0.391
MOD_Plk_4	152	158	PF00069	0.457
MOD_Plk_4	181	187	PF00069	0.417
MOD_Plk_4	271	277	PF00069	0.435
MOD_Plk_4	286	292	PF00069	0.378
MOD_Plk_4	39	45	PF00069	0.485
MOD_Plk_4	427	433	PF00069	0.510
MOD_Plk_4	448	454	PF00069	0.554
MOD_Plk_4	463	469	PF00069	0.276
MOD_Plk_4	491	497	PF00069	0.355
MOD_Plk_4	502	508	PF00069	0.314
MOD_Plk_4	579	585	PF00069	0.490
MOD_Plk_4	855	861	PF00069	0.676
MOD_Plk_4	919	925	PF00069	0.598
MOD_Plk_4	960	966	PF00069	0.628
MOD_ProDKin_1	18	24	PF00069	0.676
MOD_ProDKin_1	652	658	PF00069	0.422
MOD_ProDKin_1	820	826	PF00069	0.763
MOD_ProDKin_1	843	849	PF00069	0.736
MOD_SUMO_for_1	367	370	PF00179	0.392
MOD_SUMO_for_1	398	401	PF00179	0.500
MOD_SUMO_rev_2	257	264	PF00179	0.377
MOD_SUMO_rev_2	936	945	PF00179	0.627
TRG_DiLeu_BaEn_1	3	8	PF01217	0.580
TRG_DiLeu_BaEn_1	40	45	PF01217	0.418
TRG_DiLeu_BaEn_2	369	375	PF01217	0.496
TRG_DiLeu_BaEn_3	40	46	PF01217	0.412
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.432
TRG_DiLeu_BaLyEn_6	516	521	PF01217	0.468
TRG_DiLeu_BaLyEn_6	809	814	PF01217	0.607
TRG_DiLeu_BaLyEn_6	821	826	PF01217	0.543
TRG_ENDOCYTIC_2	238	241	PF00928	0.448
TRG_ENDOCYTIC_2	276	279	PF00928	0.361
TRG_ENDOCYTIC_2	288	291	PF00928	0.463
TRG_ENDOCYTIC_2	353	356	PF00928	0.346
TRG_ENDOCYTIC_2	371	374	PF00928	0.392
TRG_ENDOCYTIC_2	610	613	PF00928	0.550
TRG_ENDOCYTIC_2	799	802	PF00928	0.687
TRG_ER_diArg_1	129	131	PF00400	0.545
TRG_ER_diArg_1	314	316	PF00400	0.506
TRG_ER_diArg_1	343	346	PF00400	0.449
TRG_ER_diArg_1	348	351	PF00400	0.416
TRG_ER_diArg_1	379	382	PF00400	0.454
TRG_ER_diArg_1	470	473	PF00400	0.432
TRG_ER_diArg_1	50	52	PF00400	0.445
TRG_ER_diArg_1	676	679	PF00400	0.533
TRG_ER_diArg_1	764	767	PF00400	0.524
TRG_ER_diArg_1	8	10	PF00400	0.508
TRG_ER_diArg_1	874	877	PF00400	0.751
TRG_NLS_MonoExtC_3	247	253	PF00514	0.512
TRG_NLS_MonoExtN_4	346	353	PF00514	0.474
TRG_Pf-PMV_PEXEL_1	435	440	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTN3	Leptomonas seymouri	62%	99%
A0A1X0NSF8	Trypanosomatidae	33%	100%
A0A422NHV7	Trypanosoma rangeli	36%	100%
A4HL32	Leishmania braziliensis	83%	100%
A4I8L3	Leishmania infantum	99%	100%
D0AAK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B3H3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q4M7	Leishmania major	92%	100%
V5AXZ4	Trypanosoma cruzi	36%	100%